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The map label for this gene is menB

Identifier: 148828146

GI number: 148828146

Start: 1556617

End: 1557474

Strand: Direct

Name: menB

Synonym: CGSHiGG_08420

Alternate gene names: 148828146

Gene position: 1556617-1557474 (Clockwise)

Preceding gene: 148828145

Following gene: 148828147

Centisome position: 82.48

GC content: 43.47

Gene sequence:

>858_bases
ATGCAAAATCCAAAAGATGATGTTTTATATGCGCCTGTTGAATGGATCGATCACAGTGAAGGCTATAGCGATATTCGCTA
TCATAAATCCACTGATGGTATTGCAAAAATTACCATTAACCGCCCTGAAGTTCGTAATGCGTTCCGTCCACAAACAGTGA
AAGAAATGATGACTGCATTTTCTGATGCACGTTTCGATGAAAACATTGGTGTCATTGTATTAACTGGCGAAGGCGAAAAA
GCATTCTGTTCTGGTGGTGACCAAAAAGTGCGTGGCGATTACGGTGGTTACAAAGATGACAGTGGCGTACATCACTTAAA
TGTATTAGATTTCCAACGCGATATTCGTTCTTGTCCAAAACCAGTTGTAGCAATGGTGGCTGGTTATGCAATTGGTGGTG
GCCATGTATTACATATGCTTTGCGACTTAACGATTGCTGCTGAAAATGCCATTTTCGGGCAAACTGGGCCAAAAGTCGGT
TCATTCGATGGCGGTTGGGGCGCAAGCTATATGGCTCGTTTAGTGGGGCAGAAAAAAGCGCGTGAAATTTGGTTCTTATG
CCGTCAATATAATGCACAAGAAGCATTAGACATGGGCTTAGTCAATACTGTTGTGCCTTACGCTGATCTTGAAAAAGAAA
CCGTGCGTTGGTGTCGTGAAATGTTACGAAATAGCCCAATCGCGATCCGTTGTTTGAAAGCGGCATTAAATGCGGATTGT
GATGGCCAAGCAGGTCTTCAAGAATTAGCGGGTAACGCAACAATGTTGTTCTACATGACTGAAGAAGGTCAAGAAGGCCG
CAATGCGTTTAACGAAAAACGCGCCCCAGACTTCAGCAAATTCAGACGTAACCCTTAA

Upstream 100 bases:

>100_bases
CTTCACAACAGATAAAGCAGCAAATGAATTTAGTTTTCCTGATCTGAAAAACTTCCGCTATAATGACCGCACTTTTTTAC
GTTAATTAAAAGGAATTCTT

Downstream 100 bases:

>100_bases
TTTATCGTTCTAAAGTGCGGTTAAAAATCTTCGTGAATTTTGACCGCACTTTTGTATTGGGAGCAAGCATGGCTGAAAAA
TCATTTAATCTTTACCGTTA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MQNPKDDVLYAPVEWIDHSEGYSDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMMTAFSDARFDENIGVIVLTGEGEK
AFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRDIRSCPKPVVAMVAGYAIGGGHVLHMLCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARLVGQKKAREIWFLCRQYNAQEALDMGLVNTVVPYADLEKETVRWCREMLRNSPIAIRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFRRNP

Sequences:

>Translated_285_residues
MQNPKDDVLYAPVEWIDHSEGYSDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMMTAFSDARFDENIGVIVLTGEGEK
AFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRDIRSCPKPVVAMVAGYAIGGGHVLHMLCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARLVGQKKAREIWFLCRQYNAQEALDMGLVNTVVPYADLEKETVRWCREMLRNSPIAIRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFRRNP
>Mature_285_residues
MQNPKDDVLYAPVEWIDHSEGYSDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMMTAFSDARFDENIGVIVLTGEGEK
AFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRDIRSCPKPVVAMVAGYAIGGGHVLHMLCDLTIAAENAIFGQTGPKVG
SFDGGWGASYMARLVGQKKAREIWFLCRQYNAQEALDMGLVNTVVPYADLEKETVRWCREMLRNSPIAIRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFRRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family

Homologues:

Organism=Homo sapiens, GI194097323, Length=245, Percent_Identity=33.469387755102, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=31.3492063492063, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4502327, Length=253, Percent_Identity=29.2490118577075, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=29.6650717703349, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=29.6650717703349, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=29.6650717703349, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI70995211, Length=239, Percent_Identity=28.8702928870293, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI25453481, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI51538573, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4757966, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI51538581, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4757968, Length=249, Percent_Identity=25.7028112449799, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI49355787, Length=249, Percent_Identity=25.7028112449799, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI157694516, Length=225, Percent_Identity=24.8888888888889, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=24.8888888888889, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI37594471, Length=142, Percent_Identity=28.8732394366197, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI37594469, Length=142, Percent_Identity=28.8732394366197, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=285, Percent_Identity=86.6666666666667, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=32.7935222672065, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI221142681, Length=207, Percent_Identity=32.3671497584541, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082183, Length=255, Percent_Identity=28.6274509803922, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787660, Length=257, Percent_Identity=28.4046692607004, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788682, Length=229, Percent_Identity=24.8908296943231, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=32.6612903225806, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=28.7735849056604, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17549921, Length=197, Percent_Identity=27.4111675126904, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=231, Percent_Identity=25.5411255411255, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=27.6515151515151, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=231, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=191, Percent_Identity=28.7958115183246, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=35.3413654618474, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=35.3413654618474, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=28.735632183908, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI21357171, Length=178, Percent_Identity=33.1460674157303, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=31.1475409836066, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922422, Length=199, Percent_Identity=28.643216080402, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24650670, Length=178, Percent_Identity=30.3370786516854, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENB_HAEIN (P44960)

Other databases:

- EMBL:   L42023
- PIR:   B64105
- RefSeq:   NP_439129.1
- ProteinModelPortal:   P44960
- SMR:   P44960
- GeneID:   949967
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0968
- NMPDR:   fig|71421.1.peg.934
- TIGR:   HI_0968
- HOGENOM:   HBG748731
- OMA:   QWCREIL
- ProtClustDB:   PRK07396
- BioCyc:   HINF71421:HI_0968-MONOMER
- BRENDA:   4.1.3.36
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198
- Gene3D:   G3DSA:1.10.12.10
- TIGRFAMs:   TIGR01929

Pfam domain/function: PF00378 ECH

EC number: =4.1.3.36

Molecular weight: Translated: 31700; Mature: 31700

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: BINDING 155-155 BINDING 161-161

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNPKDDVLYAPVEWIDHSEGYSDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMMTAF
CCCCCCCEEECCHHHHCCCCCCCHHEEECCCCCEEEEEECCHHHHHCCCCHHHHHHHHHH
SDARFDENIGVIVLTGEGEKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRDIRSCPK
HHCCCCCCCCEEEEECCCCCHHHCCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHHCCH
PVVAMVAGYAIGGGHVLHMLCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARLVGQKKA
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYNAQEALDMGLVNTVVPYADLEKETVRWCREMLRNSPIAIRCLKAALNADC
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFRRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MQNPKDDVLYAPVEWIDHSEGYSDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMMTAF
CCCCCCCEEECCHHHHCCCCCCCHHEEECCCCCEEEEEECCHHHHHCCCCHHHHHHHHHH
SDARFDENIGVIVLTGEGEKAFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRDIRSCPK
HHCCCCCCCCEEEEECCCCCHHHCCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHHCCH
PVVAMVAGYAIGGGHVLHMLCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARLVGQKKA
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRQYNAQEALDMGLVNTVVPYADLEKETVRWCREMLRNSPIAIRCLKAALNADC
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRAPDFSKFRRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800