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The map label for this gene is hemA

Identifier: 150400490

GI number: 150400490

Start: 59127

End: 60278

Strand: Reverse

Name: hemA

Synonym: Maeo_0052

Alternate gene names: 150400490

Gene position: 60278-59127 (Counterclockwise)

Preceding gene: 150400491

Following gene: 150400489

Centisome position: 3.84

GC content: 31.08

Gene sequence:

>1152_bases
ATGCTTTTATTTAGGGCGGATTATAATAACTATGCTGTATCGGAGCTCCAAAAATTAAGGTTCGATGAAGACGAATTTTA
TAAAAAATATGATAATTGTGTATTGGTTCAAACCTGTAATAGGATAGAAATTTATTTCGATAAAAATGCCAAAATTATAG
ATATAAATGAATTTGCTGAATTTGAAATGATAAAATCTAACAATGCAATAAAACACCTATTAAGAACGGCGTCAGGATTA
AACTCTATGATAGTGGGGGAAGACCAAATAATCGGGCAAATAAAAAATAGCCATCGTAAAGCAAAGGAGCTTAAAAAAAC
CACGAAATATTTGGATACAATTTTTTTAAAGGCAATACACACAGGGCAAAAAGTTAGAAATAATACCAAAATAAATAAAG
GCTGTGTCTCCATCGGTAGTGCCGCCGTTCAATTAGCTGAAAAAACCGTAGGATTAAATAATAAAAATATCCTTGTAGTT
GGAGCGGGAGAAATAGCTACGCTGGTGGCTAAGGCACTTATTGAGAAAAATATACGGGCTATTGTGGTATCAAATAGAAC
CTATGAACGGGCGGAGCTCCTTGCAAAAAAATTAAATGGTATGGCCGTGCATTTTGACAAATTGGGAGAGGCTATAAATT
ACAACGATATAATTATATGTGCCACAGGAGCTCCCCATGCAATAATAGATAAGGATAGATTAAAAAATATCAAAGGATAT
AAAGTATTAATAGATATAGCAAATCCCCGAGATGTTAGCGATGATGTTATGGAGCTCCCGAATATTAAATTATACACCAT
TGACGATTTAAAAATGGTATCTGAGGAGAATCTAAAAAAAAGAAAGGACGAAATACCCCGTGTTGAAAAAATTATTGAAG
AGGAACTGTCTGTATTAACAAAACAACTACGAAAACTTAAATTTGAAAATACTATTAAAAATTATGATTTATATATCGAA
AATCTAAGAAAAAGGGAAATGAATAAAGCCCTAAACATGATAGAAAATGGAAAAGACCCAACCGTAGTATTGGAAAAGTT
TTCCAAAGTTTTTGCCAATAAACTAATTTCAGATTTTGTAAATATAGTTAATGATGATACAATAGGAGATATTGAACGAG
TTGTAAATAAATTAAATAAAAATAAAATATAA

Upstream 100 bases:

>100_bases
TAATTGATAAATATACTAAATAAAAAATAATAATAATAATAATAATAATATATGAAAATATGATGAATAGTAAGGAATAA
AATAAACTACGGTGTGTATA

Downstream 100 bases:

>100_bases
ATCGTGGTAAAATGGAAATAGAAAAAATGATAAAACAATTAAATCCAAAATTCAGAAATATAGACGGTAAAAAATTATTA
ATAGCAATTGCCATTGATGA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MLLFRADYNNYAVSELQKLRFDEDEFYKKYDNCVLVQTCNRIEIYFDKNAKIIDINEFAEFEMIKSNNAIKHLLRTASGL
NSMIVGEDQIIGQIKNSHRKAKELKKTTKYLDTIFLKAIHTGQKVRNNTKINKGCVSIGSAAVQLAEKTVGLNNKNILVV
GAGEIATLVAKALIEKNIRAIVVSNRTYERAELLAKKLNGMAVHFDKLGEAINYNDIIICATGAPHAIIDKDRLKNIKGY
KVLIDIANPRDVSDDVMELPNIKLYTIDDLKMVSEENLKKRKDEIPRVEKIIEEELSVLTKQLRKLKFENTIKNYDLYIE
NLRKREMNKALNMIENGKDPTVVLEKFSKVFANKLISDFVNIVNDDTIGDIERVVNKLNKNKI

Sequences:

>Translated_383_residues
MLLFRADYNNYAVSELQKLRFDEDEFYKKYDNCVLVQTCNRIEIYFDKNAKIIDINEFAEFEMIKSNNAIKHLLRTASGL
NSMIVGEDQIIGQIKNSHRKAKELKKTTKYLDTIFLKAIHTGQKVRNNTKINKGCVSIGSAAVQLAEKTVGLNNKNILVV
GAGEIATLVAKALIEKNIRAIVVSNRTYERAELLAKKLNGMAVHFDKLGEAINYNDIIICATGAPHAIIDKDRLKNIKGY
KVLIDIANPRDVSDDVMELPNIKLYTIDDLKMVSEENLKKRKDEIPRVEKIIEEELSVLTKQLRKLKFENTIKNYDLYIE
NLRKREMNKALNMIENGKDPTVVLEKFSKVFANKLISDFVNIVNDDTIGDIERVVNKLNKNKI
>Mature_383_residues
MLLFRADYNNYAVSELQKLRFDEDEFYKKYDNCVLVQTCNRIEIYFDKNAKIIDINEFAEFEMIKSNNAIKHLLRTASGL
NSMIVGEDQIIGQIKNSHRKAKELKKTTKYLDTIFLKAIHTGQKVRNNTKINKGCVSIGSAAVQLAEKTVGLNNKNILVV
GAGEIATLVAKALIEKNIRAIVVSNRTYERAELLAKKLNGMAVHFDKLGEAINYNDIIICATGAPHAIIDKDRLKNIKGY
KVLIDIANPRDVSDDVMELPNIKLYTIDDLKMVSEENLKKRKDEIPRVEKIIEEELSVLTKQLRKLKFENTIKNYDLYIE
NLRKREMNKALNMIENGKDPTVVLEKFSKVFANKLISDFVNIVNDDTIGDIERVVNKLNKNKI

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=387, Percent_Identity=30.4909560723514, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_META3 (A6UT22)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324256.1
- ProteinModelPortal:   A6UT22
- SMR:   A6UT22
- STRING:   A6UT22
- GeneID:   5326829
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0052
- eggNOG:   arNOG04783
- HOGENOM:   HBG732626
- OMA:   GEDQIIG
- ProtClustDB:   PRK00045
- BioCyc:   MAEO419665:MAEO_0052-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 43752; Mature: 43752

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 39-39 BINDING 82-82 BINDING 93-93

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLFRADYNNYAVSELQKLRFDEDEFYKKYDNCVLVQTCNRIEIYFDKNAKIIDINEFAE
CEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCEEEEEECCEEEEEECCCCEEEECCHHHH
FEMIKSNNAIKHLLRTASGLNSMIVGEDQIIGQIKNSHRKAKELKKTTKYLDTIFLKAIH
HHHHHCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGQKVRNNTKINKGCVSIGSAAVQLAEKTVGLNNKNILVVGAGEIATLVAKALIEKNIRA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCEE
IVVSNRTYERAELLAKKLNGMAVHFDKLGEAINYNDIIICATGAPHAIIDKDRLKNIKGY
EEEECCCHHHHHHHHHHHCCCEEEHHHHCCCCCCCCEEEEECCCCCCEECHHHHCCCCCE
KVLIDIANPRDVSDDVMELPNIKLYTIDDLKMVSEENLKKRKDEIPRVEKIIEEELSVLT
EEEEEECCCCCCCHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KQLRKLKFENTIKNYDLYIENLRKREMNKALNMIENGKDPTVVLEKFSKVFANKLISDFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NIVNDDTIGDIERVVNKLNKNKI
HHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLFRADYNNYAVSELQKLRFDEDEFYKKYDNCVLVQTCNRIEIYFDKNAKIIDINEFAE
CEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCEEEEEECCEEEEEECCCCEEEECCHHHH
FEMIKSNNAIKHLLRTASGLNSMIVGEDQIIGQIKNSHRKAKELKKTTKYLDTIFLKAIH
HHHHHCCHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGQKVRNNTKINKGCVSIGSAAVQLAEKTVGLNNKNILVVGAGEIATLVAKALIEKNIRA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCEE
IVVSNRTYERAELLAKKLNGMAVHFDKLGEAINYNDIIICATGAPHAIIDKDRLKNIKGY
EEEECCCHHHHHHHHHHHCCCEEEHHHHCCCCCCCCEEEEECCCCCCEECHHHHCCCCCE
KVLIDIANPRDVSDDVMELPNIKLYTIDDLKMVSEENLKKRKDEIPRVEKIIEEELSVLT
EEEEEECCCCCCCHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KQLRKLKFENTIKNYDLYIENLRKREMNKALNMIENGKDPTVVLEKFSKVFANKLISDFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NIVNDDTIGDIERVVNKLNKNKI
HHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA