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The map label for this gene is pnk [H]

Identifier: 150399549

GI number: 150399549

Start: 829777

End: 831480

Strand: Reverse

Name: pnk [H]

Synonym: Mevan_0798

Alternate gene names: 150399549

Gene position: 831480-829777 (Counterclockwise)

Preceding gene: 150399551

Following gene: 150399546

Centisome position: 48.34

GC content: 32.04

Gene sequence:

>1704_bases
ATGGACATGCTTGAAATGGCGTTAACCATTACTAAGAATATCGAAAAAAGTATAAAGCCATTAATTGGTTGGGAAAAATC
AAATGAAGTAGTTAAAATTGGTGCAGATGGGACGCCAACAAAAAGAATAGACTTAGTTGCAGAAAATACTGCAATAAGTT
CGATAGAAAAGTTCGGTTCAGCAATACTTGTTAGTGAAGAAATTGGATTTAAAAAAATTGGAAAAAATAATCCGGAGTAC
GTAATAGTGCTCGACCCTGTTGATGGAACATATAATTCTTTAAAGGACATTCCTTTTTATTCAGCATCAATTGCAATTGG
TAGATTAAACGGTAACACTGAAAAACCCGATGAATTAATTAAAAATCTTAAAATGAAAGACCTTGAAGTTGGTGTTGTAA
GAAATATTGCAACAGGTGACACTTACTACGCTAAAAGGGGACAGGGGGCATATTTTTTAAAAAAAGATGAAAAAAAAGCA
ATATCTATTTCAAATACTTCAAATCTTAAAGACTCCTCAATAGGACTTTTTGCACATGATATTTCTGGAGAAACTCTTGA
TTTTATAAAAGATAGGAAATTCAGGCGTATAAGACTTTTTGGTTCGATTGCACTTGAAATGTGTTATGTTGCAAGGGGTT
CTCTTGATGCTTTTATAAATGTAAATGAAACAACTAGATTATGCGATATTGCAGCAGGTTACGTTATAATTAAGGAAGCA
GGAGGATATGTAACGGATAAAAATGGACAGGAAATAAACCTTAGCTTAGATGTAAATTCAAAAACTTCAATAATATGTTC
AAATGAAATACTCCATAAAAAGCTTGTAGGAATTTTTGGAAACAAATGGAGCCTTAAACCAACAAATATCGGCATAGTTT
CAAGGATTGATAGGGAAGAATCTACTGAACTTGCATTAAATGTTATAAATTATTTGGAGTCAAAAGGAATAAAATATGCA
CTTGATATTGGTACTTACGATGCTTTAAAAAGCAGGTTACCTGAAAAATGTAATATCATTACTAAAATTGAAGATATATC
CCATGTAATATCTATCGGAGGAGATGGTACTGTACTTCGAACCTCAAAAATGATTAACGGAAATGAAATTCCTATAATTT
GCATAAACATGGGCACAGTTGGATTTTTAACTGAATTTAGTAAGGAAGATGTGTTTTTTGCAATAGATTCAGTAGCTTCT
GGAAGCTATAAGATTGAAAAACGAACAAAACTTCTAAGTTTTTTGAGATTTTCTGACGGAAAACAGCAAATTTTACCGGA
TTCCCTAAATGAAGTTGTTATAACAACAAAAAACCCTGCAAAAATGCTACATTTTGAAGTCCATATAAATGGGGGTATGG
TAGAGGATGTACGGGCAGATGGGATTATAATTTCAACACCAAATGGATCAACTGCATATTCTTTAAGTGCAGGGGGCCCA
ATAATTGAACCAACAGTGGATGGTTTCGTAATAGTTCCAATATGTCCATTTAAACTTTCTTCAAGGCCGTTAGTTGTAAA
TGCAAATTCAGAAATAAAAATTAAGATACTAAAAAAGTCAACATTTATTGTAGTTGATGGAAATATTGAATTTGAGGCAA
AAGCAGGCGATGAATTAGTTCTTAGAAAATCCGAATCATACGCATATTTCGTAAAGGGGGATAATTTTTATAACAAGTTA
AAAAAATTGAGTTTAATGGAATAG

Upstream 100 bases:

>100_bases
GATAATAATCATTCATACACCTTTGAACAAAGTTTTAAATCATTTCATGTTTTTGTTATTTATTTATAATACGTAATGGT
TATTTAATACTGGTGAAAAA

Downstream 100 bases:

>100_bases
ATTATTGTTTATTCTTTCTTTTTAAATACCATATTTTTTACAAGATATATAAAAGCGTATGCTAAAATGATTAAAATCAG
TAGGGCAGCTAATAAAAAAG

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase [H]

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MDMLEMALTITKNIEKSIKPLIGWEKSNEVVKIGADGTPTKRIDLVAENTAISSIEKFGSAILVSEEIGFKKIGKNNPEY
VIVLDPVDGTYNSLKDIPFYSASIAIGRLNGNTEKPDELIKNLKMKDLEVGVVRNIATGDTYYAKRGQGAYFLKKDEKKA
ISISNTSNLKDSSIGLFAHDISGETLDFIKDRKFRRIRLFGSIALEMCYVARGSLDAFINVNETTRLCDIAAGYVIIKEA
GGYVTDKNGQEINLSLDVNSKTSIICSNEILHKKLVGIFGNKWSLKPTNIGIVSRIDREESTELALNVINYLESKGIKYA
LDIGTYDALKSRLPEKCNIITKIEDISHVISIGGDGTVLRTSKMINGNEIPIICINMGTVGFLTEFSKEDVFFAIDSVAS
GSYKIEKRTKLLSFLRFSDGKQQILPDSLNEVVITTKNPAKMLHFEVHINGGMVEDVRADGIIISTPNGSTAYSLSAGGP
IIEPTVDGFVIVPICPFKLSSRPLVVNANSEIKIKILKKSTFIVVDGNIEFEAKAGDELVLRKSESYAYFVKGDNFYNKL
KKLSLME

Sequences:

>Translated_567_residues
MDMLEMALTITKNIEKSIKPLIGWEKSNEVVKIGADGTPTKRIDLVAENTAISSIEKFGSAILVSEEIGFKKIGKNNPEY
VIVLDPVDGTYNSLKDIPFYSASIAIGRLNGNTEKPDELIKNLKMKDLEVGVVRNIATGDTYYAKRGQGAYFLKKDEKKA
ISISNTSNLKDSSIGLFAHDISGETLDFIKDRKFRRIRLFGSIALEMCYVARGSLDAFINVNETTRLCDIAAGYVIIKEA
GGYVTDKNGQEINLSLDVNSKTSIICSNEILHKKLVGIFGNKWSLKPTNIGIVSRIDREESTELALNVINYLESKGIKYA
LDIGTYDALKSRLPEKCNIITKIEDISHVISIGGDGTVLRTSKMINGNEIPIICINMGTVGFLTEFSKEDVFFAIDSVAS
GSYKIEKRTKLLSFLRFSDGKQQILPDSLNEVVITTKNPAKMLHFEVHINGGMVEDVRADGIIISTPNGSTAYSLSAGGP
IIEPTVDGFVIVPICPFKLSSRPLVVNANSEIKIKILKKSTFIVVDGNIEFEAKAGDELVLRKSESYAYFVKGDNFYNKL
KKLSLME
>Mature_567_residues
MDMLEMALTITKNIEKSIKPLIGWEKSNEVVKIGADGTPTKRIDLVAENTAISSIEKFGSAILVSEEIGFKKIGKNNPEY
VIVLDPVDGTYNSLKDIPFYSASIAIGRLNGNTEKPDELIKNLKMKDLEVGVVRNIATGDTYYAKRGQGAYFLKKDEKKA
ISISNTSNLKDSSIGLFAHDISGETLDFIKDRKFRRIRLFGSIALEMCYVARGSLDAFINVNETTRLCDIAAGYVIIKEA
GGYVTDKNGQEINLSLDVNSKTSIICSNEILHKKLVGIFGNKWSLKPTNIGIVSRIDREESTELALNVINYLESKGIKYA
LDIGTYDALKSRLPEKCNIITKIEDISHVISIGGDGTVLRTSKMINGNEIPIICINMGTVGFLTEFSKEDVFFAIDSVAS
GSYKIEKRTKLLSFLRFSDGKQQILPDSLNEVVITTKNPAKMLHFEVHINGGMVEDVRADGIIISTPNGSTAYSLSAGGP
IIEPTVDGFVIVPICPFKLSSRPLVVNANSEIKIKILKKSTFIVVDGNIEFEAKAGDELVLRKSESYAYFVKGDNFYNKL
KKLSLME

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus [H]

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the NAD kinase family [H]

Homologues:

Organism=Homo sapiens, GI55743112, Length=306, Percent_Identity=29.4117647058824, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI221625487, Length=244, Percent_Identity=28.6885245901639, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI5031789, Length=244, Percent_Identity=28.6885245901639, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI7657236, Length=224, Percent_Identity=27.2321428571429, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788968, Length=225, Percent_Identity=34.6666666666667, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325068, Length=200, Percent_Identity=33.5, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320794, Length=215, Percent_Identity=33.0232558139535, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322509, Length=220, Percent_Identity=31.8181818181818, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320493, Length=290, Percent_Identity=26.2068965517241, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573830, Length=214, Percent_Identity=32.7102803738318, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161077047, Length=214, Percent_Identity=32.7102803738318, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573828, Length=214, Percent_Identity=32.7102803738318, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28573826, Length=214, Percent_Identity=32.7102803738318, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28573832, Length=214, Percent_Identity=32.7102803738318, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653422, Length=239, Percent_Identity=28.4518828451883, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI20129957, Length=241, Percent_Identity=28.2157676348548, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281363323, Length=239, Percent_Identity=28.4518828451883, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281363321, Length=239, Percent_Identity=28.4518828451883, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24653424, Length=239, Percent_Identity=28.4518828451883, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24664918, Length=192, Percent_Identity=32.8125, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664922, Length=189, Percent_Identity=30.6878306878307, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21357957, Length=199, Percent_Identity=30.1507537688442, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664926, Length=206, Percent_Identity=28.6407766990291, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR021175
- InterPro:   IPR000760
- InterPro:   IPR002504 [H]

Pfam domain/function: PF00459 Inositol_P; PF01513 NAD_kinase [H]

EC number: =2.7.1.23 [H]

Molecular weight: Translated: 62454; Mature: 62454

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMLEMALTITKNIEKSIKPLIGWEKSNEVVKIGADGTPTKRIDLVAENTAISSIEKFGS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEEECCHHHHHHHHCCC
AILVSEEIGFKKIGKNNPEYVIVLDPVDGTYNSLKDIPFYSASIAIGRLNGNTEKPDELI
EEEEECCCCHHHHCCCCCCEEEEECCCCCCCHHHHCCCEEEEEEEEEECCCCCCCHHHHH
KNLKMKDLEVGVVRNIATGDTYYAKRGQGAYFLKKDEKKAISISNTSNLKDSSIGLFAHD
HCCCCCCEEEEEEEEECCCCCEEEECCCCEEEEECCCCCEEEECCCCCCCCCCCEEEEEC
ISGETLDFIKDRKFRRIRLFGSIALEMCYVARGSLDAFINVNETTRLCDIAAGYVIIKEA
CCCCHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCEEEEEEECCCCEEEEHHCCEEEEEEC
GGYVTDKNGQEINLSLDVNSKTSIICSNEILHKKLVGIFGNKWSLKPTNIGIVSRIDREE
CCEEECCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHCCCCEECCCCCCEEEEECCCCC
STELALNVINYLESKGIKYALDIGTYDALKSRLPEKCNIITKIEDISHVISIGGDGTVLR
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCEEEEEHHCEEEEEECCCCEEEE
TSKMINGNEIPIICINMGTVGFLTEFSKEDVFFAIDSVASGSYKIEKRTKLLSFLRFSDG
EEEEECCCCCEEEEEECCCEEHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCCC
KQQILPDSLNEVVITTKNPAKMLHFEVHINGGMVEDVRADGIIISTPNGSTAYSLSAGGP
CCCCCCCCCCCEEEEECCCCEEEEEEEEECCCEEECCCCCEEEEECCCCCEEEEECCCCC
IIEPTVDGFVIVPICPFKLSSRPLVVNANSEIKIKILKKSTFIVVDGNIEFEAKAGDELV
EECCCCCCEEEEEECCCEECCCCEEEECCCEEEEEEEECEEEEEECCCEEEEECCCCEEE
LRKSESYAYFVKGDNFYNKLKKLSLME
EEECCCEEEEEECCHHHHHHHHHCCCC
>Mature Secondary Structure
MDMLEMALTITKNIEKSIKPLIGWEKSNEVVKIGADGTPTKRIDLVAENTAISSIEKFGS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEEECCHHHHHHHHCCC
AILVSEEIGFKKIGKNNPEYVIVLDPVDGTYNSLKDIPFYSASIAIGRLNGNTEKPDELI
EEEEECCCCHHHHCCCCCCEEEEECCCCCCCHHHHCCCEEEEEEEEEECCCCCCCHHHHH
KNLKMKDLEVGVVRNIATGDTYYAKRGQGAYFLKKDEKKAISISNTSNLKDSSIGLFAHD
HCCCCCCEEEEEEEEECCCCCEEEECCCCEEEEECCCCCEEEECCCCCCCCCCCEEEEEC
ISGETLDFIKDRKFRRIRLFGSIALEMCYVARGSLDAFINVNETTRLCDIAAGYVIIKEA
CCCCHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCEEEEEEECCCCEEEEHHCCEEEEEEC
GGYVTDKNGQEINLSLDVNSKTSIICSNEILHKKLVGIFGNKWSLKPTNIGIVSRIDREE
CCEEECCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHCCCCEECCCCCCEEEEECCCCC
STELALNVINYLESKGIKYALDIGTYDALKSRLPEKCNIITKIEDISHVISIGGDGTVLR
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCCEEEEEHHCEEEEEECCCCEEEE
TSKMINGNEIPIICINMGTVGFLTEFSKEDVFFAIDSVASGSYKIEKRTKLLSFLRFSDG
EEEEECCCCCEEEEEECCCEEHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHCCCC
KQQILPDSLNEVVITTKNPAKMLHFEVHINGGMVEDVRADGIIISTPNGSTAYSLSAGGP
CCCCCCCCCCCEEEEECCCCEEEEEEEEECCCEEECCCCCEEEEECCCCCEEEEECCCCC
IIEPTVDGFVIVPICPFKLSSRPLVVNANSEIKIKILKKSTFIVVDGNIEFEAKAGDELV
EECCCCCCEEEEEECCCEECCCCEEEECCCEEEEEEEECEEEEEECCCEEEEECCCCEEE
LRKSESYAYFVKGDNFYNKLKKLSLME
EEECCCEEEEEECCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA