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The map label for this gene is licA [H]

Identifier: 148826061

GI number: 148826061

Start: 1057627

End: 1058622

Strand: Direct

Name: licA [H]

Synonym: CGSHiEE_05255

Alternate gene names: 148826061

Gene position: 1057627-1058622 (Clockwise)

Preceding gene: 148826060

Following gene: 148826062

Centisome position: 58.33

GC content: 33.03

Gene sequence:

>996_bases
ATGCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATC
AATCAATCAATCAATCAATCAAATTGTAGGATTTGTTAAAACTTGCTACAAGCCTGAGGAAGTATTTCATTTTCTTCATC
AGCATTCCATTCCTTTTTCCTCCATTGGAGGAATGACCAATCAAAATGTTCTACTTAATATTTCTGGAGTTAAGTTTGTA
TTACGGATCCCTAATGCTGTAAATTTATCACTTATAAATCGAGAATATGAGGCATTCAATAATGCTCAGGCATATCGTGC
TGGCTTGAATGTAGAAACTCCCGTATTAGATGCCAAAAGTGGCGTAAAACTGACTCGCTATTTAGAAAATAGTAAGCCGT
TAAGTCAGATACAATTAAACGAGCAAAGTTGTTTGTCTCAAGTTGTGAATAATTTATATCGTTTACACAATAGTGAATTT
GTTTTCCGTAATGTATTTAGCGTATTCGATGAGTTTCGCCAATATTTTTCATTGCTAGAAAACAAATCCGCTTTTTTTCA
AGCAGATCCTAGAATGGATAAACTTTCAGCTGTATTTTGGCAATTTGAAGAAATCAATAAAGAGATAATTTTACGTCCGT
GCCACAATGATTTAGTCCCTGAAAATATGTTATTACAAGATGATCGGCTATTTTTTATCGATTGGGAATATTCGGGCTTA
AATGATCCGCTATTTGATATAGCTACTATCATTGAGGAAGCTCATTTATCGAAAGAAGCTGCTGATTTTCTATTAGAAAC
CTATTGCAATCAGACAAATAAATATCACAAGACAGAATTTCAAATCGCTCAAAAACGGTTAAAAATCCATCGTTTTTGCC
AAAATGTATTGTGGTTTTTATGGACAAAAGTAAAAGAAGAACACGGCGAGAATTTTGGCGATTATGCGTTAAAACGCTTA
GACGCAGCATTTAAACTGTTAGAGGAATTGCCATAA

Upstream 100 bases:

>100_bases
AAAAGTTGAATAAATTCATAAGATTCAGAGCCTTACAAAAATAACTTTAACGTGTTAAAATCAAACAAAATTTAAATATA
AAAATGAATACAAAAATGCT

Downstream 100 bases:

>100_bases
TGCGTGGCTATCTCTTTGGCATACTGTCCGCTGTATTTTGGGCATTATCTGGACTGTTGTATAATGAATTGCCATTAAGT
GAATATACTGCGTTAGGGAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQHSIPFSSIGGMTNQNVLLNISGVKFV
LRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEF
VFRNVFSVFDEFRQYFSLLENKSAFFQADPRMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGL
NDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAQKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRL
DAAFKLLEELP

Sequences:

>Translated_331_residues
MQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQHSIPFSSIGGMTNQNVLLNISGVKFV
LRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEF
VFRNVFSVFDEFRQYFSLLENKSAFFQADPRMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGL
NDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAQKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRL
DAAFKLLEELP
>Mature_331_residues
MQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQHSIPFSSIGGMTNQNVLLNISGVKFV
LRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEF
VFRNVFSVFDEFRQYFSLLENKSAFFQADPRMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGL
NDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAQKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRL
DAAFKLLEELP

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 38590; Mature: 38590

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQHSIPFS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
SIGGMTNQNVLLNISGVKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKS
HHCCCCCCCEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCC
GVKLTRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLE
CCHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NKSAFFQADPRMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGL
CCCHHEECCCCHHHHHHHHHHHHHHCHHHEEECCCCCCCCCCCEECCCCEEEEEEECCCC
NDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAQKRLKIHRFCQNVLWFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WTKVKEEHGENFGDYALKRLDAAFKLLEELP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQHSIPFS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
SIGGMTNQNVLLNISGVKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKS
HHCCCCCCCEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCC
GVKLTRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLE
CCHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NKSAFFQADPRMDKLSAVFWQFEEINKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGL
CCCHHEECCCCHHHHHHHHHHHHHHCHHHEEECCCCCCCCCCCEECCCCEEEEEEECCCC
NDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAQKRLKIHRFCQNVLWFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WTKVKEEHGENFGDYALKRLDAAFKLLEELP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]