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The map label for this gene is ilvY [H]

Identifier: 148826667

GI number: 148826667

Start: 1720061

End: 1720861

Strand: Direct

Name: ilvY [H]

Synonym: CGSHiEE_08690

Alternate gene names: 148826667

Gene position: 1720061-1720861 (Clockwise)

Preceding gene: 148826661

Following gene: 148826668

Centisome position: 94.87

GC content: 40.57

Gene sequence:

>801_bases
ATGTCTCCCTCTACCCTTTCCCGTCAAATTCAACGATTGGAAGACGAGTTAGGGAAGACACTTTTTATTCGTGATAATCG
TCAAGTCAAACTTACTGAATATGGCGAGAAATTTTTACAATTTGCTAAAACAGAATGGCAAAACTGGCAACAATTTAAAC
AACAACTGAAAGATGAATCCGATGAACTTTGCGGTGAAATTAAACTTTTTTGTTCTGTAACCGCATCTTATAGCCATCTT
CCTCACGTACTTAAACAGTTTCGCCAGCGTTATCCTAAAGTGGAAATTCAACTGACTACGGGTGATCCAGCGTTAGCACT
AGAATTAATTCAAGCACAACAAGTCGATCTCGCGCTTGCGGGGAAACCAAATAATCTGCCCTCTAGTGTAGTGTTTCATA
AAATAGATGATATTAGTTTGTCCCTAATTGCCCCGCGAGTGGCTTGTTTGGCGACACAATTATTGCAAGAAAAACCTATT
GATTGGCAGCAAATGCCTTTTATTTTCCCTGTTGAAGGGCACGCTCGGCAGCGGATTGAACAATGGTTAAGGGAGAAACA
AATTAAACACCCGAAAATTTATGCTACTGTTGCGGGACACGAAGGAATTGTGCCAATGGTGGGATTAGGATTTGGATTAG
CAATGTTGCCTGATGCAGTAATTGACAGCAGCCCAATGAATAACCAAATTTCCAGACTTAATCTTGATAAGCCTATTGAG
CCTTTTGAATTAGGTATTTGCACCCAAAAAAGAAATCTCGAACAGCCCCTAGTCCGTGCATTTTGGGCGATGTTAGAATA
G

Upstream 100 bases:

>100_bases
TATTAAATAAAAGAAGAAATTATGGAATTTACCGACCTACAAATATTCATCCACCTCAGTGATACAAAAAACTTCACCAA
AACCGCCACCCAAAACCAAC

Downstream 100 bases:

>100_bases
AATAAATAATGGTTTAAAATAAGGATTTCTTATGTTTAAAGGTATTCTCGTTTCATTATTAGCCTCTTTTCTATTTGGCT
ATATGTATTATTTTTCTACG

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSPSTLSRQIQRLEDELGKTLFIRDNRQVKLTEYGEKFLQFAKTEWQNWQQFKQQLKDESDELCGEIKLFCSVTASYSHL
PHVLKQFRQRYPKVEIQLTTGDPALALELIQAQQVDLALAGKPNNLPSSVVFHKIDDISLSLIAPRVACLATQLLQEKPI
DWQQMPFIFPVEGHARQRIEQWLREKQIKHPKIYATVAGHEGIVPMVGLGFGLAMLPDAVIDSSPMNNQISRLNLDKPIE
PFELGICTQKRNLEQPLVRAFWAMLE

Sequences:

>Translated_266_residues
MSPSTLSRQIQRLEDELGKTLFIRDNRQVKLTEYGEKFLQFAKTEWQNWQQFKQQLKDESDELCGEIKLFCSVTASYSHL
PHVLKQFRQRYPKVEIQLTTGDPALALELIQAQQVDLALAGKPNNLPSSVVFHKIDDISLSLIAPRVACLATQLLQEKPI
DWQQMPFIFPVEGHARQRIEQWLREKQIKHPKIYATVAGHEGIVPMVGLGFGLAMLPDAVIDSSPMNNQISRLNLDKPIE
PFELGICTQKRNLEQPLVRAFWAMLE
>Mature_265_residues
SPSTLSRQIQRLEDELGKTLFIRDNRQVKLTEYGEKFLQFAKTEWQNWQQFKQQLKDESDELCGEIKLFCSVTASYSHLP
HVLKQFRQRYPKVEIQLTTGDPALALELIQAQQVDLALAGKPNNLPSSVVFHKIDDISLSLIAPRVACLATQLLQEKPID
WQQMPFIFPVEGHARQRIEQWLREKQIKHPKIYATVAGHEGIVPMVGLGFGLAMLPDAVIDSSPMNNQISRLNLDKPIEP
FELGICTQKRNLEQPLVRAFWAMLE

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=268, Percent_Identity=48.8805970149254, Blast_Score=263, Evalue=8e-72,
Organism=Escherichia coli, GI1787806, Length=239, Percent_Identity=25.5230125523013, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI145693105, Length=265, Percent_Identity=24.9056603773585, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787601, Length=119, Percent_Identity=27.7310924369748, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788706, Length=150, Percent_Identity=29.3333333333333, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788296, Length=226, Percent_Identity=26.1061946902655, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 30484; Mature: 30352

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSTLSRQIQRLEDELGKTLFIRDNRQVKLTEYGEKFLQFAKTEWQNWQQFKQQLKDES
CCCHHHHHHHHHHHHHHCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DELCGEIKLFCSVTASYSHLPHVLKQFRQRYPKVEIQLTTGDPALALELIQAQQVDLALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCEEEC
GKPNNLPSSVVFHKIDDISLSLIAPRVACLATQLLQEKPIDWQQMPFIFPVEGHARQRIE
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEECCCHHHHHHH
QWLREKQIKHPKIYATVAGHEGIVPMVGLGFGLAMLPDAVIDSSPMNNQISRLNLDKPIE
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCC
PFELGICTQKRNLEQPLVRAFWAMLE
HHHHCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SPSTLSRQIQRLEDELGKTLFIRDNRQVKLTEYGEKFLQFAKTEWQNWQQFKQQLKDES
CCHHHHHHHHHHHHHHCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DELCGEIKLFCSVTASYSHLPHVLKQFRQRYPKVEIQLTTGDPALALELIQAQQVDLALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCEEEC
GKPNNLPSSVVFHKIDDISLSLIAPRVACLATQLLQEKPIDWQQMPFIFPVEGHARQRIE
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEECCCHHHHHHH
QWLREKQIKHPKIYATVAGHEGIVPMVGLGFGLAMLPDAVIDSSPMNNQISRLNLDKPIE
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCC
PFELGICTQKRNLEQPLVRAFWAMLE
HHHHCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]