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The map label for this gene is mtaD

Identifier: 150399551

GI number: 150399551

Start: 832344

End: 833612

Strand: Reverse

Name: mtaD

Synonym: Mevan_0800

Alternate gene names: 150399551

Gene position: 833612-832344 (Counterclockwise)

Preceding gene: 150399552

Following gene: 150399549

Centisome position: 48.46

GC content: 30.5

Gene sequence:

>1269_bases
ATGATTTTGGTAAAAGATGCAATTATTAACGGAAAAAAACAGGATTTACTTGTTGAAGGGAATATTATTAAAAAAATTGG
AAATGTTCCAATTTCTGAAGTTTCAAAAGACGAAACAGAAATAATTGACGGAAAAAATTGTATTTTAATTCCGGGATTGG
TAAATACGCATACCCATATTCCAATGTCACTTTTTAGGGGGGTTGCAGATGATATTCCTTTAATGGAGTGGTTAAGTGGC
CATATTTGGCCAATGGAATCAAAATTAAATGAAAAAATAGTATATGCTGGAACCCTACTTGGGGCAGTTGAAATGATTAA
AAGCGGAACAACTGCATTTAATGACATGTATTTTTTCCTTGATTCGATAATTAAGGCAGTAGATGAAACAGGAATTAGGT
CAACAATTGCATATGGAATGATTGATTTATTTAATGAAGAAAAAAGGGAAAAAGAATTAAAATCTGCGAAAAAATCTATT
GAAATGATTAAAAAATTAAATAATTCAAGAATTACGGGGGCTTTAGGCCCACATGCACCGTATACTTGTTCAAAAGAACT
GTTGGAAAGTACAAATGCTCTTGCAAGGGAGTATAATGTTCCAATTCATATTCACATGAACGAAACCGTTGATGAAATAA
ATCAAGTTTTGGAAAAAACAAAAATGAGGCCTTTTGAATACTTAAACTCATTTGGGTTTTTTGACAATGTAACTACCGTT
TGTGCACACTGTGTTCATTTAAATGACTCTGAAATCAAGATAATAAAAGAAAAAAATATCTTTGTAGCACATAATCCTAT
AAGTAACTTAAAATTGGCATCAGGAGTGTCCCCTGTAGCAAAATTATTAGAAAACGAAGTTAATATAACTCTTGGAACTG
ATGGATGCGGTAGTAATAATAGTTTAAATTTATTTGAAGAAATGAAAACAGCAGCTTTAATACATAAAGGGGTAAATTTA
AATCCTGTTTTAGTAACTGCAAAAGAAGCATTTGAATTTGGAACCCTAAACGGTGCAAAAGCATTAAATATTAATTCTGG
AGAAATAAAAGAAGGAAAACTTGCAGATTTTGCACTTATAAATGTTAAAAAACCTTACTTAACACCGAGAGAAAATATTG
AATCACACTTAGTTTATTCATTTAATGGTGCAGTTGATAGTGTTGTAATTGATGGTAAACTTACTTTAAAGGATGGAAAA
ATGGTAACTATTGATGAAGAAAAAGTTTACGAACTTGCAGAAGAGGCATATTTAGAATTAACTAAATAA

Upstream 100 bases:

>100_bases
ACTTAATAAATAATTTATAAATTTACTTTTAAATCTATAAATTGGATTTAAAAGTTGTAAATTAGTCGCTTAATAATTTT
TAAATTTAGGGTTGATTTTA

Downstream 100 bases:

>100_bases
AATCTTTTTTTAAATTTTCATTTAAATATATTAAAAATTCTTCTTCTATTTTTTTAAAATTAATTTTTTCATGCTCAATA
CTTTTAAATTCTTTTAAAAA

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MILVKDAIINGKKQDLLVEGNIIKKIGNVPISEVSKDETEIIDGKNCILIPGLVNTHTHIPMSLFRGVADDIPLMEWLSG
HIWPMESKLNEKIVYAGTLLGAVEMIKSGTTAFNDMYFFLDSIIKAVDETGIRSTIAYGMIDLFNEEKREKELKSAKKSI
EMIKKLNNSRITGALGPHAPYTCSKELLESTNALAREYNVPIHIHMNETVDEINQVLEKTKMRPFEYLNSFGFFDNVTTV
CAHCVHLNDSEIKIIKEKNIFVAHNPISNLKLASGVSPVAKLLENEVNITLGTDGCGSNNSLNLFEEMKTAALIHKGVNL
NPVLVTAKEAFEFGTLNGAKALNINSGEIKEGKLADFALINVKKPYLTPRENIESHLVYSFNGAVDSVVIDGKLTLKDGK
MVTIDEEKVYELAEEAYLELTK

Sequences:

>Translated_422_residues
MILVKDAIINGKKQDLLVEGNIIKKIGNVPISEVSKDETEIIDGKNCILIPGLVNTHTHIPMSLFRGVADDIPLMEWLSG
HIWPMESKLNEKIVYAGTLLGAVEMIKSGTTAFNDMYFFLDSIIKAVDETGIRSTIAYGMIDLFNEEKREKELKSAKKSI
EMIKKLNNSRITGALGPHAPYTCSKELLESTNALAREYNVPIHIHMNETVDEINQVLEKTKMRPFEYLNSFGFFDNVTTV
CAHCVHLNDSEIKIIKEKNIFVAHNPISNLKLASGVSPVAKLLENEVNITLGTDGCGSNNSLNLFEEMKTAALIHKGVNL
NPVLVTAKEAFEFGTLNGAKALNINSGEIKEGKLADFALINVKKPYLTPRENIESHLVYSFNGAVDSVVIDGKLTLKDGK
MVTIDEEKVYELAEEAYLELTK
>Mature_422_residues
MILVKDAIINGKKQDLLVEGNIIKKIGNVPISEVSKDETEIIDGKNCILIPGLVNTHTHIPMSLFRGVADDIPLMEWLSG
HIWPMESKLNEKIVYAGTLLGAVEMIKSGTTAFNDMYFFLDSIIKAVDETGIRSTIAYGMIDLFNEEKREKELKSAKKSI
EMIKKLNNSRITGALGPHAPYTCSKELLESTNALAREYNVPIHIHMNETVDEINQVLEKTKMRPFEYLNSFGFFDNVTTV
CAHCVHLNDSEIKIIKEKNIFVAHNPISNLKLASGVSPVAKLLENEVNITLGTDGCGSNNSLNLFEEMKTAALIHKGVNL
NPVLVTAKEAFEFGTLNGAKALNINSGEIKEGKLADFALINVKKPYLTPRENIESHLVYSFNGAVDSVVIDGKLTLKDGK
MVTIDEEKVYELAEEAYLELTK

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=386, Percent_Identity=29.2746113989637, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1789249, Length=395, Percent_Identity=28.3544303797468, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87082177, Length=432, Percent_Identity=25.2314814814815, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319963, Length=349, Percent_Identity=24.6418338108883, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24643849, Length=357, Percent_Identity=29.1316526610644, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_METVS (A6UQD4)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323318.1
- ProteinModelPortal:   A6UQD4
- SMR:   A6UQD4
- STRING:   A6UQD4
- GeneID:   5324649
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_0800
- eggNOG:   arNOG04550
- HOGENOM:   HBG668170
- OMA:   KVIDMAT
- ProtClustDB:   CLSK876616
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 46768; Mature: 46768

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: BINDING 86-86 BINDING 178-178 BINDING 208-208 BINDING 294-294

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVKDAIINGKKQDLLVEGNIIKKIGNVPISEVSKDETEIIDGKNCILIPGLVNTHTHI
CEEEECHHHCCCCCCEEEECHHHHHHCCCCHHHCCCCCHHEECCCCEEEECCCCCCCCCC
PMSLFRGVADDIPLMEWLSGHIWPMESKLNEKIVYAGTLLGAVEMIKSGTTAFNDMYFFL
CHHHHHHHCCCCCHHHHHCCCCCCCHHCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHH
DSIIKAVDETGIRSTIAYGMIDLFNEEKREKELKSAKKSIEMIKKLNNSRITGALGPHAP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
YTCSKELLESTNALAREYNVPIHIHMNETVDEINQVLEKTKMRPFEYLNSFGFFDNVTTV
CHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHH
CAHCVHLNDSEIKIIKEKNIFVAHNPISNLKLASGVSPVAKLLENEVNITLGTDGCGSNN
HHHHHCCCCCCEEEEEECCEEEEECCCCCCCHHCCCHHHHHHHCCCCEEEEECCCCCCCC
SLNLFEEMKTAALIHKGVNLNPVLVTAKEAFEFGTLNGAKALNINSGEIKEGKLADFALI
CCHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEEE
NVKKPYLTPRENIESHLVYSFNGAVDSVVIDGKLTLKDGKMVTIDEEKVYELAEEAYLEL
EECCCCCCCCCCCCCEEEEEECCCCCEEEECCEEEEECCCEEEECHHHHHHHHHHHHHCC
TK
CC
>Mature Secondary Structure
MILVKDAIINGKKQDLLVEGNIIKKIGNVPISEVSKDETEIIDGKNCILIPGLVNTHTHI
CEEEECHHHCCCCCCEEEECHHHHHHCCCCHHHCCCCCHHEECCCCEEEECCCCCCCCCC
PMSLFRGVADDIPLMEWLSGHIWPMESKLNEKIVYAGTLLGAVEMIKSGTTAFNDMYFFL
CHHHHHHHCCCCCHHHHHCCCCCCCHHCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHH
DSIIKAVDETGIRSTIAYGMIDLFNEEKREKELKSAKKSIEMIKKLNNSRITGALGPHAP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
YTCSKELLESTNALAREYNVPIHIHMNETVDEINQVLEKTKMRPFEYLNSFGFFDNVTTV
CHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHH
CAHCVHLNDSEIKIIKEKNIFVAHNPISNLKLASGVSPVAKLLENEVNITLGTDGCGSNN
HHHHHCCCCCCEEEEEECCEEEEECCCCCCCHHCCCHHHHHHHCCCCEEEEECCCCCCCC
SLNLFEEMKTAALIHKGVNLNPVLVTAKEAFEFGTLNGAKALNINSGEIKEGKLADFALI
CCHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEEE
NVKKPYLTPRENIESHLVYSFNGAVDSVVIDGKLTLKDGKMVTIDEEKVYELAEEAYLEL
EECCCCCCCCCCCCCEEEEEECCCCCEEEECCEEEEECCCEEEECHHHHHHHHHHHHHCC
TK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA