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The map label for this gene is hemA

Identifier: 150399845

GI number: 150399845

Start: 1114572

End: 1115711

Strand: Reverse

Name: hemA

Synonym: Mevan_1100

Alternate gene names: 150399845

Gene position: 1115711-1114572 (Counterclockwise)

Preceding gene: 150399846

Following gene: 150399844

Centisome position: 64.87

GC content: 29.82

Gene sequence:

>1140_bases
ATGTTGGTTATTAAAGCAGATTATAAAAAATATCCATTACCGGTTCTTGAAAGCATGCGAATTAATGAAGATGAATTTTA
CGGTAAGTACGATGCTTGCATAATTGTTCAAACTTGTAACCGGATAGAAGCATATTTTGACGAAGAAATAAATGATATTG
AAAAAATAATACCTGATTTCAAGGGTTTTGACGTAATTAAGGGAAAAAAGGCAACATTACATTTTTTAAATGTTGCTTGT
GGAATGGATTCAATGATTCTTGGTGAAAACCAAATTTTAGGGCAGATAAAATCAAGTTACCATAAATCTAAAGAACTTAA
AAAAACATCTAAATACCTTGAAAATCTTTTTTTAAAGGCAATACATGTTGGACAGCGCGTAAGGGCCGAAACTAAGATTA
ATGAAGGAGGTGTTTCAATAGGGAGTGCAGCTGTTGAGCTTGCAGAAATGAAACTTGGCCTTAAAAATAGAAACGTTCTT
TTAATTGGTGCTGGAGAAATTGGAACCCTTGTTGCAAAGGCACTAATTGAAAAACATATAAAAGCAGTAATTGTTGCAAA
TAGAACGTATGAAAGAGCAGAAACACTTGCAAAAGAGTTAAAAGGAATGGCTGTTCATTTTGACAAATTAAAGGAAGCTA
TTAATTTTAGCGATGTTATAATCTGTGCTACGTCATCTCCGCATTATATACTTGAAAAAAGCGACCTTTTAGATGTTGGT
AACAAAATAATTATAGATATTGCAAACCCTCGTGATGTAGATGATTCAGTTAGAGAGCTTGAAAATATATCCCTTTACAC
AATTGATGATTTAAGAAATATTTCTGATAAAAATTTACAAAAAAGGCTTAAAGAAGTCCCAATTGTTGAAAATATAATTG
AAGAAGAATATGGTATACTGTTAAAACAGATTGAAAAAACTAATGTTGAAGAAGTAATAAAAGATTTTAATACATATATT
GAGGACGTTAGAAAAAAAGAACTTGAAAAAGCAGTTAGATTATGTAAAAATAAAAGTCCTGATGAAATAATGGAAAATTT
TTCTAAAGCATTTGTAAAACGTATAACTCATGATTTTGTTTCTTATTCATTAAGTGTTTCAAAAGAAGACCTTTTAAACT
CCATATGGTGGAAAAAATAA

Upstream 100 bases:

>100_bases
AAAGACCAAGAATTACGTAAAAAAATTCTTGAAAAGGTATTTTCTAATAAACAGTTTAAGCTGGAATTTTTAGAACTGAT
TGAAAAACATAGGTGAATCT

Downstream 100 bases:

>100_bases
GTTTTATACCGTATAATTAAGCGGTATGATTAGATTATATAATTTAAGTCAAGTTCCATAATTACTAAGCGAAATTTTGG
TGGAAAAATGGTAAATATAG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MLVIKADYKKYPLPVLESMRINEDEFYGKYDACIIVQTCNRIEAYFDEEINDIEKIIPDFKGFDVIKGKKATLHFLNVAC
GMDSMILGENQILGQIKSSYHKSKELKKTSKYLENLFLKAIHVGQRVRAETKINEGGVSIGSAAVELAEMKLGLKNRNVL
LIGAGEIGTLVAKALIEKHIKAVIVANRTYERAETLAKELKGMAVHFDKLKEAINFSDVIICATSSPHYILEKSDLLDVG
NKIIIDIANPRDVDDSVRELENISLYTIDDLRNISDKNLQKRLKEVPIVENIIEEEYGILLKQIEKTNVEEVIKDFNTYI
EDVRKKELEKAVRLCKNKSPDEIMENFSKAFVKRITHDFVSYSLSVSKEDLLNSIWWKK

Sequences:

>Translated_379_residues
MLVIKADYKKYPLPVLESMRINEDEFYGKYDACIIVQTCNRIEAYFDEEINDIEKIIPDFKGFDVIKGKKATLHFLNVAC
GMDSMILGENQILGQIKSSYHKSKELKKTSKYLENLFLKAIHVGQRVRAETKINEGGVSIGSAAVELAEMKLGLKNRNVL
LIGAGEIGTLVAKALIEKHIKAVIVANRTYERAETLAKELKGMAVHFDKLKEAINFSDVIICATSSPHYILEKSDLLDVG
NKIIIDIANPRDVDDSVRELENISLYTIDDLRNISDKNLQKRLKEVPIVENIIEEEYGILLKQIEKTNVEEVIKDFNTYI
EDVRKKELEKAVRLCKNKSPDEIMENFSKAFVKRITHDFVSYSLSVSKEDLLNSIWWKK
>Mature_379_residues
MLVIKADYKKYPLPVLESMRINEDEFYGKYDACIIVQTCNRIEAYFDEEINDIEKIIPDFKGFDVIKGKKATLHFLNVAC
GMDSMILGENQILGQIKSSYHKSKELKKTSKYLENLFLKAIHVGQRVRAETKINEGGVSIGSAAVELAEMKLGLKNRNVL
LIGAGEIGTLVAKALIEKHIKAVIVANRTYERAETLAKELKGMAVHFDKLKEAINFSDVIICATSSPHYILEKSDLLDVG
NKIIIDIANPRDVDDSVRELENISLYTIDDLRNISDKNLQKRLKEVPIVENIIEEEYGILLKQIEKTNVEEVIKDFNTYI
EDVRKKELEKAVRLCKNKSPDEIMENFSKAFVKRITHDFVSYSLSVSKEDLLNSIWWKK

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=388, Percent_Identity=30.6701030927835, Blast_Score=164, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_METVS (A6UR78)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323612.1
- ProteinModelPortal:   A6UR78
- SMR:   A6UR78
- STRING:   A6UR78
- GeneID:   5324539
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1100
- eggNOG:   arNOG04783
- HOGENOM:   HBG732626
- OMA:   IVANRTY
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:1.10.1200.70
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 43234; Mature: 43234

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 39-39 BINDING 84-84 BINDING 95-95

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIKADYKKYPLPVLESMRINEDEFYGKYDACIIVQTCNRIEAYFDEEINDIEKIIPDF
CEEEECCCCCCCCCHHHHCCCCCHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC
KGFDVIKGKKATLHFLNVACGMDSMILGENQILGQIKSSYHKSKELKKTSKYLENLFLKA
CCCCCCCCCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHVGQRVRAETKINEGGVSIGSAAVELAEMKLGLKNRNVLLIGAGEIGTLVAKALIEKHI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHH
KAVIVANRTYERAETLAKELKGMAVHFDKLKEAINFSDVIICATSSPHYILEKSDLLDVG
HEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCHHHHHCC
NKIIIDIANPRDVDDSVRELENISLYTIDDLRNISDKNLQKRLKEVPIVENIIEEEYGIL
CEEEEEECCCCCCCHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHH
LKQIEKTNVEEVIKDFNTYIEDVRKKELEKAVRLCKNKSPDEIMENFSKAFVKRITHDFV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SYSLSVSKEDLLNSIWWKK
HHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure
MLVIKADYKKYPLPVLESMRINEDEFYGKYDACIIVQTCNRIEAYFDEEINDIEKIIPDF
CEEEECCCCCCCCCHHHHCCCCCHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC
KGFDVIKGKKATLHFLNVACGMDSMILGENQILGQIKSSYHKSKELKKTSKYLENLFLKA
CCCCCCCCCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IHVGQRVRAETKINEGGVSIGSAAVELAEMKLGLKNRNVLLIGAGEIGTLVAKALIEKHI
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHH
KAVIVANRTYERAETLAKELKGMAVHFDKLKEAINFSDVIICATSSPHYILEKSDLLDVG
HEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECCHHHHHCC
NKIIIDIANPRDVDDSVRELENISLYTIDDLRNISDKNLQKRLKEVPIVENIIEEEYGIL
CEEEEEECCCCCCCHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHH
LKQIEKTNVEEVIKDFNTYIEDVRKKELEKAVRLCKNKSPDEIMENFSKAFVKRITHDFV
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SYSLSVSKEDLLNSIWWKK
HHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA