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The map label for this gene is hisD [H]

Identifier: 148358785

GI number: 148358785

Start: 1449176

End: 1450471

Strand: Reverse

Name: hisD [H]

Synonym: LPC_0666

Alternate gene names: 148358785

Gene position: 1450471-1449176 (Counterclockwise)

Preceding gene: 148358786

Following gene: 148358784

Centisome position: 40.56

GC content: 41.98

Gene sequence:

>1296_bases
ATGCTAACGATAAAAAACTGGCAATTACTGCCTGAGAACGATAAAAGGCGATGCCTTTCAAGGCCACGAGACAATTCTGC
AATACAGGAAAATGTGCTGGAAATTATAAATCAGGTCCAATTATCAGGAGATAAAGCACTTTACGATTTAACCAAACGGT
TTGATAGAGTCAATTTACAATATTTACAGATCTCACAGGAAAAAATTAGACAAGCCAGCATACCGCAAAATGCCTTAATC
GCCATAAAACAAGCTATTGAAACAATCTCGTCATATCACCAGTCTTTGTTGCCTGAAAATACCGAGATTTCGACTGCATC
AGGAATTACAATCCGCAATGTCTACAGACCAATCCAAAAAGTTGGCTTGTATGTGCCTGGAGGAAATAAAACACCTTTAG
TTTCTTCACTTCTCATGCAGGCAATACCGGCAAAGGTAGCGGGCTGCCCAATAAAAGTGCTTTGTACCCCCCCTGATGCA
GAAGGGGAAATTAACGAGCATATCCTGGTAGCTGCAAGATTATGTGGTATCGACACAATTTACGCTATAGGTGGAGCTCA
AGCCATAGCAGCTATGGCTTATGGCACTGAAAGTGTCATCAAAGTGGATAAAATATTCGGACCGGGTAATAGCTATGTCA
CTCAGGCAAAAACTTTAGTTGCAATTGACGCCGACGGAGCTGCGATTGACATGCCCGCTGGGCCATCTGAAGTAATGATT
CTTGCAGATACTGAGGCAAACCCTGAATTTATTGCTGCAGATTTATTAGCCCAGGCTGAACATGGCCCGGATTCACAGGT
TATTTTAATTTGTGATGAATGTGAATTGGCAAACCAGGTTAATCAACAGCTGGAAATTCAGATGAGTTACTTGTCAAGAA
TAGAATTTATCAAACAATCTCTTGCGAATAGCAGGATAATTATCTGTTCTAATCAATCGGAACAGCTGGATATTATCAAC
TCCTACGCTCCGGAACACCTGATCATTAACAGAAAAAACCCCGAACCATGGATTGAGAAAATCGTAGCTGCCGGAACAGT
ATTTCTTGGCTCTTGGGCCGCAGAAACAATGGGTGACTATGTAACAGGAAGCAATCACGTCTTACCTACCAGTGGTTTTT
CCAGAAATCATAGCGGGCTTTCTACTCTTGATTTTATGACACGATTTACCGTGCAAGCCATAAATCAGGAGGCTATCCGT
AATTTAGGTCCAGCGGCAATGACTTTAGCGGAAATAGAGGGTTTGGATGCTCATGCCAATGCCGTTCAAATAAGACTCAA
TACTCTGGGGGATTAA

Upstream 100 bases:

>100_bases
CCAGTGAAGGTGTTTTTTGGAATACTTTAGAGACTATCCAATATTTAGGTGCCAGCTCCATCCTGGTATTACCTATTGAA
AAGATGCTGGAGTAATTCAT

Downstream 100 bases:

>100_bases
ATGTCCATACTCAATCTTGTTCGTGCAGATCTATTAAATAGTCAAAATTATGTCCCCGGTGGTGAGAGTGCTCGCTATCG
ATCACATGCCAATGAACTGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLTIKNWQLLPENDKRRCLSRPRDNSAIQENVLEIINQVQLSGDKALYDLTKRFDRVNLQYLQISQEKIRQASIPQNALI
AIKQAIETISSYHQSLLPENTEISTASGITIRNVYRPIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDA
EGEINEHILVAARLCGIDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPSEVMI
LADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEFIKQSLANSRIIICSNQSEQLDIIN
SYAPEHLIINRKNPEPWIEKIVAAGTVFLGSWAAETMGDYVTGSNHVLPTSGFSRNHSGLSTLDFMTRFTVQAINQEAIR
NLGPAAMTLAEIEGLDAHANAVQIRLNTLGD

Sequences:

>Translated_431_residues
MLTIKNWQLLPENDKRRCLSRPRDNSAIQENVLEIINQVQLSGDKALYDLTKRFDRVNLQYLQISQEKIRQASIPQNALI
AIKQAIETISSYHQSLLPENTEISTASGITIRNVYRPIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDA
EGEINEHILVAARLCGIDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPSEVMI
LADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEFIKQSLANSRIIICSNQSEQLDIIN
SYAPEHLIINRKNPEPWIEKIVAAGTVFLGSWAAETMGDYVTGSNHVLPTSGFSRNHSGLSTLDFMTRFTVQAINQEAIR
NLGPAAMTLAEIEGLDAHANAVQIRLNTLGD
>Mature_431_residues
MLTIKNWQLLPENDKRRCLSRPRDNSAIQENVLEIINQVQLSGDKALYDLTKRFDRVNLQYLQISQEKIRQASIPQNALI
AIKQAIETISSYHQSLLPENTEISTASGITIRNVYRPIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDA
EGEINEHILVAARLCGIDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPSEVMI
LADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEFIKQSLANSRIIICSNQSEQLDIIN
SYAPEHLIINRKNPEPWIEKIVAAGTVFLGSWAAETMGDYVTGSNHVLPTSGFSRNHSGLSTLDFMTRFTVQAINQEAIR
NLGPAAMTLAEIEGLDAHANAVQIRLNTLGD

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=435, Percent_Identity=45.0574712643678, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319819, Length=434, Percent_Identity=40.3225806451613, Blast_Score=315, Evalue=8e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46942; Mature: 46942

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIKNWQLLPENDKRRCLSRPRDNSAIQENVLEIINQVQLSGDKALYDLTKRFDRVNLQ
CEEECCCEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEE
YLQISQEKIRQASIPQNALIAIKQAIETISSYHQSLLPENTEISTASGITIRNVYRPIQK
EEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
VGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDAEGEINEHILVAARLCGIDTI
CEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHEEHHHHHCCHHH
YAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPSEVMI
HHHCCHHHHHHHHCCCHHHEEEEEEECCCCCCEECCEEEEEEECCCCEEECCCCCCCEEE
LADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEFIKQS
EEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LANSRIIICSNQSEQLDIINSYAPEHLIINRKNPEPWIEKIVAAGTVFLGSWAAETMGDY
HCCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHCCC
VTGSNHVLPTSGFSRNHSGLSTLDFMTRFTVQAINQEAIRNLGPAAMTLAEIEGLDAHAN
CCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCCCCCCC
AVQIRLNTLGD
EEEEEEECCCC
>Mature Secondary Structure
MLTIKNWQLLPENDKRRCLSRPRDNSAIQENVLEIINQVQLSGDKALYDLTKRFDRVNLQ
CEEECCCEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEE
YLQISQEKIRQASIPQNALIAIKQAIETISSYHQSLLPENTEISTASGITIRNVYRPIQK
EEEECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
VGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDAEGEINEHILVAARLCGIDTI
CEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHEEHHHHHCCHHH
YAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPSEVMI
HHHCCHHHHHHHHCCCHHHEEEEEEECCCCCCEECCEEEEEEECCCCEEECCCCCCCEEE
LADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEFIKQS
EEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LANSRIIICSNQSEQLDIINSYAPEHLIINRKNPEPWIEKIVAAGTVFLGSWAAETMGDY
HCCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHCCC
VTGSNHVLPTSGFSRNHSGLSTLDFMTRFTVQAINQEAIRNLGPAAMTLAEIEGLDAHAN
CCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHCCCCCCCC
AVQIRLNTLGD
EEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA