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The map label for this gene is metC [H]

Identifier: 150396328

GI number: 150396328

Start: 1179427

End: 1180836

Strand: Direct

Name: metC [H]

Synonym: Smed_1109

Alternate gene names: 150396328

Gene position: 1179427-1180836 (Clockwise)

Preceding gene: 150396323

Following gene: 150396331

Centisome position: 31.19

GC content: 61.06

Gene sequence:

>1410_bases
ATGGAAGGGTCAAGAGAGGTCTCCGAATTTACGAATTTCGATGTGAAAAACGTGAAACTCGCCAGAAGTTTAGGCGGTTT
GGCGCTGGAATTGCCGGTCATGAACAAAAAACCGCCAGTTGGCCTCCTTCCGGACCACGAGGCTCGCCACTTGAATTTTT
CCTTGACCCGGCCGGTATCCCGTCCGATGAGTCGGCAGCGGAATTCAACAGCGGATGTTTCAATGGCAGACAAGACGAAC
GCGCGAGCGGAGCAGGGCATCAATACCCGTCTCGCACACACCGGCAATAACCCTTCCGACTATCACGGCTTCGTCAATCC
ACCGGTGGTACACGCTTCCACCGTGCTCTTCCCGAATGCGAGGACGATGGAGACGCGGTCTCAGAAATATACCTATGGCA
CGCGCGGCACGCCGACCACCGACGCGCTTTGTGAGGCGATCAACGAACTGGAGGGCGCGGCCGGGACGATCCTCGTTCCC
TCGGGCCTCGCAGCGGTCACTGTGCCTTTCCTCGCCTATCTCTCCTCGGGCGACCATGTCCTTATCGTCGATTCGGTCTA
TTTTCCCACCCGCCACTTCTGCGACACTATGCTCACAAGGCTCGGCGTTACCGTTGAATATTATGACCCGTCCATCGGGG
CGGGCATAGAGAATCTGATCAGGCCGAACACGCGGCTGGTGCATACCGAAGCGCCGGGCTCGAATACGTTCGAGATGCAG
GATATACCGGCGATTGCCGCCGCCGCGCACCGGCATGGCTGCATCGTGACCATGGACAACACCTGGGCGACGCCCGTCTA
TTTCCGGCCGCTCGATTACGGCGTCGACGTTTCGATCCACGCGGCGACCAAATATCCCTCGGGTCACTCGGACGTTCTGC
TTGGAACCGTATCGGCCAACGCGGCCCATTGGCCGGCACTGAGCGAGGCGATGGTGACACTGGGTGTCTGCGTTTCGCCG
GACGACAGCTATCAGATCCTGCGCGGCCTGCGCACAATGGGCGTCCGCCTGGAGCGACACCAGGCAAGCGCGCTTGCGAT
TGCCGAATGGCTCGAGGGCCGCGAGGAGGTGGCGCGGGTGCTTCATCCGGCACTGCCGAGCTTTCCGGGCCATGAGTTGT
GGAAGCGCGATTTCGGCGGCGCAAGCGGAATATTCTCCTTCGTGCTCAAGGCCGATCCCGAAAACGGCAAGGCAAAGGCG
CATGCCTTCCTGGACGCGCTCTCGATCTTCGGACTCGGCTACTCCTGGGGCGGATTCGAGAGCCTCGCCGTTCACGTGAA
CCTCTCCGATCGCAAGGTCGCCAAGGCGCCTCAGGAGGGGCCGGTCATCCGGCTGCAGATCGGGCTCGAAGACGTGCCGG
ACATCCGCCGGGATGTTGAAGCCGGTCTCGCTGCCGCAAATGCGCTCTGA

Upstream 100 bases:

>100_bases
TTCGGTTGTCGTTTGGTCCCGTCTGCACAGTCGCGCGTTTTCGCGCGTGCAGCCTCAGCCACCCTCCTGGCGTGAGTACA
ATCTATCTCATGCTCAAAAC

Downstream 100 bases:

>100_bases
CGCCGAATGACGCGGTGGGGAAGGCGATGAGGCGCCTCCCCATCACTTTTGCGCGCCATAGCCGAAAAGCCAGTCGAAAT
CCGCGGCAAGTGCTTCCGGT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MEGSREVSEFTNFDVKNVKLARSLGGLALELPVMNKKPPVGLLPDHEARHLNFSLTRPVSRPMSRQRNSTADVSMADKTN
ARAEQGINTRLAHTGNNPSDYHGFVNPPVVHASTVLFPNARTMETRSQKYTYGTRGTPTTDALCEAINELEGAAGTILVP
SGLAAVTVPFLAYLSSGDHVLIVDSVYFPTRHFCDTMLTRLGVTVEYYDPSIGAGIENLIRPNTRLVHTEAPGSNTFEMQ
DIPAIAAAAHRHGCIVTMDNTWATPVYFRPLDYGVDVSIHAATKYPSGHSDVLLGTVSANAAHWPALSEAMVTLGVCVSP
DDSYQILRGLRTMGVRLERHQASALAIAEWLEGREEVARVLHPALPSFPGHELWKRDFGGASGIFSFVLKADPENGKAKA
HAFLDALSIFGLGYSWGGFESLAVHVNLSDRKVAKAPQEGPVIRLQIGLEDVPDIRRDVEAGLAAANAL

Sequences:

>Translated_469_residues
MEGSREVSEFTNFDVKNVKLARSLGGLALELPVMNKKPPVGLLPDHEARHLNFSLTRPVSRPMSRQRNSTADVSMADKTN
ARAEQGINTRLAHTGNNPSDYHGFVNPPVVHASTVLFPNARTMETRSQKYTYGTRGTPTTDALCEAINELEGAAGTILVP
SGLAAVTVPFLAYLSSGDHVLIVDSVYFPTRHFCDTMLTRLGVTVEYYDPSIGAGIENLIRPNTRLVHTEAPGSNTFEMQ
DIPAIAAAAHRHGCIVTMDNTWATPVYFRPLDYGVDVSIHAATKYPSGHSDVLLGTVSANAAHWPALSEAMVTLGVCVSP
DDSYQILRGLRTMGVRLERHQASALAIAEWLEGREEVARVLHPALPSFPGHELWKRDFGGASGIFSFVLKADPENGKAKA
HAFLDALSIFGLGYSWGGFESLAVHVNLSDRKVAKAPQEGPVIRLQIGLEDVPDIRRDVEAGLAAANAL
>Mature_469_residues
MEGSREVSEFTNFDVKNVKLARSLGGLALELPVMNKKPPVGLLPDHEARHLNFSLTRPVSRPMSRQRNSTADVSMADKTN
ARAEQGINTRLAHTGNNPSDYHGFVNPPVVHASTVLFPNARTMETRSQKYTYGTRGTPTTDALCEAINELEGAAGTILVP
SGLAAVTVPFLAYLSSGDHVLIVDSVYFPTRHFCDTMLTRLGVTVEYYDPSIGAGIENLIRPNTRLVHTEAPGSNTFEMQ
DIPAIAAAAHRHGCIVTMDNTWATPVYFRPLDYGVDVSIHAATKYPSGHSDVLLGTVSANAAHWPALSEAMVTLGVCVSP
DDSYQILRGLRTMGVRLERHQASALAIAEWLEGREEVARVLHPALPSFPGHELWKRDFGGASGIFSFVLKADPENGKAKA
HAFLDALSIFGLGYSWGGFESLAVHVNLSDRKVAKAPQEGPVIRLQIGLEDVPDIRRDVEAGLAAANAL

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=341, Percent_Identity=36.0703812316716, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI299473759, Length=341, Percent_Identity=32.8445747800587, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI25453487, Length=340, Percent_Identity=31.4705882352941, Blast_Score=155, Evalue=7e-38,
Organism=Escherichia coli, GI1789383, Length=394, Percent_Identity=45.6852791878173, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1790375, Length=387, Percent_Identity=31.7829457364341, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=32.4324324324324, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17560056, Length=373, Percent_Identity=33.7801608579088, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17538055, Length=340, Percent_Identity=34.7058823529412, Blast_Score=188, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6321170, Length=346, Percent_Identity=44.7976878612717, Blast_Score=322, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6319307, Length=395, Percent_Identity=30.126582278481, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323333, Length=408, Percent_Identity=25.9803921568627, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6321254, Length=420, Percent_Identity=25.2380952380952, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=242, Percent_Identity=28.099173553719, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922554, Length=394, Percent_Identity=35.7868020304569, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 50760; Mature: 50760

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGSREVSEFTNFDVKNVKLARSLGGLALELPVMNKKPPVGLLPDHEARHLNFSLTRPVS
CCCCHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHH
RPMSRQRNSTADVSMADKTNARAEQGINTRLAHTGNNPSDYHGFVNPPVVHASTVLFPNA
HHHHHCCCCCCCEEECCCCCCHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCC
RTMETRSQKYTYGTRGTPTTDALCEAINELEGAAGTILVPSGLAAVTVPFLAYLSSGDHV
CCHHCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCEE
LIVDSVYFPTRHFCDTMLTRLGVTVEYYDPSIGAGIENLIRPNTRLVHTEAPGSNTFEMQ
EEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCEECC
DIPAIAAAAHRHGCIVTMDNTWATPVYFRPLDYGVDVSIHAATKYPSGHSDVLLGTVSAN
CCCHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCEEEEEECCC
AAHWPALSEAMVTLGVCVSPDDSYQILRGLRTMGVRLERHQASALAIAEWLEGREEVARV
CCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHHCCEEHHHHHHHHHHHHHHCCHHHHHHH
LHPALPSFPGHELWKRDFGGASGIFSFVLKADPENGKAKAHAFLDALSIFGLGYSWGGFE
HHHCCCCCCCHHHHHHHCCCHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCE
SLAVHVNLSDRKVAKAPQEGPVIRLQIGLEDVPDIRRDVEAGLAAANAL
EEEEEEECCCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEGSREVSEFTNFDVKNVKLARSLGGLALELPVMNKKPPVGLLPDHEARHLNFSLTRPVS
CCCCHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHH
RPMSRQRNSTADVSMADKTNARAEQGINTRLAHTGNNPSDYHGFVNPPVVHASTVLFPNA
HHHHHCCCCCCCEEECCCCCCHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCC
RTMETRSQKYTYGTRGTPTTDALCEAINELEGAAGTILVPSGLAAVTVPFLAYLSSGDHV
CCHHCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCEE
LIVDSVYFPTRHFCDTMLTRLGVTVEYYDPSIGAGIENLIRPNTRLVHTEAPGSNTFEMQ
EEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHCCCCEEEEECCCCCCCEECC
DIPAIAAAAHRHGCIVTMDNTWATPVYFRPLDYGVDVSIHAATKYPSGHSDVLLGTVSAN
CCCHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCEEEEEECCC
AAHWPALSEAMVTLGVCVSPDDSYQILRGLRTMGVRLERHQASALAIAEWLEGREEVARV
CCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHHCCEEHHHHHHHHHHHHHHCCHHHHHHH
LHPALPSFPGHELWKRDFGGASGIFSFVLKADPENGKAKAHAFLDALSIFGLGYSWGGFE
HHHCCCCCCCHHHHHHHCCCHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCE
SLAVHVNLSDRKVAKAPQEGPVIRLQIGLEDVPDIRRDVEAGLAAANAL
EEEEEEECCCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]