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The map label for this gene is wecC

Identifier: 150400916

GI number: 150400916

Start: 506957

End: 508273

Strand: Direct

Name: wecC

Synonym: Maeo_0484

Alternate gene names: 150400916

Gene position: 506957-508273 (Clockwise)

Preceding gene: 150400915

Following gene: 150400917

Centisome position: 32.3

GC content: 31.81

Gene sequence:

>1317_bases
ATGAAGTTGGACAAATCAAAGCAAAAGGAAATAAATAAAATATGTGTGGTAGGTCTTGGATATATCGGATTACCTACTGC
ATCAATGCTTGCGATACAGGGGTATAAGGTCATAGGAGTAGATATAGACGAAGAACGGGTAAAAACCATAAGGGATGGAA
AATTAATTATAAATGAACAGGGACTTATGACATTATTGACAGGGGCCATAACCTCCGGAAATTTAGTTGTAAAAACTGAA
CCCGAAGAAGCAGATGTATATATAATATGTGTCCCAACTCCTGCTACGGCTGATAAAAACGGTAAGAAATGTGATTTAAT
TTGTGTTCTAAGTGCGGTAAATAATATAAAACCATATTTAAAAGACGGAGATTTAATAATAATAGAAAGTACAATACCTC
CAAAAACCACTGAAAAAATATACGACGATATATCTAAAAATACAGGTAAAAATATATATATGGCATATTGTCCGGAAAGG
GTGCTTCCCGGCAATATATTAAAGGAACTTGTGGAAAATGACAGGACAATAGGAGGAATAAATAAAAAATCCGCACAACT
TGCAAAGGAAATATATGCCTCATTTATAGAAGGTAATTTATACATAACAGATTCTACCACTGCGGAAATGGTAAAATTAA
TGGAAAACACATTCAGAGATGTAAATATAGCACTTGCAAATGAATTTGCAAAAGTATCCACAGAATTAGATATTAATGTA
TGGGATGCCATCAATCTTGCAAATAAACATCCCCGAGTAAATATATTAAATCCTGGCCCGGGGGTTGGAGGACATTGTAT
TAGTATAGACCCATGGTTTATTGTAGGGAGCTCCGAGAATGCTGAACTAATTAAGAAGGCACGAAATTTAAATGATGATA
TGCCTAAATATGTTGCCTCATTGATAATAAAAGAATTTAAAGAAATGGGAATATGCAATCCAAAAGTTGGAATTTTTGGA
ATTACCTATAAAGGAGATGTGGAGGACACTCGGGAAACACCTGCACGGGCAATAATTGATTATTTATTACAGAATGATTT
TGAAGTATCTATATATGACCCATATGCCAAGGATTTTGAATATCCATTAAATACAATAGAAGAAAGCATAAAAAATTCAG
ATGCCCTTATTTTTTTAACAGACCATAGTGAATTTAAAAATTTTGAAAAAGAAGATATTAAAGAAATATCTCATATGATG
AAAAATAAAATTGTAATGGATATGAAAAATACATTAAATCATAATTTATGGGAAGAACAAGGTTTTAATGTTAAATTATT
AGGTGATGGAAAATCATGGATTGTTAAGACATTATAA

Upstream 100 bases:

>100_bases
CCTGGGAAAAAAACTATTCAAATATTAAATACATTAAATAATTTATTTTTTTTATCTTTATTTTTATTTTTATTTTTTTA
TTACATACATCGGTGATTAA

Downstream 100 bases:

>100_bases
AAATAATATAATATAAAATATTAAAATATATAATTAAAAAATATGGTATAGTTAATCTTCGGTCGTTTTCACTAAACTGT
CTCAAAATCGCAAAGCGATT

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKLDKSKQKEINKICVVGLGYIGLPTASMLAIQGYKVIGVDIDEERVKTIRDGKLIINEQGLMTLLTGAITSGNLVVKTE
PEEADVYIICVPTPATADKNGKKCDLICVLSAVNNIKPYLKDGDLIIIESTIPPKTTEKIYDDISKNTGKNIYMAYCPER
VLPGNILKELVENDRTIGGINKKSAQLAKEIYASFIEGNLYITDSTTAEMVKLMENTFRDVNIALANEFAKVSTELDINV
WDAINLANKHPRVNILNPGPGVGGHCISIDPWFIVGSSENAELIKKARNLNDDMPKYVASLIIKEFKEMGICNPKVGIFG
ITYKGDVEDTRETPARAIIDYLLQNDFEVSIYDPYAKDFEYPLNTIEESIKNSDALIFLTDHSEFKNFEKEDIKEISHMM
KNKIVMDMKNTLNHNLWEEQGFNVKLLGDGKSWIVKTL

Sequences:

>Translated_438_residues
MKLDKSKQKEINKICVVGLGYIGLPTASMLAIQGYKVIGVDIDEERVKTIRDGKLIINEQGLMTLLTGAITSGNLVVKTE
PEEADVYIICVPTPATADKNGKKCDLICVLSAVNNIKPYLKDGDLIIIESTIPPKTTEKIYDDISKNTGKNIYMAYCPER
VLPGNILKELVENDRTIGGINKKSAQLAKEIYASFIEGNLYITDSTTAEMVKLMENTFRDVNIALANEFAKVSTELDINV
WDAINLANKHPRVNILNPGPGVGGHCISIDPWFIVGSSENAELIKKARNLNDDMPKYVASLIIKEFKEMGICNPKVGIFG
ITYKGDVEDTRETPARAIIDYLLQNDFEVSIYDPYAKDFEYPLNTIEESIKNSDALIFLTDHSEFKNFEKEDIKEISHMM
KNKIVMDMKNTLNHNLWEEQGFNVKLLGDGKSWIVKTL
>Mature_438_residues
MKLDKSKQKEINKICVVGLGYIGLPTASMLAIQGYKVIGVDIDEERVKTIRDGKLIINEQGLMTLLTGAITSGNLVVKTE
PEEADVYIICVPTPATADKNGKKCDLICVLSAVNNIKPYLKDGDLIIIESTIPPKTTEKIYDDISKNTGKNIYMAYCPER
VLPGNILKELVENDRTIGGINKKSAQLAKEIYASFIEGNLYITDSTTAEMVKLMENTFRDVNIALANEFAKVSTELDINV
WDAINLANKHPRVNILNPGPGVGGHCISIDPWFIVGSSENAELIKKARNLNDDMPKYVASLIIKEFKEMGICNPKVGIFG
ITYKGDVEDTRETPARAIIDYLLQNDFEVSIYDPYAKDFEYPLNTIEESIKNSDALIFLTDHSEFKNFEKEDIKEISHMM
KNKIVMDMKNTLNHNLWEEQGFNVKLLGDGKSWIVKTL

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA)

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4507813, Length=469, Percent_Identity=26.6524520255864, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI296040443, Length=457, Percent_Identity=24.0700218818381, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI296040438, Length=370, Percent_Identity=24.8648648648649, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI48994968, Length=407, Percent_Identity=40.7862407862408, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1788340, Length=358, Percent_Identity=26.2569832402235, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560350, Length=465, Percent_Identity=26.4516129032258, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17136908, Length=464, Percent_Identity=26.0775862068966, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WECC_META3 (A6UU98)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324682.1
- ProteinModelPortal:   A6UU98
- SMR:   A6UU98
- STRING:   A6UU98
- GeneID:   5326336
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0484
- eggNOG:   arNOG05577
- HOGENOM:   HBG400967
- OMA:   DVYIICV
- BioCyc:   MAEO419665:MAEO_0484-MONOMER
- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11374
- PIRSF:   PIRSF000124
- TIGRFAMs:   TIGR03026

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N; SSF48179 6DGDH_C_like; SSF52413 UDP-Glc/GDP-Man_DH_C

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48982; Mature: 48982

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: ACT_SITE 266-266

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDKSKQKEINKICVVGLGYIGLPTASMLAIQGYKVIGVDIDEERVKTIRDGKLIINEQ
CCCCCHHHHHHHHEEEEECCCCCCCCHHHEEECCEEEEEECCCHHHHHHHCCCEEEEECC
GLMTLLTGAITSGNLVVKTEPEEADVYIICVPTPATADKNGKKCDLICVLSAVNNIKPYL
CHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEEEEHHHHCCCCCC
KDGDLIIIESTIPPKTTEKIYDDISKNTGKNIYMAYCPERVLPGNILKELVENDRTIGGI
CCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCC
NKKSAQLAKEIYASFIEGNLYITDSTTAEMVKLMENTFRDVNIALANEFAKVSTELDINV
CHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCEEEEEHHHHHHHCEEEEEEE
WDAINLANKHPRVNILNPGPGVGGHCISIDPWFIVGSSENAELIKKARNLNDDMPKYVAS
EHHCCCCCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHCCCCCHHHHHHH
LIIKEFKEMGICNPKVGIFGITYKGDVEDTRETPARAIIDYLLQNDFEVSIYDPYAKDFE
HHHHHHHHCCCCCCCCEEEEEEEECCCCHHHCCHHHHHHHHHHCCCCEEEEECCCHHCCC
YPLNTIEESIKNSDALIFLTDHSEFKNFEKEDIKEISHMMKNKIVMDMKNTLNHNLWEEQ
CCHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
GFNVKLLGDGKSWIVKTL
CCEEEEEECCCCEEEECC
>Mature Secondary Structure
MKLDKSKQKEINKICVVGLGYIGLPTASMLAIQGYKVIGVDIDEERVKTIRDGKLIINEQ
CCCCCHHHHHHHHEEEEECCCCCCCCHHHEEECCEEEEEECCCHHHHHHHCCCEEEEECC
GLMTLLTGAITSGNLVVKTEPEEADVYIICVPTPATADKNGKKCDLICVLSAVNNIKPYL
CHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEEEEHHHHCCCCCC
KDGDLIIIESTIPPKTTEKIYDDISKNTGKNIYMAYCPERVLPGNILKELVENDRTIGGI
CCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCC
NKKSAQLAKEIYASFIEGNLYITDSTTAEMVKLMENTFRDVNIALANEFAKVSTELDINV
CHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCEEEEEHHHHHHHCEEEEEEE
WDAINLANKHPRVNILNPGPGVGGHCISIDPWFIVGSSENAELIKKARNLNDDMPKYVAS
EHHCCCCCCCCEEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHCCCCCHHHHHHH
LIIKEFKEMGICNPKVGIFGITYKGDVEDTRETPARAIIDYLLQNDFEVSIYDPYAKDFE
HHHHHHHHCCCCCCCCEEEEEEEECCCCHHHCCHHHHHHHHHHCCCCEEEEECCCHHCCC
YPLNTIEESIKNSDALIFLTDHSEFKNFEKEDIKEISHMMKNKIVMDMKNTLNHNLWEEQ
CCHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
GFNVKLLGDGKSWIVKTL
CCEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA