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The map label for this gene is add

Identifier: 148824517

GI number: 148824517

Start: 3712744

End: 3713841

Strand: Reverse

Name: add

Synonym: TBFG_13344

Alternate gene names: 148824517

Gene position: 3713841-3712744 (Counterclockwise)

Preceding gene: 148824518

Following gene: 148824516

Centisome position: 83.94

GC content: 64.85

Gene sequence:

>1098_bases
ATGACCGCTGCGCCGACCCTGCAGACGATCAGGCTAGCCCCCAAGGCGTTGCTGCACGATCACCTCGACGGCGGGCTGCG
GCCGGCCACCGTGCTGGACATTGCCGGGCAGGTCGGATACGACGACCTGCCGGCAACTGACGTCGACGCGCTGGCAAGTT
GGTTTCGCACCCAGTCGCACAGCGGCTCGCTGGAGCGCTACCTGGAACCGTTTTCGCACACGGTGGCGGTGATGCAGACT
CCCGAGGCCTTGTATCGGGTCGCCTTCGAATGCGCGCAAGACCTGGCCGCCGATTCGGTGGTCTATGCCGAGGTGCGGTT
CGCGCCGGAGCTGCACATCAGCTGCGGGCTGTCGTTCGACGACGTCGTCGACACCGTTCTGACGGGCTTCGCCGCCGGCG
AGAAGGCGTGTGCCGCCGATGGTCAACCCATCACCGTCCGCTGTCTGGTCACCGCGATGCGGCACGCCGCAATGTCCCGG
GAGATCGCAGAGTTGGCGATCCGGTTCCGGGACAAGGGAGTTGTCGGATTCGACATCGCCGGCGCGGAGGCCGGCCACCC
GCCAACCCGGCACTTGGATGCATTCGAGTACATGCGTGATCACAACGCGCGCTTCACGATTCATGCCGGTGAGGCGTTCG
GGTTGCCGTCCATCCACGAGGCGATCGCCTTCTGCGGTGCCGACCGGCTGGGTCACGGGGTGCGGATCGTCGACGACATC
GACGTGGATGCCGACGGCGGTTTCCAGTTGGGTCGGCTGGCAGCTATCCTGCGGGACAAGCGAATTCCGCTGGAGCTGTG
CCCCAGCTCCAACGTGCAGACCGGCGCGGTCGCAAGCATCGCCGAGCATCCGTTCGACCTACTGGCTCGGGCCCGGTTCC
GGGTGACCGTCAATACCGACAACCGGCTGATGAGCGACACCTCGATGAGCCTCGAAATGCATCGTTTGGTAGAGGCTTTC
GGTTATGGCTGGAGCGACCTGGCGCGCTTCACCGTCAATGCGATGAAATCCGCGTTCATTCCGTTCGACCAGCGGCTGGC
GATAATCGACGAAGTGATCAAGCCGCGGTTCGCGGCGCTCATGGGTCACAGCGAGTAA

Upstream 100 bases:

>100_bases
CCGAGCGCTTTGGTGCGGCGCGAGCCGAGCTGGCCGGCGGTTGGAGTATCCGGGACAGTCCGCCGCAGGTGCGGCCGCTA
ATCGTCGATCGGATCGTCTG

Downstream 100 bases:

>100_bases
TCAGCAAGTTCTCTGGTATATCGCACCTAGCGTCCAGTTGCTTGCCAGATCGCTTTCGTACCGTCATCGCATGTACCGGT
TCGCGTGCCGCACGCTCATG

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPATDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQT
PEALYRVAFECAQDLAADSVVYAEVRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSR
EIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
DVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAF
GYGWSDLARFTVNAMKSAFIPFDQRLAIIDEVIKPRFAALMGHSE

Sequences:

>Translated_365_residues
MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPATDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQT
PEALYRVAFECAQDLAADSVVYAEVRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSR
EIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
DVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAF
GYGWSDLARFTVNAMKSAFIPFDQRLAIIDEVIKPRFAALMGHSE
>Mature_364_residues
TAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPATDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQTP
EALYRVAFECAQDLAADSVVYAEVRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSRE
IAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDID
VDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAFG
YGWSDLARFTVNAMKSAFIPFDQRLAIIDEVIKPRFAALMGHSE

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=358, Percent_Identity=27.3743016759777, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1787910, Length=340, Percent_Identity=29.4117647058824, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32565969, Length=348, Percent_Identity=29.5977011494253, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17538512, Length=350, Percent_Identity=29.7142857142857, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324188, Length=304, Percent_Identity=23.6842105263158, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24645260, Length=352, Percent_Identity=25, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_MYCBO (P63908)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_856987.1
- ProteinModelPortal:   P63908
- SMR:   P63908
- EnsemblBacteria:   EBMYCT00000014553
- GeneID:   1093675
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3342c
- GeneTree:   EBGT00050000016615
- HOGENOM:   HBG630382
- OMA:   PYYMAMN
- ProtClustDB:   PRK09358
- BioCyc:   MBOV233413:MB3342C-MONOMER
- BRENDA:   3.5.4.4
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 39744; Mature: 39612

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 211-211 BINDING 21-21 BINDING 23-23 BINDING 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPATDVDALASWFRTQSH
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
SGSLERYLEPFSHTVAVMQTPEALYRVAFECAQDLAADSVVYAEVRFAPELHISCGLSFD
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEEEEECCCHH
DVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSREIAELAIRFRDKGVVGFDIA
HHHHHHHHHHHCCCCHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCHHHHCCCEEEEEEC
DVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARARFRVTVNTD
CCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHCCHHHHHCCEEEEEECCC
NRLMSDTSMSLEMHRLVEAFGYGWSDLARFTVNAMKSAFIPFDQRLAIIDEVIKPRFAAL
CCEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MGHSE
HCCCC
>Mature Secondary Structure 
TAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPATDVDALASWFRTQSH
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
SGSLERYLEPFSHTVAVMQTPEALYRVAFECAQDLAADSVVYAEVRFAPELHISCGLSFD
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEEEEECCCHH
DVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSREIAELAIRFRDKGVVGFDIA
HHHHHHHHHHHCCCCHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCHHHHCCCEEEEEEC
DVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARARFRVTVNTD
CCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHCCHHHHHCCEEEEEECCC
NRLMSDTSMSLEMHRLVEAFGYGWSDLARFTVNAMKSAFIPFDQRLAIIDEVIKPRFAAL
CCEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MGHSE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972