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The map label for this gene is ptpA [H]

Identifier: 150003663

GI number: 150003663

Start: 1455693

End: 1457906

Strand: Direct

Name: ptpA [H]

Synonym: BVU_1094

Alternate gene names: 150003663

Gene position: 1455693-1457906 (Clockwise)

Preceding gene: 150003662

Following gene: 150003664

Centisome position: 28.19

GC content: 47.74

Gene sequence:

>2214_bases
ATGAGAAAATTAATCAATCTGATTGCCTTATTAATCATGGCTTCATCTGTAACATGGGCACAAGACAAGAAAAGTTTCAC
ACTGGAAGACTTGATGCCGGGAGGAAACAATTATTATAACCTGCTTCCACAAAACCTGTATGGTTTGCAATGGTGGGGAG
ATGTATGCATCAACGCCGACATAGAAGAGGTAAAAACCATCCAGCCGGCAAATGGGAAGGAAAACGTACTTATCACTTTG
CAGGAAGTGAATGAACTGTTGGCAAACAAGGAATTAGGGAAAATCAACCACTTCAGGAATGCATCTTTCCCATACGCTGA
AAAGATGATGCTGGTAAATACCACATCCAATAAAGTGCTGATCGATTTAACTAAAAAGGAAATAATATGGAGTCAGCCTC
TCTCTCCTAAAGCCGCCAACCAGGACTGGAACAAGGAAAGCCGTTCATTGGCTTATACCCTTGACAACAATCTGTTTGTA
ACGACTGCCGACGGGAAAACGCAACAAGTCACCGACGAACCGAAAGGCATCGTATGCGGACAAAGTGTACACCGTCAGGA
ATTTGGTATCTCGAAAGGTACTTTCTGGAGTCCGAAAGGAAATCTGCTTGCTTTCTACCACATGGACGAAAGCATGGTAA
CCGATTATCCACAAGTAAATACCTCCACCCGCATAGCGACACTGGAGCCGGACAAGTATCCGATGGCAGGAATGACCAGC
CACAAAGTGACTGTCGGCATCTACAATCCGGAGACCCAAAAAACAGTTTATCTGAAAGCCGGAGACCCTACCGACCGTTA
TTTTACCAATATCAGCTGGAGTCCTGACGAAAAAAGCGTTTATGTCATTGAACTGAACCGTGACCAGAACCATGCCCTGC
TATGCTGCTATGACGCGGAAACAGGAGAGCCACTGAAAAGCAATCCCCTTTACGAAGAGAAGCATACTAAATATGTAGAA
CCCCAACATCCCATCGTCTTTCTGCCTTGGGACCACACGAAGTTCATCTATCAGAGCCAGCGCGACGGCTACAACCATCT
TTACCTGATGGACACCAAGACTTCCGTATATCCGGAATCACATGGAGCCGCGGCCGGAGGTTCTTACCGGGAAAGCTACA
AGACCAGACAGCTTACCCAAGGCAACTGGGTAGTACAAAACATCCTCGGATTCAATGAAAAGACCAAGGAAGTCATCATC
ATGAGCACAGAGGTTTCCCCTTTGCAGAGCAACGCATACGCTGTGAATGTAAAGACAGGCAAACGCCGCCTCATCGGCAA
TAAAGACGGTATGCATCATGTACAACTGTCCGGTAGCGGCAACTATGTGATAGACAATTATACTTCTTTCACCATTCCCC
GGAATATCGAGATCGTTCCCACTTCCGGAAAGGGAAAGACTATCAGCCTGTTGACCGCCACCAATCCGTTGGAAGCATAC
AATATGCCCGAAATCACTGTCGGTACCCTCAAGGCAGCCGACGGCAAGACCGACTTATACTACCGCCTGATAAAGCCGGT
GAATTTTGACCCCAACAAAAAATACCCGGCCGTAGTCTACGTGTATGGCGGACCACATGCCCAACTAATCCACAACAACC
GCAACTATGACGCCCGCGGATGGGATATTTACATGGCACAACTGGGTTACGTCATGCTGACCGTTGACAACCGGGGCAGT
GACAACCGGGGACTGGAATTTGAGAACTGTACGTTCCGCCAATTGGGAACCGAAGAGATGAAAGACCAGGTAAAAGGAGT
GGATTTCTTAAAATCATTGGGTTATGTGGACAATAACCGCATTGGCGTACATGGTTGGAGCTTCGGTGGTTTCATGACCA
CCAACTTGATGCTGACTTACCCCGAACTATTCAAAGTAGGAGTAGCCGGCGGTCCTGTCATCGACTGGGCTTACTACGAA
GTAATGTACGGCGAACGCTACATGGATACTCCGCAAACCAACCCCGAAGGCTACAAGAACGCCAACCTGAAGCTGAGAGC
CGGAAACCTGAAAGGACGTCTGGAAGTGATCATTGGCGCCAATGACCCCACTTGTGTTCCCCAGCACAGCATCAGTTTCC
TCCGTGCCTGCATTGATGCCGGAACCCAACCCGATTTCTTTATGTATCCGGGCGACGGTCATAATATGTTCGGACGCGAC
CGTGTGCACTTGTATGAACGCATTACACGCTATTTTGAAGACCACTTAAAATAA

Upstream 100 bases:

>100_bases
ACACCGCAACTTTGGTGACAGACGTGAAGGCCGCGACAATTTCAAAAGCAGTCCCCGTAAATTTGACGACAATAAGGAAA
AGACAGAAGAATAAACAGTT

Downstream 100 bases:

>100_bases
ACAAAAGATAAGATTATGAAACTGTTGCTATTAGGCTCAGGCGGACGTGAACACGCCCTGGCATGGAAGATTGCTCAAAG
TCCCAAAATCGAGAAACTCT

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 737; Mature: 737

Protein sequence:

>737_residues
MRKLINLIALLIMASSVTWAQDKKSFTLEDLMPGGNNYYNLLPQNLYGLQWWGDVCINADIEEVKTIQPANGKENVLITL
QEVNELLANKELGKINHFRNASFPYAEKMMLVNTTSNKVLIDLTKKEIIWSQPLSPKAANQDWNKESRSLAYTLDNNLFV
TTADGKTQQVTDEPKGIVCGQSVHRQEFGISKGTFWSPKGNLLAFYHMDESMVTDYPQVNTSTRIATLEPDKYPMAGMTS
HKVTVGIYNPETQKTVYLKAGDPTDRYFTNISWSPDEKSVYVIELNRDQNHALLCCYDAETGEPLKSNPLYEEKHTKYVE
PQHPIVFLPWDHTKFIYQSQRDGYNHLYLMDTKTSVYPESHGAAAGGSYRESYKTRQLTQGNWVVQNILGFNEKTKEVII
MSTEVSPLQSNAYAVNVKTGKRRLIGNKDGMHHVQLSGSGNYVIDNYTSFTIPRNIEIVPTSGKGKTISLLTATNPLEAY
NMPEITVGTLKAADGKTDLYYRLIKPVNFDPNKKYPAVVYVYGGPHAQLIHNNRNYDARGWDIYMAQLGYVMLTVDNRGS
DNRGLEFENCTFRQLGTEEMKDQVKGVDFLKSLGYVDNNRIGVHGWSFGGFMTTNLMLTYPELFKVGVAGGPVIDWAYYE
VMYGERYMDTPQTNPEGYKNANLKLRAGNLKGRLEVIIGANDPTCVPQHSISFLRACIDAGTQPDFFMYPGDGHNMFGRD
RVHLYERITRYFEDHLK

Sequences:

>Translated_737_residues
MRKLINLIALLIMASSVTWAQDKKSFTLEDLMPGGNNYYNLLPQNLYGLQWWGDVCINADIEEVKTIQPANGKENVLITL
QEVNELLANKELGKINHFRNASFPYAEKMMLVNTTSNKVLIDLTKKEIIWSQPLSPKAANQDWNKESRSLAYTLDNNLFV
TTADGKTQQVTDEPKGIVCGQSVHRQEFGISKGTFWSPKGNLLAFYHMDESMVTDYPQVNTSTRIATLEPDKYPMAGMTS
HKVTVGIYNPETQKTVYLKAGDPTDRYFTNISWSPDEKSVYVIELNRDQNHALLCCYDAETGEPLKSNPLYEEKHTKYVE
PQHPIVFLPWDHTKFIYQSQRDGYNHLYLMDTKTSVYPESHGAAAGGSYRESYKTRQLTQGNWVVQNILGFNEKTKEVII
MSTEVSPLQSNAYAVNVKTGKRRLIGNKDGMHHVQLSGSGNYVIDNYTSFTIPRNIEIVPTSGKGKTISLLTATNPLEAY
NMPEITVGTLKAADGKTDLYYRLIKPVNFDPNKKYPAVVYVYGGPHAQLIHNNRNYDARGWDIYMAQLGYVMLTVDNRGS
DNRGLEFENCTFRQLGTEEMKDQVKGVDFLKSLGYVDNNRIGVHGWSFGGFMTTNLMLTYPELFKVGVAGGPVIDWAYYE
VMYGERYMDTPQTNPEGYKNANLKLRAGNLKGRLEVIIGANDPTCVPQHSISFLRACIDAGTQPDFFMYPGDGHNMFGRD
RVHLYERITRYFEDHLK
>Mature_737_residues
MRKLINLIALLIMASSVTWAQDKKSFTLEDLMPGGNNYYNLLPQNLYGLQWWGDVCINADIEEVKTIQPANGKENVLITL
QEVNELLANKELGKINHFRNASFPYAEKMMLVNTTSNKVLIDLTKKEIIWSQPLSPKAANQDWNKESRSLAYTLDNNLFV
TTADGKTQQVTDEPKGIVCGQSVHRQEFGISKGTFWSPKGNLLAFYHMDESMVTDYPQVNTSTRIATLEPDKYPMAGMTS
HKVTVGIYNPETQKTVYLKAGDPTDRYFTNISWSPDEKSVYVIELNRDQNHALLCCYDAETGEPLKSNPLYEEKHTKYVE
PQHPIVFLPWDHTKFIYQSQRDGYNHLYLMDTKTSVYPESHGAAAGGSYRESYKTRQLTQGNWVVQNILGFNEKTKEVII
MSTEVSPLQSNAYAVNVKTGKRRLIGNKDGMHHVQLSGSGNYVIDNYTSFTIPRNIEIVPTSGKGKTISLLTATNPLEAY
NMPEITVGTLKAADGKTDLYYRLIKPVNFDPNKKYPAVVYVYGGPHAQLIHNNRNYDARGWDIYMAQLGYVMLTVDNRGS
DNRGLEFENCTFRQLGTEEMKDQVKGVDFLKSLGYVDNNRIGVHGWSFGGFMTTNLMLTYPELFKVGVAGGPVIDWAYYE
VMYGERYMDTPQTNPEGYKNANLKLRAGNLKGRLEVIIGANDPTCVPQHSISFLRACIDAGTQPDFFMYPGDGHNMFGRD
RVHLYERITRYFEDHLK

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=642, Percent_Identity=27.4143302180685, Blast_Score=201, Evalue=3e-51,
Organism=Homo sapiens, GI37577089, Length=642, Percent_Identity=27.4143302180685, Blast_Score=200, Evalue=4e-51,
Organism=Homo sapiens, GI194394146, Length=373, Percent_Identity=30.5630026809651, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI295842359, Length=643, Percent_Identity=25.6609642301711, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI295842403, Length=643, Percent_Identity=25.6609642301711, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI85787627, Length=643, Percent_Identity=25.6609642301711, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI52426756, Length=643, Percent_Identity=25.6609642301711, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI295849272, Length=643, Percent_Identity=25.6609642301711, Blast_Score=174, Evalue=4e-43,
Organism=Homo sapiens, GI16933540, Length=781, Percent_Identity=25.3521126760563, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI18765694, Length=780, Percent_Identity=23.4615384615385, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI86792863, Length=620, Percent_Identity=24.6774193548387, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI86792774, Length=620, Percent_Identity=24.6774193548387, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI86792778, Length=620, Percent_Identity=24.6774193548387, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI37577091, Length=641, Percent_Identity=25.1170046801872, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI18450278, Length=450, Percent_Identity=24.4444444444444, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508019, Length=654, Percent_Identity=25.0764525993884, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17508017, Length=654, Percent_Identity=25.0764525993884, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17550672, Length=580, Percent_Identity=23.9655172413793, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17564634, Length=582, Percent_Identity=25.6013745704467, Blast_Score=121, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17564632, Length=582, Percent_Identity=25.6013745704467, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321817, Length=620, Percent_Identity=25.3225806451613, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324793, Length=628, Percent_Identity=22.9299363057325, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45550825, Length=677, Percent_Identity=24.9630723781388, Blast_Score=179, Evalue=8e-45,
Organism=Drosophila melanogaster, GI45553511, Length=677, Percent_Identity=24.9630723781388, Blast_Score=179, Evalue=8e-45,
Organism=Drosophila melanogaster, GI45551969, Length=677, Percent_Identity=24.9630723781388, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17933704, Length=641, Percent_Identity=25.8970358814353, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI161083744, Length=641, Percent_Identity=25.7410296411856, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI221331178, Length=641, Percent_Identity=26.0530421216849, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24582257, Length=262, Percent_Identity=29.7709923664122, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24582032, Length=631, Percent_Identity=24.0887480190174, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551475, Length=224, Percent_Identity=26.3392857142857, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI221372263, Length=224, Percent_Identity=26.3392857142857, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI221372266, Length=224, Percent_Identity=26.3392857142857, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 83574; Mature: 83574

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLINLIALLIMASSVTWAQDKKSFTLEDLMPGGNNYYNLLPQNLYGLQWWGDVCINAD
CHHHHHHHHHHHHHCCCEECCCCCCEEHHHCCCCCCCEEEECCCCCCCEEEEEEEEECCC
IEEVKTIQPANGKENVLITLQEVNELLANKELGKINHFRNASFPYAEKMMLVNTTSNKVL
HHHHHEECCCCCCCCEEEEHHHHHHHHCCCCCCCHHHCCCCCCCCHHEEEEEEECCCEEE
IDLTKKEIIWSQPLSPKAANQDWNKESRSLAYTLDNNLFVTTADGKTQQVTDEPKGIVCG
EEEECCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCEEEC
QSVHRQEFGISKGTFWSPKGNLLAFYHMDESMVTDYPQVNTSTRIATLEPDKYPMAGMTS
CHHHHHHCCCCCCCEECCCCCEEEEEECCCHHHCCCCCCCCCEEEEEECCCCCCCCCCCC
HKVTVGIYNPETQKTVYLKAGDPTDRYFTNISWSPDEKSVYVIELNRDQNHALLCCYDAE
CEEEEEEECCCCCEEEEEECCCCCHHEEEECCCCCCCCEEEEEEECCCCCCEEEEEEECC
TGEPLKSNPLYEEKHTKYVEPQHPIVFLPWDHTKFIYQSQRDGYNHLYLMDTKTSVYPES
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEECCCEECCCC
HGAAAGGSYRESYKTRQLTQGNWVVQNILGFNEKTKEVIIMSTEVSPLQSNAYAVNVKTG
CCCCCCCCHHHHHHHHEECCCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEECC
KRRLIGNKDGMHHVQLSGSGNYVIDNYTSFTIPRNIEIVPTSGKGKTISLLTATNPLEAY
CEEECCCCCCCEEEEECCCCCEEEECCEEEECCCCEEEEECCCCCCEEEEEEECCCHHHC
NMPEITVGTLKAADGKTDLYYRLIKPVNFDPNKKYPAVVYVYGGPHAQLIHNNRNYDARG
CCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCC
WDIYMAQLGYVMLTVDNRGSDNRGLEFENCTFRQLGTEEMKDQVKGVDFLKSLGYVDNNR
EEEEEEECCEEEEEEECCCCCCCCEEECCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCE
IGVHGWSFGGFMTTNLMLTYPELFKVGVAGGPVIDWAYYEVMYGERYMDTPQTNPEGYKN
EEEEEECCCCEEEEEEEEECHHHHEECCCCCCEEEHEEEEEEECCEECCCCCCCCCCCCC
ANLKLRAGNLKGRLEVIIGANDPTCVPQHSISFLRACIDAGTQPDFFMYPGDGHNMFGRD
CCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCC
RVHLYERITRYFEDHLK
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKLINLIALLIMASSVTWAQDKKSFTLEDLMPGGNNYYNLLPQNLYGLQWWGDVCINAD
CHHHHHHHHHHHHHCCCEECCCCCCEEHHHCCCCCCCEEEECCCCCCCEEEEEEEEECCC
IEEVKTIQPANGKENVLITLQEVNELLANKELGKINHFRNASFPYAEKMMLVNTTSNKVL
HHHHHEECCCCCCCCEEEEHHHHHHHHCCCCCCCHHHCCCCCCCCHHEEEEEEECCCEEE
IDLTKKEIIWSQPLSPKAANQDWNKESRSLAYTLDNNLFVTTADGKTQQVTDEPKGIVCG
EEEECCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCEEEC
QSVHRQEFGISKGTFWSPKGNLLAFYHMDESMVTDYPQVNTSTRIATLEPDKYPMAGMTS
CHHHHHHCCCCCCCEECCCCCEEEEEECCCHHHCCCCCCCCCEEEEEECCCCCCCCCCCC
HKVTVGIYNPETQKTVYLKAGDPTDRYFTNISWSPDEKSVYVIELNRDQNHALLCCYDAE
CEEEEEEECCCCCEEEEEECCCCCHHEEEECCCCCCCCEEEEEEECCCCCCEEEEEEECC
TGEPLKSNPLYEEKHTKYVEPQHPIVFLPWDHTKFIYQSQRDGYNHLYLMDTKTSVYPES
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEEEECCCEECCCC
HGAAAGGSYRESYKTRQLTQGNWVVQNILGFNEKTKEVIIMSTEVSPLQSNAYAVNVKTG
CCCCCCCCHHHHHHHHEECCCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEEECC
KRRLIGNKDGMHHVQLSGSGNYVIDNYTSFTIPRNIEIVPTSGKGKTISLLTATNPLEAY
CEEECCCCCCCEEEEECCCCCEEEECCEEEECCCCEEEEECCCCCCEEEEEEECCCHHHC
NMPEITVGTLKAADGKTDLYYRLIKPVNFDPNKKYPAVVYVYGGPHAQLIHNNRNYDARG
CCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCC
WDIYMAQLGYVMLTVDNRGSDNRGLEFENCTFRQLGTEEMKDQVKGVDFLKSLGYVDNNR
EEEEEEECCEEEEEEECCCCCCCCEEECCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCE
IGVHGWSFGGFMTTNLMLTYPELFKVGVAGGPVIDWAYYEVMYGERYMDTPQTNPEGYKN
EEEEEECCCCEEEEEEEEECHHHHEECCCCCCEEEHEEEEEEECCEECCCCCCCCCCCCC
ANLKLRAGNLKGRLEVIIGANDPTCVPQHSISFLRACIDAGTQPDFFMYPGDGHNMFGRD
CCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCC
RVHLYERITRYFEDHLK
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA