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The map label for this gene is mutL [H]

Identifier: 148652628

GI number: 148652628

Start: 972509

End: 974461

Strand: Direct

Name: mutL [H]

Synonym: PsycPRwf_0819

Alternate gene names: 148652628

Gene position: 972509-974461 (Clockwise)

Preceding gene: 148652627

Following gene: 148652629

Centisome position: 32.65

GC content: 49.77

Gene sequence:

>1953_bases
ATGATGTTTCGCCGTAACCCGCTCGATGGCTTAGCCGACACTGGCCTACAGGTCAGCACTCAGGCTCAGCATAGTAATCG
CATAAAAAAACTGCCGCCTTTATTGGTCAATCAGCTGGCAGCAGGCGAGGTGGTGACTCGGCCTGCCTCAGTGGTCAAAG
AGCTGATTGAAAATGCGCTCGATGCTGGCGCGCGCCAAATTGATGTGCGCATTACTCAAGGCGGTATGGGCATTATTGAG
GTGGCCGATGATGGCTGCGGCATTCATCCTGAGGATATGGTAATGGCGGTGACCCGCTTTGCCACCAGTAAAATCGCTGA
TGTGGCGCATTTGCAAGGCATAGCCACTTTAGGGTTTCGTGGTGAAGCACTGGCCGCTACAGCCGCTGTGTCCCGACTGA
CCTTAACCAGCTGCTGTGATGACAGCGGTATTGGCCGACAGCTTAATGTGGCCGGTATTTTAGAGGACACGCCGCAATTG
GTGCCGGTAGTGCATCGCCGTGGCACCACAGTAAGCGTAAAGGACTTGTATTTTAATGTGCCGGCAAGACGTGGCAATCT
AAAGGCCATCTCGACTGAGTTTATGCACATCGAGACGGTGGTCAAACAGTTGGCATTGGTAGCAAGTGATGTCAGCTTTA
GCCTTTGGCATAATGACAAACGTCGTTTTAATTTTGCCGCCATCAATGCCGAGCCGTCATCGCCGTTAACCGTATCTTCG
TCTAACCTTGCCTCAGAAGCCTTATCTACCCAAGTGATGCAAGCCTTGCTGACACGATTAAAATCGGTGCTACCCCCAAG
TCATGAGCAAGCAAGTTTATTACATGACAACAACTTGCAGGTGTTATCCTTAGATTTAGAGGCGCTGCGTGTGCAATATG
AGGGCATGCGCGGCATCAACCGCAGCCAAGAGCCACTAGGCATTGAAGGGCTGATAATTCCAAGTACAAAGGCACTGGCC
AATCATCCTTATAAGCTGATTTATATCAATGGTCGCTTGGTCAAAGACAAGCGTATTGCCCAGAGCCTACGTGAGAGCAT
TAATGGCTTTGATCACATTGCCAGCCTAGGCTACGTGCTGTTTTTTAATCTGCCCAAGGCGTGGCTAAATCTTAATGTGC
ATCCCTCGAAGCTGTGCATAAAAATCCAAAATCTGGCCAATGTCATGGCGCACTTTGAGGTGGGCGTGCGTGAGGCCTTG
CAGCGTTGGCAGAAGCGTCAGCCGATAATACAGCCGATAGTGCAGCCGCCGCAATACCAGATCAACGCCCAAGCATCAGT
GCAAGTGGCGCAGTCCCACTCTCACCAGATATCTGTCAGCCAAGGCTCTAAGCGGATTGCACCATCTAATCACATAGACT
ACCCGCACAATAGCAGTGCTACAGCGTCTGAGACGACAGTACCTCAGTTAAAACAGCCGGTACAGACAAATGAGTCGATA
GCCTATTATCAGACACAGGGCCACCACGGCCAGTATACGCAAAGCCACCCCCATGTCGTCTCTGATTCACGCTTATCAGG
TTTTGACACTGTAACAGACTTGCCTCCTGTGTCTTTTACCCAAAAAGATGGCCCAGTGCAGTGCTTATATTTGTTAAAGG
ACAGTCTGTTGAATGAGAGTCTGTTGAGTGACAGTCTTTTAAGTGATCAGCAGCTGGCGTTATTACAAATACAGCACACC
CTGTATGTCTTTTTAGAGACTGAGTTGATACGGTGGCTACAGGCTAGCTTCTGTACGCTGCTAGAGGACGAATGGCAGAG
ACACTATAAAGACTATCAAGCCTGCGTGAGTCAAGGGCAAAAACTAGCCTGGATAAACACCCAGCTACAAAACCTAGCTA
AAGCGGCTCAAAACCAATGGAAGCAGCCTTGGAGCAAGCAATTGGCCGACCAAGCGCTTGGCGAGCTGCCTTTATCGCAG
CTGATTCAATTAATACTAAAAAACGACCCGTAA

Upstream 100 bases:

>100_bases
TGACTTGATCTTTTGCAGTGATTTGGTTGCTCATATCCTTAATTATTTGCCCTAATTTATTTGTCCTCATTTATTTATCG
TCCAGCTTTGAGCTTTATAC

Downstream 100 bases:

>100_bases
AATCAGTTAGGTTTATGACAGTGTCCAAGCCGTTTATAACCGCTAATCCAATCAAAAAAAACCATAACCATAAGAGTAGA
TACCATGGGTGATGTTGATA

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MMFRRNPLDGLADTGLQVSTQAQHSNRIKKLPPLLVNQLAAGEVVTRPASVVKELIENALDAGARQIDVRITQGGMGIIE
VADDGCGIHPEDMVMAVTRFATSKIADVAHLQGIATLGFRGEALAATAAVSRLTLTSCCDDSGIGRQLNVAGILEDTPQL
VPVVHRRGTTVSVKDLYFNVPARRGNLKAISTEFMHIETVVKQLALVASDVSFSLWHNDKRRFNFAAINAEPSSPLTVSS
SNLASEALSTQVMQALLTRLKSVLPPSHEQASLLHDNNLQVLSLDLEALRVQYEGMRGINRSQEPLGIEGLIIPSTKALA
NHPYKLIYINGRLVKDKRIAQSLRESINGFDHIASLGYVLFFNLPKAWLNLNVHPSKLCIKIQNLANVMAHFEVGVREAL
QRWQKRQPIIQPIVQPPQYQINAQASVQVAQSHSHQISVSQGSKRIAPSNHIDYPHNSSATASETTVPQLKQPVQTNESI
AYYQTQGHHGQYTQSHPHVVSDSRLSGFDTVTDLPPVSFTQKDGPVQCLYLLKDSLLNESLLSDSLLSDQQLALLQIQHT
LYVFLETELIRWLQASFCTLLEDEWQRHYKDYQACVSQGQKLAWINTQLQNLAKAAQNQWKQPWSKQLADQALGELPLSQ
LIQLILKNDP

Sequences:

>Translated_650_residues
MMFRRNPLDGLADTGLQVSTQAQHSNRIKKLPPLLVNQLAAGEVVTRPASVVKELIENALDAGARQIDVRITQGGMGIIE
VADDGCGIHPEDMVMAVTRFATSKIADVAHLQGIATLGFRGEALAATAAVSRLTLTSCCDDSGIGRQLNVAGILEDTPQL
VPVVHRRGTTVSVKDLYFNVPARRGNLKAISTEFMHIETVVKQLALVASDVSFSLWHNDKRRFNFAAINAEPSSPLTVSS
SNLASEALSTQVMQALLTRLKSVLPPSHEQASLLHDNNLQVLSLDLEALRVQYEGMRGINRSQEPLGIEGLIIPSTKALA
NHPYKLIYINGRLVKDKRIAQSLRESINGFDHIASLGYVLFFNLPKAWLNLNVHPSKLCIKIQNLANVMAHFEVGVREAL
QRWQKRQPIIQPIVQPPQYQINAQASVQVAQSHSHQISVSQGSKRIAPSNHIDYPHNSSATASETTVPQLKQPVQTNESI
AYYQTQGHHGQYTQSHPHVVSDSRLSGFDTVTDLPPVSFTQKDGPVQCLYLLKDSLLNESLLSDSLLSDQQLALLQIQHT
LYVFLETELIRWLQASFCTLLEDEWQRHYKDYQACVSQGQKLAWINTQLQNLAKAAQNQWKQPWSKQLADQALGELPLSQ
LIQLILKNDP
>Mature_650_residues
MMFRRNPLDGLADTGLQVSTQAQHSNRIKKLPPLLVNQLAAGEVVTRPASVVKELIENALDAGARQIDVRITQGGMGIIE
VADDGCGIHPEDMVMAVTRFATSKIADVAHLQGIATLGFRGEALAATAAVSRLTLTSCCDDSGIGRQLNVAGILEDTPQL
VPVVHRRGTTVSVKDLYFNVPARRGNLKAISTEFMHIETVVKQLALVASDVSFSLWHNDKRRFNFAAINAEPSSPLTVSS
SNLASEALSTQVMQALLTRLKSVLPPSHEQASLLHDNNLQVLSLDLEALRVQYEGMRGINRSQEPLGIEGLIIPSTKALA
NHPYKLIYINGRLVKDKRIAQSLRESINGFDHIASLGYVLFFNLPKAWLNLNVHPSKLCIKIQNLANVMAHFEVGVREAL
QRWQKRQPIIQPIVQPPQYQINAQASVQVAQSHSHQISVSQGSKRIAPSNHIDYPHNSSATASETTVPQLKQPVQTNESI
AYYQTQGHHGQYTQSHPHVVSDSRLSGFDTVTDLPPVSFTQKDGPVQCLYLLKDSLLNESLLSDSLLSDQQLALLQIQHT
LYVFLETELIRWLQASFCTLLEDEWQRHYKDYQACVSQGQKLAWINTQLQNLAKAAQNQWKQPWSKQLADQALGELPLSQ
LIQLILKNDP

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=189, Percent_Identity=38.6243386243386, Blast_Score=141, Evalue=3e-33,
Organism=Homo sapiens, GI4505913, Length=200, Percent_Identity=34, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI310128478, Length=203, Percent_Identity=33.4975369458128, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI4505911, Length=197, Percent_Identity=32.48730964467, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI189458896, Length=197, Percent_Identity=32.48730964467, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI189458898, Length=197, Percent_Identity=32.994923857868, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI310128480, Length=145, Percent_Identity=32.4137931034483, Blast_Score=84, Evalue=6e-16,
Organism=Escherichia coli, GI1790612, Length=421, Percent_Identity=33.4916864608076, Blast_Score=200, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71991825, Length=412, Percent_Identity=28.1553398058252, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17562796, Length=374, Percent_Identity=23.7967914438503, Blast_Score=104, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323819, Length=189, Percent_Identity=37.5661375661376, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324247, Length=454, Percent_Identity=23.7885462555066, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=328, Percent_Identity=26.5243902439024, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=108, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136968, Length=356, Percent_Identity=30.6179775280899, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17136970, Length=190, Percent_Identity=31.0526315789474, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71970; Mature: 71970

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFRRNPLDGLADTGLQVSTQAQHSNRIKKLPPLLVNQLAAGEVVTRPASVVKELIENAL
CCCCCCCCCCHHCCCCEEEECHHHHCHHHHCCHHHHHHHHCCHHHCCCHHHHHHHHHHHH
DAGARQIDVRITQGGMGIIEVADDGCGIHPEDMVMAVTRFATSKIADVAHLQGIATLGFR
HCCCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GEALAATAAVSRLTLTSCCDDSGIGRQLNVAGILEDTPQLVPVVHRRGTTVSVKDLYFNV
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCEEEEEHEEEEC
PARRGNLKAISTEFMHIETVVKQLALVASDVSFSLWHNDKRRFNFAAINAEPSSPLTVSS
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCCCCEEECC
SNLASEALSTQVMQALLTRLKSVLPPSHEQASLLHDNNLQVLSLDLEALRVQYEGMRGIN
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCEEEEEECHHHHHHHHHHCCCCC
RSQEPLGIEGLIIPSTKALANHPYKLIYINGRLVKDKRIAQSLRESINGFDHIASLGYVL
CCCCCCCCCEEEECCCHHHHCCCEEEEEECCEEECHHHHHHHHHHHHHHHHHHHHHHHHE
FFNLPKAWLNLNVHPSKLCIKIQNLANVMAHFEVGVREALQRWQKRQPIIQPIVQPPQYQ
EEECCHHHEECCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEE
INAQASVQVAQSHSHQISVSQGSKRIAPSNHIDYPHNSSATASETTVPQLKQPVQTNESI
ECCCHHEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCE
AYYQTQGHHGQYTQSHPHVVSDSRLSGFDTVTDLPPVSFTQKDGPVQCLYLLKDSLLNES
EEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LLSDSLLSDQQLALLQIQHTLYVFLETELIRWLQASFCTLLEDEWQRHYKDYQACVSQGQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLAWINTQLQNLAKAAQNQWKQPWSKQLADQALGELPLSQLIQLILKNDP
EEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MMFRRNPLDGLADTGLQVSTQAQHSNRIKKLPPLLVNQLAAGEVVTRPASVVKELIENAL
CCCCCCCCCCHHCCCCEEEECHHHHCHHHHCCHHHHHHHHCCHHHCCCHHHHHHHHHHHH
DAGARQIDVRITQGGMGIIEVADDGCGIHPEDMVMAVTRFATSKIADVAHLQGIATLGFR
HCCCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GEALAATAAVSRLTLTSCCDDSGIGRQLNVAGILEDTPQLVPVVHRRGTTVSVKDLYFNV
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCEEEEEHEEEEC
PARRGNLKAISTEFMHIETVVKQLALVASDVSFSLWHNDKRRFNFAAINAEPSSPLTVSS
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCCCCEEECC
SNLASEALSTQVMQALLTRLKSVLPPSHEQASLLHDNNLQVLSLDLEALRVQYEGMRGIN
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCEEEEEECHHHHHHHHHHCCCCC
RSQEPLGIEGLIIPSTKALANHPYKLIYINGRLVKDKRIAQSLRESINGFDHIASLGYVL
CCCCCCCCCEEEECCCHHHHCCCEEEEEECCEEECHHHHHHHHHHHHHHHHHHHHHHHHE
FFNLPKAWLNLNVHPSKLCIKIQNLANVMAHFEVGVREALQRWQKRQPIIQPIVQPPQYQ
EEECCHHHEECCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEE
INAQASVQVAQSHSHQISVSQGSKRIAPSNHIDYPHNSSATASETTVPQLKQPVQTNESI
ECCCHHEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCE
AYYQTQGHHGQYTQSHPHVVSDSRLSGFDTVTDLPPVSFTQKDGPVQCLYLLKDSLLNES
EEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LLSDSLLSDQQLALLQIQHTLYVFLETELIRWLQASFCTLLEDEWQRHYKDYQACVSQGQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLAWINTQLQNLAKAAQNQWKQPWSKQLADQALGELPLSQLIQLILKNDP
EEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA