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The map label for this gene is lagD [H]

Identifier: 148358434

GI number: 148358434

Start: 312759

End: 314348

Strand: Direct

Name: lagD [H]

Synonym: LPC_0300

Alternate gene names: 148358434

Gene position: 312759-314348 (Clockwise)

Preceding gene: 148358433

Following gene: 148358435

Centisome position: 8.74

GC content: 36.6

Gene sequence:

>1590_bases
ATGAATGCAAAACCAATTAATTCAATTATTGATGTATTAGATCGCCAAACAATCTCATCCATCGCGATGATTAGTGTGAT
TATCAGCTTACTGTCATTGAGTATCCCCATTGCTGCCCAAACACTTGTGAATTTAATTGCTTTTGGCAAGCTATTACAAC
CCGTCATTACATTAAGTTTGATGGTATTGGTTTTGATGATGGCTCTAGGTGCTCTCCATATATGGCAAATTGTAATTATT
GAGGTAATTCAGCAAAAACTGATGGTTAAAGTCAGTTTAAGTCTGACACGACATTTTACCCACATGTCCCTTGATAATTT
TTCGACACATCATGGACCGGAGTTGGTCAATCGATTTTTTGAAATAGTCACTATCAAAAAATCACTGGCAAGTTTATTGT
TATATGGCATTAATTTGGGGTTACAACTTTTTTTTGGACTATTGCTGATTCTAATTTATCACCCTCTTTTCCTTTTGTTT
GATATTTTCATCATTATTGGCATTCTATTGATCATTTTTATCCCCTATAAAAAAGCATTAGACAGCGCTAAAAAAGAATG
CTCTGAAAAACACGTCGTAGGCGCTTGGTTAGAGGAAATTTTGATTAACCGGTACCTGTTCCGTTTTAATTTACACCACC
GTTATGTGACGCAACAAACGGATAAAAAATTGGTTGCTTTCTTAAAAGCAAGAAACACCCATTTTAAGCAACTTATCAAG
CATCAAATCGGTTTTTACATGCTGTCTGCTTTGGCCAGCAGCCTTTTATTGGGATTGGGGGGCTATCTTGTTATTAATAA
TCAATTAAGTCTGGGCCAATTGGTTGCCGCAGAAATCGTTTTAGGTGCTCTGATTTACTCATTTAGACGCTTTGGTGCCC
TTTTAGAAAATTATTATGATCTGGTCGCCTCAGAAAATAAAATCGATGCAGTACTTAACCTGTCACTTGAACAGGTGAAA
GAAGATGAGCACGGTGAGTTATTGACTCCAATTAATAGTATCCAGCTAGAGATGGATAGCAAGAATAAGGCATTGATAGC
AGTTGATAAGCCTTTATTGGTGTTTTCGGAAAAATCAGATTTATGCCAATTGTTTGTTGAGCAACTATTTGGGTTCCAAG
ATCCTGTGTCACTTCATGTGCTTATTAACGAGATTCCTTGTGCGAAAAGAACCCTCATTTCTCTTCGTCGTTTTAGTTTA
TTGATTGCTGAACCCCAGTGGTTTACCGGAAGCATTTATGACAATTTAGTACTTAATCATCGTAATATGTCTAACAAAAT
CATTATTGAACAATTACAGAATGTTGGACTTGCTGATAAAATCATACAACTGCCGGAAGGTCTACACACCATTGTCTATG
AATGGCAGGATGTGTTTACTTCAGTTGAGCTCACCAAATTGATGTTGGTCAGGGCTCTTCTATTACAACCTGAATTAATT
GTTATTGATCGCGCTTTTGACATCCTTAATCATCAAGAAGTGAATGAGATGATGGAATTGGTATTGTCTTTAAAAAATAC
GCTACTACTGATCGTGAGCCAACGGTCCGATTTTAACTATTTAAATAACCGCCTGGTGATTTCCTCATGA

Upstream 100 bases:

>100_bases
ACAGCAATAAAGCAATTGAATCGCTTGAGTTTTTTATATTGCAAAAATTAAAACATTAATAGCATAAACAAGAATCAAGG
GTAAAAGGGATGTTTAGGGA

Downstream 100 bases:

>100_bases
AATTACATGCTTATTCTATGATTAGTAAACTTCCCAAGCCTCAAAAAATAGCGAAAATAATTTTCATTGTTTTTGTTGCC
ATTATTCTTTTCTTAAGTTT

Product: toxin secretion ABC transporter HlyB/MsbA family transporter ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MNAKPINSIIDVLDRQTISSIAMISVIISLLSLSIPIAAQTLVNLIAFGKLLQPVITLSLMVLVLMMALGALHIWQIVII
EVIQQKLMVKVSLSLTRHFTHMSLDNFSTHHGPELVNRFFEIVTIKKSLASLLLYGINLGLQLFFGLLLILIYHPLFLLF
DIFIIIGILLIIFIPYKKALDSAKKECSEKHVVGAWLEEILINRYLFRFNLHHRYVTQQTDKKLVAFLKARNTHFKQLIK
HQIGFYMLSALASSLLLGLGGYLVINNQLSLGQLVAAEIVLGALIYSFRRFGALLENYYDLVASENKIDAVLNLSLEQVK
EDEHGELLTPINSIQLEMDSKNKALIAVDKPLLVFSEKSDLCQLFVEQLFGFQDPVSLHVLINEIPCAKRTLISLRRFSL
LIAEPQWFTGSIYDNLVLNHRNMSNKIIIEQLQNVGLADKIIQLPEGLHTIVYEWQDVFTSVELTKLMLVRALLLQPELI
VIDRAFDILNHQEVNEMMELVLSLKNTLLLIVSQRSDFNYLNNRLVISS

Sequences:

>Translated_529_residues
MNAKPINSIIDVLDRQTISSIAMISVIISLLSLSIPIAAQTLVNLIAFGKLLQPVITLSLMVLVLMMALGALHIWQIVII
EVIQQKLMVKVSLSLTRHFTHMSLDNFSTHHGPELVNRFFEIVTIKKSLASLLLYGINLGLQLFFGLLLILIYHPLFLLF
DIFIIIGILLIIFIPYKKALDSAKKECSEKHVVGAWLEEILINRYLFRFNLHHRYVTQQTDKKLVAFLKARNTHFKQLIK
HQIGFYMLSALASSLLLGLGGYLVINNQLSLGQLVAAEIVLGALIYSFRRFGALLENYYDLVASENKIDAVLNLSLEQVK
EDEHGELLTPINSIQLEMDSKNKALIAVDKPLLVFSEKSDLCQLFVEQLFGFQDPVSLHVLINEIPCAKRTLISLRRFSL
LIAEPQWFTGSIYDNLVLNHRNMSNKIIIEQLQNVGLADKIIQLPEGLHTIVYEWQDVFTSVELTKLMLVRALLLQPELI
VIDRAFDILNHQEVNEMMELVLSLKNTLLLIVSQRSDFNYLNNRLVISS
>Mature_529_residues
MNAKPINSIIDVLDRQTISSIAMISVIISLLSLSIPIAAQTLVNLIAFGKLLQPVITLSLMVLVLMMALGALHIWQIVII
EVIQQKLMVKVSLSLTRHFTHMSLDNFSTHHGPELVNRFFEIVTIKKSLASLLLYGINLGLQLFFGLLLILIYHPLFLLF
DIFIIIGILLIIFIPYKKALDSAKKECSEKHVVGAWLEEILINRYLFRFNLHHRYVTQQTDKKLVAFLKARNTHFKQLIK
HQIGFYMLSALASSLLLGLGGYLVINNQLSLGQLVAAEIVLGALIYSFRRFGALLENYYDLVASENKIDAVLNLSLEQVK
EDEHGELLTPINSIQLEMDSKNKALIAVDKPLLVFSEKSDLCQLFVEQLFGFQDPVSLHVLINEIPCAKRTLISLRRFSL
LIAEPQWFTGSIYDNLVLNHRNMSNKIIIEQLQNVGLADKIIQLPEGLHTIVYEWQDVFTSVELTKLMLVRALLLQPELI
VIDRAFDILNHQEVNEMMELVLSLKNTLLLIVSQRSDFNYLNNRLVISS

Specific function: LagD (TC 3.A.1) is involved in processing the signal peptide and probably also in export of the bacteriocin lactococcin G [H]

COG id: COG2274

COG function: function code V; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 peptidase C39 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR005897
- InterPro:   IPR005074 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran; PF03412 Peptidase_C39 [H]

EC number: NA

Molecular weight: Translated: 60111; Mature: 60111

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHCCEEEECC
>Mature Secondary Structure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EEHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7565085 [H]