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The map label for this gene is arlS [H]

Identifier: 150007700

GI number: 150007700

Start: 1223349

End: 1224524

Strand: Direct

Name: arlS [H]

Synonym: BDI_1055

Alternate gene names: 150007700

Gene position: 1223349-1224524 (Clockwise)

Preceding gene: 150007699

Following gene: 150007702

Centisome position: 25.43

GC content: 50.94

Gene sequence:

>1176_bases
ATGAAGACAGGAAACAAGATCGCTCTCTTTTACTCGGCCATTACCATAGGCGTGATAGCCGTCGTGACGCTTGTCTTCTA
TTGGGTTTCCACGAGCTATATCTCTCGCCTGTACTATTCTTACCTGACGGAAAAAGCCTATGCCACGGCACAGAAGCATT
GGGAGAAGGACGAGACCGACGACGAGAGCTATGCCCGTATCCAACAGCGTTACGAGGAAACCCTTCCCGTCGCTACCGAG
ATATTGCTGAACGCCGATAGCTTGGAGACCCGGCAAGTGCTGTCCCGTTATCTGGACGCCACGCAGGTGAGATCTCTATA
CCAAGAGGATATCGTTCACTTCAAGCACGATACGCAAATGGGAGCGGCTTTGTATTATCCCGACAACGAGGGGAATTTCA
TCGTGATTGTCCTTTCCGGGAATCAGTATGGGATGGATATCCAGCATCGGATCGGCTGGCTGTTGCTGGGATTGATATTG
GTTAGCTCGGTATTGATCTATTTTGTCGGCAGACTATACGCGACCCGGATGGTAGACCGGATCGACGCTGCTTACCAAAG
TGAGAAAGCGTTTATCAGCAACGCCTCGCATGAGTTGAACAATCCACTGACAGCCATTCAAGGCGAATGCGAGATCAGCC
TGCTGAAAGAGCGCTCCCCGGAGGAATACCAAGCGGCATTAAGACGTATCGCCACGGAGACGAGCCGTATCATACAATTG
ATCAAACACCTGCTGTTCCTGTCGCACGGGGATAAGGAGATCCAGAAAAGCGCGATGGAGACGATCTTCCTAGCGGACTT
CTTGATGCAGTTCTCCTCGGCCCGGATCTCGTTCTCCCCGGATAATTTCTCTTATATGATCAGTGCCAATCCCTATTTAT
TGAAGATAGCGATCAAGAATATCTTGAGCAACGCCTGTAAGTATTCGGACGATAAATCGGTAGAGATGCGGCTTCGAGGC
AGTGTCTTGACCATATCCGACCGAGGTATCGGCATTCCTCCCGAGGAATTGAAACGAATCTTCCAACCCTTTTACAGGGC
GAGCAATACCCGGGAATACGCCGGGCATGGTGTCGGGCTAAGCCTCTCGCTACGCATATTGAGCACCTATGGGGCGAAGG
TGAATATTATTTCTGATCTAGGGGTTGGGACGAGCGTGGAGATCGACTTTGGGTAG

Upstream 100 bases:

>100_bases
TGGTTGATGTCTACGTGAATTATTTGCGCACGAAGATAGACAAGGACTTCGAACCTAAGCTAATCCATACCGTGGTGGGC
GTGGGCTATATGATGGAAGC

Downstream 100 bases:

>100_bases
CCGTCAGGTATTCTTTAGCCGGACCTGTTATTTCGACAGACTCCGGCGTTACCCCTATCGCCTCTTCCGAAGATATAAGT
CCACGATCTACCAAGCGATC

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKTGNKIALFYSAITIGVIAVVTLVFYWVSTSYISRLYYSYLTEKAYATAQKHWEKDETDDESYARIQQRYEETLPVATE
ILLNADSLETRQVLSRYLDATQVRSLYQEDIVHFKHDTQMGAALYYPDNEGNFIVIVLSGNQYGMDIQHRIGWLLLGLIL
VSSVLIYFVGRLYATRMVDRIDAAYQSEKAFISNASHELNNPLTAIQGECEISLLKERSPEEYQAALRRIATETSRIIQL
IKHLLFLSHGDKEIQKSAMETIFLADFLMQFSSARISFSPDNFSYMISANPYLLKIAIKNILSNACKYSDDKSVEMRLRG
SVLTISDRGIGIPPEELKRIFQPFYRASNTREYAGHGVGLSLSLRILSTYGAKVNIISDLGVGTSVEIDFG

Sequences:

>Translated_391_residues
MKTGNKIALFYSAITIGVIAVVTLVFYWVSTSYISRLYYSYLTEKAYATAQKHWEKDETDDESYARIQQRYEETLPVATE
ILLNADSLETRQVLSRYLDATQVRSLYQEDIVHFKHDTQMGAALYYPDNEGNFIVIVLSGNQYGMDIQHRIGWLLLGLIL
VSSVLIYFVGRLYATRMVDRIDAAYQSEKAFISNASHELNNPLTAIQGECEISLLKERSPEEYQAALRRIATETSRIIQL
IKHLLFLSHGDKEIQKSAMETIFLADFLMQFSSARISFSPDNFSYMISANPYLLKIAIKNILSNACKYSDDKSVEMRLRG
SVLTISDRGIGIPPEELKRIFQPFYRASNTREYAGHGVGLSLSLRILSTYGAKVNIISDLGVGTSVEIDFG
>Mature_391_residues
MKTGNKIALFYSAITIGVIAVVTLVFYWVSTSYISRLYYSYLTEKAYATAQKHWEKDETDDESYARIQQRYEETLPVATE
ILLNADSLETRQVLSRYLDATQVRSLYQEDIVHFKHDTQMGAALYYPDNEGNFIVIVLSGNQYGMDIQHRIGWLLLGLIL
VSSVLIYFVGRLYATRMVDRIDAAYQSEKAFISNASHELNNPLTAIQGECEISLLKERSPEEYQAALRRIATETSRIIQL
IKHLLFLSHGDKEIQKSAMETIFLADFLMQFSSARISFSPDNFSYMISANPYLLKIAIKNILSNACKYSDDKSVEMRLRG
SVLTISDRGIGIPPEELKRIFQPFYRASNTREYAGHGVGLSLSLRILSTYGAKVNIISDLGVGTSVEIDFG

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=207, Percent_Identity=31.4009661835749, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786783, Length=220, Percent_Identity=26.3636363636364, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789403, Length=221, Percent_Identity=29.8642533936652, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=26.2008733624454, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=220, Percent_Identity=26.8181818181818, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=26.7543859649123, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI48994928, Length=228, Percent_Identity=27.1929824561404, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=194, Percent_Identity=28.8659793814433, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=203, Percent_Identity=26.1083743842365, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788549, Length=215, Percent_Identity=28.3720930232558, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790861, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788393, Length=211, Percent_Identity=25.1184834123223, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789149, Length=234, Percent_Identity=25.2136752136752, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=28.0542986425339, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44302; Mature: 44302

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGNKIALFYSAITIGVIAVVTLVFYWVSTSYISRLYYSYLTEKAYATAQKHWEKDETD
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DESYARIQQRYEETLPVATEILLNADSLETRQVLSRYLDATQVRSLYQEDIVHFKHDTQM
CHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GAALYYPDNEGNFIVIVLSGNQYGMDIQHRIGWLLLGLILVSSVLIYFVGRLYATRMVDR
CEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDAAYQSEKAFISNASHELNNPLTAIQGECEISLLKERSPEEYQAALRRIATETSRIIQL
HHHHHHHHHHHHHCCHHHHCCCHHHCCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHHHH
IKHLLFLSHGDKEIQKSAMETIFLADFLMQFSSARISFSPDNFSYMISANPYLLKIAIKN
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCEEHHHHHHH
ILSNACKYSDDKSVEMRLRGSVLTISDRGIGIPPEELKRIFQPFYRASNTREYAGHGVGL
HHHHHHCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCC
SLSLRILSTYGAKVNIISDLGVGTSVEIDFG
EEEEEEEECCCCEEEEEEECCCCCEEEEECC
>Mature Secondary Structure
MKTGNKIALFYSAITIGVIAVVTLVFYWVSTSYISRLYYSYLTEKAYATAQKHWEKDETD
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DESYARIQQRYEETLPVATEILLNADSLETRQVLSRYLDATQVRSLYQEDIVHFKHDTQM
CHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GAALYYPDNEGNFIVIVLSGNQYGMDIQHRIGWLLLGLILVSSVLIYFVGRLYATRMVDR
CEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDAAYQSEKAFISNASHELNNPLTAIQGECEISLLKERSPEEYQAALRRIATETSRIIQL
HHHHHHHHHHHHHCCHHHHCCCHHHCCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHHHH
IKHLLFLSHGDKEIQKSAMETIFLADFLMQFSSARISFSPDNFSYMISANPYLLKIAIKN
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCEEHHHHHHH
ILSNACKYSDDKSVEMRLRGSVLTISDRGIGIPPEELKRIFQPFYRASNTREYAGHGVGL
HHHHHHCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCC
SLSLRILSTYGAKVNIISDLGVGTSVEIDFG
EEEEEEEECCCCEEEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA