Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 148643347

GI number: 148643347

Start: 1291240

End: 1292259

Strand: Reverse

Name: purE [H]

Synonym: Msm_1287

Alternate gene names: 148643347

Gene position: 1292259-1291240 (Counterclockwise)

Preceding gene: 148643348

Following gene: 148643346

Centisome position: 69.73

GC content: 33.14

Gene sequence:

>1020_bases
ATGACACCAAAAGTAATGATAATTCTGGGAAGTGGGTCAGATATTGCTATCGCTGAAAAAAGTATGAAGATTTTGGAAAA
ACTTGAAATACCATATAGTTTGAAAATAGCTTCAGCACATAGAACACCTGATCTTGTAAGAGAACTTGTTGTACAGGGAA
CCAATGCAGGTATAAAAGTATTTATTGGAATTGCAGGATTAGCTGCTCATCTTCCAGGAGCAATAGCTGCATATACTCAC
AAACCGGTTATTGGAGTTCCTGTAGATGTTAAAGTTAGCGGACTGGATGCACTATATTCTTCAGTTCAAATGCCTTATCC
CTCTCCTGTAGCTACTGTTGGAATTGATAGGGGAGATAATGGAGCTATTTTAGCTGCACAAATCCTAGGGCTTTATGACG
AGGAAATACGCAAAAAAGTATTGGAATTAAAAGAAGAATATAAACAGAAAGTCATTAAAAATAATGAAGAAATTGTTCAA
AAAATAGACAATCCACATATTACCAATGACTTTTTAAGGATTAAAAACCTCGAATTAAATGAAACTACAGAAGAATTTAA
TGGAAGCTACATTAATAAAAATGCTGAGGTAGTCATTATTGTTGGAAGACATACTGATTTAATTACTGGAAAAAAAGTAA
GTGTTACACTAGACAGACTTAAAATACCTCATGATATGCAAGTAATTTGCCCGATTAGATCAGGAAAAAAATTCAGAGCA
TATGTAAACACTATGAAAAATGCTAAAATATTTATTGGAATTAATTCCAACTCTTCCCAGGTAAGTGGAGGTCTTGTAGG
TCTTACTGAAAAGCCTGTTATTGGAGTTCCATGTGAAAATGAACTTGGAAATAATTACCTGCTTTCAACTGTAAATATGC
CACCAGGAGTACCTGTAGCTACTGTTGGTGTTAATAATGGTCGTAATGCTGCTGTTTTAAGTGGTGAAATACTTTCTATT
AACAATCCTGTTCTTTTAGAGCTTTTAGAAAAATTAAAAAATAAAAAAATCAACATATAA

Upstream 100 bases:

>100_bases
CTTAGATAAATACACTGCTTATGAAGTTGAAATTAAATAACTTTTAATATAAAATTAAACAAATATCAATTATTAATATT
TTTTTAGAAGGTATTTTAAA

Downstream 100 bases:

>100_bases
GGGATAATTATGGATATCAAAGATGAAAACATTATTGAAATAACAACTGAGCTTTCAAGCGAGTTTGAAGTAGCTAAAGA
GCTAAGGAAATATCCTAAAG

Product: phosphoribosylaminoimidazole carboxylase (NCAIR mutase), PurE

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTPKVMIILGSGSDIAIAEKSMKILEKLEIPYSLKIASAHRTPDLVRELVVQGTNAGIKVFIGIAGLAAHLPGAIAAYTH
KPVIGVPVDVKVSGLDALYSSVQMPYPSPVATVGIDRGDNGAILAAQILGLYDEEIRKKVLELKEEYKQKVIKNNEEIVQ
KIDNPHITNDFLRIKNLELNETTEEFNGSYINKNAEVVIIVGRHTDLITGKKVSVTLDRLKIPHDMQVICPIRSGKKFRA
YVNTMKNAKIFIGINSNSSQVSGGLVGLTEKPVIGVPCENELGNNYLLSTVNMPPGVPVATVGVNNGRNAAVLSGEILSI
NNPVLLELLEKLKNKKINI

Sequences:

>Translated_339_residues
MTPKVMIILGSGSDIAIAEKSMKILEKLEIPYSLKIASAHRTPDLVRELVVQGTNAGIKVFIGIAGLAAHLPGAIAAYTH
KPVIGVPVDVKVSGLDALYSSVQMPYPSPVATVGIDRGDNGAILAAQILGLYDEEIRKKVLELKEEYKQKVIKNNEEIVQ
KIDNPHITNDFLRIKNLELNETTEEFNGSYINKNAEVVIIVGRHTDLITGKKVSVTLDRLKIPHDMQVICPIRSGKKFRA
YVNTMKNAKIFIGINSNSSQVSGGLVGLTEKPVIGVPCENELGNNYLLSTVNMPPGVPVATVGVNNGRNAAVLSGEILSI
NNPVLLELLEKLKNKKINI
>Mature_338_residues
TPKVMIILGSGSDIAIAEKSMKILEKLEIPYSLKIASAHRTPDLVRELVVQGTNAGIKVFIGIAGLAAHLPGAIAAYTHK
PVIGVPVDVKVSGLDALYSSVQMPYPSPVATVGIDRGDNGAILAAQILGLYDEEIRKKVLELKEEYKQKVIKNNEEIVQK
IDNPHITNDFLRIKNLELNETTEEFNGSYINKNAEVVIIVGRHTDLITGKKVSVTLDRLKIPHDMQVICPIRSGKKFRAY
VNTMKNAKIFIGINSNSSQVSGGLVGLTEKPVIGVPCENELGNNYLLSTVNMPPGVPVATVGVNNGRNAAVLSGEILSIN
NPVLLELLEKLKNKKINI

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=42.2077922077922, Blast_Score=95, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=160, Percent_Identity=41.875, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 36736; Mature: 36605

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKVMIILGSGSDIAIAEKSMKILEKLEIPYSLKIASAHRTPDLVRELVVQGTNAGIKV
CCCEEEEEEECCCCEEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEE
FIGIAGLAAHLPGAIAAYTHKPVIGVPVDVKVSGLDALYSSVQMPYPSPVATVGIDRGDN
EEEEHHHHHHCCCCEEEECCCCEEECCCEEEECCHHHHHHHCCCCCCCCEEEEEECCCCC
GAILAAQILGLYDEEIRKKVLELKEEYKQKVIKNNEEIVQKIDNPHITNDFLRIKNLELN
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEECCCCC
ETTEEFNGSYINKNAEVVIIVGRHTDLITGKKVSVTLDRLKIPHDMQVICPIRSGKKFRA
CCHHHHCCCEECCCCCEEEEEECCCCEECCCEEEEEEEHCCCCCCCEEEEECCCCCHHHH
YVNTMKNAKIFIGINSNSSQVSGGLVGLTEKPVIGVPCENELGNNYLLSTVNMPPGVPVA
HHHHCCCCEEEEEECCCCCCCCCCEEEECCCCEEECCCCCCCCCCEEEEEECCCCCCCEE
TVGVNNGRNAAVLSGEILSINNPVLLELLEKLKNKKINI
EEECCCCCCEEEEECEEEECCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TPKVMIILGSGSDIAIAEKSMKILEKLEIPYSLKIASAHRTPDLVRELVVQGTNAGIKV
CCEEEEEEECCCCEEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCEEE
FIGIAGLAAHLPGAIAAYTHKPVIGVPVDVKVSGLDALYSSVQMPYPSPVATVGIDRGDN
EEEEHHHHHHCCCCEEEECCCCEEECCCEEEECCHHHHHHHCCCCCCCCEEEEEECCCCC
GAILAAQILGLYDEEIRKKVLELKEEYKQKVIKNNEEIVQKIDNPHITNDFLRIKNLELN
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEECCCCC
ETTEEFNGSYINKNAEVVIIVGRHTDLITGKKVSVTLDRLKIPHDMQVICPIRSGKKFRA
CCHHHHCCCEECCCCCEEEEEECCCCEECCCEEEEEEEHCCCCCCCEEEEECCCCCHHHH
YVNTMKNAKIFIGINSNSSQVSGGLVGLTEKPVIGVPCENELGNNYLLSTVNMPPGVPVA
HHHHCCCCEEEEEECCCCCCCCCCEEEECCCCEEECCCCCCCCCCEEEEEECCCCCCCEE
TVGVNNGRNAAVLSGEILSINNPVLLELLEKLKNKKINI
EEECCCCCCEEEEECEEEECCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2993814 [H]