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The map label for this gene is hisC [H]

Identifier: 148358784

GI number: 148358784

Start: 1448081

End: 1449175

Strand: Reverse

Name: hisC [H]

Synonym: LPC_0665

Alternate gene names: 148358784

Gene position: 1449175-1448081 (Counterclockwise)

Preceding gene: 148358785

Following gene: 148358783

Centisome position: 40.52

GC content: 38.26

Gene sequence:

>1095_bases
ATGTCCATACTCAATCTTGTTCGTGCAGATCTATTAAATAGTCAAAATTATGTCCCCGGTGGTGAGAGTGCTCGCTATCG
ATCACATGCCAATGAACTGCCTTGGTCACCAGTTACTATGGGGGAGCACAATTTAAATTATTACCCAAACATTGGCTTAC
AAATAGAGCTGCAAAAGCAATTGGCAAAACGTTATCAAATCAATTCCGATCAAATCATACTGACCAGAGGAAGTGATGAT
GGCATTGATTTGACAACCAGACTTTTTCTAACTGCCGGAAAAGACGCTTTCATGCAATTTCCCCCTACTTTTCCTATGTA
CGCTTTTTATGTTCGGCTACAACAAGCAGAATTGATCGAATGTCCTTTGGATAGAAGGACTAATTTTCGCCTCACCCTGG
ATCAAATTGAAAATAGCTGGAAACCAAACTGCAAAGTTATCATGTTTTGTAGTCCCAATAACCCGACTGGTAATTTGGTG
GATTTAAATTTAATTGCCAAGACATGTGAACTGTATGCGAATCAATCTATTATAGTTGTGGACGAGGCGTATATAGAGTT
TGCAAATGCACCAAGCGCTACGTCCTTAATTGGAGAGTTTGAAAATCTGATTGTCTTAAGAACCCTGTCGAAAGCCTTTG
GGCTGGCTGGATTACGCTTAGGCTGCATTATAGCCCAGAGTCCTATTATTCAAGCTTTTAATAAAATCATTGCCCCCTAT
TCCATTGCCACTCCTAGTATGGAGCTGGCTAAAAGAGCTTTGAATAATAGCGATTGGTTCACAAAAGCTATTGAGCAAAT
CAAATCATCTCGTGCCTGGGTTATAAAAAAATTCACCGATAATCCAATCATTCAAAAAATTTATCCTACTGAAACCAATT
TCATTCTCATTCAAACACGATTTTCAAAACAATTAACCACTTGGCTTGCCCATTATGGCATCGCAGTAAGAGATTTTCCT
TCGTCCTCTTTATTGCATGATCACCTTCGTATTACGGTGGGTCATGATGAGCAAAATCAATTATTGATTAATGCCTTATC
CTCATTTAACGCTGATGTAGCAGGATTAAATTATGAAAAAGATTTTATTTATTGA

Upstream 100 bases:

>100_bases
CCGTAATTTAGGTCCAGCGGCAATGACTTTAGCGGAAATAGAGGGTTTGGATGCTCATGCCAATGCCGTTCAAATAAGAC
TCAATACTCTGGGGGATTAA

Downstream 100 bases:

>100_bases
CCGCGATGGCACTTTAGTTGAAGAACCCTTTGATTTTCAAGTAGACTCTCTGGATAAAATTAAATTAACTTCTGGAGTAA
TACCAGCACTATTGCAATTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQLAKRYQINSDQIILTRGSDD
GIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLV
DLNLIAKTCELYANQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
SIATPSMELAKRALNNSDWFTKAIEQIKSSRAWVIKKFTDNPIIQKIYPTETNFILIQTRFSKQLTTWLAHYGIAVRDFP
SSSLLHDHLRITVGHDEQNQLLINALSSFNADVAGLNYEKDFIY

Sequences:

>Translated_364_residues
MSILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQLAKRYQINSDQIILTRGSDD
GIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLV
DLNLIAKTCELYANQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
SIATPSMELAKRALNNSDWFTKAIEQIKSSRAWVIKKFTDNPIIQKIYPTETNFILIQTRFSKQLTTWLAHYGIAVRDFP
SSSLLHDHLRITVGHDEQNQLLINALSSFNADVAGLNYEKDFIY
>Mature_363_residues
SILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQLAKRYQINSDQIILTRGSDDG
IDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLVD
LNLIAKTCELYANQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPYS
IATPSMELAKRALNNSDWFTKAIEQIKSSRAWVIKKFTDNPIIQKIYPTETNFILIQTRFSKQLTTWLAHYGIAVRDFPS
SSLLHDHLRITVGHDEQNQLLINALSSFNADVAGLNYEKDFIY

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=359, Percent_Identity=33.983286908078, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788722, Length=235, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=336, Percent_Identity=30.6547619047619, Blast_Score=140, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41236; Mature: 41105

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQ
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEECCCCCCCCCCCCCEEEEHHHH
LAKRYQINSDQIILTRGSDDGIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIE
HHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCHHHEECCCCCCHHHHHHHHHHHHHHC
CPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLVDLNLIAKTCELYANQSIIVV
CCCCCCCCEEEEHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHCCCCEEEE
DEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
EHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHCCC
SIATPSMELAKRALNNSDWFTKAIEQIKSSRAWVIKKFTDNPIIQKIYPTETNFILIQTR
CCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCEEEEEEC
FSKQLTTWLAHYGIAVRDFPSSSLLHDHLRITVGHDEQNQLLINALSSFNADVAGLNYEK
HHHHHHHHHHHCCEEEEECCCCHHEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCC
DFIY
CCCC
>Mature Secondary Structure 
SILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEHNLNYYPNIGLQIELQKQ
CHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEECCCCCCCCCCCCCEEEEHHHH
LAKRYQINSDQIILTRGSDDGIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIE
HHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCHHHEECCCCCCHHHHHHHHHHHHHHC
CPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLVDLNLIAKTCELYANQSIIVV
CCCCCCCCEEEEHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHCCCCEEEE
DEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
EHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHCCC
SIATPSMELAKRALNNSDWFTKAIEQIKSSRAWVIKKFTDNPIIQKIYPTETNFILIQTR
CCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCCEEEEEEC
FSKQLTTWLAHYGIAVRDFPSSSLLHDHLRITVGHDEQNQLLINALSSFNADVAGLNYEK
HHHHHHHHHHHCCEEEEECCCCHHEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCC
DFIY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA