Click here to switch to the map view.

The map label for this gene is hisB [H]

Identifier: 148358783

GI number: 148358783

Start: 1447045

End: 1448103

Strand: Reverse

Name: hisB [H]

Synonym: LPC_0664

Alternate gene names: 148358783

Gene position: 1448103-1447045 (Counterclockwise)

Preceding gene: 148358784

Following gene: 148358782

Centisome position: 40.49

GC content: 40.13

Gene sequence:

>1059_bases
ATGAAAAAGATTTTATTTATTGACCGCGATGGCACTTTAGTTGAAGAACCCTTTGATTTTCAAGTAGACTCTCTGGATAA
AATTAAATTAACTTCTGGAGTAATACCAGCACTATTGCAATTACAAAAAGCTGGCTTTACCTTCATTATGGTATCCAATC
AAAATGGCATAGGAACCGTAACTTTTCCAGAAGAGGATTTTGCTGTTTGCCATGAATTTATCCTGGATCTGTTTTCCTCT
CAAGGCATTCTTTTTGATGAGATTTTTATATGCCCTCACACCCCTGAAGACAATTGTATTTGTAGAAAACCTAAAACTGG
CTTGCTCGAACCTTACTTAAAAGAAACAGCATTTGCCAAACAATATTCATGGGTAATTGGCGACCGGGATACTGATAAAG
AGTTTGCTGATAATCTGGGCGTTAATTTCTTGCCCATTTCGAAAACACATACTTGGAAAATGGTGGTTTCTGCAATTATC
AACGATGCTCGCAAAGCGTCTGTGCAAAGAAAAACAAAAGAGACGTCAATAGATTTGTCAGTTCAACTGGATAGCGATCA
AACCAGTGTTATAGACACCCCTATCCCTTTCTTCACTCACATGTTGGAACAAGTAGCAAAGCACGGGGGCTTTGATTTGC
GATTGCAAGCTTCTGGAGATTTGGAAGTAGATGAGCACCACTTGATTGAGGATACAGCCATTGCGTTAGGAGAAGCAATT
AGAACAGCGCTGGGTGACAAATGGGGAATTAACCGTTACGGTTATACTCTTCCTATGGATGAATCATTAGCTACCATTGC
AATCGATATTAGTGGCAGAAGTTTTTGTGACTTCAAAGGTCAGTTTACTCGTGAATTTATTGGCGGTATGGCAACAGAAA
TGATCCCTCACTTTTTCCAATCACTATCGAGTGCGTTGGGGGCGACTATCCATATCCAGGTAACAGGCACCAATCATCAC
CACATGATCGAAGCATGCTTCAAAGTTTTAGGTAGAGCCTTGCGACAGGCATGCTCAAGAACGAATAATTATCTACCTTC
AACCAAGGGTGTATTATGA

Upstream 100 bases:

>100_bases
TTGCATGATCACCTTCGTATTACGGTGGGTCATGATGAGCAAAATCAATTATTGATTAATGCCTTATCCTCATTTAACGC
TGATGTAGCAGGATTAAATT

Downstream 100 bases:

>100_bases
TTGCTGTGATTGATGTCAGTGGTAATAATTTAACTTCTCTGACAAATGCATTGATTCGATTGGGAGGGCATTTTGCACTG
ACCCATGATGCTGAAGAAAT

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKKILFIDRDGTLVEEPFDFQVDSLDKIKLTSGVIPALLQLQKAGFTFIMVSNQNGIGTVTFPEEDFAVCHEFILDLFSS
QGILFDEIFICPHTPEDNCICRKPKTGLLEPYLKETAFAKQYSWVIGDRDTDKEFADNLGVNFLPISKTHTWKMVVSAII
NDARKASVQRKTKETSIDLSVQLDSDQTSVIDTPIPFFTHMLEQVAKHGGFDLRLQASGDLEVDEHHLIEDTAIALGEAI
RTALGDKWGINRYGYTLPMDESLATIAIDISGRSFCDFKGQFTREFIGGMATEMIPHFFQSLSSALGATIHIQVTGTNHH
HMIEACFKVLGRALRQACSRTNNYLPSTKGVL

Sequences:

>Translated_352_residues
MKKILFIDRDGTLVEEPFDFQVDSLDKIKLTSGVIPALLQLQKAGFTFIMVSNQNGIGTVTFPEEDFAVCHEFILDLFSS
QGILFDEIFICPHTPEDNCICRKPKTGLLEPYLKETAFAKQYSWVIGDRDTDKEFADNLGVNFLPISKTHTWKMVVSAII
NDARKASVQRKTKETSIDLSVQLDSDQTSVIDTPIPFFTHMLEQVAKHGGFDLRLQASGDLEVDEHHLIEDTAIALGEAI
RTALGDKWGINRYGYTLPMDESLATIAIDISGRSFCDFKGQFTREFIGGMATEMIPHFFQSLSSALGATIHIQVTGTNHH
HMIEACFKVLGRALRQACSRTNNYLPSTKGVL
>Mature_352_residues
MKKILFIDRDGTLVEEPFDFQVDSLDKIKLTSGVIPALLQLQKAGFTFIMVSNQNGIGTVTFPEEDFAVCHEFILDLFSS
QGILFDEIFICPHTPEDNCICRKPKTGLLEPYLKETAFAKQYSWVIGDRDTDKEFADNLGVNFLPISKTHTWKMVVSAII
NDARKASVQRKTKETSIDLSVQLDSDQTSVIDTPIPFFTHMLEQVAKHGGFDLRLQASGDLEVDEHHLIEDTAIALGEAI
RTALGDKWGINRYGYTLPMDESLATIAIDISGRSFCDFKGQFTREFIGGMATEMIPHFFQSLSSALGATIHIQVTGTNHH
HMIEACFKVLGRALRQACSRTNNYLPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=353, Percent_Identity=51.2747875354108, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1786399, Length=150, Percent_Identity=31.3333333333333, Blast_Score=78, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=37.5, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 39286; Mature: 39286

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2 ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILFIDRDGTLVEEPFDFQVDSLDKIKLTSGVIPALLQLQKAGFTFIMVSNQNGIGTV
CCEEEEEECCCCEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCEEEEEEECCCCEEEE
TFPEEDFAVCHEFILDLFSSQGILFDEIFICPHTPEDNCICRKPKTGLLEPYLKETAFAK
ECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHH
QYSWVIGDRDTDKEFADNLGVNFLPISKTHTWKMVVSAIINDARKASVQRKTKETSIDLS
HHEEEECCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
VQLDSDQTSVIDTPIPFFTHMLEQVAKHGGFDLRLQASGDLEVDEHHLIEDTAIALGEAI
EEECCCCCEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
RTALGDKWGINRYGYTLPMDESLATIAIDISGRSFCDFKGQFTREFIGGMATEMIPHFFQ
HHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHH
SLSSALGATIHIQVTGTNHHHMIEACFKVLGRALRQACSRTNNYLPSTKGVL
HHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKKILFIDRDGTLVEEPFDFQVDSLDKIKLTSGVIPALLQLQKAGFTFIMVSNQNGIGTV
CCEEEEEECCCCEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCEEEEEEECCCCEEEE
TFPEEDFAVCHEFILDLFSSQGILFDEIFICPHTPEDNCICRKPKTGLLEPYLKETAFAK
ECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHH
QYSWVIGDRDTDKEFADNLGVNFLPISKTHTWKMVVSAIINDARKASVQRKTKETSIDLS
HHEEEECCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
VQLDSDQTSVIDTPIPFFTHMLEQVAKHGGFDLRLQASGDLEVDEHHLIEDTAIALGEAI
EEECCCCCEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
RTALGDKWGINRYGYTLPMDESLATIAIDISGRSFCDFKGQFTREFIGGMATEMIPHFFQ
HHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHH
SLSSALGATIHIQVTGTNHHHMIEACFKVLGRALRQACSRTNNYLPSTKGVL
HHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA