BacMap

Definition	Methanococcus aeolicus Nankai-3, complete genome.
Accession	NC_009635
Length	1,569,500

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The map label for this gene is psmB

Identifier: 150400488

GI number: 150400488

Start: 57525

End: 58178

Strand: Reverse

Name: psmB

Synonym: Maeo_0050

Alternate gene names: 150400488

Gene position: 58178-57525 (Counterclockwise)

Preceding gene: 150400489

Following gene: 150400487

Centisome position: 3.71

GC content: 34.56

Gene sequence:

>654_bases
ATGATAGCAAATAACGACCAATATAAAGAATACATGAAAGGAACTACAACTGTGGGGATAGTTTGTAATGATGGAATAGT
ATTGGCAACAGATAAAAGAGCAACCATGGGGAATCTTATTGCCGATAAAGAAGCAAAAAAGTTATATAAGATAGATGACT
ATATGGCAATGACAATAGCTGGAAGTGTGGGGGATGCTCAGTCCTTAGTAAGAATAATATCAGCAGAAGCAAATTTATAT
AAATTAAGAACTGGAAATAACATTCCCCCTCATTCATGTGCTATGCTTTTAAGTAATGTGCTTCATGGTAGCAGACATTT
TCCTTTTTTAATTCAGTTAATAATCGGAGGATATGATACTATTCATGGTGCTAAGTTATTCTCCCTTGATGCAGTGGGCG
GATTAAATGAGGAAACCTCATTCACAGCAACAGGTTCTGGTTCGCCTACGGCATTTGGTGTGTTAGAAGAAGAATATAAA
AAAGATATGACAATAAATAAGGGAAAATTACTTGCCATTAAATCTTTAACTGCTGCCATGAAAAGAGATGCTTTTTCAGG
AAATGGCATATCTCTTGCAGTAATTGACAAAAATGGAGTAAAGATATACTCTGATGAAGAGATAGAGGAGCTCTCCAATA
TATTATATAAATAA

Upstream 100 bases:

>100_bases
ATTTAAGCATATATTGTAGATAAATTATGCCTATTTTTAACATTATTCTGATGACTATTTTATAAATTAAATAAATAAGA
ACACTATTTTGAGGGATTAA

Downstream 100 bases:

>100_bases
GAAAATAAAAATAAAACAGATAGGCTAAGCATAAATAAGAAAATAAAATTTTATTTTTCATTTTATTATGTTTTTATTAT
ATTATAATGCGCTATTGTTG

Product: proteasome endopeptidase complex

Products: NA

Alternate protein names: 20S proteasome beta subunit; Proteasome core protein PsmB

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MIANNDQYKEYMKGTTTVGIVCNDGIVLATDKRATMGNLIADKEAKKLYKIDDYMAMTIAGSVGDAQSLVRIISAEANLY
KLRTGNNIPPHSCAMLLSNVLHGSRHFPFLIQLIIGGYDTIHGAKLFSLDAVGGLNEETSFTATGSGSPTAFGVLEEEYK
KDMTINKGKLLAIKSLTAAMKRDAFSGNGISLAVIDKNGVKIYSDEEIEELSNILYK

Sequences:

>Translated_217_residues
MIANNDQYKEYMKGTTTVGIVCNDGIVLATDKRATMGNLIADKEAKKLYKIDDYMAMTIAGSVGDAQSLVRIISAEANLY
KLRTGNNIPPHSCAMLLSNVLHGSRHFPFLIQLIIGGYDTIHGAKLFSLDAVGGLNEETSFTATGSGSPTAFGVLEEEYK
KDMTINKGKLLAIKSLTAAMKRDAFSGNGISLAVIDKNGVKIYSDEEIEELSNILYK
>Mature_217_residues
MIANNDQYKEYMKGTTTVGIVCNDGIVLATDKRATMGNLIADKEAKKLYKIDDYMAMTIAGSVGDAQSLVRIISAEANLY
KLRTGNNIPPHSCAMLLSNVLHGSRHFPFLIQLIIGGYDTIHGAKLFSLDAVGGLNEETSFTATGSGSPTAFGVLEEEYK
KDMTINKGKLLAIKSLTAAMKRDAFSGNGISLAVIDKNGVKIYSDEEIEELSNILYK

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506201, Length=197, Percent_Identity=29.9492385786802, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI73747875, Length=209, Percent_Identity=28.7081339712919, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI4758970, Length=209, Percent_Identity=28.7081339712919, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI23110925, Length=195, Percent_Identity=30.2564102564103, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI4506191, Length=195, Percent_Identity=31.2820512820513, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI4506203, Length=186, Percent_Identity=32.7956989247312, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4506193, Length=197, Percent_Identity=26.9035532994924, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI156713442, Length=205, Percent_Identity=28.2926829268293, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI4506185, Length=205, Percent_Identity=28.2926829268293, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI153791216, Length=188, Percent_Identity=29.2553191489362, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI22538465, Length=190, Percent_Identity=24.2105263157895, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4506205, Length=193, Percent_Identity=24.8704663212435, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI195539356, Length=148, Percent_Identity=27.027027027027, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI23110942, Length=211, Percent_Identity=27.0142180094787, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI4506183, Length=123, Percent_Identity=30.0813008130081, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI222144262, Length=110, Percent_Identity=30, Blast_Score=64, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17508499, Length=193, Percent_Identity=31.6062176165803, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508495, Length=191, Percent_Identity=32.9842931937173, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17541700, Length=194, Percent_Identity=25.7731958762887, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535357, Length=191, Percent_Identity=26.1780104712042, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508491, Length=216, Percent_Identity=28.7037037037037, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554384, Length=196, Percent_Identity=25, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508493, Length=215, Percent_Identity=27.4418604651163, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508497, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325360, Length=198, Percent_Identity=29.7979797979798, Blast_Score=102, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321574, Length=207, Percent_Identity=29.951690821256, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324731, Length=199, Percent_Identity=30.6532663316583, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322459, Length=200, Percent_Identity=26, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320849, Length=191, Percent_Identity=25.6544502617801, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321692, Length=208, Percent_Identity=28.8461538461538, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320941, Length=190, Percent_Identity=24.7368421052632, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24584895, Length=202, Percent_Identity=30.6930693069307, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24639979, Length=192, Percent_Identity=32.8125, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI20130281, Length=204, Percent_Identity=28.4313725490196, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355573, Length=198, Percent_Identity=31.3131313131313, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24652553, Length=198, Percent_Identity=31.3131313131313, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573221, Length=200, Percent_Identity=30, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24653999, Length=188, Percent_Identity=26.063829787234, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664391, Length=192, Percent_Identity=28.125, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581176, Length=198, Percent_Identity=26.7676767676768, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355629, Length=188, Percent_Identity=23.4042553191489, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136420, Length=212, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281360341, Length=203, Percent_Identity=25.615763546798, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586406, Length=203, Percent_Identity=25.615763546798, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586400, Length=203, Percent_Identity=25.615763546798, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586402, Length=203, Percent_Identity=25.615763546798, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129563, Length=188, Percent_Identity=22.8723404255319, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737605, Length=200, Percent_Identity=24, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB_META3 (A6UT20)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324254.1
- ProteinModelPortal:   A6UT20
- SMR:   A6UT20
- MEROPS:   T01.002
- GeneID:   5327362
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0050
- eggNOG:   arNOG10234
- HOGENOM:   HBG499923
- OMA:   MAYGVLE
- ProtClustDB:   CLSK876502
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR016050
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 23479; Mature: 23479

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 15-15

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIANNDQYKEYMKGTTTVGIVCNDGIVLATDKRATMGNLIADKEAKKLYKIDDYMAMTIA
CCCCCHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHHCHHHHHHHHHCCEEEEEEE
GSVGDAQSLVRIISAEANLYKLRTGNNIPPHSCAMLLSNVLHGSRHFPFLIQLIIGGYDT
CCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
IHGAKLFSLDAVGGLNEETSFTATGSGSPTAFGVLEEEYKKDMTINKGKLLAIKSLTAAM
CCCCEEEEEECCCCCCCCCEEEECCCCCCCEEHHHHHHHHCCCCCCCCCEEEHHHHHHHH
KRDAFSGNGISLAVIDKNGVKIYSDEEIEELSNILYK
HHCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MIANNDQYKEYMKGTTTVGIVCNDGIVLATDKRATMGNLIADKEAKKLYKIDDYMAMTIA
CCCCCHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHHCHHHHHHHHHCCEEEEEEE
GSVGDAQSLVRIISAEANLYKLRTGNNIPPHSCAMLLSNVLHGSRHFPFLIQLIIGGYDT
CCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
IHGAKLFSLDAVGGLNEETSFTATGSGSPTAFGVLEEEYKKDMTINKGKLLAIKSLTAAM
CCCCEEEEEECCCCCCCCCEEEECCCCCCCEEHHHHHHHHCCCCCCCCCEEEHHHHHHHH
KRDAFSGNGISLAVIDKNGVKIYSDEEIEELSNILYK
HHCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA