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The map label for this gene is hisG [H]

Identifier: 148652314

GI number: 148652314

Start: 596809

End: 597480

Strand: Direct

Name: hisG [H]

Synonym: PsycPRwf_0502

Alternate gene names: 148652314

Gene position: 596809-597480 (Clockwise)

Preceding gene: 148652313

Following gene: 148652315

Centisome position: 20.03

GC content: 47.02

Gene sequence:

>672_bases
ATGACTGAAACAAATGAAATATTAAACCAAGCCGATAGTGACTATGATGGTCTAACTTTGGCATTATCTAAAGGGCGTAT
TCTAAAAGAGACGCTGCCTTTGCTAAAAGCGGCAGGCATCGAGCTTTTAGAGGACCCAGATAAATCTCGCAAACTGATTT
TTCCCACCTCACATGACAAGGTTCGGGTACTGATTCTGCGGGCCAGTGATGTGCCGACCTATGTAGAGCACGGGGCGGCC
GACTTCGGCGTAGCGGGTAAAGATGTGTTGTTAGAGTATGGCGCCAAACACGTGTATGAGCTGCTGGATCTAAAAATTGC
TCAGTGTAAACTGATGACTGCAGGCATTAAAGGTGTGGCGTTGCCCAATCGTCGCCTGCGCATTGCTACCAAATATGTCA
ATGTGGCGCGTGCATATTTTGCCAGTCAAGGTCAGCAAGTAGATATTATCAAGCTGTATGGCTCGATGGAGCTGGCGCCT
TTGGTTGGCCTGGGTGATTTAATTGTCGACGTGGTCGATACCGGCAATACTTTACGTGCTAACGGTCTTGAGCCGCTTGA
TCACATTTGCGATGTCTCGTCACGTCTGATTGTCAATCAGGTCAGCTACAAGCGTAAATACAGCCTGCTTGAGCCAATTT
TAGACAGCTTTAAGCAAAGTATTGGTGATTAG

Upstream 100 bases:

>100_bases
TCAATCCGGTAACTGATGCAGCAGAAGCCGATAGCTTGGATGACTAAAGCCCGCTTGGTTATAACAAAAATACTCTCATC
TTATTAAGACATACCCGACT

Downstream 100 bases:

>100_bases
TACGGACATAGAGCATTGATAACCACTTGCTATTATTGATATTTAAACCAGTGTAGGGCAAAACCTAGCAGTTTTGCGTG
ATACACTGGTTTTTTTAAGT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MTETNEILNQADSDYDGLTLALSKGRILKETLPLLKAAGIELLEDPDKSRKLIFPTSHDKVRVLILRASDVPTYVEHGAA
DFGVAGKDVLLEYGAKHVYELLDLKIAQCKLMTAGIKGVALPNRRLRIATKYVNVARAYFASQGQQVDIIKLYGSMELAP
LVGLGDLIVDVVDTGNTLRANGLEPLDHICDVSSRLIVNQVSYKRKYSLLEPILDSFKQSIGD

Sequences:

>Translated_223_residues
MTETNEILNQADSDYDGLTLALSKGRILKETLPLLKAAGIELLEDPDKSRKLIFPTSHDKVRVLILRASDVPTYVEHGAA
DFGVAGKDVLLEYGAKHVYELLDLKIAQCKLMTAGIKGVALPNRRLRIATKYVNVARAYFASQGQQVDIIKLYGSMELAP
LVGLGDLIVDVVDTGNTLRANGLEPLDHICDVSSRLIVNQVSYKRKYSLLEPILDSFKQSIGD
>Mature_222_residues
TETNEILNQADSDYDGLTLALSKGRILKETLPLLKAAGIELLEDPDKSRKLIFPTSHDKVRVLILRASDVPTYVEHGAAD
FGVAGKDVLLEYGAKHVYELLDLKIAQCKLMTAGIKGVALPNRRLRIATKYVNVARAYFASQGQQVDIIKLYGSMELAPL
VGLGDLIVDVVDTGNTLRANGLEPLDHICDVSSRLIVNQVSYKRKYSLLEPILDSFKQSIGD

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=191, Percent_Identity=30.8900523560209, Blast_Score=68, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=31.8918918918919, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 24509; Mature: 24377

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETNEILNQADSDYDGLTLALSKGRILKETLPLLKAAGIELLEDPDKSRKLIFPTSHDK
CCCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEECCCCCC
VRVLILRASDVPTYVEHGAADFGVAGKDVLLEYGAKHVYELLDLKIAQCKLMTAGIKGVA
EEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LPNRRLRIATKYVNVARAYFASQGQQVDIIKLYGSMELAPLVGLGDLIVDVVDTGNTLRA
CCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEC
NGLEPLDHICDVSSRLIVNQVSYKRKYSLLEPILDSFKQSIGD
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TETNEILNQADSDYDGLTLALSKGRILKETLPLLKAAGIELLEDPDKSRKLIFPTSHDK
CCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEECCCCCC
VRVLILRASDVPTYVEHGAADFGVAGKDVLLEYGAKHVYELLDLKIAQCKLMTAGIKGVA
EEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LPNRRLRIATKYVNVARAYFASQGQQVDIIKLYGSMELAPLVGLGDLIVDVVDTGNTLRA
CCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEC
NGLEPLDHICDVSSRLIVNQVSYKRKYSLLEPILDSFKQSIGD
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA