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The map label for this gene is metC [H]

Identifier: 148825602

GI number: 148825602

Start: 522676

End: 523866

Strand: Direct

Name: metC [H]

Synonym: CGSHiEE_02660

Alternate gene names: 148825602

Gene position: 522676-523866 (Clockwise)

Preceding gene: 148825599

Following gene: 148825604

Centisome position: 28.83

GC content: 37.36

Gene sequence:

>1191_bases
ATGCAAACAAAATATGATCTTTCAACAATGTTTATTCATTCTGGTCGTCAAAAACGTTTTTCACAAGGATCGGTAAACCC
TGTTTTACAGCGAGCTTCTTCATTACTATTTGACAGTATTGAAGATAAAAAACACGCTACTCAACATAGAGCAAAAGGCG
AATTATTTTATGGCAGAAGAGGGACGCTAACACATTTTGCTTTACAAGATTTAATGTGCGAAATGGAGGGGGGGGCAGGT
TGTTATCTTTATCCTTGTGGTACAGCAGCAGTAACTAATTCGATTCTTTCTTTTGTTAAAACTGGCGACCATGTGTTAAT
GAGTGGCGCAGCTTACGAGCCAACCCAATATTTCTGTAATATTGTGCTGAAAAAAATGCAGATCGATATAACTTATTACG
ATCCTCTTATTGGTGCAGATATTGCAACGCTTATTCAACCGAATACAAAAGTACTTTTCTTAGAAGCACCGAGTTCTATT
ACAATGGAAATTCCCGATATTCCGACTATTGTGAAGGCTGCAAGAAAGGTGAACCCTAATATTGTGATTATGATTGATAA
TACTTGGTCGGCAGGTGTTCTATTTAAAGCGTTAGAGCATGATATTGATATTTCTATTCAGGCGGGTACGAAATATTTAG
TGGGTCATTCAGATATTATGATTGGTACTGCCGTTGCGAATGCGCGAACTTGGGATCAACTTAGAGAACATTCCTATTTA
ATGGGGCAAATGGTTGATGCAGATTCTGCTTATACGACTGCTCGTGGTATCCGTACATTGGGGGTACGATTAAAACAACA
TCAGGAAAGCAGTATTAAAGTGGCAAAATGGTTGAGTGAGCAACCAGAAGTAAGAACTGTGTATCATCCAGCTTTACCAA
GTTGCCCTGGTCATGAATTCTTTTTACGTGATTTTAGTGGAAGCAGTGGTTTATTTTCTTTTGAATTAACCCAGCGATTA
ACTTCAGAGCAAGTATCAAAATTTATGGATCATTTTCAACTGTTCGCTATGGCTTATTCATGGGGAGGATTTGAGTCTCT
AATTCTTTGTAATCAACCAGAAGAAATTGCACATATTCGTCCAAATATTAAACGTAATCTTACAGGTTCATTAATTCGTG
TGCATATTGGTTTTGAAAATGTGGATGAACTAATTGCAGATTTGAAAGCTGGTTTTGAGCGAATTGCTTAA

Upstream 100 bases:

>100_bases
TTCCATTGCCTAATACCGCAGATGAAGTAAAATCAGGTGCGGATAGGAATTGAAACCATAGTTATTTTTGCCCTATAAGT
TAATTTAAATAAGGAAATAT

Downstream 100 bases:

>100_bases
AAGTGCGGATAAAAAAATGCCTGTTTTACACAGGCATTTTTTATAGGATTATTTTTGTTCTGAAACTAAACCAATTTGGG
TACCGTCAGCAAAATGAATT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQHRAKGELFYGRRGTLTHFALQDLMCEMEGGAG
CYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGADIATLIQPNTKVLFLEAPSSI
TMEIPDIPTIVKAARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVRTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRL
TSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA

Sequences:

>Translated_396_residues
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQHRAKGELFYGRRGTLTHFALQDLMCEMEGGAG
CYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGADIATLIQPNTKVLFLEAPSSI
TMEIPDIPTIVKAARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVRTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRL
TSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
>Mature_396_residues
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQHRAKGELFYGRRGTLTHFALQDLMCEMEGGAG
CYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGADIATLIQPNTKVLFLEAPSSI
TMEIPDIPTIVKAARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVRTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRL
TSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=325, Percent_Identity=29.2307692307692, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI299473759, Length=242, Percent_Identity=30.9917355371901, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI25453487, Length=325, Percent_Identity=27.0769230769231, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=65.8097686375321, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1790375, Length=391, Percent_Identity=29.156010230179, Blast_Score=154, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=332, Percent_Identity=32.2289156626506, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17538055, Length=390, Percent_Identity=29.4871794871795, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71980708, Length=349, Percent_Identity=31.2320916905444, Blast_Score=175, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321170, Length=341, Percent_Identity=39.2961876832845, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6319307, Length=405, Percent_Identity=26.4197530864197, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323333, Length=361, Percent_Identity=25.207756232687, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321904, Length=400, Percent_Identity=25.25, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321254, Length=267, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922554, Length=393, Percent_Identity=29.2620865139949, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44296; Mature: 44296

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQHRAKGELFYGRR
CCCCCCHHHHEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GTLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCN
CCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
IVLKKMQIDITYYDPLIGADIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKAARKVNPN
HHHHHHEEEEEEECCHHCCCHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCC
IVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
EEEEECCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCEEEEEECCCCHHHHHHHHHHHH
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVRTVYHPALPSCPGHEF
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCE
FLRDFSGSSGLFSFELTQRLTSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIR
EEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCC
PNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
CCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQHRAKGELFYGRR
CCCCCCHHHHEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GTLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCN
CCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
IVLKKMQIDITYYDPLIGADIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKAARKVNPN
HHHHHHEEEEEEECCHHCCCHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCC
IVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
EEEEECCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCEEEEEECCCCHHHHHHHHHHHH
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVRTVYHPALPSCPGHEF
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCE
FLRDFSGSSGLFSFELTQRLTSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIR
EEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCC
PNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
CCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]