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The map label for this gene is lon [H]

Identifier: 150005673

GI number: 150005673

Start: 3981192

End: 3983669

Strand: Reverse

Name: lon [H]

Synonym: BVU_3163

Alternate gene names: 150005673

Gene position: 3983669-3981192 (Counterclockwise)

Preceding gene: 150005675

Following gene: 150005672

Centisome position: 77.16

GC content: 42.53

Gene sequence:

>2478_bases
ATGAAGAGGAATAAGAAAGAGGATATTTTGTTGAATACTGATAACGATGACATCTCTATGTTAGCTGAAATCCAAACGGA
TCCGGATGAAGTAACTGCTATGGAATTTAATAAAGAAATACCTGTTATGCCTTTACGCAACATGGTAATGTTTCCATCTG
TAGTAATGCCTGTGACCATTGGACGCCCCAGCACATTGAAATTGATAAATGCTGCATACAAGAAAAAACTTCCCATAGCG
GTAGTTTGTCAGATACAGGGAGATATGGACGATCCCGGTTTTAATGATGTGTACCATGTAGGAGTTATCGGGAAGATTCT
CCGTGTATTCGAAATGCCAGGTGGAAATACCACAGTAATTATGCAGTCAAACGGGCCCAAAGTACATTTGGACAGTATCA
CCAAAACGTCTCCATATTTGAAAGGGATGGTGACTCCTATTCCGGAGGCAAATGACCAACTGGAAACGGACGAATTCAAA
GCATTGATTGACACCTGCAAGGATTTGACGAGTAAGTTCATAGAGGCTTCCGAGAAGATGAGTCCGGATACGGTTTTTGC
AATCAAGAACTTGGACAATCCGGAAATTTTGGTAAATTTCATTTGTGCAAACTTCCCTATTCCGGTAGAAGAAAAGATAA
AATTGCTAAAAGCTGGCGATTTGCAAAGCCGCCTGTATATGCTGGTCAAGATCTTAAATCGTGAAGTACAATTGGCTGAT
ATCAAACAAAGCATTCAAATGCGTACACGCGAAGATATTGACCGTCAGCAACGCGAATATTTCTTGCAGCAACAAATTAA
AAACATACAGGATGAACTGGGTGCCGGACAGGAAGATGAAATAGATGAACTCCGCCAAAAAGGAAAAACCAAGAAATGGA
GTCCGGAAATGGCAGAACTCTTTGAAAAAGAAGTTTCCAAATTGGAAAGGACAAATTCCCAATCACCGGATTTCAATGTG
CAACTTACCTATTTGCAAACCCTGTTAGGATTACCTTGGAATGTCTTTACCACTGACAACCTGAATATAAGTAATGCCGA
AAAGACATTGAACAAAGACCACTACGGACTAGAGAAAGTAAAGGAGCGTATCCTTGAACATTTAGCAGTGCTGAAACTAA
AAGGTGATATGAAATCACCCATCATCTGCCTTTATGGTCCTCCGGGAGTCGGTAAAACTTCTTTAGGACGTTCCATAGCG
GCATCATTGAAACGTAAATATGTACGTATGTCATTGGGTGGTGTGCATGACGAAGCCGAGATCCGTGGCCATCGTAAAAC
TTATATCGGTGCCATGCCGGGCCGTATCATCAAAAGTTTGATAAAAGCCGAGTCCTCTAATCCGGTTATCATTTTGGACG
AAATAGACAAACTGGGCAGTGACCACCGCGGAGATCCCAGTTCCGCTATGCTGGAAGTGCTTGACCCCGAACAGAACAAC
ACTTTCCACGATAACTATTTGGATGTAGATTACGACTTGTCTAAAGTAATGTTCATCGCTACGGCAAACAATTTGAGCAC
CATCCCTCCTGCTCTGCTGGACCGTATGGAGTTGATAGAGGTCAGCGGATATATCACAGAAGAAAAAGTAGAAATAGCCC
GCCGGCATCTTGTTCCCAAAGAACTGGAAGCCAACGGCATTAAAAAAGAATATGTGAAGTTCTCTAAAGCTGCCTTGGAA
TGTATTGTAGAAAATTATACTCGTGAAAGCGGGGTGCGCGAACTTGAGAAGAAGATAAACAAGGTAATGCGTAAAATAGC
GTTGGAATTTGCACGTGACGGCTATGAAGTGATGCATGAAATAAAACCTGCCGATGTACGCAAATATCTGGGCACGCCAG
AATATAGCCGCGACAAATACCAAGGAAATGAATACGCCGGTGTTGTCACAGGGCTGGCGTGGACAGCTGTCGGAGGTGAA
ATTTTGTTTGTAGAAACCAGTTTAAGCAAAGGAAAAGGCGGTAAACTGACATTGACCGGGAACTTGGGTGACGTAATGAA
AGAGTCGGCCATGCTGGCTTTGGAATATCTCAAGGCACATACCAAACTGCTGAATTTACAGGAAGATATCTTTGACAATT
GGAATATCCACATCCATGTACCTGAAGGAGCCATCCCTAAAGATGGTCCGTCAGCCGGTATCACCATGGTGACTTCATTG
GCATCCGCCCTCACCCAGCGTAAAGTGAAAGCAAATCTGGCAATGACAGGCGAGATCACATTACGTGGAAAAGTCCTGCC
CGTAGGCGGTATCAAAGAAAAGATCCTAGCCGCTAAACGCGCCGGAATCAAAGACATCATTTTATGTGAGGAAAACCGCA
AGAACATTGAAGAAATTCAGCCGATGTATCTAGAAGGACTGACATTCCATTATGTCACGGATATTAAGGAAGTATTGGCT
TTGGCTCTCACCAATGAAAAAGTAAACGATGCCATTGATTTTAATATTACCAATCAAAAAACAGAAGAAAAGAAATAA

Upstream 100 bases:

>100_bases
ACTCAATTAGTTCCCATGAATTTTCCTTATTCGACAAGGAATGATTAACTTTGTCCCCGTTTTGGGCATTGGGCTCAATT
TAACACAAGAGGAATAAATT

Downstream 100 bases:

>100_bases
ATATGACTTTTGACTTACAATATACAGACCCCAAATCGAATGCCCGTGCCGGATTGATAACAACTGACCACGGGCAAATA
GAAACCCCCATCTTTATGCC

Product: ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 825; Mature: 825

Protein sequence:

>825_residues
MKRNKKEDILLNTDNDDISMLAEIQTDPDEVTAMEFNKEIPVMPLRNMVMFPSVVMPVTIGRPSTLKLINAAYKKKLPIA
VVCQIQGDMDDPGFNDVYHVGVIGKILRVFEMPGGNTTVIMQSNGPKVHLDSITKTSPYLKGMVTPIPEANDQLETDEFK
ALIDTCKDLTSKFIEASEKMSPDTVFAIKNLDNPEILVNFICANFPIPVEEKIKLLKAGDLQSRLYMLVKILNREVQLAD
IKQSIQMRTREDIDRQQREYFLQQQIKNIQDELGAGQEDEIDELRQKGKTKKWSPEMAELFEKEVSKLERTNSQSPDFNV
QLTYLQTLLGLPWNVFTTDNLNISNAEKTLNKDHYGLEKVKERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGRSIA
ASLKRKYVRMSLGGVHDEAEIRGHRKTYIGAMPGRIIKSLIKAESSNPVIILDEIDKLGSDHRGDPSSAMLEVLDPEQNN
TFHDNYLDVDYDLSKVMFIATANNLSTIPPALLDRMELIEVSGYITEEKVEIARRHLVPKELEANGIKKEYVKFSKAALE
CIVENYTRESGVRELEKKINKVMRKIALEFARDGYEVMHEIKPADVRKYLGTPEYSRDKYQGNEYAGVVTGLAWTAVGGE
ILFVETSLSKGKGGKLTLTGNLGDVMKESAMLALEYLKAHTKLLNLQEDIFDNWNIHIHVPEGAIPKDGPSAGITMVTSL
ASALTQRKVKANLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKDIILCEENRKNIEEIQPMYLEGLTFHYVTDIKEVLA
LALTNEKVNDAIDFNITNQKTEEKK

Sequences:

>Translated_825_residues
MKRNKKEDILLNTDNDDISMLAEIQTDPDEVTAMEFNKEIPVMPLRNMVMFPSVVMPVTIGRPSTLKLINAAYKKKLPIA
VVCQIQGDMDDPGFNDVYHVGVIGKILRVFEMPGGNTTVIMQSNGPKVHLDSITKTSPYLKGMVTPIPEANDQLETDEFK
ALIDTCKDLTSKFIEASEKMSPDTVFAIKNLDNPEILVNFICANFPIPVEEKIKLLKAGDLQSRLYMLVKILNREVQLAD
IKQSIQMRTREDIDRQQREYFLQQQIKNIQDELGAGQEDEIDELRQKGKTKKWSPEMAELFEKEVSKLERTNSQSPDFNV
QLTYLQTLLGLPWNVFTTDNLNISNAEKTLNKDHYGLEKVKERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGRSIA
ASLKRKYVRMSLGGVHDEAEIRGHRKTYIGAMPGRIIKSLIKAESSNPVIILDEIDKLGSDHRGDPSSAMLEVLDPEQNN
TFHDNYLDVDYDLSKVMFIATANNLSTIPPALLDRMELIEVSGYITEEKVEIARRHLVPKELEANGIKKEYVKFSKAALE
CIVENYTRESGVRELEKKINKVMRKIALEFARDGYEVMHEIKPADVRKYLGTPEYSRDKYQGNEYAGVVTGLAWTAVGGE
ILFVETSLSKGKGGKLTLTGNLGDVMKESAMLALEYLKAHTKLLNLQEDIFDNWNIHIHVPEGAIPKDGPSAGITMVTSL
ASALTQRKVKANLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKDIILCEENRKNIEEIQPMYLEGLTFHYVTDIKEVLA
LALTNEKVNDAIDFNITNQKTEEKK
>Mature_825_residues
MKRNKKEDILLNTDNDDISMLAEIQTDPDEVTAMEFNKEIPVMPLRNMVMFPSVVMPVTIGRPSTLKLINAAYKKKLPIA
VVCQIQGDMDDPGFNDVYHVGVIGKILRVFEMPGGNTTVIMQSNGPKVHLDSITKTSPYLKGMVTPIPEANDQLETDEFK
ALIDTCKDLTSKFIEASEKMSPDTVFAIKNLDNPEILVNFICANFPIPVEEKIKLLKAGDLQSRLYMLVKILNREVQLAD
IKQSIQMRTREDIDRQQREYFLQQQIKNIQDELGAGQEDEIDELRQKGKTKKWSPEMAELFEKEVSKLERTNSQSPDFNV
QLTYLQTLLGLPWNVFTTDNLNISNAEKTLNKDHYGLEKVKERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGRSIA
ASLKRKYVRMSLGGVHDEAEIRGHRKTYIGAMPGRIIKSLIKAESSNPVIILDEIDKLGSDHRGDPSSAMLEVLDPEQNN
TFHDNYLDVDYDLSKVMFIATANNLSTIPPALLDRMELIEVSGYITEEKVEIARRHLVPKELEANGIKKEYVKFSKAALE
CIVENYTRESGVRELEKKINKVMRKIALEFARDGYEVMHEIKPADVRKYLGTPEYSRDKYQGNEYAGVVTGLAWTAVGGE
ILFVETSLSKGKGGKLTLTGNLGDVMKESAMLALEYLKAHTKLLNLQEDIFDNWNIHIHVPEGAIPKDGPSAGITMVTSL
ASALTQRKVKANLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKDIILCEENRKNIEEIQPMYLEGLTFHYVTDIKEVLA
LALTNEKVNDAIDFNITNQKTEEKK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=628, Percent_Identity=45.0636942675159, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI31377667, Length=847, Percent_Identity=36.9539551357733, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=43.1168831168831, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=654, Percent_Identity=39.6024464831804, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=576, Percent_Identity=39.4097222222222, Blast_Score=443, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319449, Length=693, Percent_Identity=39.1053391053391, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24666867, Length=690, Percent_Identity=42.6086956521739, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221513036, Length=690, Percent_Identity=42.6086956521739, Blast_Score=538, Evalue=1e-153,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 92661; Mature: 92661

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNKKEDILLNTDNDDISMLAEIQTDPDEVTAMEFNKEIPVMPLRNMVMFPSVVMPVTI
CCCCCCCCEEEECCCCCEEEEEEECCCCHHEEHHHCCCCCCCCCCCHHHHCCCHHEEEEC
GRPSTLKLINAAYKKKLPIAVVCQIQGDMDDPGFNDVYHVGVIGKILRVFEMPGGNTTVI
CCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEE
MQSNGPKVHLDSITKTSPYLKGMVTPIPEANDQLETDEFKALIDTCKDLTSKFIEASEKM
EECCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
SPDTVFAIKNLDNPEILVNFICANFPIPVEEKIKLLKAGDLQSRLYMLVKILNREVQLAD
CCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
IKQSIQMRTREDIDRQQREYFLQQQIKNIQDELGAGQEDEIDELRQKGKTKKWSPEMAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHH
FEKEVSKLERTNSQSPDFNVQLTYLQTLLGLPWNVFTTDNLNISNAEKTLNKDHYGLEKV
HHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCEEEECCCCCCCCHHHHHCCCCCCHHHH
KERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGRSIAASLKRKYVRMSLGGVHDEAE
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IRGHRKTYIGAMPGRIIKSLIKAESSNPVIILDEIDKLGSDHRGDPSSAMLEVLDPEQNN
HCCCCHHEECCCCHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCCHHHHHHEECCCCCC
TFHDNYLDVDYDLSKVMFIATANNLSTIPPALLDRMELIEVSGYITEEKVEIARRHLVPK
CCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
ELEANGIKKEYVKFSKAALECIVENYTRESGVRELEKKINKVMRKIALEFARDGYEVMHE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IKPADVRKYLGTPEYSRDKYQGNEYAGVVTGLAWTAVGGEILFVETSLSKGKGGKLTLTG
CCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEC
NLGDVMKESAMLALEYLKAHTKLLNLQEDIFDNWNIHIHVPEGAIPKDGPSAGITMVTSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
ASALTQRKVKANLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKDIILCEENRKNIEEIQ
HHHHHHHHHHHCEEEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHC
PMYLEGLTFHYVTDIKEVLALALTNEKVNDAIDFNITNQKTEEKK
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MKRNKKEDILLNTDNDDISMLAEIQTDPDEVTAMEFNKEIPVMPLRNMVMFPSVVMPVTI
CCCCCCCCEEEECCCCCEEEEEEECCCCHHEEHHHCCCCCCCCCCCHHHHCCCHHEEEEC
GRPSTLKLINAAYKKKLPIAVVCQIQGDMDDPGFNDVYHVGVIGKILRVFEMPGGNTTVI
CCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEE
MQSNGPKVHLDSITKTSPYLKGMVTPIPEANDQLETDEFKALIDTCKDLTSKFIEASEKM
EECCCCEEEECCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
SPDTVFAIKNLDNPEILVNFICANFPIPVEEKIKLLKAGDLQSRLYMLVKILNREVQLAD
CCCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
IKQSIQMRTREDIDRQQREYFLQQQIKNIQDELGAGQEDEIDELRQKGKTKKWSPEMAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHH
FEKEVSKLERTNSQSPDFNVQLTYLQTLLGLPWNVFTTDNLNISNAEKTLNKDHYGLEKV
HHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCEEEECCCCCCCCHHHHHCCCCCCHHHH
KERILEHLAVLKLKGDMKSPIICLYGPPGVGKTSLGRSIAASLKRKYVRMSLGGVHDEAE
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IRGHRKTYIGAMPGRIIKSLIKAESSNPVIILDEIDKLGSDHRGDPSSAMLEVLDPEQNN
HCCCCHHEECCCCHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCCHHHHHHEECCCCCC
TFHDNYLDVDYDLSKVMFIATANNLSTIPPALLDRMELIEVSGYITEEKVEIARRHLVPK
CCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
ELEANGIKKEYVKFSKAALECIVENYTRESGVRELEKKINKVMRKIALEFARDGYEVMHE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IKPADVRKYLGTPEYSRDKYQGNEYAGVVTGLAWTAVGGEILFVETSLSKGKGGKLTLTG
CCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEC
NLGDVMKESAMLALEYLKAHTKLLNLQEDIFDNWNIHIHVPEGAIPKDGPSAGITMVTSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
ASALTQRKVKANLAMTGEITLRGKVLPVGGIKEKILAAKRAGIKDIILCEENRKNIEEIQ
HHHHHHHHHHHCEEEEEEEEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHC
PMYLEGLTFHYVTDIKEVLALALTNEKVNDAIDFNITNQKTEEKK
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA