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The map label for this gene is hisI

Identifier: 150400489

GI number: 150400489

Start: 58723

End: 59115

Strand: Reverse

Name: hisI

Synonym: Maeo_0051

Alternate gene names: 150400489

Gene position: 59115-58723 (Counterclockwise)

Preceding gene: 150400490

Following gene: 150400488

Centisome position: 3.77

GC content: 28.24

Gene sequence:

>393_bases
ATGGAAATAGAAAAAATGATAAAACAATTAAATCCAAAATTCAGAAATATAGACGGTAAAAAATTATTAATAGCAATTGC
CATTGATGAGGATAAAACCGTTCTTATGACTGCATTTATGGATGAAGAAGCATTGAAAACCACATTAGAAACTGGATATA
TGCATTATTATTCCACCAGCAGAGATAAAATTTGGAGAAAAGGAGAAGAAAGCGGAAATGTTCAAAAAGTAAAAGAAATA
TATGCCGATTGTGATAAAGACGCTTTATTATTTGTGGTTGAACAGAAAGGTTGGGCTTGTCATGAGAATTATTATACTTG
CTTCCATTATAAATTAAATCTTAAAAATAATGATATAGAAATAGTGGGGGAAAATATGGTAAATAAATATTAA

Upstream 100 bases:

>100_bases
TAATTTCAGATTTTGTAAATATAGTTAATGATGATACAATAGGAGATATTGAACGAGTTGTAAATAAATTAAATAAAAAT
AAAATATAAATCGTGGTAAA

Downstream 100 bases:

>100_bases
ATATTATATTAAATATTAATATAGATAAATAATTTGGATATGTTGAAAAACCGTGAAGTGCCCTGCCTTAATTGACAGGG
AGCTCCCGCCGACATTATAG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MEIEKMIKQLNPKFRNIDGKKLLIAIAIDEDKTVLMTAFMDEEALKTTLETGYMHYYSTSRDKIWRKGEESGNVQKVKEI
YADCDKDALLFVVEQKGWACHENYYTCFHYKLNLKNNDIEIVGENMVNKY

Sequences:

>Translated_130_residues
MEIEKMIKQLNPKFRNIDGKKLLIAIAIDEDKTVLMTAFMDEEALKTTLETGYMHYYSTSRDKIWRKGEESGNVQKVKEI
YADCDKDALLFVVEQKGWACHENYYTCFHYKLNLKNNDIEIVGENMVNKY
>Mature_130_residues
MEIEKMIKQLNPKFRNIDGKKLLIAIAIDEDKTVLMTAFMDEEALKTTLETGYMHYYSTSRDKIWRKGEESGNVQKVKEI
YADCDKDALLFVVEQKGWACHENYYTCFHYKLNLKNNDIEIVGENMVNKY

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=75, Percent_Identity=42.6666666666667, Blast_Score=74, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319819, Length=88, Percent_Identity=38.6363636363636, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_META3 (A6UT21)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324255.1
- ProteinModelPortal:   A6UT21
- SMR:   A6UT21
- STRING:   A6UT21
- GeneID:   5327330
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0051
- eggNOG:   arNOG12274
- HOGENOM:   HBG294308
- OMA:   MHYYSTS
- ProtClustDB:   PRK00051
- BioCyc:   MAEO419665:MAEO_0051-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15301; Mature: 15301

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEKMIKQLNPKFRNIDGKKLLIAIAIDEDKTVLMTAFMDEEALKTTLETGYMHYYSTS
CCHHHHHHHCCCHHCCCCCCEEEEEEEECCCCEEEEEEECCHHHHHHHHHHCEEEEEECC
RDKIWRKGEESGNVQKVKEIYADCDKDALLFVVEQKGWACHENYYTCFHYKLNLKNNDIE
CHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEECCCCEEEEEEEEECCCCCEE
IVGENMVNKY
EEECCCCCCC
>Mature Secondary Structure
MEIEKMIKQLNPKFRNIDGKKLLIAIAIDEDKTVLMTAFMDEEALKTTLETGYMHYYSTS
CCHHHHHHHCCCHHCCCCCCEEEEEEEECCCCEEEEEEECCHHHHHHHHHHCEEEEEECC
RDKIWRKGEESGNVQKVKEIYADCDKDALLFVVEQKGWACHENYYTCFHYKLNLKNNDIE
CHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEECCCCEEEEEEEEECCCCCEE
IVGENMVNKY
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA