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The map label for this gene is lpxD

Identifier: 150008714

GI number: 150008714

Start: 2488264

End: 2489307

Strand: Direct

Name: lpxD

Synonym: BDI_2104

Alternate gene names: 150008714

Gene position: 2488264-2489307 (Clockwise)

Preceding gene: 150008713

Following gene: 150008715

Centisome position: 51.72

GC content: 47.61

Gene sequence:

>1044_bases
ATGGAGTTTTCAGCCCAACAAATTGCCGGCTTCCTGAACGGAACGATTGAAGGAGATCCGAACGTTAAAGTCAGCAACTT
CTCTAAAATAGAAGAAGGAAAGCCAGGTACATTGACCTTTTTGGCGAATCTTAAATATGCGCATCATATTTATAATACCG
AGGCAAGCATTGTTTTGGTGAATAATGATTTCAAACCGGAACAACCGATAAGAGCCACACTTGTAAAAGTAGAGAACGCT
TATGCGGCGCTCGCGATGTTATTAAATTTGGTAGAGCAATCGAAGAGCAAAAAGAAGGGGGTTGATTCTACCGCTTTTAT
CGCCGCTTCCGCGACCGTGAGCGACGATTGTTATGTCGGTAACTTCGCCTACATCGGAGAAGGCGTAAAAATGGGTAAGA
ACTGTATGGTATACCCGCACGCTTATATCGGTGATCACGTGACGGTAGGAGATAACTGCGTATTCTATCCGCATGCCACC
GTTTACGAGAATTGTATAATCGGCAATAATTGTATCCTTCATGCCGGTAGCGTAGTCGGGGCTGACGGTTTCGGATTCGC
TCCCGAAGGTGAGACTTACAAGAAAATCCCGCAATTAGGCAACGTTATTATCGAGGATGATGTAGAGATCGGAGCCAATA
CGACAATTGACCGTGCGGTGATGGATTCTACGATCATTCACCGAGGCGTTAAGCTGGACAATCTCGTACAAATCGCTCAT
AACGTGGAGGTAGGCGAGAATACCGTGATGGCGGCGCAAGTCGGCATCGCCGGTTCCGTAAAAGTAGGAAAGCATTGTAT
GTTTGGCGGACAAGTTGGTTTGGCCGGACATATCCATGTGGCGGACCACGTCGTATTCGGAGCTCAGGCTGGCGTTATCA
GCGACGTGAAGGAAGCGACGACATTGCTCGGGGCGCCGGCGATCAACGCTAAGAACTTCATGCGTTCCAGCGCGATCTTC
AACCGTCTTCCGGATATATACCGCTCGCTGGGGCAAATGCAACGGGAGATCGAACAACTCAAGAAAGAAATTAATAAACA
ATAA

Upstream 100 bases:

>100_bases
GCAAAGCATAGGCTATATAAAGAATTTTCACCATTTTTGCAAACTAACTGTCTATAAACAGCGGACAGTCAACGAAGATA
CATATATAATTGAATAAGTA

Downstream 100 bases:

>100_bases
AGACCTATGCAAAAACAGAAAACGCTTGCGGCAAGTTTCTCCTTGAAAGGAAAAGGGTTGCATACCGGATTAGATATAGA
GATTACGTTTAATCCCGCAC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MEFSAQQIAGFLNGTIEGDPNVKVSNFSKIEEGKPGTLTFLANLKYAHHIYNTEASIVLVNNDFKPEQPIRATLVKVENA
YAALAMLLNLVEQSKSKKKGVDSTAFIAASATVSDDCYVGNFAYIGEGVKMGKNCMVYPHAYIGDHVTVGDNCVFYPHAT
VYENCIIGNNCILHAGSVVGADGFGFAPEGETYKKIPQLGNVIIEDDVEIGANTTIDRAVMDSTIIHRGVKLDNLVQIAH
NVEVGENTVMAAQVGIAGSVKVGKHCMFGGQVGLAGHIHVADHVVFGAQAGVISDVKEATTLLGAPAINAKNFMRSSAIF
NRLPDIYRSLGQMQREIEQLKKEINKQ

Sequences:

>Translated_347_residues
MEFSAQQIAGFLNGTIEGDPNVKVSNFSKIEEGKPGTLTFLANLKYAHHIYNTEASIVLVNNDFKPEQPIRATLVKVENA
YAALAMLLNLVEQSKSKKKGVDSTAFIAASATVSDDCYVGNFAYIGEGVKMGKNCMVYPHAYIGDHVTVGDNCVFYPHAT
VYENCIIGNNCILHAGSVVGADGFGFAPEGETYKKIPQLGNVIIEDDVEIGANTTIDRAVMDSTIIHRGVKLDNLVQIAH
NVEVGENTVMAAQVGIAGSVKVGKHCMFGGQVGLAGHIHVADHVVFGAQAGVISDVKEATTLLGAPAINAKNFMRSSAIF
NRLPDIYRSLGQMQREIEQLKKEINKQ
>Mature_347_residues
MEFSAQQIAGFLNGTIEGDPNVKVSNFSKIEEGKPGTLTFLANLKYAHHIYNTEASIVLVNNDFKPEQPIRATLVKVENA
YAALAMLLNLVEQSKSKKKGVDSTAFIAASATVSDDCYVGNFAYIGEGVKMGKNCMVYPHAYIGDHVTVGDNCVFYPHAT
VYENCIIGNNCILHAGSVVGADGFGFAPEGETYKKIPQLGNVIIEDDVEIGANTTIDRAVMDSTIIHRGVKLDNLVQIAH
NVEVGENTVMAAQVGIAGSVKVGKHCMFGGQVGLAGHIHVADHVVFGAQAGVISDVKEATTLLGAPAINAKNFMRSSAIF
NRLPDIYRSLGQMQREIEQLKKEINKQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=333, Percent_Identity=33.6336336336336, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786378, Length=270, Percent_Identity=27.037037037037, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_PARD8 (A6LDS1)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001303457.1
- ProteinModelPortal:   A6LDS1
- SMR:   A6LDS1
- STRING:   A6LDS1
- GeneID:   5307253
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_2104
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- ProtClustDB:   PRK00892
- BioCyc:   PDIS435591:BDI_2104-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37314; Mature: 37314

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSAQQIAGFLNGTIEGDPNVKVSNFSKIEEGKPGTLTFLANLKYAHHIYNTEASIVLV
CCCCHHHHHHHHCCEECCCCCEEECCCHHHCCCCCCEEEEEECCHHHHHEECCCEEEEEE
NNDFKPEQPIRATLVKVENAYAALAMLLNLVEQSKSKKKGVDSTAFIAASATVSDDCYVG
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECEECCCCEEC
NFAYIGEGVKMGKNCMVYPHAYIGDHVTVGDNCVFYPHATVYENCIIGNNCILHAGSVVG
CHHEECCCHHCCCCEEEECCHHCCCEEEECCCEEECCCHHHHCCEEECCCEEEEECCEEC
ADGFGFAPEGETYKKIPQLGNVIIEDDVEIGANTTIDRAVMDSTIIHRGVKLDNLVQIAH
CCCCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NVEVGENTVMAAQVGIAGSVKVGKHCMFGGQVGLAGHIHVADHVVFGAQAGVISDVKEAT
CCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEEHHHEEECCCCCHHHHHHHHH
TLLGAPAINAKNFMRSSAIFNRLPDIYRSLGQMQREIEQLKKEINKQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEFSAQQIAGFLNGTIEGDPNVKVSNFSKIEEGKPGTLTFLANLKYAHHIYNTEASIVLV
CCCCHHHHHHHHCCEECCCCCEEECCCHHHCCCCCCEEEEEECCHHHHHEECCCEEEEEE
NNDFKPEQPIRATLVKVENAYAALAMLLNLVEQSKSKKKGVDSTAFIAASATVSDDCYVG
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECEECCCCEEC
NFAYIGEGVKMGKNCMVYPHAYIGDHVTVGDNCVFYPHATVYENCIIGNNCILHAGSVVG
CHHEECCCHHCCCCEEEECCHHCCCEEEECCCEEECCCHHHHCCEEECCCEEEEECCEEC
ADGFGFAPEGETYKKIPQLGNVIIEDDVEIGANTTIDRAVMDSTIIHRGVKLDNLVQIAH
CCCCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NVEVGENTVMAAQVGIAGSVKVGKHCMFGGQVGLAGHIHVADHVVFGAQAGVISDVKEAT
CCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEEHHHEEECCCCCHHHHHHHHH
TLLGAPAINAKNFMRSSAIFNRLPDIYRSLGQMQREIEQLKKEINKQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA