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The map label for this gene is lpxC/fabZ [H]

Identifier: 150008715

GI number: 150008715

Start: 2489314

End: 2490699

Strand: Direct

Name: lpxC/fabZ [H]

Synonym: BDI_2105

Alternate gene names: 150008715

Gene position: 2489314-2490699 (Clockwise)

Preceding gene: 150008714

Following gene: 150008716

Centisome position: 51.74

GC content: 46.97

Gene sequence:

>1386_bases
ATGCAAAAACAGAAAACGCTTGCGGCAAGTTTCTCCTTGAAAGGAAAAGGGTTGCATACCGGATTAGATATAGAGATTAC
GTTTAATCCCGCACCCGAGAACCATGGATACAAGATCAAACGTGTCGATATGGAAGGCCAACCGACGATTGACGCCTTGG
CTGAGAACGTGGTTAATACACAGCGAGGTACGGTGCTTAGCAAGAATGGCGTTCAAGTAAGTACGATCGAGCATGCGATG
GCTGCTTTATACGCTTACGAGATTGATAACTGCTTGATCGAGGTAAACGCACCCGAATTTCCGATCCTAGACGGGAGTTC
TCGCTTCTTCTCTGAGGAAATCCAAAAGACAGGGGTCGTTGAGCAAAATGCTCCGAAGGATTATTATATCGTAAAGCACA
AGATCGAGGTAAAAGATGAAGAAACCGGTTCTTCGTTGATCATCCTTCCGGATGATAAGTTTAGCGTGAACGTATTGATC
TCATTCGATTCGCCCGTGCTTTCCAACCAATTCGCCACGTTGAACGATCTCAGCGAATTCCCGACAGAATTGGCGGCTTC
ACGTACGTTCGTATTCGTACGCGAAGTGGAGATGTTGCTCAACCACAACTTGATCAAGGGTGGCGATTTAGACAACGCGA
TCGTTATCTACGACCAGAAGATACCGCAAGAATCTTTGGACAAATTGGCAGATATGCTGAACATCCCTCACAAGAACGTG
CAGGAATTAGGCTATATCAATAACAAGCCGCTTGTATTCGATAACGAACCGGCACGTCATAAATTGATCGACGTGATCGG
AGATATCGCCTTGATCGGTAAGCCGATCCGCGGACGTGTGATCGCTACCCGTCCGGGACATAAGATCAATAACCAGTTAG
CTCGTATGATCCGCAAGGATATCAAGATGAACGAGGTGCAAGCCCCGGTATACGATCCGAACCGTGAGCCGGTGATGGAT
ATCAACCGTATCCGTGAATTATTGCCGCACCGCTATCCATTCTTATTGGTTGACAAGATCATCGAGGTTGGCGGGAACTA
TATCGTAGGTGTGAAGAACATCACGACCAACGAACCGTTCTTCCAAGGGCATTTCCCTCAGGAGCCGGTCATGCCGGGAG
TTCTACAGGTTGAGGCTATGGCACAAACAGGTGGTTTGCTAGTCTTGAATTCCGTAGATGAGCCAGAGCGCTATTCTACC
TACTTCATGAAAATAGATGGCGTGAAATTCCGCCAAAAAGTCGTTCCGGGCGATACGTTGATCTTACGTCTGGAATTATT
GGCACCGATCCGTCGCGGGATCTCTACCATGAAAGGGTATGTATTCGTTGGTGATAAATTGGTTAGTGAAGCCGAGTTCA
TGGCTCAGATTGTAAAAAACAAATAA

Upstream 100 bases:

>100_bases
CGCGATCTTCAACCGTCTTCCGGATATATACCGCTCGCTGGGGCAAATGCAACGGGAGATCGAACAACTCAAGAAAGAAA
TTAATAAACAATAAAGACCT

Downstream 100 bases:

>100_bases
TAAGATAAAGTACGATAATGAATATATCTCCTCTAGCAGTCGTTCATCCAGAGGCCCAGATCGGCCAGAATGTAACTATC
GATCCGTTTGCCGTGATTGA

Product: bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase

Products: NA

Alternate protein names: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; UDP-3-O-acyl-GlcNAc deacetylase; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl ACP dehydrase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MQKQKTLAASFSLKGKGLHTGLDIEITFNPAPENHGYKIKRVDMEGQPTIDALAENVVNTQRGTVLSKNGVQVSTIEHAM
AALYAYEIDNCLIEVNAPEFPILDGSSRFFSEEIQKTGVVEQNAPKDYYIVKHKIEVKDEETGSSLIILPDDKFSVNVLI
SFDSPVLSNQFATLNDLSEFPTELAASRTFVFVREVEMLLNHNLIKGGDLDNAIVIYDQKIPQESLDKLADMLNIPHKNV
QELGYINNKPLVFDNEPARHKLIDVIGDIALIGKPIRGRVIATRPGHKINNQLARMIRKDIKMNEVQAPVYDPNREPVMD
INRIRELLPHRYPFLLVDKIIEVGGNYIVGVKNITTNEPFFQGHFPQEPVMPGVLQVEAMAQTGGLLVLNSVDEPERYST
YFMKIDGVKFRQKVVPGDTLILRLELLAPIRRGISTMKGYVFVGDKLVSEAEFMAQIVKNK

Sequences:

>Translated_461_residues
MQKQKTLAASFSLKGKGLHTGLDIEITFNPAPENHGYKIKRVDMEGQPTIDALAENVVNTQRGTVLSKNGVQVSTIEHAM
AALYAYEIDNCLIEVNAPEFPILDGSSRFFSEEIQKTGVVEQNAPKDYYIVKHKIEVKDEETGSSLIILPDDKFSVNVLI
SFDSPVLSNQFATLNDLSEFPTELAASRTFVFVREVEMLLNHNLIKGGDLDNAIVIYDQKIPQESLDKLADMLNIPHKNV
QELGYINNKPLVFDNEPARHKLIDVIGDIALIGKPIRGRVIATRPGHKINNQLARMIRKDIKMNEVQAPVYDPNREPVMD
INRIRELLPHRYPFLLVDKIIEVGGNYIVGVKNITTNEPFFQGHFPQEPVMPGVLQVEAMAQTGGLLVLNSVDEPERYST
YFMKIDGVKFRQKVVPGDTLILRLELLAPIRRGISTMKGYVFVGDKLVSEAEFMAQIVKNK
>Mature_461_residues
MQKQKTLAASFSLKGKGLHTGLDIEITFNPAPENHGYKIKRVDMEGQPTIDALAENVVNTQRGTVLSKNGVQVSTIEHAM
AALYAYEIDNCLIEVNAPEFPILDGSSRFFSEEIQKTGVVEQNAPKDYYIVKHKIEVKDEETGSSLIILPDDKFSVNVLI
SFDSPVLSNQFATLNDLSEFPTELAASRTFVFVREVEMLLNHNLIKGGDLDNAIVIYDQKIPQESLDKLADMLNIPHKNV
QELGYINNKPLVFDNEPARHKLIDVIGDIALIGKPIRGRVIATRPGHKINNQLARMIRKDIKMNEVQAPVYDPNREPVMD
INRIRELLPHRYPFLLVDKIIEVGGNYIVGVKNITTNEPFFQGHFPQEPVMPGVLQVEAMAQTGGLLVLNSVDEPERYST
YFMKIDGVKFRQKVVPGDTLILRLELLAPIRRGISTMKGYVFVGDKLVSEAEFMAQIVKNK

Specific function: Involved in saturated fatty acids biosynthesis [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thioester dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=301, Percent_Identity=33.8870431893688, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1786377, Length=141, Percent_Identity=48.2269503546099, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013114
- InterPro:   IPR010084
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF07977 FabA; PF03331 LpxC [H]

EC number: 3.5.1.-; 4.2.1.-

Molecular weight: Translated: 51731; Mature: 51731

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKQKTLAASFSLKGKGLHTGLDIEITFNPAPENHGYKIKRVDMEGQPTIDALAENVVNT
CCCCCEEEEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHCC
QRGTVLSKNGVQVSTIEHAMAALYAYEIDNCLIEVNAPEFPILDGSSRFFSEEIQKTGVV
CCCEEEECCCCEEHHHHHHHHHHHHEECCCEEEEECCCCCCEECCCHHHHHHHHHHCCCC
EQNAPKDYYIVKHKIEVKDEETGSSLIILPDDKFSVNVLISFDSPVLSNQFATLNDLSEF
CCCCCCCEEEEEEEEEECCCCCCCEEEEEECCCEEEEEEEEECCCHHCCCCCCHHHHHHH
PTELAASRTFVFVREVEMLLNHNLIKGGDLDNAIVIYDQKIPQESLDKLADMLNIPHKNV
HHHHHHCCEEEHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCH
QELGYINNKPLVFDNEPARHKLIDVIGDIALIGKPIRGRVIATRPGHKINNQLARMIRKD
HHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHH
IKMNEVQAPVYDPNREPVMDINRIRELLPHRYPFLLVDKIIEVGGNYIVGVKNITTNEPF
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCC
FQGHFPQEPVMPGVLQVEAMAQTGGLLVLNSVDEPERYSTYFMKIDGVKFRQKVVPGDTL
CCCCCCCCCCCCCCEEEEEHHCCCCEEEEECCCCCHHHEEEEEEECCCCHHHHCCCCCEE
ILRLELLAPIRRGISTMKGYVFVGDKLVSEAEFMAQIVKNK
EEHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKQKTLAASFSLKGKGLHTGLDIEITFNPAPENHGYKIKRVDMEGQPTIDALAENVVNT
CCCCCEEEEEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHCC
QRGTVLSKNGVQVSTIEHAMAALYAYEIDNCLIEVNAPEFPILDGSSRFFSEEIQKTGVV
CCCEEEECCCCEEHHHHHHHHHHHHEECCCEEEEECCCCCCEECCCHHHHHHHHHHCCCC
EQNAPKDYYIVKHKIEVKDEETGSSLIILPDDKFSVNVLISFDSPVLSNQFATLNDLSEF
CCCCCCCEEEEEEEEEECCCCCCCEEEEEECCCEEEEEEEEECCCHHCCCCCCHHHHHHH
PTELAASRTFVFVREVEMLLNHNLIKGGDLDNAIVIYDQKIPQESLDKLADMLNIPHKNV
HHHHHHCCEEEHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCH
QELGYINNKPLVFDNEPARHKLIDVIGDIALIGKPIRGRVIATRPGHKINNQLARMIRKD
HHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHH
IKMNEVQAPVYDPNREPVMDINRIRELLPHRYPFLLVDKIIEVGGNYIVGVKNITTNEPF
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCC
FQGHFPQEPVMPGVLQVEAMAQTGGLLVLNSVDEPERYSTYFMKIDGVKFRQKVVPGDTL
CCCCCCCCCCCCCCEEEEEHHCCCCEEEEECCCCCHHHEEEEEEECCCCHHHHCCCCCEE
ILRLELLAPIRRGISTMKGYVFVGDKLVSEAEFMAQIVKNK
EEHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]