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The map label for this gene is pyrE [H]

Identifier: 150399552

GI number: 150399552

Start: 833700

End: 834257

Strand: Reverse

Name: pyrE [H]

Synonym: Mevan_0801

Alternate gene names: 150399552

Gene position: 834257-833700 (Counterclockwise)

Preceding gene: 150399555

Following gene: 150399551

Centisome position: 48.5

GC content: 33.15

Gene sequence:

>558_bases
TTGATAAATACGGAAGAAATGAGTTTAAAAAATGAATTGGTAAATCTTTTAAAAGAGGTAAACTGCGTCAAGTTTGGCGA
CTTTATACTCGCATCAGGAAAAGAGAGCAAATACTATGTAGATATTAAAAAAGCCACTACAAATCCTAAGGTATTAAAAG
CAGCTGCAAAATTGGTAAAACACTACGCTTCAAAAGAAAATTACGAAAACTTAAAAATTGCGGGAGTAGAGCTTGGTTCA
GTTTCTATTGCAACAGCGGTATCGTTAGAAATAGAAAAAGACCTTTTAATAATTAGGAAAAAAGCAAAAGAATATGGGAC
AAAAAATAAAATTGAAGGAGAATTAAATCAAAAAGACAATGTAATCGTGATGGAAGACGTTACCACAACGGGAAGTAGTG
TTTCAAAGGCTGTTGATGAAATTAGGGCATCTGGAGGTATCGTGAAGAAAATTTACGTAATTGTTGATAGGCTGGAGGGT
GCAAAAGAAAATTTAGCACAAAACAACGTTGAACTAGTCCCTTTAGTTACAATCGAAGAACTTGGACTTAATAAATAA

Upstream 100 bases:

>100_bases
ACCATTAATTTTTTGAGAAAAGATATATCTACTACCTTAATATAATAATTCAAATAGCATTTATAGTTTACTTTTTTGTT
CGGATTATAAGGTGATATTT

Downstream 100 bases:

>100_bases
TTTATAAATTTACTTTTAAATCTATAAATTGGATTTAAAAGTTGTAAATTAGTCGCTTAATAATTTTTAAATTTAGGGTT
GATTTTAATGATTTTGGTAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MINTEEMSLKNELVNLLKEVNCVKFGDFILASGKESKYYVDIKKATTNPKVLKAAAKLVKHYASKENYENLKIAGVELGS
VSIATAVSLEIEKDLLIIRKKAKEYGTKNKIEGELNQKDNVIVMEDVTTTGSSVSKAVDEIRASGGIVKKIYVIVDRLEG
AKENLAQNNVELVPLVTIEELGLNK

Sequences:

>Translated_185_residues
MINTEEMSLKNELVNLLKEVNCVKFGDFILASGKESKYYVDIKKATTNPKVLKAAAKLVKHYASKENYENLKIAGVELGS
VSIATAVSLEIEKDLLIIRKKAKEYGTKNKIEGELNQKDNVIVMEDVTTTGSSVSKAVDEIRASGGIVKKIYVIVDRLEG
AKENLAQNNVELVPLVTIEELGLNK
>Mature_185_residues
MINTEEMSLKNELVNLLKEVNCVKFGDFILASGKESKYYVDIKKATTNPKVLKAAAKLVKHYASKENYENLKIAGVELGS
VSIATAVSLEIEKDLLIIRKKAKEYGTKNKIEGELNQKDNVIVMEDVTTTGSSVSKAVDEIRASGGIVKKIYVIVDRLEG
AKENLAQNNVELVPLVTIEELGLNK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=171, Percent_Identity=31.5789473684211, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508631, Length=165, Percent_Identity=32.1212121212121, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17554964, Length=177, Percent_Identity=29.3785310734463, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17933654, Length=165, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20355; Mature: 20355

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINTEEMSLKNELVNLLKEVNCVKFGDFILASGKESKYYVDIKKATTNPKVLKAAAKLVK
CCCCHHHHHHHHHHHHHHHCCHHEECCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHH
HYASKENYENLKIAGVELGSVSIATAVSLEIEKDLLIIRKKAKEYGTKNKIEGELNQKDN
HHHCCCCCCCEEEEEEEECCEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VIVMEDVTTTGSSVSKAVDEIRASGGIVKKIYVIVDRLEGAKENLAQNNVELVPLVTIEE
EEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCEEEEEEEECC
LGLNK
CCCCC
>Mature Secondary Structure
MINTEEMSLKNELVNLLKEVNCVKFGDFILASGKESKYYVDIKKATTNPKVLKAAAKLVK
CCCCHHHHHHHHHHHHHHHCCHHEECCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHH
HYASKENYENLKIAGVELGSVSIATAVSLEIEKDLLIIRKKAKEYGTKNKIEGELNQKDN
HHHCCCCCCCEEEEEEEECCEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VIVMEDVTTTGSSVSKAVDEIRASGGIVKKIYVIVDRLEGAKENLAQNNVELVPLVTIEE
EEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCEEEEEEEECC
LGLNK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA