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The map label for this gene is dxr

Identifier: 148824061

GI number: 148824061

Start: 3193300

End: 3194541

Strand: Reverse

Name: dxr

Synonym: TBFG_12886

Alternate gene names: 148824061

Gene position: 3194541-3193300 (Counterclockwise)

Preceding gene: 148824067

Following gene: 148824060

Centisome position: 72.2

GC content: 67.95

Gene sequence:

>1242_bases
GTGACCAACTCGACCGACGGGCGCGCTGACGGCCGGTTGCGGGTGGTGGTGCTGGGCAGTACCGGCTCGATCGGCACCCA
GGCGCTTCAGGTCATCGCCGACAATCCGGACCGTTTCGAGGTAGTCGGGCTGGCCGCTGGCGGCGCCCATCTGGACACGT
TGCTGCGACAACGTGCGCAGACCGGGGTGACCAATATTGCCGTCGCTGACGAGCACGCGGCGCAGCGGGTCGGCGACATC
CCCTACCACGGATCCGACGCCGCCACCCGGCTGGTCGAGCAGACCGAGGCCGACGTCGTCCTCAATGCGCTGGTCGGCGC
GTTGGGCCTGCGACCGACGTTGGCCGCGCTCAAGACGGGTGCCCGGCTGGCGCTGGCCAACAAGGAATCGCTGGTCGCCG
GTGGTTCGCTGGTGCTGCGGGCGGCGCGGCCCGGTCAGATCGTGCCGGTCGACTCCGAACACTCCGCGCTGGCCCAGTGC
CTGCGCGGCGGCACTCCCGACGAGGTCGCCAAGCTGGTGCTGACGGCCTCGGGAGGGCCGTTTCGGGGCTGGTCCGCGGC
CGACCTCGAGCATGTCACCCCCGAGCAGGCTGGCGCGCATCCTACGTGGTCGATGGGCCCGATGAACACGCTGAATTCGG
CGTCGCTGGTCAACAAGGGACTTGAGGTCATCGAAACCCACCTGCTGTTCGGCATCCCCTACGACCGCATCGATGTCGTG
GTGCACCCCCAGTCGATCATCCATTCGATGGTCACCTTCATCGACGGTTCGACGATCGCCCAGGCCAGTCCCCCGGACAT
GAAGCTACCGATTTCGTTAGCGCTGGGCTGGCCGCGTCGGGTCAGCGGCGCCGCTGCTGCCTGTGATTTCCATACCGCGT
CGAGCTGGGAGTTCGAGCCGTTGGACACCGACGTCTTCCCCGCGGTCGAGTTGGCCCGGCAGGCCGGCGTAGCCGGTGGC
TGCATGACCGCGGTTTACAATGCGGCGAACGAAGAAGCAGCAGCGGCGTTCCTTGCTGGCCGGATCGGCTTCCCGGCCAT
CGTCGGCATCATCGCCGACGTGTTGCACGCTGCCGACCAATGGGCCGTCGAACCCGCTACCGTGGATGACGTACTCGACG
CGCAGCGCTGGGCCCGCGAGCGAGCGCAGCGCGCGGTATCTGGTATGGCTTCGGTGGCGATCGCAAGCACGGCGAAGCCG
GGCGCAGCGGGTCGACACGCATCGACGTTAGAAAGGTCCTGA

Upstream 100 bases:

>100_bases
GCATCAAGACGATTGCATTCCACGGGGAAGTGTGGCTACCGGTGGACGCGTCGTGATCCGGCGGCGCGGTGACAACGAGG
TGGTGGCGCACAATGATGAG

Downstream 100 bases:

>100_bases
CACCTCGATGATGTTTGTTACCGGCATTGTGCTGTTCGCGCTCGCGATCCTGATTTCGGTGGCCCTGCACGAATGTGGTC
ACATGTGGGTCGCGCGCCGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDI
PYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQC
LRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVV
VHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGG
CMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKP
GAAGRHASTLERS

Sequences:

>Translated_413_residues
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDI
PYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQC
LRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVV
VHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGG
CMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKP
GAAGRHASTLERS
>Mature_412_residues
TNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIP
YHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCL
RGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVV
HPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGC
MTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPG
AAGRHASTLERS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=399, Percent_Identity=40.1002506265664, Blast_Score=249, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_MYCBO (P64013)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856540.1
- ProteinModelPortal:   P64013
- SMR:   P64013
- EnsemblBacteria:   EBMYCT00000014478
- GeneID:   1092213
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2895c
- GeneTree:   EBGT00050000016490
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   MBOV233413:MB2895C-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42854; Mature: 42723

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: BINDING 128-128 BINDING 153-153 BINDING 177-177 BINDING 200-200 BINDING 222-222

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQ
CCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHH
TGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTG
CCCCEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGP
CEEEECCCCCEEECCCEEEEECCCCCEEECCCCHHHHHHHHCCCCHHHHHEEEEEECCCC
FRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVV
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEP
ECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHCCCCHHEECCCCCCCCCCCC
LDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQ
CCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
WAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
TNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQ
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHH
TGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTG
CCCCEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGP
CEEEECCCCCEEECCCEEEEECCCCCEEECCCCHHHHHHHHCCCCHHHHHEEEEEECCCC
FRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVV
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEP
ECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHCCCCHHEECCCCCCCCCCCC
LDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQ
CCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
WAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972