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The map label for this gene is cysK [H]

Identifier: 150007617

GI number: 150007617

Start: 1125789

End: 1126736

Strand: Reverse

Name: cysK [H]

Synonym: BDI_0970

Alternate gene names: 150007617

Gene position: 1126736-1125789 (Counterclockwise)

Preceding gene: 150007618

Following gene: 150007609

Centisome position: 23.42

GC content: 55.06

Gene sequence:

>948_bases
ATGGCAAGAATAGCAAGACAACTGACCGACCTTGTCGGCAACACTCCCCTGTTGGAGTTCTCTAATTTCAACGCGAGCAA
GGGCCTTAAAGCCCAAGTAATCGGCAAGCTGGAATATTTCAACCCGGCTGGTAGCGTAAAAGACCGCATCGCCTTGGCGA
TGATCGAGGACGCCGAGGCTAAAGGCTTGTTGAGACCCGGCGCTACCATTATCGAACCGACCAGCGGTAATACCGGAGTC
GGACTCGCTTTTGTCTCCGCCTCGAAAGGCTACAAATTAATCCTGACCATGCCGGATACCATGAGTGCCGAGCGTCGTAA
CTTATTGAAAGCGTTAGGTGCCCGGCTCGTCCTCACCCCCGGGGCAGAAGGCATGAAAGGAGCCATCGCCAAAGCGGAGG
AACTGCGTGATGCGACTCCCGGTTCCATCATCCTACAACAATTCGAGAATCCCGCCAACCCGGCCATGCATATCCGCACG
ACCGCCGAGGAGATCTGGCGTGATACGGATGGTAAAGTAGACCTGTTTGTAGCCGGCGTAGGAACCGGAGGCACGGTCAG
CGGTGTCGGTGCCGGATTGAAAGCTCACAACCCGAACGTACAAATCGTAGCGGTAGAGCCTAGCGATTCACCGGTACTTT
CCGGAGGCAAGCCCGGCCCGCACAAGATACAGGGCATCGGAGCTGGCTTTATCCCCAAGACCTACAACGGGGAGGTAGTT
GACAATATCCTGCAAGTAACGAACGATGACGCTATCCGTACCAGCCGCGAACTGGCCGGGAAGGAAGGGTTGCTGGTAGG
AATATCTTCCGGCGCCGCTGTATACGCCGCCGTGGAACTAGCTAAACTTCCGGAGAATGAGGGAAAAACGATCGTGGCGT
TGCTTCCGGACACAGGAGAAAGGTATCTCTCCACGGTTCTATATGCTTTCGAGGAATATCCTCTATAG

Upstream 100 bases:

>100_bases
GTAAAAAAATACCCGGTTTATGGTATATGCCGTAAACAATCCATCCACTATCTTTGTCATATAAATAAAAGAATCCAGAA
ACAACAAAATTCATTTGTAT

Downstream 100 bases:

>100_bases
GCTTTTATCGGTTTATCTGATGTCATAGAATCTGAGTCGAAAACACTATAGTGTTTGTGGATAAACACAATAGTATTCAG
ACTAAAACACTACTGTATTC

Product: putative cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MARIARQLTDLVGNTPLLEFSNFNASKGLKAQVIGKLEYFNPAGSVKDRIALAMIEDAEAKGLLRPGATIIEPTSGNTGV
GLAFVSASKGYKLILTMPDTMSAERRNLLKALGARLVLTPGAEGMKGAIAKAEELRDATPGSIILQQFENPANPAMHIRT
TAEEIWRDTDGKVDLFVAGVGTGGTVSGVGAGLKAHNPNVQIVAVEPSDSPVLSGGKPGPHKIQGIGAGFIPKTYNGEVV
DNILQVTNDDAIRTSRELAGKEGLLVGISSGAAVYAAVELAKLPENEGKTIVALLPDTGERYLSTVLYAFEEYPL

Sequences:

>Translated_315_residues
MARIARQLTDLVGNTPLLEFSNFNASKGLKAQVIGKLEYFNPAGSVKDRIALAMIEDAEAKGLLRPGATIIEPTSGNTGV
GLAFVSASKGYKLILTMPDTMSAERRNLLKALGARLVLTPGAEGMKGAIAKAEELRDATPGSIILQQFENPANPAMHIRT
TAEEIWRDTDGKVDLFVAGVGTGGTVSGVGAGLKAHNPNVQIVAVEPSDSPVLSGGKPGPHKIQGIGAGFIPKTYNGEVV
DNILQVTNDDAIRTSRELAGKEGLLVGISSGAAVYAAVELAKLPENEGKTIVALLPDTGERYLSTVLYAFEEYPL
>Mature_314_residues
ARIARQLTDLVGNTPLLEFSNFNASKGLKAQVIGKLEYFNPAGSVKDRIALAMIEDAEAKGLLRPGATIIEPTSGNTGVG
LAFVSASKGYKLILTMPDTMSAERRNLLKALGARLVLTPGAEGMKGAIAKAEELRDATPGSIILQQFENPANPAMHIRTT
AEEIWRDTDGKVDLFVAGVGTGGTVSGVGAGLKAHNPNVQIVAVEPSDSPVLSGGKPGPHKIQGIGAGFIPKTYNGEVVD
NILQVTNDDAIRTSRELAGKEGLLVGISSGAAVYAAVELAKLPENEGKTIVALLPDTGERYLSTVLYAFEEYPL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=304, Percent_Identity=41.7763157894737, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI295821200, Length=304, Percent_Identity=41.7763157894737, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI4557415, Length=304, Percent_Identity=41.7763157894737, Blast_Score=243, Evalue=1e-64,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=53.1446540880503, Blast_Score=300, Evalue=6e-83,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=41.5032679738562, Blast_Score=230, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=55.1495016611296, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=52.8239202657807, Blast_Score=307, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=53.2203389830509, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=55.1839464882943, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=50.4983388704319, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=53.9906103286385, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17534315, Length=311, Percent_Identity=41.8006430868167, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25147552, Length=311, Percent_Identity=38.9067524115756, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17561716, Length=117, Percent_Identity=49.5726495726496, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=40.8227848101266, Blast_Score=224, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=34.8484848484849, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=41.9354838709677, Blast_Score=228, Evalue=3e-60,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=41.9354838709677, Blast_Score=228, Evalue=3e-60,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33016; Mature: 32885

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIARQLTDLVGNTPLLEFSNFNASKGLKAQVIGKLEYFNPAGSVKDRIALAMIEDAEA
CCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCHHHHEEEEEEECCCC
KGLLRPGATIIEPTSGNTGVGLAFVSASKGYKLILTMPDTMSAERRNLLKALGARLVLTP
CCEECCCCEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECC
GAEGMKGAIAKAEELRDATPGSIILQQFENPANPAMHIRTTAEEIWRDTDGKVDLFVAGV
CCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEECHHHHHCCCCCCEEEEEEEC
GTGGTVSGVGAGLKAHNPNVQIVAVEPSDSPVLSGGKPGPHKIQGIGAGFIPKTYNGEVV
CCCCCCHHCCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHH
DNILQVTNDDAIRTSRELAGKEGLLVGISSGAAVYAAVELAKLPENEGKTIVALLPDTGE
HHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHCCCCCCCEEEEECCCCCH
RYLSTVLYAFEEYPL
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARIARQLTDLVGNTPLLEFSNFNASKGLKAQVIGKLEYFNPAGSVKDRIALAMIEDAEA
CHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCHHHHEEEEEEECCCC
KGLLRPGATIIEPTSGNTGVGLAFVSASKGYKLILTMPDTMSAERRNLLKALGARLVLTP
CCEECCCCEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECC
GAEGMKGAIAKAEELRDATPGSIILQQFENPANPAMHIRTTAEEIWRDTDGKVDLFVAGV
CCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEECHHHHHCCCCCCEEEEEEEC
GTGGTVSGVGAGLKAHNPNVQIVAVEPSDSPVLSGGKPGPHKIQGIGAGFIPKTYNGEVV
CCCCCCHHCCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHH
DNILQVTNDDAIRTSRELAGKEGLLVGISSGAAVYAAVELAKLPENEGKTIVALLPDTGE
HHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHCCCCCCCEEEEECCCCCH
RYLSTVLYAFEEYPL
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]