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The map label for this gene is citZ [H]

Identifier: 150004511

GI number: 150004511

Start: 2542040

End: 2543383

Strand: Direct

Name: citZ [H]

Synonym: BVU_1961

Alternate gene names: 150004511

Gene position: 2542040-2543383 (Clockwise)

Preceding gene: 150004510

Following gene: 150004514

Centisome position: 49.23

GC content: 43.68

Gene sequence:

>1344_bases
ATGAAGAAAGAATATATCATTTACAAACTCTCCGAGGATATGAAGAATGCAACCCGGATTGAGAACGAATTGTTCAAGAA
GTTTGATGTAAAGCGCGGATTGCGTAACGAAGATGGCACCGGTGTTTTGGTAGGGTTGACCAAGATAGGCAATGTAGTAG
GGTATGAACGTATTCCCGGTGGAGGATTGAAGCCGATTCCCGGCAAACTTTTCTATCGTGGGTATGATTTGGAAGATTTG
GCACATAGTATCATTAAGGAGAAACGTTTTGGTTTTGAGGAGGTGGCTTATCTGTTATTGTCCGGTCATTTGCCTGACAA
GGAAGAGTTGGCGTCTTTCTGTGAGTTGATTAATGACAATACTCCGTTGGAACAGAAGACCAAAATGAATATCATTGAGT
TGGAGGGAAATAACATTATGAACATTCTGGCCCGTAGCGTGCTTGAAATGTACCGTTTTGACCCGCAGGCGGATGATACT
TCGCGTGATAACCTGATGCGTCAGAGTATTGACTTGATATCCAAATTCCCGACCATTATTGCATACGCTTATAACATGTT
GCGCCATGCCACGTATGGTCGTTCGTTGCATATCCGTCATCCGCGTGAAAAACTGTCTATCGCAGAAAACTTCCTGTATA
TGTTGAAAAAGGATTATACGGAACTTGATGCGCGCACGCTTGATTTGCTGTTGGTACTTCAGGCTGAACACGGAGGTGGT
AATAACTCTACTTTTACCGTCCGTGTAGTTTCGTCCAGCCGTACGGATACTTATTCGGCCATCGCCGCAGGTATCGGCTC
GTTGAAAGGTCCGCTTCATGGAGGGGCAAATATCCAGGTGGCGGATATGTTCCATCATTTGCAGGAAAATATCAAGGATT
GGACCAATGTGGACGAAATTGATACTTACTTTACCCGTATGTTGAATAAGGAAGCGTATGATAAGTCCGGTCTGATTTAT
GGTATCGGTCATGCGGTCTATACGATATCCGATCCTCGTGCCATCTTGTTGAAAGAATTGGCTCGTGATTTGGCAAAAGA
AAAAGGCAAGGAAGAAGAATTTGCTTTCCTGGAATTGTTGGAAGAACGTGCCATCGCTATGTTCGGAAAGATTAAGAATA
ACGGCAAGACGGTGTCCAGTAATATCGATTTCTATTCAGGTTTCGTATATGAAATGATTGGTCTGCCACAGGAAATATTT
ACACCTTTGTTTGCGATGGCTCGTATCGTGGGGTGGTGCGCACACCGCAATGAGGAGCTGAATTTTGAAGGAAAACGCAT
TATTCGTCCGGCATACAAGAATGTGTTGGAAGAACTGGAATATGTGCCTTTGAAACAGAGATAA

Upstream 100 bases:

>100_bases
ACATGACCTTGCCCGTTTTATGCCCGGAGGTGTCTCGCTTGGCACGTCGGCATTTACAAAAGAAATAATAGAAAGAATAA
ACTCCTAAAAACTCACGGAT

Downstream 100 bases:

>100_bases
CGGTTTAGAGGCACCTCGGTTGGCGATAAGCTTTGGTATTATTGTTTTAGCTTGGCGGCAATGAGGTCTGTATTGTTGTA
AAGAAAAGTAAGATATCTTC

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKKEYIIYKLSEDMKNATRIENELFKKFDVKRGLRNEDGTGVLVGLTKIGNVVGYERIPGGGLKPIPGKLFYRGYDLEDL
AHSIIKEKRFGFEEVAYLLLSGHLPDKEELASFCELINDNTPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPQADDT
SRDNLMRQSIDLISKFPTIIAYAYNMLRHATYGRSLHIRHPREKLSIAENFLYMLKKDYTELDARTLDLLLVLQAEHGGG
NNSTFTVRVVSSSRTDTYSAIAAGIGSLKGPLHGGANIQVADMFHHLQENIKDWTNVDEIDTYFTRMLNKEAYDKSGLIY
GIGHAVYTISDPRAILLKELARDLAKEKGKEEEFAFLELLEERAIAMFGKIKNNGKTVSSNIDFYSGFVYEMIGLPQEIF
TPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLEELEYVPLKQR

Sequences:

>Translated_447_residues
MKKEYIIYKLSEDMKNATRIENELFKKFDVKRGLRNEDGTGVLVGLTKIGNVVGYERIPGGGLKPIPGKLFYRGYDLEDL
AHSIIKEKRFGFEEVAYLLLSGHLPDKEELASFCELINDNTPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPQADDT
SRDNLMRQSIDLISKFPTIIAYAYNMLRHATYGRSLHIRHPREKLSIAENFLYMLKKDYTELDARTLDLLLVLQAEHGGG
NNSTFTVRVVSSSRTDTYSAIAAGIGSLKGPLHGGANIQVADMFHHLQENIKDWTNVDEIDTYFTRMLNKEAYDKSGLIY
GIGHAVYTISDPRAILLKELARDLAKEKGKEEEFAFLELLEERAIAMFGKIKNNGKTVSSNIDFYSGFVYEMIGLPQEIF
TPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLEELEYVPLKQR
>Mature_447_residues
MKKEYIIYKLSEDMKNATRIENELFKKFDVKRGLRNEDGTGVLVGLTKIGNVVGYERIPGGGLKPIPGKLFYRGYDLEDL
AHSIIKEKRFGFEEVAYLLLSGHLPDKEELASFCELINDNTPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPQADDT
SRDNLMRQSIDLISKFPTIIAYAYNMLRHATYGRSLHIRHPREKLSIAENFLYMLKKDYTELDARTLDLLLVLQAEHGGG
NNSTFTVRVVSSSRTDTYSAIAAGIGSLKGPLHGGANIQVADMFHHLQENIKDWTNVDEIDTYFTRMLNKEAYDKSGLIY
GIGHAVYTISDPRAILLKELARDLAKEKGKEEEFAFLELLEERAIAMFGKIKNNGKTVSSNIDFYSGFVYEMIGLPQEIF
TPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLEELEYVPLKQR

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=359, Percent_Identity=26.7409470752089, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786527, Length=394, Percent_Identity=32.2335025380711, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1786939, Length=372, Percent_Identity=31.4516129032258, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17555174, Length=371, Percent_Identity=25.6064690026954, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319850, Length=412, Percent_Identity=26.6990291262136, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324328, Length=256, Percent_Identity=30.46875, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6325257, Length=460, Percent_Identity=25, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640124, Length=338, Percent_Identity=27.810650887574, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24640126, Length=338, Percent_Identity=27.810650887574, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21356863, Length=451, Percent_Identity=23.2815964523282, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 51046; Mature: 51046

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEYIIYKLSEDMKNATRIENELFKKFDVKRGLRNEDGTGVLVGLTKIGNVVGYERIPG
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCHHCCCCCCC
GGLKPIPGKLFYRGYDLEDLAHSIIKEKRFGFEEVAYLLLSGHLPDKEELASFCELINDN
CCCCCCCCHHEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
TPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPQADDTSRDNLMRQSIDLISKFPTII
CCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AYAYNMLRHATYGRSLHIRHPREKLSIAENFLYMLKKDYTELDARTLDLLLVLQAEHGGG
HHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCC
NNSTFTVRVVSSSRTDTYSAIAAGIGSLKGPLHGGANIQVADMFHHLQENIKDWTNVDEI
CCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHH
DTYFTRMLNKEAYDKSGLIYGIGHAVYTISDPRAILLKELARDLAKEKGKEEEFAFLELL
HHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
EERAIAMFGKIKNNGKTVSSNIDFYSGFVYEMIGLPQEIFTPLFAMARIVGWCAHRNEEL
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
NFEGKRIIRPAYKNVLEELEYVPLKQR
CCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKEYIIYKLSEDMKNATRIENELFKKFDVKRGLRNEDGTGVLVGLTKIGNVVGYERIPG
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCHHCCCCCCC
GGLKPIPGKLFYRGYDLEDLAHSIIKEKRFGFEEVAYLLLSGHLPDKEELASFCELINDN
CCCCCCCCHHEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
TPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPQADDTSRDNLMRQSIDLISKFPTII
CCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AYAYNMLRHATYGRSLHIRHPREKLSIAENFLYMLKKDYTELDARTLDLLLVLQAEHGGG
HHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCC
NNSTFTVRVVSSSRTDTYSAIAAGIGSLKGPLHGGANIQVADMFHHLQENIKDWTNVDEI
CCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHH
DTYFTRMLNKEAYDKSGLIYGIGHAVYTISDPRAILLKELARDLAKEKGKEEEFAFLELL
HHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
EERAIAMFGKIKNNGKTVSSNIDFYSGFVYEMIGLPQEIFTPLFAMARIVGWCAHRNEEL
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
NFEGKRIIRPAYKNVLEELEYVPLKQR
CCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006016; 12397186 [H]