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The map label for this gene is cusR [H]

Identifier: 150007699

GI number: 150007699

Start: 1222675

End: 1223352

Strand: Direct

Name: cusR [H]

Synonym: BDI_1054

Alternate gene names: 150007699

Gene position: 1222675-1223352 (Clockwise)

Preceding gene: 150007698

Following gene: 150007700

Centisome position: 25.41

GC content: 48.82

Gene sequence:

>678_bases
ATGGCGAAGATATTATTAGTAGAAGACGAGGTAAACATCGCCTCTTTTATAGAAAGAGGCTTGCGGGAGTTCGGGCATGA
GGTATATGTCGCTTATGACGGTGCCGCTGGTTGGGAACTGACACAGAAGAACGATTTCCAATTGCTGATTCTGGATATTA
TAATGCCGAAGATGAACGGCCTGCAACTTTGCAAACAGTACCGGCAACGGTTCGGTTACCATGCTCCCGTGATCATGCTG
ACCGCCTTGGGAACCACCGAGGATATCGTTAGTGGGCTGGATGCCGGGGCGGATGATTATCTGGTAAAACCTTTCAGCTT
CCAAGAGCTCGAGGCCCGCATAAAGGCGTTATTACGTCGATCGGGAAACGAATCCGTCCATATGGCTCTTCGGTGCGGGG
ATCTGGTCTTAGATCCTCCAAGCCATCGGGCTATACGGAATGGGCAGGTCATCGATTTGACGGTAAAGGAATATAGGCTC
TTGGAATATTTCATACAGAACCAAGGAACGGCCCTGAGCCGGATGAACTTGCTAAAGAATGTCTGGGACAAGGATTTCGA
TACCAATACGAACGTGGTTGATGTCTACGTGAATTATTTGCGCACGAAGATAGACAAGGACTTCGAACCTAAGCTAATCC
ATACCGTGGTGGGCGTGGGCTATATGATGGAAGCATGA

Upstream 100 bases:

>100_bases
TCACAACCGTGAAAAGAACGTTTCACCTCTGTGATACGATTAGCATCACCCTAAGTACGCATTATTAATGATGGACATTC
TTATTAATACATACGATACA

Downstream 100 bases:

>100_bases
AGACAGGAAACAAGATCGCTCTCTTTTACTCGGCCATTACCATAGGCGTGATAGCCGTCGTGACGCTTGTCTTCTATTGG
GTTTCCACGAGCTATATCTC

Product: two-component system response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MAKILLVEDEVNIASFIERGLREFGHEVYVAYDGAAGWELTQKNDFQLLILDIIMPKMNGLQLCKQYRQRFGYHAPVIML
TALGTTEDIVSGLDAGADDYLVKPFSFQELEARIKALLRRSGNESVHMALRCGDLVLDPPSHRAIRNGQVIDLTVKEYRL
LEYFIQNQGTALSRMNLLKNVWDKDFDTNTNVVDVYVNYLRTKIDKDFEPKLIHTVVGVGYMMEA

Sequences:

>Translated_225_residues
MAKILLVEDEVNIASFIERGLREFGHEVYVAYDGAAGWELTQKNDFQLLILDIIMPKMNGLQLCKQYRQRFGYHAPVIML
TALGTTEDIVSGLDAGADDYLVKPFSFQELEARIKALLRRSGNESVHMALRCGDLVLDPPSHRAIRNGQVIDLTVKEYRL
LEYFIQNQGTALSRMNLLKNVWDKDFDTNTNVVDVYVNYLRTKIDKDFEPKLIHTVVGVGYMMEA
>Mature_224_residues
AKILLVEDEVNIASFIERGLREFGHEVYVAYDGAAGWELTQKNDFQLLILDIIMPKMNGLQLCKQYRQRFGYHAPVIMLT
ALGTTEDIVSGLDAGADDYLVKPFSFQELEARIKALLRRSGNESVHMALRCGDLVLDPPSHRAIRNGQVIDLTVKEYRLL
EYFIQNQGTALSRMNLLKNVWDKDFDTNTNVVDVYVNYLRTKIDKDFEPKLIHTVVGVGYMMEA

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=46.8468468468468, Blast_Score=204, Evalue=4e-54,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=40.8071748878924, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=36.6515837104072, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=39.2241379310345, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.9775784753363, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=31.7180616740088, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=32.7354260089686, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.3008849557522, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=34.5132743362832, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=31.8777292576419, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.3144104803493, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=27.2340425531915, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790437, Length=115, Percent_Identity=31.304347826087, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=33.6065573770492, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=37.2549019607843, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=116, Percent_Identity=37.0689655172414, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25678; Mature: 25547

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILLVEDEVNIASFIERGLREFGHEVYVAYDGAAGWELTQKNDFQLLILDIIMPKMNG
CCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCEEEEEEHHHCCCCH
LQLCKQYRQRFGYHAPVIMLTALGTTEDIVSGLDAGADDYLVKPFSFQELEARIKALLRR
HHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHH
SGNESVHMALRCGDLVLDPPSHRAIRNGQVIDLTVKEYRLLEYFIQNQGTALSRMNLLKN
CCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHH
VWDKDFDTNTNVVDVYVNYLRTKIDKDFEPKLIHTVVGVGYMMEA
HHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKILLVEDEVNIASFIERGLREFGHEVYVAYDGAAGWELTQKNDFQLLILDIIMPKMNG
CEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCEEEEEEHHHCCCCH
LQLCKQYRQRFGYHAPVIMLTALGTTEDIVSGLDAGADDYLVKPFSFQELEARIKALLRR
HHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHH
SGNESVHMALRCGDLVLDPPSHRAIRNGQVIDLTVKEYRLLEYFIQNQGTALSRMNLLKN
CCCCCEEEEEEECCEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHH
VWDKDFDTNTNVVDVYVNYLRTKIDKDFEPKLIHTVVGVGYMMEA
HHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]