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The map label for this gene is dprE1 [H]

Identifier: 150396285

GI number: 150396285

Start: 1132307

End: 1133632

Strand: Direct

Name: dprE1 [H]

Synonym: Smed_1064

Alternate gene names: 150396285

Gene position: 1132307-1133632 (Clockwise)

Preceding gene: 150396284

Following gene: 150396288

Centisome position: 29.94

GC content: 63.88

Gene sequence:

>1326_bases
ATGAGAATGGACGACTTCGAAAGCGCGGCGCGTTCTGGAAGGCGGCCTCGGCCGTCCATTTCCCCCGATGATTACGAGGA
CGCGACAGGCTCCGTCGCACCCATGGCCTTTCTTCCCGTCGGCAATGGGTTGAGCCTTGGCGACGTTTGCCGCAACGAAG
GCGGGACGCCTATCGATAGCAGAAAGCTCAACCGGACCCTGACTTTCGATTCGGGGAGCGGCGCCATCCGCTGCGAGGCC
GGCGTCAGTCTTGCCGAGCTTCTCGCCCGCGCAGCCCCGCATCGCTTCTTTCTCCCCGTGACGCCCGCAACCGGCCTCGT
CACCGTCGGCGGCGCCGTGGCCAACGACATACACGGTGGCAATCATCATGCGCGCGGCTCCTTCGGCAATCACGTCCGGC
GCCTGACCTTGCTCCGGTCGAGCGGTGAGCGGCTGGTCTGTACGCCGGAGGAGAACGCAGAACTCTTCGCCGCCACGATC
GGCGGATTGGGATTGACCGGGTTGATCCTCGATGTCGAGCTCCGGTTGATGAAAGTGCCTTCGCCGCATGTCCAGCGGCA
TGTGCTTCGCTTCGACAGCCTCGAGCAATATTTCGCTCTGGCGGAGCGGGCCGCGGAAGAGCACGAATATTGCGTAGCCT
GGCTCGATCAGCTGGCGACGGGCCGGCGCGCGGGCAGGGGCGTGCTTTTCGCGGCTGATCACGCCGACGGCGCTTGTGAG
CTTCCTGACGTTTTGAAAAGGCCGAAGCTCGCCGTTCCCGTTTCACCACCCTTCAGCCTATTCAACAGGCTGACGCTCAG
AGCCTTGAACGAATACCGCTTCCGCAAAGCGGGCACTGGCGAGACCGTTTCGACCGAGGACTGGCCGTCCTATTTCCATC
GCCTCGATGCGGTTGGCGGGTGGGGCCGGCTCTACGGCCGGCGTGGCTTTTGCCAGCATCACAGCGTTTATCCCGCCGCG
ACGGCGCCGGAGACCACGGCGCGATTGTTGGAAGCAGCACGGCGGGCCGGTCATGCTTCCGTGCGCACAACGCTGCAGCG
TTTCGGAGACATCGCCTCCCGTGGGCTTCTTTCATTTGCGCGGCCGGGCTTCACCCTGATTCTGGATTTCGCGAACCAGG
GAAGAGCGACCGTCAAGCTGCTCGACACTCTCGATGAGATCGTCATTTCGGCCGGTGGCGCCGTGAATCCGTGCCAGGAT
TTCCGCATGAGCCGAGCCGTCTTCGAAGCGTCCTTCCCCTCTTGGAAAAGACTGGAGGCGCTGCGCGATCCGGCGATCGT
CTCGGACTTCTGGCGACGCACCGCACTCGCCACCGGAACGACCTGA

Upstream 100 bases:

>100_bases
GGTTCGCATGGAACTCCGATCAGAATGACGGATTGGCGAGAGGCACTGAATTGGTTCCTTGACCGCTGACGGCGCGGTCG
ATGGAGGAGTTGAGGCGGCA

Downstream 100 bases:

>100_bases
TCTTGCGCCCGCATCCCGGAAAGCTGCGCGCGATCTACCGTTTCTGCCCCCTAATGTTCATGTTGAATTCCACGACGTTG
GAGTAAATCGGCGTCCCGAC

Product: FAD linked oxidase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRMDDFESAARSGRRPRPSISPDDYEDATGSVAPMAFLPVGNGLSLGDVCRNEGGTPIDSRKLNRTLTFDSGSGAIRCEA
GVSLAELLARAAPHRFFLPVTPATGLVTVGGAVANDIHGGNHHARGSFGNHVRRLTLLRSSGERLVCTPEENAELFAATI
GGLGLTGLILDVELRLMKVPSPHVQRHVLRFDSLEQYFALAERAAEEHEYCVAWLDQLATGRRAGRGVLFAADHADGACE
LPDVLKRPKLAVPVSPPFSLFNRLTLRALNEYRFRKAGTGETVSTEDWPSYFHRLDAVGGWGRLYGRRGFCQHHSVYPAA
TAPETTARLLEAARRAGHASVRTTLQRFGDIASRGLLSFARPGFTLILDFANQGRATVKLLDTLDEIVISAGGAVNPCQD
FRMSRAVFEASFPSWKRLEALRDPAIVSDFWRRTALATGTT

Sequences:

>Translated_441_residues
MRMDDFESAARSGRRPRPSISPDDYEDATGSVAPMAFLPVGNGLSLGDVCRNEGGTPIDSRKLNRTLTFDSGSGAIRCEA
GVSLAELLARAAPHRFFLPVTPATGLVTVGGAVANDIHGGNHHARGSFGNHVRRLTLLRSSGERLVCTPEENAELFAATI
GGLGLTGLILDVELRLMKVPSPHVQRHVLRFDSLEQYFALAERAAEEHEYCVAWLDQLATGRRAGRGVLFAADHADGACE
LPDVLKRPKLAVPVSPPFSLFNRLTLRALNEYRFRKAGTGETVSTEDWPSYFHRLDAVGGWGRLYGRRGFCQHHSVYPAA
TAPETTARLLEAARRAGHASVRTTLQRFGDIASRGLLSFARPGFTLILDFANQGRATVKLLDTLDEIVISAGGAVNPCQD
FRMSRAVFEASFPSWKRLEALRDPAIVSDFWRRTALATGTT
>Mature_441_residues
MRMDDFESAARSGRRPRPSISPDDYEDATGSVAPMAFLPVGNGLSLGDVCRNEGGTPIDSRKLNRTLTFDSGSGAIRCEA
GVSLAELLARAAPHRFFLPVTPATGLVTVGGAVANDIHGGNHHARGSFGNHVRRLTLLRSSGERLVCTPEENAELFAATI
GGLGLTGLILDVELRLMKVPSPHVQRHVLRFDSLEQYFALAERAAEEHEYCVAWLDQLATGRRAGRGVLFAADHADGACE
LPDVLKRPKLAVPVSPPFSLFNRLTLRALNEYRFRKAGTGETVSTEDWPSYFHRLDAVGGWGRLYGRRGFCQHHSVYPAA
TAPETTARLLEAARRAGHASVRTTLQRFGDIASRGLLSFARPGFTLILDFANQGRATVKLLDTLDEIVISAGGAVNPCQD
FRMSRAVFEASFPSWKRLEALRDPAIVSDFWRRTALATGTT

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 48004; Mature: 48004

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMDDFESAARSGRRPRPSISPDDYEDATGSVAPMAFLPVGNGLSLGDVCRNEGGTPIDS
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCCH
RKLNRTLTFDSGSGAIRCEAGVSLAELLARAAPHRFFLPVTPATGLVTVGGAVANDIHGG
HHCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCEEEEECCCCCCEEEECCHHHHCCCCC
NHHARGSFGNHVRRLTLLRSSGERLVCTPEENAELFAATIGGLGLTGLILDVELRLMKVP
CCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEHHCCCCHHHHHEEEEEEEEECC
SPHVQRHVLRFDSLEQYFALAERAAEEHEYCVAWLDQLATGRRAGRGVLFAADHADGACE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
LPDVLKRPKLAVPVSPPFSLFNRLTLRALNEYRFRKAGTGETVSTEDWPSYFHRLDAVGG
CHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
WGRLYGRRGFCQHHSVYPAATAPETTARLLEAARRAGHASVRTTLQRFGDIASRGLLSFA
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
RPGFTLILDFANQGRATVKLLDTLDEIVISAGGAVNPCQDFRMSRAVFEASFPSWKRLEA
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
LRDPAIVSDFWRRTALATGTT
HCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRMDDFESAARSGRRPRPSISPDDYEDATGSVAPMAFLPVGNGLSLGDVCRNEGGTPIDS
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCCCCCH
RKLNRTLTFDSGSGAIRCEAGVSLAELLARAAPHRFFLPVTPATGLVTVGGAVANDIHGG
HHCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCEEEEECCCCCCEEEECCHHHHCCCCC
NHHARGSFGNHVRRLTLLRSSGERLVCTPEENAELFAATIGGLGLTGLILDVELRLMKVP
CCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEHHCCCCHHHHHEEEEEEEEECC
SPHVQRHVLRFDSLEQYFALAERAAEEHEYCVAWLDQLATGRRAGRGVLFAADHADGACE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
LPDVLKRPKLAVPVSPPFSLFNRLTLRALNEYRFRKAGTGETVSTEDWPSYFHRLDAVGG
CHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCC
WGRLYGRRGFCQHHSVYPAATAPETTARLLEAARRAGHASVRTTLQRFGDIASRGLLSFA
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
RPGFTLILDFANQGRATVKLLDTLDEIVISAGGAVNPCQDFRMSRAVFEASFPSWKRLEA
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
LRDPAIVSDFWRRTALATGTT
HCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]