Click here to switch to the map view.

The map label for this gene is sfcA [H]

Identifier: 148358822

GI number: 148358822

Start: 1488979

End: 1490703

Strand: Reverse

Name: sfcA [H]

Synonym: LPC_0705

Alternate gene names: 148358822

Gene position: 1490703-1488979 (Counterclockwise)

Preceding gene: 148358827

Following gene: 148358818

Centisome position: 41.68

GC content: 40.41

Gene sequence:

>1725_bases
ATGCTTGATTTTAGTTTGAATCGTGATCCCCAAACGGGCGAGTTATACATAGAAACCTCATTATGTGGGAAGCCTTTACT
GACTACGCCGCAATTAAACAAAGGAACAGCATTTACTCAGGAAGAAAGAAAAGATTTTGGTCTTTTAGGCAAGTTACCAC
ACCGCGTAGAAACTCTTGATGAACAAGTAAAGCGTGCCTATCTTCAATATTCAAGTTACACGACACGTTTGCAGCAACAT
ATTTATTTAAATAATTTACATGATAAAAACCAAATAGTATTTTACAAACTGCTAAGTCGTCATTTGGGGGAAATGCTTCC
CATCATCTATACACCAATCGTTGGTGCTGCAGCCAAGAGGTTTAGTCATGAATACAGACAGCCACGAGGATTGTATATTG
CTCATTCGGATAAAAACCAGCTTGAGGAAATAATTAATAACCGTTCGAATCCAGACATAGACCTTGTTGTAGTGACCGAT
GGTGAGGGAGTCCTAGGCATCGGCGATCAAGGGATAGGAGGAATGGATATACCTGTTGCAAAACTAATGGTTTACAGCTT
ATGTGGTGGGATTGATCCAACTCGCACATTACCCATATTTCTTGATGTAGGAACTAACAACCAAGAATTATTAAATGACC
CTATGTATCTGGGTTGCCGTCACCCCAGAATAAAAAGCTCAGAATACGACGATTTTATCAAAACTTTTGTCAATGAAATC
CATAAGCAATTTCCAAATGCTTTTTTGCATTGGGAAGATTTTGGTCGAGGCAATGCTCGACGAATCCTGGATCAATTTCA
AGATGAATTGTGTACTTTTAATGATGATATTCAGGGAACTGGTGCAGTAACACTGGCAGCAATTTTGGCAGCATGTGATG
TGACTGGACTACCCTTACATGAACACAGAATCGTTGTGTTTGGAGCTGGCTCAGCAGGTACTGGTATTAGCGACCAAATT
GTTGATGCGATGGTGAAAAGCGGATTGAGCCTAACTGATGCTTATGACAGATTCTGGTTAATAGACAAACAGGGTTTATT
ACTTGCGACTGACCAAGAGCTTACTGATGCTCAAAAACCCTATGCACGGAATCCTATAGATATACAATCCTGGGAAATTA
ATAATAAACAACATCCTTCGTTTACTGACACTATCAGACATGTCAAACCTACCATTTTAATTGGCTGTTCAGCGCAAACG
GGCGCATTTTCACAAGATATTGTGGAAACTATGTCGACAGCCTGCGAGCGGCCAATCATTTTCCCTTTATCAAATCCTGA
TGAAAAATGTGAAGCACAACCTTCAGATATATTGGCATGGAGTAAAGGACGGGCATTAATTGCTACTGGAACCGCTTTTG
CCCCGATTGAATATCAGAACCGAATGGTGCAAATAGCTCAATGCAACAATGCCTTGGTATTCCCTGGAATTGGATTGGGT
GTCTTGGCGGTAAGTGCCTCTCGTTTAACCAAAGATATGATATTGGCTGCCGCTCAAACTTTAAGTAAATTTGCGCCAAG
TAAAAAGGACAGTTTTTTGCCCCTTTTACCCTCATTAGACAATGCACAAATTGTAGCTAAAGAAATAGCTATTGCCGTAG
CTCAGTGTGCAATAGACTCAGGCTATGCTCAAAAAAATCAAGACAAGGATCTACCCCGGTTAATTGATGAACTCTTTTGG
GAGCCTAGATATCTGCCTTTTAGAAAAAAAGGATGGAGTGAATAG

Upstream 100 bases:

>100_bases
TATCACTAAGTACTTATTCATACCCGCCCTCTTGATGTAAACTACAAAAAGTCGATATTATCACCAGTCAGCAAGTAACG
CTATCTTATGAGAATACCAT

Downstream 100 bases:

>100_bases
AATAAAGCTCTATGACTATATTATTGAGAAATAAATTTTCTTAATTCTTAGTCTGAGGGGTTGGTGAAATTAATCGTTAC
ATTTTTTATAGTCCCGCTCT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 3 [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLDEQVKRAYLQYSSYTTRLQQH
IYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKRFSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTD
GEGVLGIGDQGIGGMDIPVAKLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNEI
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLHEHRIVVFGAGSAGTGISDQI
VDAMVKSGLSLTDAYDRFWLIDKQGLLLATDQELTDAQKPYARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQT
GAFSQDIVETMSTACERPIIFPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDSGYAQKNQDKDLPRLIDELFW
EPRYLPFRKKGWSE

Sequences:

>Translated_574_residues
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLDEQVKRAYLQYSSYTTRLQQH
IYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKRFSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTD
GEGVLGIGDQGIGGMDIPVAKLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNEI
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLHEHRIVVFGAGSAGTGISDQI
VDAMVKSGLSLTDAYDRFWLIDKQGLLLATDQELTDAQKPYARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQT
GAFSQDIVETMSTACERPIIFPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDSGYAQKNQDKDLPRLIDELFW
EPRYLPFRKKGWSE
>Mature_574_residues
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLDEQVKRAYLQYSSYTTRLQQH
IYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKRFSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTD
GEGVLGIGDQGIGGMDIPVAKLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNEI
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLHEHRIVVFGAGSAGTGISDQI
VDAMVKSGLSLTDAYDRFWLIDKQGLLLATDQELTDAQKPYARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQT
GAFSQDIVETMSTACERPIIFPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDSGYAQKNQDKDLPRLIDELFW
EPRYLPFRKKGWSE

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505145, Length=547, Percent_Identity=37.2943327239488, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI4505143, Length=525, Percent_Identity=36.7619047619048, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI62420882, Length=548, Percent_Identity=36.8613138686131, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI62420880, Length=548, Percent_Identity=36.8613138686131, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI239049447, Length=548, Percent_Identity=36.8613138686131, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI270265879, Length=458, Percent_Identity=39.9563318777293, Blast_Score=352, Evalue=5e-97,
Organism=Escherichia coli, GI87081919, Length=564, Percent_Identity=45.2127659574468, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17537199, Length=518, Percent_Identity=36.1003861003861, Blast_Score=339, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6322823, Length=578, Percent_Identity=42.3875432525952, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI281362674, Length=546, Percent_Identity=37.1794871794872, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI21356279, Length=546, Percent_Identity=37.1794871794872, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281362672, Length=546, Percent_Identity=37.1794871794872, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24646388, Length=537, Percent_Identity=36.1266294227188, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24646386, Length=537, Percent_Identity=36.1266294227188, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78707242, Length=546, Percent_Identity=33.5164835164835, Blast_Score=334, Evalue=8e-92,
Organism=Drosophila melanogaster, GI78707238, Length=546, Percent_Identity=33.5164835164835, Blast_Score=334, Evalue=8e-92,
Organism=Drosophila melanogaster, GI78707232, Length=512, Percent_Identity=32.8125, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI281363505, Length=511, Percent_Identity=32.6810176125245, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI78707236, Length=511, Percent_Identity=32.6810176125245, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI78707240, Length=513, Percent_Identity=34.307992202729, Blast_Score=324, Evalue=8e-89,
Organism=Drosophila melanogaster, GI281363503, Length=507, Percent_Identity=32.5443786982249, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI19922384, Length=526, Percent_Identity=28.3269961977186, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 63942; Mature: 63942

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLD
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHH
EQVKRAYLQYSSYTTRLQQHIYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTDGEGVLGIGDQGIGGMDIPVA
HHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCHHH
KLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNEI
HHHHHHHHCCCCCCCEEEEEEEECCCCHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHH
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLH
HHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
EHRIVVFGAGSAGTGISDQIVDAMVKSGLSLTDAYDRFWLIDKQGLLLATDQELTDAQKP
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCEECCCCEEEEEECCCEEEECCCHHHHCCCC
YARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQTGAFSQDIVETMSTACERPII
CCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEE
FPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
EECCCCCHHHCCCCCCEEEECCCCEEEEECCEECCCHHHCCEEEEEECCCEEEECCCCHH
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
GYAQKNQDKDLPRLIDELFWEPRYLPFRKKGWSE
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLD
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHH
EQVKRAYLQYSSYTTRLQQHIYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTDGEGVLGIGDQGIGGMDIPVA
HHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCHHH
KLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNEI
HHHHHHHHCCCCCCCEEEEEEEECCCCHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHH
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLH
HHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
EHRIVVFGAGSAGTGISDQIVDAMVKSGLSLTDAYDRFWLIDKQGLLLATDQELTDAQKP
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCEECCCCEEEEEECCCEEEECCCHHHHCCCC
YARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQTGAFSQDIVETMSTACERPII
CCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEE
FPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
EECCCCCHHHCCCCCCEEEECCCCEEEEECCEECCCHHHCCEEEEEECCCEEEECCCCHH
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
GYAQKNQDKDLPRLIDELFWEPRYLPFRKKGWSE
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]