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The map label for this gene is lpd3 [H]

Identifier: 148260619

GI number: 148260619

Start: 1789181

End: 1790572

Strand: Reverse

Name: lpd3 [H]

Synonym: Acry_1621

Alternate gene names: 148260619

Gene position: 1790572-1789181 (Counterclockwise)

Preceding gene: 148260620

Following gene: 148260610

Centisome position: 52.83

GC content: 67.67

Gene sequence:

>1392_bases
ATGGCCGATCAGTTCGACGTCATCGTCATCGGGGCCGGTCCGGGCGGCTATGTCTGCGCCATCCGCGCCGCCCAGCTCGG
CATGAAGGTCGCGTGCGTGGAAAAGCGCGCGACCCTCGGCGGCACCTGCCTCAATGTGGGCTGCATCCCCTCCAAGGCGC
TGCTGCAATCGTCCGAGAACTACCACGAGCTCCTGCACGGCTTCGCCCGCCACGGCGTCTCCGCCGAGAACGTGTCCTTC
GATCTCGGCAAGATGATGGGCCACAAGGACGAGGTCGTCGGCGCCAACACCAAGGGCGTCGAGTTCCTGTTCAAGAAGAA
CAAGGTCACCTGGCTCAAGGGCGCCGCGTCGTTCAAATCCGCCAACACGATCGTGGTGGACGGCAAGGAATACGGCGCAA
GACACATCGTCATCGCCACCGGAAGCGAGAGCGTGCCGCTCCCCGGCGTCGAGGTCGACGAGACGCAGATCGTCACCTCC
ACCGGCGCCATCGCGCTGGAGAGCGTGCCGAAGCATCTCGTGGTGATCGGCGGCGGCTATATCGGCCTCGAACTCGGCAG
CGTCTGGCGCCGCCTCGGCGCCGAGGTCACCGTGGTCGAGTTCCTCGACCGGCTGGTGCCGACGATGGATGGCGAGGTCG
CCACCGCCTTCCAGAAAACCCTCGGCAAGCTCGGCATGAAGTTCAAGCTCGGCACCAAGGTCACCGGTGCGGCGAAGACC
GCCAAGGGCGTCACCCTCACGCTCGAACCCGCCAAGGGCGGCGCCGCCGAAACGCTGGAGGCGGATGTCGTGCTCGTCGC
GATCGGCCGCCGCGCCCATACCGAAGGGCTCGGGCTCGACGCGGTGGGTGTGGCGACCGACGAGCGCGGCCGGGTGAAGA
CGAATGGCCACTACGCCACCAGCGTCCCCGGCATCTACGCGATCGGCGACGTCATCGCCGGGCCGATGCTCGCCCACAAG
GCCGAGGAAGAGGGCGTCGCCCTCGCCGAGCTGCTGGCCGGTCAGGCGGGCCATGTGAACTACGGCGCCATCCCCGGCGT
GGTCTACACCTGGCCGGAAGTCGCCTCCGTCGGCAAGACCGAGGAAGAGCTCAAAGCCGAAGGCGTCGCCTACAAGGTCG
GCAAATTCCCGTTCACGGCGAATGGCCGCGCCCGCGCCATGGGCGATACCGACGGGTTCGTGAAACTCCTCTCCGACAAG
ACGACCGACAAGCTGCTCGGCGCCCACATCATCGGGCCGGATGCCGGCACGATCATCGCCGAGCTGGTGCTGGCGATCGA
GTTCGGCGCCTCGGCCGAGGATGTCGCGCGCACCAGCCACGCCCATCCCTCGCTCAACGAGGCGGTGAAGGAAGCGGCGC
TGGCGGTCGACGGGCGGGCGCTGCACATCTGA

Upstream 100 bases:

>100_bases
CGCATCATCGACGGGCGCGAGGCGGTCTCCTTCCTCGTCCGGGTGAAGGAGAGCATCGAGGATCCGCGCCGCCTGCTGCT
GGACATCTGAGGAGCGCATC

Downstream 100 bases:

>100_bases
CGTTCCGTCGGATGAACTAAATTTCCCGTGTCCCGATCTCCGTGCAGGAGATCGGGACATTTCGTTCCGCGTTCAGGACA
TCAGGGCAGATCGATGTCCA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MADQFDVIVIGAGPGGYVCAIRAAQLGMKVACVEKRATLGGTCLNVGCIPSKALLQSSENYHELLHGFARHGVSAENVSF
DLGKMMGHKDEVVGANTKGVEFLFKKNKVTWLKGAASFKSANTIVVDGKEYGARHIVIATGSESVPLPGVEVDETQIVTS
TGAIALESVPKHLVVIGGGYIGLELGSVWRRLGAEVTVVEFLDRLVPTMDGEVATAFQKTLGKLGMKFKLGTKVTGAAKT
AKGVTLTLEPAKGGAAETLEADVVLVAIGRRAHTEGLGLDAVGVATDERGRVKTNGHYATSVPGIYAIGDVIAGPMLAHK
AEEEGVALAELLAGQAGHVNYGAIPGVVYTWPEVASVGKTEEELKAEGVAYKVGKFPFTANGRARAMGDTDGFVKLLSDK
TTDKLLGAHIIGPDAGTIIAELVLAIEFGASAEDVARTSHAHPSLNEAVKEAALAVDGRALHI

Sequences:

>Translated_463_residues
MADQFDVIVIGAGPGGYVCAIRAAQLGMKVACVEKRATLGGTCLNVGCIPSKALLQSSENYHELLHGFARHGVSAENVSF
DLGKMMGHKDEVVGANTKGVEFLFKKNKVTWLKGAASFKSANTIVVDGKEYGARHIVIATGSESVPLPGVEVDETQIVTS
TGAIALESVPKHLVVIGGGYIGLELGSVWRRLGAEVTVVEFLDRLVPTMDGEVATAFQKTLGKLGMKFKLGTKVTGAAKT
AKGVTLTLEPAKGGAAETLEADVVLVAIGRRAHTEGLGLDAVGVATDERGRVKTNGHYATSVPGIYAIGDVIAGPMLAHK
AEEEGVALAELLAGQAGHVNYGAIPGVVYTWPEVASVGKTEEELKAEGVAYKVGKFPFTANGRARAMGDTDGFVKLLSDK
TTDKLLGAHIIGPDAGTIIAELVLAIEFGASAEDVARTSHAHPSLNEAVKEAALAVDGRALHI
>Mature_462_residues
ADQFDVIVIGAGPGGYVCAIRAAQLGMKVACVEKRATLGGTCLNVGCIPSKALLQSSENYHELLHGFARHGVSAENVSFD
LGKMMGHKDEVVGANTKGVEFLFKKNKVTWLKGAASFKSANTIVVDGKEYGARHIVIATGSESVPLPGVEVDETQIVTST
GAIALESVPKHLVVIGGGYIGLELGSVWRRLGAEVTVVEFLDRLVPTMDGEVATAFQKTLGKLGMKFKLGTKVTGAAKTA
KGVTLTLEPAKGGAAETLEADVVLVAIGRRAHTEGLGLDAVGVATDERGRVKTNGHYATSVPGIYAIGDVIAGPMLAHKA
EEEGVALAELLAGQAGHVNYGAIPGVVYTWPEVASVGKTEEELKAEGVAYKVGKFPFTANGRARAMGDTDGFVKLLSDKT
TDKLLGAHIIGPDAGTIIAELVLAIEFGASAEDVARTSHAHPSLNEAVKEAALAVDGRALHI

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=54.6840958605665, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=30.2832244008715, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI22035672, Length=463, Percent_Identity=31.9654427645788, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=27.7292576419214, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=27.4841437632135, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=27.4841437632135, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=27.4841437632135, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=27.4841437632135, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=27.4841437632135, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI291045268, Length=450, Percent_Identity=26.2222222222222, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=40.7894736842105, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=31.1688311688312, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=30.8045977011494, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=27.8260869565217, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=57.6754385964912, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=30.6079664570231, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71983419, Length=364, Percent_Identity=31.043956043956, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=364, Percent_Identity=31.043956043956, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=26.875, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17559934, Length=267, Percent_Identity=22.8464419475655, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=52.6539278131635, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=35.1063829787234, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6325166, Length=460, Percent_Identity=28.0434782608696, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=58.6433260393873, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17737741, Length=483, Percent_Identity=30.0207039337474, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24640549, Length=485, Percent_Identity=29.2783505154639, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24640553, Length=485, Percent_Identity=29.2783505154639, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24640551, Length=489, Percent_Identity=29.6523517382413, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48092; Mature: 47961

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQFDVIVIGAGPGGYVCAIRAAQLGMKVACVEKRATLGGTCLNVGCIPSKALLQSSEN
CCCCEEEEEEECCCCCEEEEEEHHHCCCEEEEEHHCCCCCCCEEEECCCCCHHHHHCCCC
YHELLHGFARHGVSAENVSFDLGKMMGHKDEVVGANTKGVEFLFKKNKVTWLKGAASFKS
HHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCEECCCCCCEEEEEECCCEEEEECCCCCCC
ANTIVVDGKEYGARHIVIATGSESVPLPGVEVDETQIVTSTGAIALESVPKHLVVIGGGY
CCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEECCCCEEEEEECCE
IGLELGSVWRRLGAEVTVVEFLDRLVPTMDGEVATAFQKTLGKLGMKFKLGTKVTGAAKT
EEEHHHHHHHHHCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCEECCCCCC
AKGVTLTLEPAKGGAAETLEADVVLVAIGRRAHTEGLGLDAVGVATDERGRVKTNGHYAT
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCEEECCEEEE
SVPGIYAIGDVIAGPMLAHKAEEEGVALAELLAGQAGHVNYGAIPGVVYTWPEVASVGKT
CCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEECHHHHHCCCC
EEELKAEGVAYKVGKFPFTANGRARAMGDTDGFVKLLSDKTTDKLLGAHIIGPDAGTIIA
HHHHHHCCCEEEECCCCCCCCCCEEECCCCCHHHHHHCCCCHHHHHCEEEECCCHHHHHH
ELVLAIEFGASAEDVARTSHAHPSLNEAVKEAALAVDGRALHI
HHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHEECCEEECC
>Mature Secondary Structure 
ADQFDVIVIGAGPGGYVCAIRAAQLGMKVACVEKRATLGGTCLNVGCIPSKALLQSSEN
CCCEEEEEEECCCCCEEEEEEHHHCCCEEEEEHHCCCCCCCEEEECCCCCHHHHHCCCC
YHELLHGFARHGVSAENVSFDLGKMMGHKDEVVGANTKGVEFLFKKNKVTWLKGAASFKS
HHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCEECCCCCCEEEEEECCCEEEEECCCCCCC
ANTIVVDGKEYGARHIVIATGSESVPLPGVEVDETQIVTSTGAIALESVPKHLVVIGGGY
CCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEECCCCEEEEEECCE
IGLELGSVWRRLGAEVTVVEFLDRLVPTMDGEVATAFQKTLGKLGMKFKLGTKVTGAAKT
EEEHHHHHHHHHCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCEECCCCCC
AKGVTLTLEPAKGGAAETLEADVVLVAIGRRAHTEGLGLDAVGVATDERGRVKTNGHYAT
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCEEECCEEEE
SVPGIYAIGDVIAGPMLAHKAEEEGVALAELLAGQAGHVNYGAIPGVVYTWPEVASVGKT
CCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEECHHHHHCCCC
EEELKAEGVAYKVGKFPFTANGRARAMGDTDGFVKLLSDKTTDKLLGAHIIGPDAGTIIA
HHHHHHCCCEEEECCCCCCCCCCEEECCCCCHHHHHHCCCCHHHHHCEEEECCCHHHHHH
ELVLAIEFGASAEDVARTSHAHPSLNEAVKEAALAVDGRALHI
HHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1722146; 2914869 [H]