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The map label for this gene is ethA [H]

Identifier: 148654139

GI number: 148654139

Start: 2917771

End: 2919405

Strand: Direct

Name: ethA [H]

Synonym: PsycPRwf_2342

Alternate gene names: 148654139

Gene position: 2917771-2919405 (Clockwise)

Preceding gene: 148654138

Following gene: 148654144

Centisome position: 97.95

GC content: 50.09

Gene sequence:

>1635_bases
ATGCGGACACAGTATTTACCGCAATTGCCGGCACTACCCAACTTACCCAAACGCGCCGCCGCTTCGGCACGCAGACTGCT
GCCGGCGCTGCCCTTTAATAAAAAGCCTGATCTTGAGGTTTTAATTATAGGCGCAGGCGTATCCGGCATTGCAACAGCCA
GTCATCTACAGCGCGACAAGCTACTTAGCCCACTGATTACACAAAAAAAAGTCGCCATTGTGGAGAAGCGAGCCGCCATT
GGGGGTACTTGGGATTTATTTAAGTACCCTGGCATTCGCTCAGACTCCGACATGACCACTTTTGGTTTTGCTCACCGCCC
CTGGCTGGGCAAAAAGACCTTGGCGGATGCCGCTTCAATTAAGCGCTATATTGAAGACACTGCTACAGAAGAAAACTTAC
AGCCTTTGATACAGTTTAATACCGAAGTGAGTGCATTAAACTGGTCAAGCCGGCACCAATACTGGCAGGCTCAGCTCACC
GACGTCACTACAGGGCAAACCCGCCATATCACCGCCCGCTTTGTCATTGGCGCCACGGGCTATTATGACTATGACGCAGG
TTATCAGCCTGTTTTTAAGGGACAGCAAGCGTTTAACGGTAAAATCGTACACCCACAGCTGTGGGATGAGACCATTGATT
ATGACAATAAACGGGTGGTGGTCATTGGCAGTGGGGCCACTGCGGTGACGTTGGTACCCGCGCTACTAAGTCGAGACGCT
TATTTGGCTTCTGCTTCACCTGCTAAGCCACAAGTTGCGGCGCAGGTCATCATGCTGCAGCGTTCACCCACTTATATCGC
CAGCATCCCAAGTGAAGATCCAAGCTATGTTCTACTCACCGAGCGATTTAAATTACCGCCCAATGCTGCCTATGGCCTAG
TTCGAGGGCGTAACATACTACTGCAGCAAAGCCTATATAGATTATCTCGAGTGGCGCCCAAACTCTTAAAAACCATCCTC
ACCCAGCGTAATAAATATGCACTTAAAGGCAGCGGTGTGGCATTAAACCACTTCGTGCCTGATTATAATCCGTGGGATGA
GCGTCTATGCGCTGTACCAGATGGTGATTTATTTAAAGCGATTCATACAGGTCATGCTGATGTGGTGACAGACCATATTG
ATCACTTTACTAAGGACGGTATACAGCTGGCTTCTGGTCGTCATTTGCCTGCAGATATTATTATCACCGCCACAGGCCTC
AAGCTACAAATGCTTGGCGGCGCTAAACTTACTATAGATGGCAAAGCTCTTGATGTCAGTGCGCGCATGAGTTACAAAGC
GGTGCTGCTAGAGGGCGTTCCTAATATGGCTGTGTTGTTCGGCTACACCAATGCCTCTTGGACACTCAAAATTGACCTCG
CTGCGGCCTATCTGACCCGATTGTTACGCCACATGCATCATTACGGCTATAAAAGCGTCATCCCCGATGCGGTAGCTACC
GATGGTGAACAGGCCAACCGACTGCCAGATACAGTCATGGGGTCACTGAGCGCCGGCTACATTCAGCGGGCCCAAAACAC
CCTACCCAAGCAAGGCGACCGGTATCCTTGGTATGTGACTAATAACTATCTAAGCGACCGTATGATGCTCAAGCAGCACC
TCGTTCATGATAAATGGCTTCGCTTTGGCCGTTAA

Upstream 100 bases:

>100_bases
ATGATTTATGCCCATTTTCTCCCCTATTAAGCGCTTAATACCTGTTCTAACTGCATCAAATACTGCAGCTGACAGCGCTG
CCCCTTTGGGATTAGCTTCA

Downstream 100 bases:

>100_bases
GCTGTTGCCATTACTTTACGCTTAGCGCCACGATCGGCAGGTAATAAAAAAAATAGGACAGCTTTCGCTATCCTATTTTT
TTAACAAACCATTAATGGCG

Product: flavoprotein involved in K+ transport-like protein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MRTQYLPQLPALPNLPKRAAASARRLLPALPFNKKPDLEVLIIGAGVSGIATASHLQRDKLLSPLITQKKVAIVEKRAAI
GGTWDLFKYPGIRSDSDMTTFGFAHRPWLGKKTLADAASIKRYIEDTATEENLQPLIQFNTEVSALNWSSRHQYWQAQLT
DVTTGQTRHITARFVIGATGYYDYDAGYQPVFKGQQAFNGKIVHPQLWDETIDYDNKRVVVIGSGATAVTLVPALLSRDA
YLASASPAKPQVAAQVIMLQRSPTYIASIPSEDPSYVLLTERFKLPPNAAYGLVRGRNILLQQSLYRLSRVAPKLLKTIL
TQRNKYALKGSGVALNHFVPDYNPWDERLCAVPDGDLFKAIHTGHADVVTDHIDHFTKDGIQLASGRHLPADIIITATGL
KLQMLGGAKLTIDGKALDVSARMSYKAVLLEGVPNMAVLFGYTNASWTLKIDLAAAYLTRLLRHMHHYGYKSVIPDAVAT
DGEQANRLPDTVMGSLSAGYIQRAQNTLPKQGDRYPWYVTNNYLSDRMMLKQHLVHDKWLRFGR

Sequences:

>Translated_544_residues
MRTQYLPQLPALPNLPKRAAASARRLLPALPFNKKPDLEVLIIGAGVSGIATASHLQRDKLLSPLITQKKVAIVEKRAAI
GGTWDLFKYPGIRSDSDMTTFGFAHRPWLGKKTLADAASIKRYIEDTATEENLQPLIQFNTEVSALNWSSRHQYWQAQLT
DVTTGQTRHITARFVIGATGYYDYDAGYQPVFKGQQAFNGKIVHPQLWDETIDYDNKRVVVIGSGATAVTLVPALLSRDA
YLASASPAKPQVAAQVIMLQRSPTYIASIPSEDPSYVLLTERFKLPPNAAYGLVRGRNILLQQSLYRLSRVAPKLLKTIL
TQRNKYALKGSGVALNHFVPDYNPWDERLCAVPDGDLFKAIHTGHADVVTDHIDHFTKDGIQLASGRHLPADIIITATGL
KLQMLGGAKLTIDGKALDVSARMSYKAVLLEGVPNMAVLFGYTNASWTLKIDLAAAYLTRLLRHMHHYGYKSVIPDAVAT
DGEQANRLPDTVMGSLSAGYIQRAQNTLPKQGDRYPWYVTNNYLSDRMMLKQHLVHDKWLRFGR
>Mature_544_residues
MRTQYLPQLPALPNLPKRAAASARRLLPALPFNKKPDLEVLIIGAGVSGIATASHLQRDKLLSPLITQKKVAIVEKRAAI
GGTWDLFKYPGIRSDSDMTTFGFAHRPWLGKKTLADAASIKRYIEDTATEENLQPLIQFNTEVSALNWSSRHQYWQAQLT
DVTTGQTRHITARFVIGATGYYDYDAGYQPVFKGQQAFNGKIVHPQLWDETIDYDNKRVVVIGSGATAVTLVPALLSRDA
YLASASPAKPQVAAQVIMLQRSPTYIASIPSEDPSYVLLTERFKLPPNAAYGLVRGRNILLQQSLYRLSRVAPKLLKTIL
TQRNKYALKGSGVALNHFVPDYNPWDERLCAVPDGDLFKAIHTGHADVVTDHIDHFTKDGIQLASGRHLPADIIITATGL
KLQMLGGAKLTIDGKALDVSARMSYKAVLLEGVPNMAVLFGYTNASWTLKIDLAAAYLTRLLRHMHHYGYKSVIPDAVAT
DGEQANRLPDTVMGSLSAGYIQRAQNTLPKQGDRYPWYVTNNYLSDRMMLKQHLVHDKWLRFGR

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 60423; Mature: 60423

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTQYLPQLPALPNLPKRAAASARRLLPALPFNKKPDLEVLIIGAGVSGIATASHLQRDK
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
LLSPLITQKKVAIVEKRAAIGGTWDLFKYPGIRSDSDMTTFGFAHRPWLGKKTLADAASI
HHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHH
KRYIEDTATEENLQPLIQFNTEVSALNWSSRHQYWQAQLTDVTTGQTRHITARFVIGATG
HHHHHHHCCHHCCCHHEEECCCEEEECCHHHHHEEEEEEEEECCCCCEEEEEEEEEECCC
YYDYDAGYQPVFKGQQAFNGKIVHPQLWDETIDYDNKRVVVIGSGATAVTLVPALLSRDA
EECCCCCCCCHHCCCHHCCCEEECHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCC
YLASASPAKPQVAAQVIMLQRSPTYIASIPSEDPSYVLLTERFKLPPNAAYGLVRGRNIL
EEECCCCCCHHHHEEEEEEECCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHCCCHHH
LQQSLYRLSRVAPKLLKTILTQRNKYALKGSGVALNHFVPDYNPWDERLCAVPDGDLFKA
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCHHHCEEECCCCHHHHH
IHTGHADVVTDHIDHFTKDGIQLASGRHLPADIIITATGLKLQMLGGAKLTIDGKALDVS
HHCCCHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCEEEEEECCEEEEECCCEEEEH
ARMSYKAVLLEGVPNMAVLFGYTNASWTLKIDLAAAYLTRLLRHMHHYGYKSVIPDAVAT
HHCCEEEEEECCCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHCCCHHHCCHHHHC
DGEQANRLPDTVMGSLSAGYIQRAQNTLPKQGDRYPWYVTNNYLSDRMMLKQHLVHDKWL
CCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
RFGR
HCCC
>Mature Secondary Structure
MRTQYLPQLPALPNLPKRAAASARRLLPALPFNKKPDLEVLIIGAGVSGIATASHLQRDK
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
LLSPLITQKKVAIVEKRAAIGGTWDLFKYPGIRSDSDMTTFGFAHRPWLGKKTLADAASI
HHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHH
KRYIEDTATEENLQPLIQFNTEVSALNWSSRHQYWQAQLTDVTTGQTRHITARFVIGATG
HHHHHHHCCHHCCCHHEEECCCEEEECCHHHHHEEEEEEEEECCCCCEEEEEEEEEECCC
YYDYDAGYQPVFKGQQAFNGKIVHPQLWDETIDYDNKRVVVIGSGATAVTLVPALLSRDA
EECCCCCCCCHHCCCHHCCCEEECHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCC
YLASASPAKPQVAAQVIMLQRSPTYIASIPSEDPSYVLLTERFKLPPNAAYGLVRGRNIL
EEECCCCCCHHHHEEEEEEECCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHCCCHHH
LQQSLYRLSRVAPKLLKTILTQRNKYALKGSGVALNHFVPDYNPWDERLCAVPDGDLFKA
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCHHHCEEECCCCHHHHH
IHTGHADVVTDHIDHFTKDGIQLASGRHLPADIIITATGLKLQMLGGAKLTIDGKALDVS
HHCCCHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCEEEEEECCEEEEECCCEEEEH
ARMSYKAVLLEGVPNMAVLFGYTNASWTLKIDLAAAYLTRLLRHMHHYGYKSVIPDAVAT
HHCCEEEEEECCCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHCCCHHHCCHHHHC
DGEQANRLPDTVMGSLSAGYIQRAQNTLPKQGDRYPWYVTNNYLSDRMMLKQHLVHDKWL
CCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
RFGR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]