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The map label for this gene is rmlA [H]

Identifier: 150400812

GI number: 150400812

Start: 391991

End: 392869

Strand: Direct

Name: rmlA [H]

Synonym: Maeo_0379

Alternate gene names: 150400812

Gene position: 391991-392869 (Clockwise)

Preceding gene: 150400811

Following gene: 150400813

Centisome position: 24.98

GC content: 30.72

Gene sequence:

>879_bases
ATGAAAGGTATAGTTTTAGCAGGAGGTTCTGGGACTAGGTTATATCCCATTACATATGCAGGAAATAAACATTTAATGCC
ACTATATAATAAACCAATGATATATTATTCACTGTCAATTTTAATGCTATCTAAAATTAAAGATATTTTAATAATTACAA
CGCCCAATGACATATCACAATATAAAAAATTATTGGGCAATGGGGCGCACTACGGAATAAATATACAATATAAAGAACAG
TCTGAACCAAAAGGACTTGCAGATGCGTTTATTATCGGAGAGGACTTTATTGGGGAGGATACCGTATGTTTGATACTTGG
AGATAATATGCTATATGGTAGTGGATTAACTGGATTTTTAATTGATGCGAAAGAAGAAATTTCAAAAAATGGGGGTAGTA
TTGTATTTGGGCAATATGTAAAAGACCCAGAACGATATGGAGTAATTAAATTTGATGAGCAAGGGGAAATTGAAGAAATT
ATAGAAAAACCAAAAAATGCTCCATCAAATTATGCTGTTATAGGTCTTTATTATTATGACAACAAAGTTATTGATATTGC
TAAAACCATAAAACCATCTAATAGAGGAGAATTGGAAATAACTGATGTAAATAATGAATATTTAAAAAATAAAAAATTAA
GCGTAAAATTATTGCCAAGAGGAACGGCATGGTTTGATGCTGGAACTCATGACAGTTTTTTAGAGGCAAGTAATTTTATA
TCTGCTGTTGAAAAAAGAATGGGATTAATGGTTGGATGTTTAGAGGAAATAGCATATCATAATGGATGGATAACAGACAA
AGAACTTTTGAACTTAGCCGAACCGTTGATGAAAACAGAATATGGGAAATATTTAGAAAAACTTGTTAATGAGAAATAA

Upstream 100 bases:

>100_bases
ATAAAAAGAACTGTTGAATGGACGAAAAATAAATAATATAAAAAAATATCGATAATATAAAATTCCCAAAAAAGAGGAAT
AAATTTCTACGAGGTGCAAA

Downstream 100 bases:

>100_bases
TATTTGTATAATTTATATTTTATTTTATAATTTATTTGGTGAAATAATGAAAATAGTAATTACTGGGGGAGCAGGATTTA
TTGGCTGCAATTTTGTTAGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKGIVLAGGSGTRLYPITYAGNKHLMPLYNKPMIYYSLSILMLSKIKDILIITTPNDISQYKKLLGNGAHYGINIQYKEQ
SEPKGLADAFIIGEDFIGEDTVCLILGDNMLYGSGLTGFLIDAKEEISKNGGSIVFGQYVKDPERYGVIKFDEQGEIEEI
IEKPKNAPSNYAVIGLYYYDNKVIDIAKTIKPSNRGELEITDVNNEYLKNKKLSVKLLPRGTAWFDAGTHDSFLEASNFI
SAVEKRMGLMVGCLEEIAYHNGWITDKELLNLAEPLMKTEYGKYLEKLVNEK

Sequences:

>Translated_292_residues
MKGIVLAGGSGTRLYPITYAGNKHLMPLYNKPMIYYSLSILMLSKIKDILIITTPNDISQYKKLLGNGAHYGINIQYKEQ
SEPKGLADAFIIGEDFIGEDTVCLILGDNMLYGSGLTGFLIDAKEEISKNGGSIVFGQYVKDPERYGVIKFDEQGEIEEI
IEKPKNAPSNYAVIGLYYYDNKVIDIAKTIKPSNRGELEITDVNNEYLKNKKLSVKLLPRGTAWFDAGTHDSFLEASNFI
SAVEKRMGLMVGCLEEIAYHNGWITDKELLNLAEPLMKTEYGKYLEKLVNEK
>Mature_292_residues
MKGIVLAGGSGTRLYPITYAGNKHLMPLYNKPMIYYSLSILMLSKIKDILIITTPNDISQYKKLLGNGAHYGINIQYKEQ
SEPKGLADAFIIGEDFIGEDTVCLILGDNMLYGSGLTGFLIDAKEEISKNGGSIVFGQYVKDPERYGVIKFDEQGEIEEI
IEKPKNAPSNYAVIGLYYYDNKVIDIAKTIKPSNRGELEITDVNNEYLKNKKLSVKLLPRGTAWFDAGTHDSFLEASNFI
SAVEKRMGLMVGCLEEIAYHNGWITDKELLNLAEPLMKTEYGKYLEKLVNEK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=239, Percent_Identity=23.4309623430962, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI11761619, Length=239, Percent_Identity=23.4309623430962, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788351, Length=290, Percent_Identity=54.8275862068965, Blast_Score=334, Evalue=5e-93,
Organism=Escherichia coli, GI1790224, Length=292, Percent_Identity=52.7397260273973, Blast_Score=327, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI133931050, Length=242, Percent_Identity=25.2066115702479, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=196, Percent_Identity=29.0816326530612, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355443, Length=239, Percent_Identity=24.6861924686192, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644084, Length=239, Percent_Identity=24.6861924686192, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32706; Mature: 32706

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIVLAGGSGTRLYPITYAGNKHLMPLYNKPMIYYSLSILMLSKIKDILIITTPNDISQ
CCCEEEECCCCCEEEEEEECCCCEECCCCCCCEEEHHHHHHHHHCCCCEEEEECCCHHHH
YKKLLGNGAHYGINIQYKEQSEPKGLADAFIIGEDFIGEDTVCLILGDNMLYGSGLTGFL
HHHHHCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEEECCEEECCCCCEEE
IDAKEEISKNGGSIVFGQYVKDPERYGVIKFDEQGEIEEIIEKPKNAPSNYAVIGLYYYD
EECHHHHHCCCCCEEEEHHHCCHHHCCEEEECCCCCHHHHHHCCCCCCCCEEEEEEEEEC
NKVIDIAKTIKPSNRGELEITDVNNEYLKNKKLSVKLLPRGTAWFDAGTHDSFLEASNFI
CEEEEEHHHCCCCCCCCEEEEECCHHHHCCCCEEEEEECCCCEEECCCCCHHHHHHHHHH
SAVEKRMGLMVGCLEEIAYHNGWITDKELLNLAEPLMKTEYGKYLEKLVNEK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIVLAGGSGTRLYPITYAGNKHLMPLYNKPMIYYSLSILMLSKIKDILIITTPNDISQ
CCCEEEECCCCCEEEEEEECCCCEECCCCCCCEEEHHHHHHHHHCCCCEEEEECCCHHHH
YKKLLGNGAHYGINIQYKEQSEPKGLADAFIIGEDFIGEDTVCLILGDNMLYGSGLTGFL
HHHHHCCCCEEEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEEECCEEECCCCCEEE
IDAKEEISKNGGSIVFGQYVKDPERYGVIKFDEQGEIEEIIEKPKNAPSNYAVIGLYYYD
EECHHHHHCCCCCEEEEHHHCCHHHCCEEEECCCCCHHHHHHCCCCCCCCEEEEEEEEEC
NKVIDIAKTIKPSNRGELEITDVNNEYLKNKKLSVKLLPRGTAWFDAGTHDSFLEASNFI
CEEEEEHHHCCCCCCCCEEEEECCHHHHCCCCEEEEEECCCCEEECCCCCHHHHHHHHHH
SAVEKRMGLMVGCLEEIAYHNGWITDKELLNLAEPLMKTEYGKYLEKLVNEK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]