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The map label for this gene is hmgA [H]

Identifier: 150399844

GI number: 150399844

Start: 1113249

End: 1114484

Strand: Reverse

Name: hmgA [H]

Synonym: Mevan_1099

Alternate gene names: 150399844

Gene position: 1114484-1113249 (Counterclockwise)

Preceding gene: 150399845

Following gene: 150399843

Centisome position: 64.79

GC content: 34.71

Gene sequence:

>1236_bases
ATGGTAAATATAGATTGTAAGATTAATATTGATGAAATCGTTGAAAAAATAGTAAATAAAGAGTTAAAGGTATATCAACT
TGATAAAATGTTTGGAGAAAAGAATGCTGTTTTAATAAGGCGAAAATACCTTGAAAAAGTATCAAATGTAAAAACGAATC
ATATTGAAAATTATACAATTGATGAAAAACTTGCAATGCAAAAAAATATTGAAAACATGATTGGCGTAGTTCAGATCCCA
TTGGGGTTTGCAGGGCCACTTTTAGTAAACGGGGCCTTTGCAAAGGGTGAATTTAATGTCCCACTTGCAACAACTGAAGG
GGCACTTGTTGCATCGGTAAATAGGGGTTGCAGCATTATTACAAAATGTGGCGGCGCTACTGTTAGAGTAATAGATGATA
AAATGACTAGGGCTCCAATAATAAAAACAAATTCGGTTGTTGATGCATTAAAACTTAAAGAATGGATTTTAGAAAATTTT
TTGAAGATAAAAGAAGTTTCAGAATCAACCACAAGACATGGTAAACTCATTTCAATAAGCCCGATTTTAATAGTTGGAAG
AAACGTATACCCAAGATTTACCTTTAAAACTGGGGATGCAATGGGTATGAACATGGTTACAATTGCAACAGAAAAAGCAT
GTTTATTTATTGAATCAGAACTTAAAAAAGAAGGAATAGATGTGGATACTATTGCACTTAGTGGAAACGTGTGTATCGAC
AAAAAACCAGCTGCAATCAACTTAATTGAAGGAAGAGGAAAAAGTGTTATTGCAGAAGTATTTTTAAAAGAAGAATACGT
GAATAAATATTTAAAAACGACTTCAAAAGCAATAGAACAAGTAAATACGTATAAAAATCTGATTGGTTCTGCAATAAGTG
GATCTTTGGGATTTAACGCACAGTATGCAAACATTGTTGGTGCAATTTTTTTGGCAACCGGCCAAGATGAAGCACATGTT
GTGGAAGGCAGTATGGGGATTACTACTGCAGAATGTACCAAAGAAGGATTATATTTTTCAGTAACGCTTCCAGATTTGCC
AATTGCAACAATTGGTGGTGGAACCCGGGTTGAACCCCAGAACGAATGTTTAGAACTCTTAGAATGTGCAGGAACAGGGA
AATCAGAAAAGTTTGCAGAAATTGTTGGTGCAAGTGTTTTAGCAGGCGAACTTTCGTTAATCGGTGCATTATCTGCAGGA
CATCTTGCAAAGGCACATTCTGAACTTGGAAGATAA

Upstream 100 bases:

>100_bases
GTGGAAAAAATAAGTTTTATACCGTATAATTAAGCGGTATGATTAGATTATATAATTTAAGTCAAGTTCCATAATTACTA
AGCGAAATTTTGGTGGAAAA

Downstream 100 bases:

>100_bases
ATTAATTTTAAGTCTCTTTCATTGATTTAATTTAATATTTATAGTTAAAGTTACTTAATTTATATACTGATTTAAAAATA
ATATATGGTATAATATAAAA

Product: 3-hydroxy-3-methylglutaryl coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MVNIDCKINIDEIVEKIVNKELKVYQLDKMFGEKNAVLIRRKYLEKVSNVKTNHIENYTIDEKLAMQKNIENMIGVVQIP
LGFAGPLLVNGAFAKGEFNVPLATTEGALVASVNRGCSIITKCGGATVRVIDDKMTRAPIIKTNSVVDALKLKEWILENF
LKIKEVSESTTRHGKLISISPILIVGRNVYPRFTFKTGDAMGMNMVTIATEKACLFIESELKKEGIDVDTIALSGNVCID
KKPAAINLIEGRGKSVIAEVFLKEEYVNKYLKTTSKAIEQVNTYKNLIGSAISGSLGFNAQYANIVGAIFLATGQDEAHV
VEGSMGITTAECTKEGLYFSVTLPDLPIATIGGGTRVEPQNECLELLECAGTGKSEKFAEIVGASVLAGELSLIGALSAG
HLAKAHSELGR

Sequences:

>Translated_411_residues
MVNIDCKINIDEIVEKIVNKELKVYQLDKMFGEKNAVLIRRKYLEKVSNVKTNHIENYTIDEKLAMQKNIENMIGVVQIP
LGFAGPLLVNGAFAKGEFNVPLATTEGALVASVNRGCSIITKCGGATVRVIDDKMTRAPIIKTNSVVDALKLKEWILENF
LKIKEVSESTTRHGKLISISPILIVGRNVYPRFTFKTGDAMGMNMVTIATEKACLFIESELKKEGIDVDTIALSGNVCID
KKPAAINLIEGRGKSVIAEVFLKEEYVNKYLKTTSKAIEQVNTYKNLIGSAISGSLGFNAQYANIVGAIFLATGQDEAHV
VEGSMGITTAECTKEGLYFSVTLPDLPIATIGGGTRVEPQNECLELLECAGTGKSEKFAEIVGASVLAGELSLIGALSAG
HLAKAHSELGR
>Mature_411_residues
MVNIDCKINIDEIVEKIVNKELKVYQLDKMFGEKNAVLIRRKYLEKVSNVKTNHIENYTIDEKLAMQKNIENMIGVVQIP
LGFAGPLLVNGAFAKGEFNVPLATTEGALVASVNRGCSIITKCGGATVRVIDDKMTRAPIIKTNSVVDALKLKEWILENF
LKIKEVSESTTRHGKLISISPILIVGRNVYPRFTFKTGDAMGMNMVTIATEKACLFIESELKKEGIDVDTIALSGNVCID
KKPAAINLIEGRGKSVIAEVFLKEEYVNKYLKTTSKAIEQVNTYKNLIGSAISGSLGFNAQYANIVGAIFLATGQDEAHV
VEGSMGITTAECTKEGLYFSVTLPDLPIATIGGGTRVEPQNECLELLECAGTGKSEKFAEIVGASVLAGELSLIGALSAG
HLAKAHSELGR

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=412, Percent_Identity=44.1747572815534, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI196049380, Length=295, Percent_Identity=46.7796610169492, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI25144592, Length=418, Percent_Identity=41.6267942583732, Blast_Score=291, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6323483, Length=419, Percent_Identity=40.5727923627685, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6323565, Length=413, Percent_Identity=39.9515738498789, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI281362379, Length=364, Percent_Identity=43.956043956044, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI45553469, Length=364, Percent_Identity=43.956043956044, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24649399, Length=364, Percent_Identity=43.956043956044, Blast_Score=245, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 44402; Mature: 44402

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNIDCKINIDEIVEKIVNKELKVYQLDKMFGEKNAVLIRRKYLEKVSNVKTNHIENYTI
CEEEEEEECHHHHHHHHHCCCCEEEEHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCC
DEKLAMQKNIENMIGVVQIPLGFAGPLLVNGAFAKGEFNVPLATTEGALVASVNRGCSII
HHHHHHHHHHHHHHEEEEECCCCCCHHHEECEEECCEECCEEEECCCCEEEECCCCCEEE
TKCGGATVRVIDDKMTRAPIIKTNSVVDALKLKEWILENFLKIKEVSESTTRHGKLISIS
EECCCCEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PILIVGRNVYPRFTFKTGDAMGMNMVTIATEKACLFIESELKKEGIDVDTIALSGNVCID
CEEEECCCCCCEEEEECCCCCCCEEEEEEECCEEEEEEHHHHHCCCCEEEEEEECCEEEC
KKPAAINLIEGRGKSVIAEVFLKEEYVNKYLKTTSKAIEQVNTYKNLIGSAISGSLGFNA
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QYANIVGAIFLATGQDEAHVVEGSMGITTAECTKEGLYFSVTLPDLPIATIGGGTRVEPQ
HHHHHEEEEEEECCCCCCEEEECCCCCEEHHHHHCCEEEEEECCCCCEEEECCCCCCCCH
NECLELLECAGTGKSEKFAEIVGASVLAGELSLIGALSAGHLAKAHSELGR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MVNIDCKINIDEIVEKIVNKELKVYQLDKMFGEKNAVLIRRKYLEKVSNVKTNHIENYTI
CEEEEEEECHHHHHHHHHCCCCEEEEHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCC
DEKLAMQKNIENMIGVVQIPLGFAGPLLVNGAFAKGEFNVPLATTEGALVASVNRGCSII
HHHHHHHHHHHHHHEEEEECCCCCCHHHEECEEECCEECCEEEECCCCEEEECCCCCEEE
TKCGGATVRVIDDKMTRAPIIKTNSVVDALKLKEWILENFLKIKEVSESTTRHGKLISIS
EECCCCEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
PILIVGRNVYPRFTFKTGDAMGMNMVTIATEKACLFIESELKKEGIDVDTIALSGNVCID
CEEEECCCCCCEEEEECCCCCCCEEEEEEECCEEEEEEHHHHHCCCCEEEEEEECCEEEC
KKPAAINLIEGRGKSVIAEVFLKEEYVNKYLKTTSKAIEQVNTYKNLIGSAISGSLGFNA
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QYANIVGAIFLATGQDEAHVVEGSMGITTAECTKEGLYFSVTLPDLPIATIGGGTRVEPQ
HHHHHEEEEEEECCCCCCEEEECCCCCEEHHHHHCCEEEEEECCCCCEEEECCCCCCCCH
NECLELLECAGTGKSEKFAEIVGASVLAGELSLIGALSAGHLAKAHSELGR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]