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The map label for this gene is ispA [H]

Identifier: 148359869

GI number: 148359869

Start: 2747327

End: 2748223

Strand: Direct

Name: ispA [H]

Synonym: LPC_1797

Alternate gene names: 148359869

Gene position: 2747327-2748223 (Clockwise)

Preceding gene: 148359868

Following gene: 148359871

Centisome position: 76.82

GC content: 39.91

Gene sequence:

>897_bases
ATGAACAAACAAGTGATTGATAAGTATACCCAAAGACATGAGCTATATCTCGAGCAATTGCTCAATGAAATAATAATACC
AGCTCCAAAAATTCGCTCCGCACTTCATTACGCTTTATTTTCAGGCGGCAAAAGAATAAGACCCATTTTGGTTTATTTAG
CTGGCGATTTAATTGATGTTGACCAGGGAGTTCTGGATATTATTGCAGCAGCGCTTGAGTTAACACATTGCTATTCCCTG
ATTCATGATGATCTTCCGGCGATGGACAATGACGATCTGCGCCGCGGTAAGCCGAGTTGTCATAAAGCATTTGATGAGGC
AACCGCTATTTTAGTCGGCGATGGCATGCAAGCTTTAGCGATTGAAGTCGTATTGACGAGATTATCGCCCCTTCTCCCCG
CAGCACAAGTCGTAGCCATTACTCAAGTATTGGTAAATGCCAGTGGAATAAGTGGAATGGTTAGTGGCCAAAGTCTTGAT
TTATCAGAACTGGCCAAATTATCAGTAACAGAAGAGCAATTAAGAGAAATTCATCTTTTGAAAACTGGAAAACTGATCCT
GGCGTGTTTTGAAATGGTTTTAGCAGCACAAAATGAGATATCAGAGCAAATCAAATCCGCACTAAGAACTTATGGGAAAC
ATATAGGGCTTGTATTTCAAATGCAAGATGATTACCTGGATCTTTACGCTCCAACTCAAATATTGGGAAAAGGTCGCTCC
TCGGATCAGGCAAACCAAAAAACCACCTTTGCAACCTTATTTAACAAGCAACAATTGGAAGAAGAAATCGCTGTTCATTA
CCAAATTGCAATGGATTCTCTACGGTTATTTGGTAGTAAAGCGGCTGCATTAATTGAATTAACCAAACAATTACAAAATC
GTAGCAATTTGTCTTGA

Upstream 100 bases:

>100_bases
GGAATTAGCCTTGCAAGACGTTGCCAAAATGCTTTGAATCAGGCAGAGCAAAAAATTGAAACGTTAACTGGTACTGATTC
CAACATTGAACTCGACTCAG

Downstream 100 bases:

>100_bases
CACCATTGATGCACCGGACAATCCAATTGATATCCGTTTTAAATTAGGACTTTCTAACAACACGTGAAACAGGAATCCAG
GTTTCTATACCTTGCTCCAT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MNKQVIDKYTQRHELYLEQLLNEIIIPAPKIRSALHYALFSGGKRIRPILVYLAGDLIDVDQGVLDIIAAALELTHCYSL
IHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVVLTRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLD
LSELAKLSVTEEQLREIHLLKTGKLILACFEMVLAAQNEISEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS

Sequences:

>Translated_298_residues
MNKQVIDKYTQRHELYLEQLLNEIIIPAPKIRSALHYALFSGGKRIRPILVYLAGDLIDVDQGVLDIIAAALELTHCYSL
IHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVVLTRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLD
LSELAKLSVTEEQLREIHLLKTGKLILACFEMVLAAQNEISEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS
>Mature_298_residues
MNKQVIDKYTQRHELYLEQLLNEIIIPAPKIRSALHYALFSGGKRIRPILVYLAGDLIDVDQGVLDIIAAALELTHCYSL
IHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVVLTRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLD
LSELAKLSVTEEQLREIHLLKTGKLILACFEMVLAAQNEISEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=259, Percent_Identity=30.1158301158301, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1786623, Length=248, Percent_Identity=41.1290322580645, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1789578, Length=239, Percent_Identity=29.7071129707113, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24651612, Length=246, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32937; Mature: 32937

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQVIDKYTQRHELYLEQLLNEIIIPAPKIRSALHYALFSGGKRIRPILVYLAGDLIDV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHH
DQGVLDIIAAALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHEEEECCCHHHHH
IEVVLTRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLDLSELAKLSVTEEQLREIHLL
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
KTGKLILACFEMVLAAQNEISEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHCCHHHHCCCCC
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKQVIDKYTQRHELYLEQLLNEIIIPAPKIRSALHYALFSGGKRIRPILVYLAGDLIDV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHH
DQGVLDIIAAALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHEEEECCCHHHHH
IEVVLTRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLDLSELAKLSVTEEQLREIHLL
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
KTGKLILACFEMVLAAQNEISEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHCCHHHHCCCCC
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]