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The map label for this gene is benD [H]

Identifier: 148654050

GI number: 148654050

Start: 2798844

End: 2799521

Strand: Direct

Name: benD [H]

Synonym: PsycPRwf_2253

Alternate gene names: 148654050

Gene position: 2798844-2799521 (Clockwise)

Preceding gene: 148654049

Following gene: 148654054

Centisome position: 93.95

GC content: 44.54

Gene sequence:

>678_bases
ATGAAGCGTTTTAATGATAAAGCCGTTATCGTGACTGGAGCTGATTCAAGCCTGGGCCGAGTCACTGCTATGAAACTGGC
CAGAGAAGGCGCTAATGTGATCTTAGTAGGCAGTAACAGCAAGGTATTACAATATATAGCAGCAGACTTGCCAGAAGACC
ATACTTGGATCAATTCAGGCAATCACTTAGCCATTACCTATCGTCTAGACCAGGCCACACCGTCAGATGAGCTGGTTACT
CACGTTTTACAAAAGTATCAAAAAATCGATGTTTTAATTAATATAAATACCTCGCTGCCTTTAGAGGGCAGCTTAGTGCA
AGCGTTAGCCCAATCTAAAGGCAGTGTAGTTAATGTTGGCTTACTGTCGGACAATAGCAGTGAGTGGAGTCTTCACGATT
ATCAGCAACAAAACCATCAGCTAGCTGAAAACACTAAGCAGCTGGCATTAACGCACAGTACGAACGGTATACGTGTCAAT
GCGGTAAATGTAGGGCTAACAGCTGACGATCGTAATAGTCATGACAGCCGTCAGCTGTTTTTACAGCACAGTCCTTTAGG
CGACCTTGTCAGCTTAGAGGACGCCTCTGAGGCCATTACTTTTTTAGCCAGTGAAGAAGCCCGTATGATTACTGGTGTCA
CCTTACCAGTCGATGGGGGATTAAGCTTAACCTATTAG

Upstream 100 bases:

>100_bases
TTACACTTTGCCAGCTTTATTATTGAAGGTTGCTATAAAGGCTAAATCTTGTCAAAATCATAAACACGAAAAACTTTTAA
ATAAAATAAGGCTAACTCTT

Downstream 100 bases:

>100_bases
ATTGTGCGTGATAAGTGAAGATAAGCAGTTGCTAGCTGTACAGCCATAAGACTCAATAAAAAAACCGCTTTAATTGAACT
GAACCCCAAATCTTGGACGG

Product: dehydrogenase

Products: NA

Alternate protein names: 2-hydro-1,2-dihydroxybenzoate dehydrogenase; DHB dehydrogenase; Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase; Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKRFNDKAVIVTGADSSLGRVTAMKLAREGANVILVGSNSKVLQYIAADLPEDHTWINSGNHLAITYRLDQATPSDELVT
HVLQKYQKIDVLININTSLPLEGSLVQALAQSKGSVVNVGLLSDNSSEWSLHDYQQQNHQLAENTKQLALTHSTNGIRVN
AVNVGLTADDRNSHDSRQLFLQHSPLGDLVSLEDASEAITFLASEEARMITGVTLPVDGGLSLTY

Sequences:

>Translated_225_residues
MKRFNDKAVIVTGADSSLGRVTAMKLAREGANVILVGSNSKVLQYIAADLPEDHTWINSGNHLAITYRLDQATPSDELVT
HVLQKYQKIDVLININTSLPLEGSLVQALAQSKGSVVNVGLLSDNSSEWSLHDYQQQNHQLAENTKQLALTHSTNGIRVN
AVNVGLTADDRNSHDSRQLFLQHSPLGDLVSLEDASEAITFLASEEARMITGVTLPVDGGLSLTY
>Mature_225_residues
MKRFNDKAVIVTGADSSLGRVTAMKLAREGANVILVGSNSKVLQYIAADLPEDHTWINSGNHLAITYRLDQATPSDELVT
HVLQKYQKIDVLININTSLPLEGSLVQALAQSKGSVVNVGLLSDNSSEWSLHDYQQQNHQLAENTKQLALTHSTNGIRVN
AVNVGLTADDRNSHDSRQLFLQHSPLGDLVSLEDASEAITFLASEEARMITGVTLPVDGGLSLTY

Specific function: Degradation of 2-hydro-1,2-dihydroxy benzoate (DHB) to catechol [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=238, Percent_Identity=29.8319327731092, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=27.2, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=272, Percent_Identity=26.4705882352941, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=274, Percent_Identity=26.2773722627737, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=245, Percent_Identity=29.3877551020408, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=28.4090909090909, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=245, Percent_Identity=28.1632653061224, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=26.9662921348315, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=271, Percent_Identity=25.830258302583, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=269, Percent_Identity=26.0223048327138, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=26.5682656826568, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=27.8195488721804, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=271, Percent_Identity=28.0442804428044, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=27.8884462151394, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=30.6772908366534, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=29.5719844357977, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=29.4820717131474, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=30.859375, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24644337, Length=119, Percent_Identity=38.655462184874, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.25 [H]

Molecular weight: Translated: 24399; Mature: 24399

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFNDKAVIVTGADSSLGRVTAMKLAREGANVILVGSNSKVLQYIAADLPEDHTWINSG
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCEEECCC
NHLAITYRLDQATPSDELVTHVLQKYQKIDVLININTSLPLEGSLVQALAQSKGSVVNVG
CEEEEEEEECCCCCHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEE
LLSDNSSEWSLHDYQQQNHQLAENTKQLALTHSTNGIRVNAVNVGLTADDRNSHDSRQLF
EEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCEEE
LQHSPLGDLVSLEDASEAITFLASEEARMITGVTLPVDGGLSLTY
EEECCCCCEEECCCHHHHEEEEECCCCEEEEEEEEECCCCEEECC
>Mature Secondary Structure
MKRFNDKAVIVTGADSSLGRVTAMKLAREGANVILVGSNSKVLQYIAADLPEDHTWINSG
CCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCEEECCC
NHLAITYRLDQATPSDELVTHVLQKYQKIDVLININTSLPLEGSLVQALAQSKGSVVNVG
CEEEEEEEECCCCCHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEE
LLSDNSSEWSLHDYQQQNHQLAENTKQLALTHSTNGIRVNAVNVGLTADDRNSHDSRQLF
EEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCCEEE
LQHSPLGDLVSLEDASEAITFLASEEARMITGVTLPVDGGLSLTY
EEECCCCCEEECCCHHHHEEEEECCCCEEEEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1740120 [H]