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The map label for this gene is purE

Identifier: 148824477

GI number: 148824477

Start: 3669892

End: 3670416

Strand: Reverse

Name: purE

Synonym: TBFG_13304

Alternate gene names: 148824477

Gene position: 3670416-3669892 (Counterclockwise)

Preceding gene: 148824479

Following gene: 148824476

Centisome position: 82.96

GC content: 71.05

Gene sequence:

>525_bases
ATGACTCCTGCCGGCGAGCGGCCCCGGGTCGGGGTGATCATGGGCAGCGACAGCGACTGGCCGGTGATGGCCGACGCTGC
GGCGGCGCTGGCCGAGTTCGACATTCCGGCCGAGGTTCGGGTTGTTTCGGCCCATCGCACCCCTGAGGCGATGTTCAGTT
ATGCGCGCGGCGCGGCCGAGCGCGGTCTCGAGGTGATCATCGCCGGAGCGGGCGGGGCCGCGCACTTGCCCGGTATGGTC
GCCGCCGCGACGCCGCTGCCGGTGATCGGGGTGCCGGTACCGCTGGGCAGGCTGGACGGCCTTGACTCCCTGCTGTCGAT
CGTGCAAATGCCGGCCGGGGTTCCGGTGGCCACGGTGTCCATCGGGGGCGCCGGTAATGCCGGACTGCTGGCGGTGCGGA
TGCTGGGAGCCGCCAACCCCCAGCTGAGGGCCCGGATCGTCGCATTCCAGGACCGGCTGGCCGACGTCGTGGCGGCCAAG
GATGCGGAACTGCAGCGGCTTGCGGGTAAGTTAACCCGCGACTAG

Upstream 100 bases:

>100_bases
GGCGGTGGACTGACGGATGGGACCCACACCGCGCCAGCGACGATGCAGTGGGGGTACCACCCGCGTGCGGGGGACGAAGC
GATGAGGAGGAGCGGCGCCT

Downstream 100 bases:

>100_bases
CACGGAGATTAGGAGGGCTCCAAGATGGTTGGATGGGCCGGAAACCCGTCGTTCGATCTGTTCAAGCTGCCCGAGGAACA
CGACGAAATGCGATCGGCGA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMV
AAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGAGNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAK
DAELQRLAGKLTRD

Sequences:

>Translated_174_residues
MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMV
AAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGAGNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAK
DAELQRLAGKLTRD
>Mature_173_residues
TPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMVA
AATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGAGNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKD
AELQRLAGKLTRD

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=59.4594594594595, Blast_Score=135, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324702, Length=159, Percent_Identity=59.1194968553459, Blast_Score=177, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURE_MYCTU (P96880)

Other databases:

- EMBL:   BX842582
- EMBL:   AE000516
- PIR:   D70979
- RefSeq:   NP_217792.1
- RefSeq:   NP_337902.1
- PDB:   3LP6
- PDBsum:   3LP6
- ProteinModelPortal:   P96880
- SMR:   P96880
- EnsemblBacteria:   EBMYCT00000002965
- EnsemblBacteria:   EBMYCT00000069508
- GeneID:   888721
- GeneID:   922446
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3375
- KEGG:   mtu:Rv3275c
- TIGR:   MT3375
- TubercuList:   Rv3275c
- GeneTree:   EBGT00050000016911
- HOGENOM:   HBG301965
- OMA:   GVVMGSS
- ProtClustDB:   CLSK792398
- BRENDA:   4.1.1.21
- GO:   GO:0040007
- InterPro:   IPR000031
- Gene3D:   G3DSA:3.40.50.7700
- PANTHER:   PTHR23046
- TIGRFAMs:   TIGR01162

Pfam domain/function: PF00731 AIRC; SSF52255 AIR_carboxyl

EC number: =5.4.99.18

Molecular weight: Translated: 17675; Mature: 17544

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: BINDING 16-16 BINDING 19-19 BINDING 46-46

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAE
CCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
RGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVS
CCEEEEEECCCCCCCCCCHHHHCCCCCEEECCCCCHHHCCHHHHHHHHHCCCCCCEEEEE
IGGAGNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKDAELQRLAGKLTRD
ECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAE
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
RGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVS
CCEEEEEECCCCCCCCCCHHHHCCCCCEEECCCCCHHHCCHHHHHHHHHCCCCCCEEEEE
IGGAGNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKDAELQRLAGKLTRD
ECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036