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The map label for this gene is acbB [H]

Identifier: 150400813

GI number: 150400813

Start: 392916

End: 393854

Strand: Direct

Name: acbB [H]

Synonym: Maeo_0380

Alternate gene names: 150400813

Gene position: 392916-393854 (Clockwise)

Preceding gene: 150400812

Following gene: 150400814

Centisome position: 25.03

GC content: 30.03

Gene sequence:

>939_bases
ATGAAAATAGTAATTACTGGGGGAGCAGGATTTATTGGCTGCAATTTTGTTAGAATGATGGTAAATAAATATCCCGATTA
TGAAATTAAAGTTTTAGATAATTTATCCTATGCTGGAAGCTTGGATAATTTAAAAGATATTTCGGATAAAATAGAATTTA
TTAAAGGAGATATCACCAACAAAGAGGCCGTAGAAAACTCATTAAAAGATGCCGATGCAGTTATACATTTTGCAGCTGAA
TCTCATGTTGATAATTCTATTGAAAATCCAGAAAATTTTGTTAAAACCAATGTATTTGGAACATATAATCTATTAGAATG
TGCTAGAAAAAATGATATTGATAAATTTTTACATATTTCCACAGATGAAACTTATGGAAGTATTGAAAGAGGTTCCTTTA
AAGAAACCGATAGATTAGATCCTGCATCACCATATTCTGCTTCAAAAGCAGGTAGTGATTTATTAGTTAGTGCATATCAT
ACAACCTATGGATTAAATACATTAATTACTCGTTCAAGCAATAATTTTGGACCATATCAATATCCTGAAAAACTTATACC
AGTTTTAATAAAAAATGCGATATACAATAATCCCCTTCCAATATATGGAGATGGATTAAATGTTAGGGATTGGATTTTTG
TAGAGGATAATTGTAGTGGTGTTGATGTGGTGTTCCACAAGGGGGAAATTGGAGAGGTATATAATATAGGAGGGGGCAAC
GAAAAAACAAATCTTGAAATCACCAAATTAATATTAAAAGAATTAAATAAGCCAGAAGAATTAATAACATTTGTGAAAGA
TAGATTGGGGCATGATAGAAGATATTCGATAGATACAAATAAAACAAAAGCTCTTGGATGGGAACCTAAATGGGAATTTG
AAGATGCATTAAAATATACTGTAAAATGGTATTTGGAAAATAAATGGTTTTGGGAATAA

Upstream 100 bases:

>100_bases
TTGATGAAAACAGAATATGGGAAATATTTAGAAAAACTTGTTAATGAGAAATAATATTTGTATAATTTATATTTTATTTT
ATAATTTATTTGGTGAAATA

Downstream 100 bases:

>100_bases
TTAATTTTTACCCAAAATTATTTAATTTGGTGGAATTATGGAAAAAATAGCAATTATTGGTTTGGGAATGATTGGATATG
AAATCACTAAAAAATATAAT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKIVITGGAGFIGCNFVRMMVNKYPDYEIKVLDNLSYAGSLDNLKDISDKIEFIKGDITNKEAVENSLKDADAVIHFAAE
SHVDNSIENPENFVKTNVFGTYNLLECARKNDIDKFLHISTDETYGSIERGSFKETDRLDPASPYSASKAGSDLLVSAYH
TTYGLNTLITRSSNNFGPYQYPEKLIPVLIKNAIYNNPLPIYGDGLNVRDWIFVEDNCSGVDVVFHKGEIGEVYNIGGGN
EKTNLEITKLILKELNKPEELITFVKDRLGHDRRYSIDTNKTKALGWEPKWEFEDALKYTVKWYLENKWFWE

Sequences:

>Translated_312_residues
MKIVITGGAGFIGCNFVRMMVNKYPDYEIKVLDNLSYAGSLDNLKDISDKIEFIKGDITNKEAVENSLKDADAVIHFAAE
SHVDNSIENPENFVKTNVFGTYNLLECARKNDIDKFLHISTDETYGSIERGSFKETDRLDPASPYSASKAGSDLLVSAYH
TTYGLNTLITRSSNNFGPYQYPEKLIPVLIKNAIYNNPLPIYGDGLNVRDWIFVEDNCSGVDVVFHKGEIGEVYNIGGGN
EKTNLEITKLILKELNKPEELITFVKDRLGHDRRYSIDTNKTKALGWEPKWEFEDALKYTVKWYLENKWFWE
>Mature_312_residues
MKIVITGGAGFIGCNFVRMMVNKYPDYEIKVLDNLSYAGSLDNLKDISDKIEFIKGDITNKEAVENSLKDADAVIHFAAE
SHVDNSIENPENFVKTNVFGTYNLLECARKNDIDKFLHISTDETYGSIERGSFKETDRLDPASPYSASKAGSDLLVSAYH
TTYGLNTLITRSSNNFGPYQYPEKLIPVLIKNAIYNNPLPIYGDGLNVRDWIFVEDNCSGVDVVFHKGEIGEVYNIGGGN
EKTNLEITKLILKELNKPEELITFVKDRLGHDRRYSIDTNKTKALGWEPKWEFEDALKYTVKWYLENKWFWE

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4- hexulose via a three-step process involving oxidation, dehydration and re

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=321, Percent_Identity=38.006230529595, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI42516563, Length=312, Percent_Identity=27.8846153846154, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI56237023, Length=342, Percent_Identity=24.5614035087719, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI56118217, Length=342, Percent_Identity=24.5614035087719, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI189083684, Length=342, Percent_Identity=24.5614035087719, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI48994969, Length=338, Percent_Identity=47.6331360946746, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1788353, Length=341, Percent_Identity=46.9208211143695, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1786974, Length=341, Percent_Identity=26.6862170087977, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788365, Length=245, Percent_Identity=23.6734693877551, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568069, Length=322, Percent_Identity=36.9565217391304, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI115532424, Length=322, Percent_Identity=34.7826086956522, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17539532, Length=314, Percent_Identity=25.796178343949, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982035, Length=346, Percent_Identity=25.1445086705202, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982038, Length=348, Percent_Identity=25, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=350, Percent_Identity=26, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321437, Length=222, Percent_Identity=24.7747747747748, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356223, Length=313, Percent_Identity=27.7955271565495, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI19923002, Length=341, Percent_Identity=29.0322580645161, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 35499; Mature: 35499

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVITGGAGFIGCNFVRMMVNKYPDYEIKVLDNLSYAGSLDNLKDISDKIEFIKGDITN
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
KEAVENSLKDADAVIHFAAESHVDNSIENPENFVKTNVFGTYNLLECARKNDIDKFLHIS
HHHHHHHHHHHHHEEEEHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEEEC
TDETYGSIERGSFKETDRLDPASPYSASKAGSDLLVSAYHTTYGLNTLITRSSNNFGPYQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCEEEEEECCCCCCCCC
YPEKLIPVLIKNAIYNNPLPIYGDGLNVRDWIFVEDNCSGVDVVFHKGEIGEVYNIGGGN
CHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEECCCCC
EKTNLEITKLILKELNKPEELITFVKDRLGHDRRYSIDTNKTKALGWEPKWEFEDALKYT
CCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCEECCCCCCCCHHHHHHEE
VKWYLENKWFWE
EEEEECCCCCCC
>Mature Secondary Structure
MKIVITGGAGFIGCNFVRMMVNKYPDYEIKVLDNLSYAGSLDNLKDISDKIEFIKGDITN
CEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
KEAVENSLKDADAVIHFAAESHVDNSIENPENFVKTNVFGTYNLLECARKNDIDKFLHIS
HHHHHHHHHHHHHEEEEHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEEEC
TDETYGSIERGSFKETDRLDPASPYSASKAGSDLLVSAYHTTYGLNTLITRSSNNFGPYQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCEEEEEECCCCCCCCC
YPEKLIPVLIKNAIYNNPLPIYGDGLNVRDWIFVEDNCSGVDVVFHKGEIGEVYNIGGGN
CHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEECCCCC
EKTNLEITKLILKELNKPEELITFVKDRLGHDRRYSIDTNKTKALGWEPKWEFEDALKYT
CCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCEECCCCCCCCHHHHHHEE
VKWYLENKWFWE
EEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]