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The map label for this gene is icd [H]

Identifier: 150004510

GI number: 150004510

Start: 2540882

End: 2542027

Strand: Direct

Name: icd [H]

Synonym: BVU_1960

Alternate gene names: 150004510

Gene position: 2540882-2542027 (Clockwise)

Preceding gene: 150004509

Following gene: 150004511

Centisome position: 49.21

GC content: 47.73

Gene sequence:

>1146_bases
ATGAAAAAGACAGTACCTTATATTACAGGAGACGGAGTGGGAGCAGAAATTACTCCCGCTATGCAAGCCATAGTGAATGC
GGCCGTGAAGAAGGCGTATGGCAATGAACATGAAATAGAATGGATGGAAGTACTGGCAGGTGAACGTGCTTTCAACGAAA
CAGGTTCCTGGTTGCCGGATGAGACGATGGAGGCTTTCAAGAAATATGGTGTGGGCATAAAAGGTCCGTTGACTACTCCC
GTAGGAGGTGGTATCCGTTCCTTGAATGTGGCTTTGCGCCAGACGCTGGATCTGTATGTGTGTCTGCGCCCCGTACGTTG
GTTCAGCGGAGTGGTATCTCCGGTGAAAGAGCCTCAGAAGGTGGATATGCATATTTTCCGCGAAAATACGGAGGATATTT
ATGCAGGTATAGAATGGGAAGCAGGCACGCCGGAAGCTGAGAAGTTTTATCGTTTTTTGCATGATGAAATGGGAGTGGCT
AAAGTGCGCTTTCCCGAATCTTCTTCATTTGGCGTGAAACCGGTGTCCAAAGAAGGAACGGAACGTCTGGTACGTGCGGC
ATGTAAATATGCTTTGGAGCATGGCTTGCCGTCAGTGACGTTGGTGCATAAAGGAAATATCATGAAGTTTACTGAAGGCG
GCTTCAAGAAATGGGGATATGAACTGGCGGAACGTGAATTCGGAGATGCCATTGCGTCAGGCAAGTTGGTGATAAAAGAC
TGCATAGCCGATGCATTCTTGCAGAATACGTTATTGATTCCCGAAGAATATTCGGTGGTGGCTACCTTGAATTTGAACGG
AGATTACATCTCGGATCAGTTGGCTGCCATGGTAGGCGGCATCGGAATTGCTCCCGGAGCGAACATCAATTACAATACCG
GTCATGCCATTTTTGAAGCGACTCACGGTACGGCTCCCAATATTGCCGGAAAGGATGTGGTGAATCCTTGTTCATTAATC
CTCTCGGCTGTCATGATGTTGGAACATTTTGGCTGGAATAAGGCGGCGGAGCTGATAGTGAATGCTTTGGAATCCAGTTT
TGGCGAAGGCAGAGCCACACATGACCTTGCCCGTTTTATGCCCGGAGGTGTCTCGCTTGGCACGTCGGCATTTACAAAAG
AAATAATAGAAAGAATAAACTCCTAA

Upstream 100 bases:

>100_bases
TGAAGATGGCACTCAGGATGGTTTTGAAGTACAGCATACTTATAATGAACAGCAGATAGGTTGGTTCCGTGCCGGCTCTG
CTTTAAATGCAAGATAAAAG

Downstream 100 bases:

>100_bases
AAACTCACGGATATGAAGAAAGAATATATCATTTACAAACTCTCCGAGGATATGAAGAATGCAACCCGGATTGAGAACGA
ATTGTTCAAGAAGTTTGATG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKKTVPYITGDGVGAEITPAMQAIVNAAVKKAYGNEHEIEWMEVLAGERAFNETGSWLPDETMEAFKKYGVGIKGPLTTP
VGGGIRSLNVALRQTLDLYVCLRPVRWFSGVVSPVKEPQKVDMHIFRENTEDIYAGIEWEAGTPEAEKFYRFLHDEMGVA
KVRFPESSSFGVKPVSKEGTERLVRAACKYALEHGLPSVTLVHKGNIMKFTEGGFKKWGYELAEREFGDAIASGKLVIKD
CIADAFLQNTLLIPEEYSVVATLNLNGDYISDQLAAMVGGIGIAPGANINYNTGHAIFEATHGTAPNIAGKDVVNPCSLI
LSAVMMLEHFGWNKAAELIVNALESSFGEGRATHDLARFMPGGVSLGTSAFTKEIIERINS

Sequences:

>Translated_381_residues
MKKTVPYITGDGVGAEITPAMQAIVNAAVKKAYGNEHEIEWMEVLAGERAFNETGSWLPDETMEAFKKYGVGIKGPLTTP
VGGGIRSLNVALRQTLDLYVCLRPVRWFSGVVSPVKEPQKVDMHIFRENTEDIYAGIEWEAGTPEAEKFYRFLHDEMGVA
KVRFPESSSFGVKPVSKEGTERLVRAACKYALEHGLPSVTLVHKGNIMKFTEGGFKKWGYELAEREFGDAIASGKLVIKD
CIADAFLQNTLLIPEEYSVVATLNLNGDYISDQLAAMVGGIGIAPGANINYNTGHAIFEATHGTAPNIAGKDVVNPCSLI
LSAVMMLEHFGWNKAAELIVNALESSFGEGRATHDLARFMPGGVSLGTSAFTKEIIERINS
>Mature_381_residues
MKKTVPYITGDGVGAEITPAMQAIVNAAVKKAYGNEHEIEWMEVLAGERAFNETGSWLPDETMEAFKKYGVGIKGPLTTP
VGGGIRSLNVALRQTLDLYVCLRPVRWFSGVVSPVKEPQKVDMHIFRENTEDIYAGIEWEAGTPEAEKFYRFLHDEMGVA
KVRFPESSSFGVKPVSKEGTERLVRAACKYALEHGLPSVTLVHKGNIMKFTEGGFKKWGYELAEREFGDAIASGKLVIKD
CIADAFLQNTLLIPEEYSVVATLNLNGDYISDQLAAMVGGIGIAPGANINYNTGHAIFEATHGTAPNIAGKDVVNPCSLI
LSAVMMLEHFGWNKAAELIVNALESSFGEGRATHDLARFMPGGVSLGTSAFTKEIIERINS

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=381, Percent_Identity=35.1706036745407, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI28178821, Length=342, Percent_Identity=28.3625730994152, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI28178816, Length=342, Percent_Identity=28.3625730994152, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4758582, Length=351, Percent_Identity=28.7749287749288, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI28178838, Length=351, Percent_Identity=28.7749287749288, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI28178819, Length=173, Percent_Identity=32.9479768786127, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1787381, Length=390, Percent_Identity=58.974358974359, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1788101, Length=370, Percent_Identity=28.6486486486486, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081683, Length=372, Percent_Identity=24.7311827956989, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=378, Percent_Identity=34.1269841269841, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144293, Length=352, Percent_Identity=29.2613636363636, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=352, Percent_Identity=29.5454545454545, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=362, Percent_Identity=27.0718232044199, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324709, Length=383, Percent_Identity=33.9425587467363, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6322097, Length=388, Percent_Identity=30.1546391752577, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324291, Length=381, Percent_Identity=30.7086614173228, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319830, Length=370, Percent_Identity=29.1891891891892, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24643270, Length=378, Percent_Identity=35.7142857142857, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24643268, Length=378, Percent_Identity=35.7142857142857, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24661184, Length=378, Percent_Identity=31.2169312169312, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161078637, Length=286, Percent_Identity=30.4195804195804, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161078635, Length=286, Percent_Identity=30.4195804195804, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI161078633, Length=286, Percent_Identity=30.4195804195804, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24650122, Length=286, Percent_Identity=30.4195804195804, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI161078639, Length=286, Percent_Identity=30.4195804195804, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI281362242, Length=381, Percent_Identity=28.3464566929134, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24648872, Length=381, Percent_Identity=28.3464566929134, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI20130355, Length=350, Percent_Identity=24.5714285714286, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 41450; Mature: 41450

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTVPYITGDGVGAEITPAMQAIVNAAVKKAYGNEHEIEWMEVLAGERAFNETGSWLPD
CCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCCCCCH
ETMEAFKKYGVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCLRPVRWFSGVVSPVKEPQK
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
VDMHIFRENTEDIYAGIEWEAGTPEAEKFYRFLHDEMGVAKVRFPESSSFGVKPVSKEGT
HHHHHHHCCCCHHEECEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHH
ERLVRAACKYALEHGLPSVTLVHKGNIMKFTEGGFKKWGYELAEREFGDAIASGKLVIKD
HHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
CIADAFLQNTLLIPEEYSVVATLNLNGDYISDQLAAMVGGIGIAPGANINYNTGHAIFEA
HHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
THGTAPNIAGKDVVNPCSLILSAVMMLEHFGWNKAAELIVNALESSFGEGRATHDLARFM
CCCCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHC
PGGVSLGTSAFTKEIIERINS
CCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKTVPYITGDGVGAEITPAMQAIVNAAVKKAYGNEHEIEWMEVLAGERAFNETGSWLPD
CCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCCCCCH
ETMEAFKKYGVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCLRPVRWFSGVVSPVKEPQK
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
VDMHIFRENTEDIYAGIEWEAGTPEAEKFYRFLHDEMGVAKVRFPESSSFGVKPVSKEGT
HHHHHHHCCCCHHEECEEECCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHH
ERLVRAACKYALEHGLPSVTLVHKGNIMKFTEGGFKKWGYELAEREFGDAIASGKLVIKD
HHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
CIADAFLQNTLLIPEEYSVVATLNLNGDYISDQLAAMVGGIGIAPGANINYNTGHAIFEA
HHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
THGTAPNIAGKDVVNPCSLILSAVMMLEHFGWNKAAELIVNALESSFGEGRATHDLARFM
CCCCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHC
PGGVSLGTSAFTKEIIERINS
CCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA