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The map label for this gene is hmgA [H]

Identifier: 148358827

GI number: 148358827

Start: 1493900

End: 1495150

Strand: Reverse

Name: hmgA [H]

Synonym: LPC_0710

Alternate gene names: 148358827

Gene position: 1495150-1493900 (Counterclockwise)

Preceding gene: 148358832

Following gene: 148358822

Centisome position: 41.81

GC content: 40.53

Gene sequence:

>1251_bases
GTGTATTTGCAAGGATTTGGTAATTATCACCACAGCGAGGCTGTTAAAGGAGCATTACCCCCAAATCAAAACTCACCTCA
ACACTGTAACTTAGGACTTTACGCAGAGCAATTGAGTGGAACCGCATTCACCCGTCCCCGACATAATAATCTTCGAAGCT
GGCTATATAGAATACTTCCTACTGTTACTCAGGGTACCTATTACCCCTATGAATTTAATATAATGCATTCTTTTGTTGAT
GAGTTCTCACCCAATGCCATGCGTTGGTCACCTCTTTATAACAGTTCTCAAATTAAATGTGATTTTGTTGAAGGGCTATT
TCATATTGCCGGTAGCCCGTTAGTCAATACCTATACTTATTATTGCAACCATTCCATGAGCGATAAATATTTCGCCAATA
ATGATGGTGAGTTATTATTTGTTCCTTATGCAGGCGAGATTCATCTGTATACTGAATTTGGCAAATTAATGCTCTCTTCC
GGATCGATCGCAGTGATACCTCGTGGCGTTAAATTTAAAGTGGAAGTAATCAGCAAGGAGGCAAAAGGTTATCTTTGCGA
AAATAGCGGAAATCCCTTAACCTTACCTCAATTAGGCCCCATTGGAGCCAATGGTTTGGCAAACCCACGACATTTTCAAT
ACCCAGTAGCCGCATTTGAAGATTCTGGCGGCGAGCATACTATAATCTGTAAAAACCAGAAAAAATTATGGTTTACTGTA
TGCAACCACTCTCCTTTAAATGTCGTGGCCTGGCATGGCAATTATGCACCATATTGTTATGATCTCAGTTTGTTCAATAC
AATTAACACAGTCAGTTTCGATCACCCTGATCCTTCCATATTCACTGTATTAACTTCAGAAAGCGAAATACCCGGTGTTT
CTAACTTGGACTTTGTTATTTTCCCACCTCGCTGGATGGTTGCCGAACATACTTTTAGACCACCTTATTTTCACAGAAAC
TACATGAATGAACTGATGGGACTTGTCTATGGTGAATATGACGCCAAGAAGGAAGGATTCATACCGGGCGGTATCAGCAT
CCATAATTGCATGACTCCACACGGCCCTGATTACGAATCTTACGAAATTGCTGCATCGCAGGATCTAAAACCAAATTATA
TCAACTCCCTGGCCTTTATGTTTGAAACCAAAGACTACTGGCAAGTAACTGAGCAAGCTTATAGGCACCCAAGCAGGCAA
GTGGATTATCTTAATTGTTGGCAAGGCTTTAAAGTAGAGTTTAGTCAATAA

Upstream 100 bases:

>100_bases
AACATCAAAAAGAATGACTAAAGCGAACGATGCTCTCGACAATTTGAACTTTTTTGGACTATCCTAGCACCATCAAAAAA
ATCTTGAAGGAGATTGAACT

Downstream 100 bases:

>100_bases
ATTGACTGCTTTTTAAGATGTAAAATTGACGGAAATTAATTAATTTGGCTTCAGTTGGGTCAATTTCGACCCAACTTGCA
TATAGTTAACTAGGTTAAAT

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MYLQGFGNYHHSEAVKGALPPNQNSPQHCNLGLYAEQLSGTAFTRPRHNNLRSWLYRILPTVTQGTYYPYEFNIMHSFVD
EFSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNTYTYYCNHSMSDKYFANNDGELLFVPYAGEIHLYTEFGKLMLSS
GSIAVIPRGVKFKVEVISKEAKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFEDSGGEHTIICKNQKKLWFTV
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVIFPPRWMVAEHTFRPPYFHRN
YMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYESYEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQ
VDYLNCWQGFKVEFSQ

Sequences:

>Translated_416_residues
MYLQGFGNYHHSEAVKGALPPNQNSPQHCNLGLYAEQLSGTAFTRPRHNNLRSWLYRILPTVTQGTYYPYEFNIMHSFVD
EFSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNTYTYYCNHSMSDKYFANNDGELLFVPYAGEIHLYTEFGKLMLSS
GSIAVIPRGVKFKVEVISKEAKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFEDSGGEHTIICKNQKKLWFTV
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVIFPPRWMVAEHTFRPPYFHRN
YMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYESYEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQ
VDYLNCWQGFKVEFSQ
>Mature_416_residues
MYLQGFGNYHHSEAVKGALPPNQNSPQHCNLGLYAEQLSGTAFTRPRHNNLRSWLYRILPTVTQGTYYPYEFNIMHSFVD
EFSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNTYTYYCNHSMSDKYFANNDGELLFVPYAGEIHLYTEFGKLMLSS
GSIAVIPRGVKFKVEVISKEAKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFEDSGGEHTIICKNQKKLWFTV
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVIFPPRWMVAEHTFRPPYFHRN
YMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYESYEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQ
VDYLNCWQGFKVEFSQ

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=433, Percent_Identity=48.9607390300231, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17507969, Length=429, Percent_Identity=48.7179487179487, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24583650, Length=431, Percent_Identity=46.4037122969838, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 47486; Mature: 47486

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLQGFGNYHHSEAVKGALPPNQNSPQHCNLGLYAEQLSGTAFTRPRHNNLRSWLYRILP
CEECCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEHHHHCCCEECCCCCCCHHHHHHHHHH
TVTQGTYYPYEFNIMHSFVDEFSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNTYTY
HHHCCEECCEEEHHHHHHHHHCCCCCEEECCCCCCCCEEEHHHHHHHHHCCCCHHEEEEE
YCNHSMSDKYFANNDGELLFVPYAGEIHLYTEFGKLMLSSGSIAVIPRGVKFKVEVISKE
EECCCCCCCEEECCCCCEEEEEECCCEEEEEECCCEEECCCCEEEEECCCEEEEEEEECC
AKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFEDSGGEHTIICKNQKKLWFTV
CCCEEEECCCCEEECCCCCCCCCCCCCCCCEEECCEEEEECCCCCEEEEECCCCEEEEEE
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVI
ECCCCCEEEEECCCCCCEEEEEEHHCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
FPPRWMVAEHTFRPPYFHRNYMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYES
ECCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
YEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQVDYLNCWQGFKVEFSQ
EEEEECCCCCCHHHHHEEEEEECCHHHHHHHHHHCCCCCCCCCEECCCCCEEEECC
>Mature Secondary Structure
MYLQGFGNYHHSEAVKGALPPNQNSPQHCNLGLYAEQLSGTAFTRPRHNNLRSWLYRILP
CEECCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEHHHHCCCEECCCCCCCHHHHHHHHHH
TVTQGTYYPYEFNIMHSFVDEFSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNTYTY
HHHCCEECCEEEHHHHHHHHHCCCCCEEECCCCCCCCEEEHHHHHHHHHCCCCHHEEEEE
YCNHSMSDKYFANNDGELLFVPYAGEIHLYTEFGKLMLSSGSIAVIPRGVKFKVEVISKE
EECCCCCCCEEECCCCCEEEEEECCCEEEEEECCCEEECCCCEEEEECCCEEEEEEEECC
AKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFEDSGGEHTIICKNQKKLWFTV
CCCEEEECCCCEEECCCCCCCCCCCCCCCCEEECCEEEEECCCCCEEEEECCCCEEEEEE
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVI
ECCCCCEEEEECCCCCCEEEEEEHHCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
FPPRWMVAEHTFRPPYFHRNYMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYES
ECCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
YEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQVDYLNCWQGFKVEFSQ
EEEEECCCCCCHHHHHEEEEEECCHHHHHHHHHHCCCCCCCCCEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA