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The map label for this gene is ndhD3 [H]

Identifier: 150004305

GI number: 150004305

Start: 2248112

End: 2249593

Strand: Reverse

Name: ndhD3 [H]

Synonym: BVU_1751

Alternate gene names: 150004305

Gene position: 2249593-2248112 (Counterclockwise)

Preceding gene: 150004306

Following gene: 150004304

Centisome position: 43.57

GC content: 43.72

Gene sequence:

>1482_bases
ATGAACATACTAAGTTTTTTCATTATAGTTCCCTTGTTGATGCTCGCGAGCCTTTGGGCTTCGCGCAGCGTCAATCAAGT
TCGCGGAGTGATGGTTGTCGGATCTTCCATATTATTGGCATTATCCGTTTACCTCACCATTGATTATATCGAACTACGCC
AAGCCGGTGCTACAGGAGAGATGCTGTTCACAGCCAGCACAGTTTGGTATGCACCACTCCATATATGTTACTCAGTAGGA
GTAGACGGTATATCAGTAGCAATGTTGCTACTTAGTTCCATTATTGTATTCACCGGTACTTTTGCATCGTGGAAGTTACA
ACCATTGACAAAAGAATATTTCATGTGGTTCACTCTATTGAGTGTAGGGGTATTCGGATTCTTCGTTTCAACAGACCTGT
TCACCATGTTCATGTTTTATGAAGTAGCCTTAATTCCAATGTATCTGCTCATCGGTGTATGGGGAAGCGGACGTAAAGAA
TATGCCGCCATGAAACTTACATTAATGTTAATGGGTGGTTCTGCATTTCTACTGATCGGAATTCTCGGTATTTTTTATGG
TGCAGGCGGTGAAACTATGAACTTGCTGGAAATCGCCAAACTGCATATACCTCATGAAATGCAACGCATCTTCTTCCCGC
TTATCTTCTTGGGGTTCGGAGTCTTAGGAGCTTTGTTCCCTTTCCATACATGGAGTCCCGATGGTCATGCTTCTGCACCG
ACTGCTGTTTCTATGCTTCACGCTGGAGTATTGATGAAACTAGGAGGTTACGGATGCTTCCGTGTTGCTATGTACCTGAT
GCCTGAAGGTGCAGCCATGTGGGGAGATGTATTCCTGATATTGACCACTATTTCTGTAGTTTACGGTGCATTCAGTGCTG
TGGTACAAACCGACTTAAAATATATCAATGCCTATTCCTCCGTATCCCACTGCGGATTGGTGCTCTTTGCCCTGCTGATG
ATGACACGCACCAGTTGTACGGGTGCTATTCTCCAAATGTTGAGTCACGGATTAATGACCGCTTTGTTCTTCGCCCTTAT
TGGTATGATATACGGACGTACCCACACTCGTGATGTCCGATTAATGGGAGGTTTGATGAAGATTATGCCTTTCCTGGCTG
TAGGTTATGTTATTGCCGGTCTTGCTAACTTGGGACTTCCGGGACTAAGTGGTTTTGTTGCTGAAATGACGGTCTTTGTA
GGTTCTTTCCAAAATGATGATACATTCCATCGCGTATGTACCCTAGTGGCAACAACAAGTATCGTCATTACCGCAGTCTA
TATCCTGCGTGTAGTAGGTAAAATTCTTTATGGTAAAGTTTTGAATCCCGAACATCTGAAACTCACAGACGCAACCTGGG
ATGAACGAGTAGCCGTTATCTGCCTCATCGCCTGTGTAGCAGGTTTAGGAATGGCTCCATTCTGGATAAGCGATCTGATC
AGTAACAGTGTAGAACCAATCATAAGTCAATTATTAAATTAA

Upstream 100 bases:

>100_bases
GGTTCCTTGCAGGTGCATTGATATTGACGCTGATACTATTAATTTAATGAATAATAAAAAATCCGCCGCATGGCCATTTT
TTAATTTTTAATTTAAAAAG

Downstream 100 bases:

>100_bases
AATTTGAGAATTAAAAATTAAAAAATAGCAATGATGGACATAACTGCAATACTCCATATGCATGCCGAACTGAGTCTGAC
AGCCGTTTTTATTCTGATGT

Product: NADH dehydrogenase I chain M

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 3; NDH-1, chain 4 3 [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MNILSFFIIVPLLMLASLWASRSVNQVRGVMVVGSSILLALSVYLTIDYIELRQAGATGEMLFTASTVWYAPLHICYSVG
VDGISVAMLLLSSIIVFTGTFASWKLQPLTKEYFMWFTLLSVGVFGFFVSTDLFTMFMFYEVALIPMYLLIGVWGSGRKE
YAAMKLTLMLMGGSAFLLIGILGIFYGAGGETMNLLEIAKLHIPHEMQRIFFPLIFLGFGVLGALFPFHTWSPDGHASAP
TAVSMLHAGVLMKLGGYGCFRVAMYLMPEGAAMWGDVFLILTTISVVYGAFSAVVQTDLKYINAYSSVSHCGLVLFALLM
MTRTSCTGAILQMLSHGLMTALFFALIGMIYGRTHTRDVRLMGGLMKIMPFLAVGYVIAGLANLGLPGLSGFVAEMTVFV
GSFQNDDTFHRVCTLVATTSIVITAVYILRVVGKILYGKVLNPEHLKLTDATWDERVAVICLIACVAGLGMAPFWISDLI
SNSVEPIISQLLN

Sequences:

>Translated_493_residues
MNILSFFIIVPLLMLASLWASRSVNQVRGVMVVGSSILLALSVYLTIDYIELRQAGATGEMLFTASTVWYAPLHICYSVG
VDGISVAMLLLSSIIVFTGTFASWKLQPLTKEYFMWFTLLSVGVFGFFVSTDLFTMFMFYEVALIPMYLLIGVWGSGRKE
YAAMKLTLMLMGGSAFLLIGILGIFYGAGGETMNLLEIAKLHIPHEMQRIFFPLIFLGFGVLGALFPFHTWSPDGHASAP
TAVSMLHAGVLMKLGGYGCFRVAMYLMPEGAAMWGDVFLILTTISVVYGAFSAVVQTDLKYINAYSSVSHCGLVLFALLM
MTRTSCTGAILQMLSHGLMTALFFALIGMIYGRTHTRDVRLMGGLMKIMPFLAVGYVIAGLANLGLPGLSGFVAEMTVFV
GSFQNDDTFHRVCTLVATTSIVITAVYILRVVGKILYGKVLNPEHLKLTDATWDERVAVICLIACVAGLGMAPFWISDLI
SNSVEPIISQLLN
>Mature_493_residues
MNILSFFIIVPLLMLASLWASRSVNQVRGVMVVGSSILLALSVYLTIDYIELRQAGATGEMLFTASTVWYAPLHICYSVG
VDGISVAMLLLSSIIVFTGTFASWKLQPLTKEYFMWFTLLSVGVFGFFVSTDLFTMFMFYEVALIPMYLLIGVWGSGRKE
YAAMKLTLMLMGGSAFLLIGILGIFYGAGGETMNLLEIAKLHIPHEMQRIFFPLIFLGFGVLGALFPFHTWSPDGHASAP
TAVSMLHAGVLMKLGGYGCFRVAMYLMPEGAAMWGDVFLILTTISVVYGAFSAVVQTDLKYINAYSSVSHCGLVLFALLM
MTRTSCTGAILQMLSHGLMTALFFALIGMIYGRTHTRDVRLMGGLMKIMPFLAVGYVIAGLANLGLPGLSGFVAEMTVFV
GSFQNDDTFHRVCTLVATTSIVITAVYILRVVGKILYGKVLNPEHLKLTDATWDERVAVICLIACVAGLGMAPFWISDLI
SNSVEPIISQLLN

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=338, Percent_Identity=31.9526627218935, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI251831117, Length=261, Percent_Identity=26.8199233716475, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788613, Length=454, Percent_Identity=31.7180616740088, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1788827, Length=237, Percent_Identity=30.8016877637131, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788831, Length=456, Percent_Identity=27.6315789473684, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788614, Length=459, Percent_Identity=27.2331154684096, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788829, Length=298, Percent_Identity=25.503355704698, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI2367154, Length=288, Percent_Identity=26.3888888888889, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693160, Length=221, Percent_Identity=27.1493212669683, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 53792; Mature: 53792

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILSFFIIVPLLMLASLWASRSVNQVRGVMVVGSSILLALSVYLTIDYIELRQAGATGE
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
MLFTASTVWYAPLHICYSVGVDGISVAMLLLSSIIVFTGTFASWKLQPLTKEYFMWFTLL
CCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHH
SVGVFGFFVSTDLFTMFMFYEVALIPMYLLIGVWGSGRKEYAAMKLTLMLMGGSAFLLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECCHHHHHHH
ILGIFYGAGGETMNLLEIAKLHIPHEMQRIFFPLIFLGFGVLGALFPFHTWSPDGHASAP
HHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
TAVSMLHAGVLMKLGGYGCFRVAMYLMPEGAAMWGDVFLILTTISVVYGAFSAVVQTDLK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YINAYSSVSHCGLVLFALLMMTRTSCTGAILQMLSHGLMTALFFALIGMIYGRTHTRDVR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LMGGLMKIMPFLAVGYVIAGLANLGLPGLSGFVAEMTVFVGSFQNDDTFHRVCTLVATTS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IVITAVYILRVVGKILYGKVLNPEHLKLTDATWDERVAVICLIACVAGLGMAPFWISDLI
HHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SNSVEPIISQLLN
HCCHHHHHHHHCC
>Mature Secondary Structure
MNILSFFIIVPLLMLASLWASRSVNQVRGVMVVGSSILLALSVYLTIDYIELRQAGATGE
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
MLFTASTVWYAPLHICYSVGVDGISVAMLLLSSIIVFTGTFASWKLQPLTKEYFMWFTLL
CCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHH
SVGVFGFFVSTDLFTMFMFYEVALIPMYLLIGVWGSGRKEYAAMKLTLMLMGGSAFLLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECCHHHHHHH
ILGIFYGAGGETMNLLEIAKLHIPHEMQRIFFPLIFLGFGVLGALFPFHTWSPDGHASAP
HHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
TAVSMLHAGVLMKLGGYGCFRVAMYLMPEGAAMWGDVFLILTTISVVYGAFSAVVQTDLK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YINAYSSVSHCGLVLFALLMMTRTSCTGAILQMLSHGLMTALFFALIGMIYGRTHTRDVR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LMGGLMKIMPFLAVGYVIAGLANLGLPGLSGFVAEMTVFVGSFQNDDTFHRVCTLVATTS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IVITAVYILRVVGKILYGKVLNPEHLKLTDATWDERVAVICLIACVAGLGMAPFWISDLI
HHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SNSVEPIISQLLN
HCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA