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The map label for this gene is yaeL [C]

Identifier: 148824060

GI number: 148824060

Start: 3192078

End: 3193292

Strand: Reverse

Name: yaeL [C]

Synonym: TBFG_12885

Alternate gene names: 148824060

Gene position: 3193292-3192078 (Counterclockwise)

Preceding gene: 148824061

Following gene: 148824059

Centisome position: 72.17

GC content: 64.77

Gene sequence:

>1215_bases
ATGATGTTTGTTACCGGCATTGTGCTGTTCGCGCTCGCGATCCTGATTTCGGTGGCCCTGCACGAATGTGGTCACATGTG
GGTCGCGCGCCGCACCGGGATGAAGGTACGTCGCTATTTCGTCGGCTTTGGCCCCACGTTGTGGTCGACCCGGCGCGGCG
AGACCGAATACGGTGTCAAAGCCGTTCCGCTGGGCGGCTTCTGTGACATCGCCGGCATGACCCCGGTCGAGGAACTCGAC
CCCGACGAACGTGACCGTGCGATGTACAAGCAGGCCACCTGGAAGCGGGTCGCAGTGTTATTCGCCGGGCCCGGAATGAA
CCTCGCTATCTGCCTGGTGCTGATCTATGCCATCGCGCTGGTCTGGGGGCTGCCTAACCTGCATCCGCCAACCAGGGCCG
TAATCGGCGAAACTGGCTGCGTTGCACAGGAAGTGAGCCAGGGCAAGCTCGAGCAGTGCACCGGGCCCGGTCCGGCGGCG
CTGGCCGGAATTCGCTCCGGTGACGTCGTGGTCAAGGTCGGTGACACCCCGGTGTCCAGTTTCGACGAGATGGCCGCCGC
GGTGCGCAAGTCACACGGCAGCGTCCCGATCGTTGTCGAGCGTGACGGCACCGCGATTGTTACCTACGTGGACATCGAAT
CCACCCAACGCTGGATCCCTAACGGGCAGGGCGGTGAGCTCCAGCCGGCAACGGTCGGTGCGATTGGGGTGGGCGCCGCC
CGGGTCGGGCCTGTGCGCTACGGCGTGTTCTCCGCCATGCCGGCCACATTCGCGGTCACCGGCGACCTGACCGTGGAGGT
GGGCAAGGCGCTGGCCGCCCTCCCGACCAAGGTAGGTGCGCTGGTGCGGGCGATCGGCGGCGGGCAGCGTGACCCGCAGA
CGCCGATAAGTGTGGTGGGCGCCAGCATCATCGGCGGCGACACCGTCGACCATGGGCTGTGGGTGGCGTTCTGGTTCTTC
TTGGCCCAGCTGAACCTCATCCTGGCTGCGATCAACCTGCTGCCGTTGCTGCCGTTCGATGGCGGCCATATTGCCGTCGC
GGTGTTCGAGAGGATCCGCAACATGGTCCGGTCGGCTCGTGGCAAGGTGGCGGCCGCACCGGTGAATTACCTCAAACTCT
TGCCGGCGACCTATGTGGTCTTGGTTCTTGTCGTCGGGTACATGCTCTTGACCGTCACCGCCGACCTGGTCAACCCGATT
AGGCTTTTCCAGTAG

Upstream 100 bases:

>100_bases
CGCGCGGTATCTGGTATGGCTTCGGTGGCGATCGCAAGCACGGCGAAGCCGGGCGCAGCGGGTCGACACGCATCGACGTT
AGAAAGGTCCTGACACCTCG

Downstream 100 bases:

>100_bases
GTAGAAAGGATTTTCAGTGACTGTAGGCTTGGGCATGCCGCAGCCCCCGGCACCCACGCTCGCTCCCCGGCGCGCCACCC
GTCAGCTGATGGTCGGCAAC

Product: transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWSTRRGETEYGVKAVPLGGFCDIAGMTPVEELD
PDERDRAMYKQATWKRVAVLFAGPGMNLAICLVLIYAIALVWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAA
LAGIRSGDVVVKVGDTPVSSFDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNGQGGELQPATVGAIGVGAA
RVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGALVRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFF
LAQLNLILAAINLLPLLPFDGGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNPI
RLFQ

Sequences:

>Translated_404_residues
MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWSTRRGETEYGVKAVPLGGFCDIAGMTPVEELD
PDERDRAMYKQATWKRVAVLFAGPGMNLAICLVLIYAIALVWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAA
LAGIRSGDVVVKVGDTPVSSFDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNGQGGELQPATVGAIGVGAA
RVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGALVRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFF
LAQLNLILAAINLLPLLPFDGGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNPI
RLFQ
>Mature_404_residues
MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWSTRRGETEYGVKAVPLGGFCDIAGMTPVEELD
PDERDRAMYKQATWKRVAVLFAGPGMNLAICLVLIYAIALVWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAA
LAGIRSGDVVVKVGDTPVSSFDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNGQGGELQPATVGAIGVGAA
RVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGALVRAIGGGQRDPQTPISVVGASIIGGDTVDHGLWVAFWFF
LAQLNLILAAINLLPLLPFDGGHIAVAVFERIRNMVRSARGKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNPI
RLFQ

Specific function: Unknown

COG id: COG0750

COG function: function code M; Predicted membrane-associated Zn-dependent proteases 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain

Homologues:

Organism=Escherichia coli, GI1786373, Length=183, Percent_Identity=30.6010928961749, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2869_MYCTU (O33351)

Other databases:

- EMBL:   BX842581
- EMBL:   AE000516
- PIR:   G70886
- RefSeq:   NP_217385.1
- RefSeq:   NP_337448.1
- ProteinModelPortal:   O33351
- MEROPS:   M50.005
- EnsemblBacteria:   EBMYCT00000003134
- EnsemblBacteria:   EBMYCT00000072599
- GeneID:   887449
- GeneID:   925339
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2937
- KEGG:   mtu:Rv2869c
- TIGR:   MT2937
- TubercuList:   Rv2869c
- GeneTree:   EBGT00050000017531
- HOGENOM:   HBG664087
- OMA:   GETEYGL
- ProtClustDB:   CLSK872116
- GO:   GO:0040007
- GO:   GO:0006508
- InterPro:   IPR001478
- InterPro:   IPR008915
- SMART:   SM00228

Pfam domain/function: PF02163 Peptidase_M50; SSF50156 PDZ

EC number: NA

Molecular weight: Translated: 42835; Mature: 42835

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50106 PDZ; PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 22-22

Signals:

None

Transmembrane regions:

HASH(0x1c1f3484)-; HASH(0x1ce2dd14)-; HASH(0x1b09a618)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWSTRRGETEYGVK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCCCCCCCCCCCEE
AVPLGGFCDIAGMTPVEELDPDERDRAMYKQATWKRVAVLFAGPGMNLAICLVLIYAIAL
EECCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHH
VWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAALAGIRSGDVVVKVGDTPVSS
HHCCCCCCCCCHHHHCCCCHHHHHHHCCCHHHCCCCCHHHHHCCCCCCEEEEECCCCCHH
FDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNGQGGELQPATVGAIGVGAA
HHHHHHHHHHCCCCCEEEEECCCCEEEEEEEECCCHHCCCCCCCCCCCCCEECEEECCHH
RVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGALVRAIGGGQRDPQTPISVVG
HCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
ASIIGGDTVDHGLWVAFWFFLAQLNLILAAINLLPLLPFDGGHIAVAVFERIRNMVRSAR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNPIRLFQ
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWSTRRGETEYGVK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCCCCCCCCCCCEE
AVPLGGFCDIAGMTPVEELDPDERDRAMYKQATWKRVAVLFAGPGMNLAICLVLIYAIAL
EECCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHH
VWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAALAGIRSGDVVVKVGDTPVSS
HHCCCCCCCCCHHHHCCCCHHHHHHHCCCHHHCCCCCHHHHHCCCCCCEEEEECCCCCHH
FDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNGQGGELQPATVGAIGVGAA
HHHHHHHHHHCCCCCEEEEECCCCEEEEEEEECCCHHCCCCCCCCCCCCCEECEEECCHH
RVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGALVRAIGGGQRDPQTPISVVG
HCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
ASIIGGDTVDHGLWVAFWFFLAQLNLILAAINLLPLLPFDGGHIAVAVFERIRNMVRSAR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNPIRLFQ
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036