Click here to switch to the map view.

The map label for this gene is mtaD

Identifier: 148643319

GI number: 148643319

Start: 1264411

End: 1265718

Strand: Reverse

Name: mtaD

Synonym: Msm_1259

Alternate gene names: 148643319

Gene position: 1265718-1264411 (Counterclockwise)

Preceding gene: 148643320

Following gene: 148643317

Centisome position: 68.3

GC content: 29.97

Gene sequence:

>1308_bases
ATGACTGATAATACTATTTTAATTAAAGATGCATTAATTTTAAACCCTTTAGATTTTAAAGAAATAAAAGGTTCTCTTTT
AATAAAAAATGATAAAATCGCAGAAATAGGTACTGATATTGATGAAAGTAATGTAGATAAGGTTATTGATGCTAAAGGTA
AAATATTACTTCCTGGATTTGTAAATACTCATACACATTTGTCAATGACTTTGTTTAGAGGATTGGCTGATGATTTGAGC
TTAGATTCATGGTTAAATGATAATATTTGGCCGATGGAAGCAAATCTTACATCTGAATACTGTTATATTGGTGCTCTTTT
AGGAGCCATTGAATTAATTAAATCCGGAACAACCACTTTTAGTGACATGTACTTTTACATGGAAGATGTTGCAAAAGCTG
TTGAAGAATCAGGAATTAGGGCAGTTTTATCTTATGGTATGATTGATTTTGGTGATGATGAAAAAAGAGAACATGAAATT
AAAGAAAACATAGCCTTATTTGAAAAATGTAATGGGATGGCTGATGGAAGAATTAAAGTATTTTTTGGACCTCATTCCCC
GTATACAGCTTCAAAGGATTTATTGGAAGATGTAAGATGGTTAGCTAATGAGTATAATACTGGAATTCATATTCATGTTA
GTGAAACTCAAAAAGAGATAAATGATTCACTTGAAGCACATGATTTAAGACCCTTTGAATATTTGGATTCAATAGGATTT
TTAGGTCCTGATGTTGTAGCTGCACATAGTGTATGGTTATCTCATAATGAAATTGAAATTATTAAAAGGAACAATGTTAA
AATTTCACATAATCCATGCAGTAATATGAAATTAGCTTCAGGTATAGCTCCAATTCAGGATTTAATCACTAATGATATTT
GTGTTGGAATTGGAACAGATGGAGCATCATCAAATAATAATTTGGATTTGATTGAGGAGTTAAGAACAGCTTCCTTACTT
CAAAAAGTTAATTTATTAAATCCTAAAGCTTTAACTTCTAATGAAGCATTAGCTATGGGAACTATCAAAGGTGCAGAAGT
TTTAGGACTTGAACAGGAAATAGGATCAATTGAAGTTGGTAAAAAAGCAGATTTAATTTTAATTGATACCAATAATGCTA
ATATGGTGCCGGATAGTTCAGCTACAAGTTCCAATATCATTTACTCCGCAAATGGTTATAATGTAGATACTACTATTTGT
GACGGTAAAATTTTAATGGAAAATAGAAAATTAACTACATTAGATGAAGAAGAAATTTATAAAAAAGCCAGAAAAGCTAT
TGAAGAGCTTAAAGAAGCTAGTAAATAA

Upstream 100 bases:

>100_bases
CTAAACGTAAAACTATCAAACCAGAAGATATTAAATTAGCTATTAAAAATTTAGAATAGTTATTTTAATTGACTTTTTTT
TATTTTTTTTAGGTGTTATT

Downstream 100 bases:

>100_bases
TTTTATCTAGCTTCAAATTTTATTTTATTTTTGTTTAGAACAATACTTCTTTTCCAGGCATCATTGCTTTCAGGGAAATC
AGACCTGAAGTGAGCTCCTC

Product: metal-dependent hydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTDNTILIKDALILNPLDFKEIKGSLLIKNDKIAEIGTDIDESNVDKVIDAKGKILLPGFVNTHTHLSMTLFRGLADDLS
LDSWLNDNIWPMEANLTSEYCYIGALLGAIELIKSGTTTFSDMYFYMEDVAKAVEESGIRAVLSYGMIDFGDDEKREHEI
KENIALFEKCNGMADGRIKVFFGPHSPYTASKDLLEDVRWLANEYNTGIHIHVSETQKEINDSLEAHDLRPFEYLDSIGF
LGPDVVAAHSVWLSHNEIEIIKRNNVKISHNPCSNMKLASGIAPIQDLITNDICVGIGTDGASSNNNLDLIEELRTASLL
QKVNLLNPKALTSNEALAMGTIKGAEVLGLEQEIGSIEVGKKADLILIDTNNANMVPDSSATSSNIIYSANGYNVDTTIC
DGKILMENRKLTTLDEEEIYKKARKAIEELKEASK

Sequences:

>Translated_435_residues
MTDNTILIKDALILNPLDFKEIKGSLLIKNDKIAEIGTDIDESNVDKVIDAKGKILLPGFVNTHTHLSMTLFRGLADDLS
LDSWLNDNIWPMEANLTSEYCYIGALLGAIELIKSGTTTFSDMYFYMEDVAKAVEESGIRAVLSYGMIDFGDDEKREHEI
KENIALFEKCNGMADGRIKVFFGPHSPYTASKDLLEDVRWLANEYNTGIHIHVSETQKEINDSLEAHDLRPFEYLDSIGF
LGPDVVAAHSVWLSHNEIEIIKRNNVKISHNPCSNMKLASGIAPIQDLITNDICVGIGTDGASSNNNLDLIEELRTASLL
QKVNLLNPKALTSNEALAMGTIKGAEVLGLEQEIGSIEVGKKADLILIDTNNANMVPDSSATSSNIIYSANGYNVDTTIC
DGKILMENRKLTTLDEEEIYKKARKAIEELKEASK
>Mature_434_residues
TDNTILIKDALILNPLDFKEIKGSLLIKNDKIAEIGTDIDESNVDKVIDAKGKILLPGFVNTHTHLSMTLFRGLADDLSL
DSWLNDNIWPMEANLTSEYCYIGALLGAIELIKSGTTTFSDMYFYMEDVAKAVEESGIRAVLSYGMIDFGDDEKREHEIK
ENIALFEKCNGMADGRIKVFFGPHSPYTASKDLLEDVRWLANEYNTGIHIHVSETQKEINDSLEAHDLRPFEYLDSIGFL
GPDVVAAHSVWLSHNEIEIIKRNNVKISHNPCSNMKLASGIAPIQDLITNDICVGIGTDGASSNNNLDLIEELRTASLLQ
KVNLLNPKALTSNEALAMGTIKGAEVLGLEQEIGSIEVGKKADLILIDTNNANMVPDSSATSSNIIYSANGYNVDTTICD
GKILMENRKLTTLDEEEIYKKARKAIEELKEASK

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=380, Percent_Identity=27.1052631578947, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789249, Length=381, Percent_Identity=28.8713910761155, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082177, Length=441, Percent_Identity=24.2630385487528, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17540282, Length=358, Percent_Identity=27.6536312849162, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319963, Length=355, Percent_Identity=27.0422535211268, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24643849, Length=392, Percent_Identity=25.5102040816327, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_METS3 (A5UMN6)

Other databases:

- EMBL:   CP000678
- RefSeq:   YP_001273832.1
- ProteinModelPortal:   A5UMN6
- SMR:   A5UMN6
- STRING:   A5UMN6
- GeneID:   5215777
- GenomeReviews:   CP000678_GR
- KEGG:   msi:Msm_1259
- eggNOG:   arNOG04550
- HOGENOM:   HBG668170
- OMA:   KENIESH
- ProtClustDB:   CLSK2791258
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 48015; Mature: 47884

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: BINDING 93-93 BINDING 185-185 BINDING 215-215 BINDING 300-300

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNTILIKDALILNPLDFKEIKGSLLIKNDKIAEIGTDIDESNVDKVIDAKGKILLPGF
CCCCEEEEEEEEEECCCCHHHCCCCEEEECCCHHHHCCCCCCCCHHHHHCCCCCEEECCC
VNTHTHLSMTLFRGLADDLSLDSWLNDNIWPMEANLTSEYCYIGALLGAIELIKSGTTTF
CCCCHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCHH
SDMYFYMEDVAKAVEESGIRAVLSYGMIDFGDDEKREHEIKENIALFEKCNGMADGRIKV
HHHHHHHHHHHHHHHHCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
FFGPHSPYTASKDLLEDVRWLANEYNTGIHIHVSETQKEINDSLEAHDLRPFEYLDSIGF
EECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCHHHCCCCHHHHHHHHCC
LGPDVVAAHSVWLSHNEIEIIKRNNVKISHNPCSNMKLASGIAPIQDLITNDICVGIGTD
CCCHHHHHHHEEECCCEEEEEEECCEEEECCCCCCCCHHCCCHHHHHHHCCCEEEEECCC
GASSNNNLDLIEELRTASLLQKVNLLNPKALTSNEALAMGTIKGAEVLGLEQEIGSIEVG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEECHHHHCCCEECC
KKADLILIDTNNANMVPDSSATSSNIIYSANGYNVDTTICDGKILMENRKLTTLDEEEIY
CCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCEEEEECCCCCCCCHHHHH
KKARKAIEELKEASK
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDNTILIKDALILNPLDFKEIKGSLLIKNDKIAEIGTDIDESNVDKVIDAKGKILLPGF
CCCEEEEEEEEEECCCCHHHCCCCEEEECCCHHHHCCCCCCCCHHHHHCCCCCEEECCC
VNTHTHLSMTLFRGLADDLSLDSWLNDNIWPMEANLTSEYCYIGALLGAIELIKSGTTTF
CCCCHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCHH
SDMYFYMEDVAKAVEESGIRAVLSYGMIDFGDDEKREHEIKENIALFEKCNGMADGRIKV
HHHHHHHHHHHHHHHHCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
FFGPHSPYTASKDLLEDVRWLANEYNTGIHIHVSETQKEINDSLEAHDLRPFEYLDSIGF
EECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCHHHCCCCHHHHHHHHCC
LGPDVVAAHSVWLSHNEIEIIKRNNVKISHNPCSNMKLASGIAPIQDLITNDICVGIGTD
CCCHHHHHHHEEECCCEEEEEEECCEEEECCCCCCCCHHCCCHHHHHHHCCCEEEEECCC
GASSNNNLDLIEELRTASLLQKVNLLNPKALTSNEALAMGTIKGAEVLGLEQEIGSIEVG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEECHHHHCCCEECC
KKADLILIDTNNANMVPDSSATSSNIIYSANGYNVDTTICDGKILMENRKLTTLDEEEIY
CCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCEEEEECCCCCCCCHHHHH
KKARKAIEELKEASK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA