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The map label for this gene is deoA

Identifier: 148824518

GI number: 148824518

Start: 3713841

End: 3715124

Strand: Reverse

Name: deoA

Synonym: TBFG_13345

Alternate gene names: 148824518

Gene position: 3715124-3713841 (Counterclockwise)

Preceding gene: 148824519

Following gene: 148824517

Centisome position: 83.97

GC content: 68.3

Gene sequence:

>1284_bases
GTGACCGACTTCGCATTCGACGCCCCGACCGTCATCCGCACCAAACGTGACGGCGGCCGGTTGTCCGACGCCGCCATCGA
CTGGGTCGTCAAGGCCTATACCGACGGCCGGGTCGCCGACGAACAGATGTCGGCGCTGCTGATGGCGATCGTTTGGCGGG
GCATGGACCGCGGCGAGATCGCCAGATGGACGGCGGCCATGCTGGCCTCGGGTGCCCGGCTGGATTTCACCGATCTGCCA
CTAGCGACCGTGGACAAGCATTCCACCGGCGGGGTAGGTGACAAAATCACGCTGCCATTGGTGCCCGTCGTCGCCGCCTG
CGGTGGCGCAGTGCCCCAGGCGTCGGGCCGCGGACTCGGCCACACCGGCGGCACCCTGGACAAGCTGGAATCCATCACCG
GGTTCACCGCGAATCTGTCCAACCAGCGGGTGCGCGAGCAGCTTTGCGACGTCGGCGCCGCGATCTTCGCCGCCGGCCAG
CTGGCGCCAGCCGATGCCAAGCTGTATGCGCTGCGCGACATTACCGGCACCGTCGAATCGCTGCCGTTGATCGCCAGTTC
GATTATGAGCAAGAAGCTGGCTGAGGGTGCGGGTGCACTGGTGCTCGACGTCAAGGTTGGTTCCGGGGCCTTCATGAGGT
CGCCAGTGCAGGCGCGCGAACTTGCGCACACCATGGTCGAACTGGGCGCGGCGCATGGCGTGCCCACCCGTGCCCTGCTG
ACGGAGATGAACTGCCCGCTGGGTCGAACCGTCGGCAATGCGCTCGAGGTGGCCGAGGCGCTGGAGGTGCTGGCCGGCGG
CGGACCGCCCGACGTGGTGGAGCTGACGTTGCGGCTGGCCGGCGAGATGCTCGAGCTTGCCGGGATCCACGGCCGGGACC
CGGCCCAGACGCTGCGGGACGGCACCGCAATGGACCGGTTTCGCCGGTTGGTTGCCGCGCAGGGAGGTGACTTGTCGAAA
CCGTTGCCGATCGGTTCGCATTCGGAAACCGTCACGGCGGGCGCGAGCGGCACAATGGGCGACATCGATGCGATGGCAGT
GGGGTTAGCGGCATGGCGACTCGGTGCGGGCAGGTCCCGCCCGGGCGCACGCGTACAGCACGGTGCGGGGGTGCGGATTC
ATCGCCGCCCGGGGGAGCCGGTTGTGGTCGGTGAGCCGTTGTTCACCCTCTACACGAATGCTCCCGAGCGCTTTGGTGCG
GCGCGAGCCGAGCTGGCCGGCGGTTGGAGTATCCGGGACAGTCCGCCGCAGGTGCGGCCGCTAATCGTCGATCGGATCGT
CTGA

Upstream 100 bases:

>100_bases
GGGGTTCCGAGCTACTGATCGACCATCCGGTGCGACCCCGCCGGCTCGGCGACCTGCTGCCCGACGCCTTCGGCCTCGAC
GACCTCCCCCGGGAACGCCG

Downstream 100 bases:

>100_bases
TGACCGCTGCGCCGACCCTGCAGACGATCAGGCTAGCCCCCAAGGCGTTGCTGCACGATCACCTCGACGGCGGGCTGCGG
CCGGCCACCGTGCTGGACAT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLP
LATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQ
LAPADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALL
TEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRRLVAAQGGDLSK
PLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGA
ARAELAGGWSIRDSPPQVRPLIVDRIV

Sequences:

>Translated_427_residues
MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLP
LATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQ
LAPADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALL
TEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRRLVAAQGGDLSK
PLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGA
ARAELAGGWSIRDSPPQVRPLIVDRIV
>Mature_426_residues
TDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLPL
ATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQL
APADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALLT
EMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRRLVAAQGGDLSKP
LPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGAA
RAELAGGWSIRDSPPQVRPLIVDRIV

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=434, Percent_Identity=44.7004608294931, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI4503445, Length=434, Percent_Identity=44.7004608294931, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI166158922, Length=434, Percent_Identity=44.7004608294931, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=41.5525114155251, Blast_Score=281, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_MYCTU (O53366)

Other databases:

- EMBL:   BX842582
- EMBL:   AE000516
- PIR:   A70843
- RefSeq:   NP_217831.1
- RefSeq:   NP_337943.1
- ProteinModelPortal:   O53366
- SMR:   O53366
- EnsemblBacteria:   EBMYCT00000001999
- EnsemblBacteria:   EBMYCT00000069115
- GeneID:   887929
- GeneID:   926344
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3415
- KEGG:   mtu:Rv3314c
- TIGR:   MT3415
- TubercuList:   Rv3314c
- GeneTree:   EBGT00050000016786
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- ProtClustDB:   PRK05820
- BRENDA:   2.4.2.4
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 44487; Mature: 44355

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEI
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
ARWTAAMLASGARLDFTDLPLATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLG
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCC
HTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQLAPADAKLYALRDITGTVES
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHH
LPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
TEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRD
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GTAMDRFRRLVAAQGGDLSKPLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSR
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
PGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGAARAELAGGWSIRDSPPQVRP
CCCCCCCCCCEEEEECCCCCEEECCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCH
LIVDRIV
HHHHHCC
>Mature Secondary Structure 
TDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEI
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
ARWTAAMLASGARLDFTDLPLATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLG
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCC
HTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQLAPADAKLYALRDITGTVES
CCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHH
LPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
TEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRD
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GTAMDRFRRLVAAQGGDLSKPLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSR
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
PGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGAARAELAGGWSIRDSPPQVRP
CCCCCCCCCCEEEEECCCCCEEECCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCH
LIVDRIV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036