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The map label for this gene is hisD [H]

Identifier: 148652315

GI number: 148652315

Start: 597669

End: 598961

Strand: Direct

Name: hisD [H]

Synonym: PsycPRwf_0503

Alternate gene names: 148652315

Gene position: 597669-598961 (Clockwise)

Preceding gene: 148652314

Following gene: 148652316

Centisome position: 20.06

GC content: 50.73

Gene sequence:

>1293_bases
ATGCGTACTTTGACCAGCACCGACCCCAATTTTGAGCAGCAGCTTACCGACTTGCTTGCCTTTGAAACTGTGAATGATAA
AGAGCTACTGGCTACTGTTGATGACATTATCCATCAAGTACGTCATGGGGGTGATGCAGCGGTACTGGCACTGACCCAAA
AGTTTGATGCTCACCCTGCAACGAGTATGCAGCAGTTAGTCTTAACACCTGACGCTTTAAAACAAGCTTTTGATCAATTA
GATGAGCCGATTAAAGCCGCCCTAAAGACAGCTGCTGAGCGTATTAAAGATTTTCATCAGCGCCAAGTACAGCCAAGCTG
GGATTATACCGATGCACTGGGCAACCGTCTGGGACAAAAAGTGACGCCGCTAGATAGAGTGGGTATCTATGTGCCCGGTG
GGCTGGCCTCTTATCCCTCGTCAGTACTTATGAATGCGGTACCTGCTAAGGTCGCTGGCGTGGCCGAGGTGATTATGGTG
GTGCCAGCGCCAAAGGGCGAGCTGAATCCCTTGGTATTGGCCGCCGCTTATTTATCTGGCGTAGATAAAGTCTTTACCAT
TGGCGGCGCGCAAGCAGTAGCGGCGTTGGCTTATGGTACAGATAGCATCGCGCAAGTGGACAAGATTACTGGGCCAGGCA
ATAAGTATGTGGCCGCAGCCAAGCGTGCGGTATTCGGTCAAGTGGGCATCGATATGATTGCCGGTCCCTCTGAAGTTTTA
GTGTATGCTGAAGGTGAGGCGGCGGACAATGCCGACTGGTTGGCGATGGATCTATTGTCTCAAGCGGAGCACGATACAGT
GGCGCAGGCGATTTTTGTGACCACCAGTGAGCAGCAATTAAATGAGGTTGCTACGGCCATTGACAATGCCCTTGAGCAGT
TGCCCAAAGCGGATATCGCCCGTGAAGCACTACAAAACCGTGGTGCACTTATTTTGGTCAAAGACCGTGCTGAGGGTCTG
GCTTTAATTAATCGTATTGCCCCTGAGCATTTAGAATTGTCACTTGATAAGCCCGATGACGTGCTGGCAGATATTCGTCA
TGCTGGCGCCATCTTTATGGGTCGTCACACCCCTGAGGCCATTGGTGATTATTGCGCAGGCCCTAACCATGTGCTGCCGA
CTTCTGGTACTGCACGCTTTTCCTCACCGCTTGGGGTGTATGACTTTCAGAAAAAATCCTCTATTATTTACTGCTCAGCT
GAAGGCTCAAAGCCACTGGCACAGATAGCAGATACTTTAGCAATGCAAGAGGACTTAGAGGCGCATGCCCGTTCGGCACG
TTACCGCAGCTAA

Upstream 100 bases:

>100_bases
GTTTTTTTAAGTGTTCTTATATGACTCTGTAAGACACTGATGCTTAGTGCTTAGTAAACATAAGCCCTTTTGGTATAACC
TTATTTTTTGAGGATTTTTC

Downstream 100 bases:

>100_bases
TTTAACACGCTTATCTGCAGCTTGTAATTCATTGACACCCGTTTGGTGGAATTGGCCTATTTAGCATAGGTACTTATGGT
CTTGGCGTCTTGATCAAAAT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MRTLTSTDPNFEQQLTDLLAFETVNDKELLATVDDIIHQVRHGGDAAVLALTQKFDAHPATSMQQLVLTPDALKQAFDQL
DEPIKAALKTAAERIKDFHQRQVQPSWDYTDALGNRLGQKVTPLDRVGIYVPGGLASYPSSVLMNAVPAKVAGVAEVIMV
VPAPKGELNPLVLAAAYLSGVDKVFTIGGAQAVAALAYGTDSIAQVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
VYAEGEAADNADWLAMDLLSQAEHDTVAQAIFVTTSEQQLNEVATAIDNALEQLPKADIAREALQNRGALILVKDRAEGL
ALINRIAPEHLELSLDKPDDVLADIRHAGAIFMGRHTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSA
EGSKPLAQIADTLAMQEDLEAHARSARYRS

Sequences:

>Translated_430_residues
MRTLTSTDPNFEQQLTDLLAFETVNDKELLATVDDIIHQVRHGGDAAVLALTQKFDAHPATSMQQLVLTPDALKQAFDQL
DEPIKAALKTAAERIKDFHQRQVQPSWDYTDALGNRLGQKVTPLDRVGIYVPGGLASYPSSVLMNAVPAKVAGVAEVIMV
VPAPKGELNPLVLAAAYLSGVDKVFTIGGAQAVAALAYGTDSIAQVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
VYAEGEAADNADWLAMDLLSQAEHDTVAQAIFVTTSEQQLNEVATAIDNALEQLPKADIAREALQNRGALILVKDRAEGL
ALINRIAPEHLELSLDKPDDVLADIRHAGAIFMGRHTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSA
EGSKPLAQIADTLAMQEDLEAHARSARYRS
>Mature_430_residues
MRTLTSTDPNFEQQLTDLLAFETVNDKELLATVDDIIHQVRHGGDAAVLALTQKFDAHPATSMQQLVLTPDALKQAFDQL
DEPIKAALKTAAERIKDFHQRQVQPSWDYTDALGNRLGQKVTPLDRVGIYVPGGLASYPSSVLMNAVPAKVAGVAEVIMV
VPAPKGELNPLVLAAAYLSGVDKVFTIGGAQAVAALAYGTDSIAQVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
VYAEGEAADNADWLAMDLLSQAEHDTVAQAIFVTTSEQQLNEVATAIDNALEQLPKADIAREALQNRGALILVKDRAEGL
ALINRIAPEHLELSLDKPDDVLADIRHAGAIFMGRHTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSA
EGSKPLAQIADTLAMQEDLEAHARSARYRS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=421, Percent_Identity=40.3800475059382, Blast_Score=281, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6319819, Length=411, Percent_Identity=37.956204379562, Blast_Score=256, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45967; Mature: 45967

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLTSTDPNFEQQLTDLLAFETVNDKELLATVDDIIHQVRHGGDAAVLALTQKFDAHPA
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCC
TSMQQLVLTPDALKQAFDQLDEPIKAALKTAAERIKDFHQRQVQPSWDYTDALGNRLGQK
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
VTPLDRVGIYVPGGLASYPSSVLMNAVPAKVAGVAEVIMVVPAPKGELNPLVLAAAYLSG
CCCHHHCCEEECCCHHHCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHC
VDKVFTIGGAQAVAALAYGTDSIAQVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
CHHHEECCCHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHCCCCCEEE
VYAEGEAADNADWLAMDLLSQAEHDTVAQAIFVTTSEQQLNEVATAIDNALEQLPKADIA
EEECCCCCCCCHHHHHHHHHHCCHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCHHHHH
REALQNRGALILVKDRAEGLALINRIAPEHLELSLDKPDDVLADIRHAGAIFMGRHTPEA
HHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCEEEECCCCHHH
IGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSAEGSKPLAQIADTLAMQEDLE
HHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
AHARSARYRS
HHHHHCCCCC
>Mature Secondary Structure
MRTLTSTDPNFEQQLTDLLAFETVNDKELLATVDDIIHQVRHGGDAAVLALTQKFDAHPA
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCC
TSMQQLVLTPDALKQAFDQLDEPIKAALKTAAERIKDFHQRQVQPSWDYTDALGNRLGQK
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
VTPLDRVGIYVPGGLASYPSSVLMNAVPAKVAGVAEVIMVVPAPKGELNPLVLAAAYLSG
CCCHHHCCEEECCCHHHCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHC
VDKVFTIGGAQAVAALAYGTDSIAQVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
CHHHEECCCHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHCCCCCEEE
VYAEGEAADNADWLAMDLLSQAEHDTVAQAIFVTTSEQQLNEVATAIDNALEQLPKADIA
EEECCCCCCCCHHHHHHHHHHCCHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCHHHHH
REALQNRGALILVKDRAEGLALINRIAPEHLELSLDKPDDVLADIRHAGAIFMGRHTPEA
HHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCEEEECCCCHHH
IGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSAEGSKPLAQIADTLAMQEDLE
HHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
AHARSARYRS
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA