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The map label for this gene is trpC [H]

Identifier: 148260235

GI number: 148260235

Start: 1370952

End: 1371764

Strand: Reverse

Name: trpC [H]

Synonym: Acry_1232

Alternate gene names: 148260235

Gene position: 1371764-1370952 (Counterclockwise)

Preceding gene: 148260236

Following gene: 148260234

Centisome position: 40.47

GC content: 69.13

Gene sequence:

>813_bases
ATGAACGACAAGATCGAACACGACGTGCTGAAGACGATCTGCGCCGACAAGCTGGCCGAGGTGGAGGCGGCGAAGGCGGA
GACCGGGCTGGAGGAGATGCGCGCACGGGCGAAGGACACGCCGCCGCCGCGCGGCTTCGCCCGCGCGCTGATGGACGCCG
CCGCCTCCGGGCGGACCGGGCTGATCGCCGAGATCAAGAAGGCGTCGCCCTCGGCCGGGCTGATCCGCGCCGATTTCAAC
CCGGCGACGATCGCCCGCGCCTATCAGGAGGGCGGGGCGGTGTGCCTTTCGGTGCTGACCGACCGGAAATATTTCCAGGG
CCAGCCCGCGCACCTGCAGGCGGCGCGCGAGGCGGTGGACCTGCCGGTGCTGCGCAAGGATTTCATCCTCGACGAGTGGC
AGATCTACGAAAGCCGCGCGATGGGGGCGGACTGCATCCTGCTGATCATGGCGGCGCTGGGCGACGAGCAGGCGCGGGCC
TTCGAGGAGCTGGCGAGCGCGCTCGACATGAGCGTGCTGGTCGAGGTGCATGACGAGGCGGAACTCGACCGCGCGCTCGG
GCTGCAGGCCCGGCTGATCGGCATCAACAACCGCAATCTCAAGACGATGCAGACCGATATCGCGGTCTCCGAACGGCTGG
CCGGGCAGATTCCGCCGGAGCGCTTCGTGGTCGCGGAAAGCGGCATCCGCGACTATGACGACATCAAGCGGCTGAAGGCG
GTGGGGGTGCAGGGCATCCTGGTCGGCGAGAGCCTGATGCGGCAGGACGACATCGTCGCCGCGACGCGCCGGCTGCTCGG
GCTCGGGGCATGA

Upstream 100 bases:

>100_bases
CGCTCGATCGATGACGGTGCCGCGGCGGCGGCGCTGGAGCGGCTACGCCGCGCCGGCGCCGGGCCGCAAGCGGCGACAAC
CCGGGAAATGGCCTGATCCA

Downstream 100 bases:

>100_bases
GCCGCCTCACCCATATCGACGAGCGGGGGGCGGCGCGGATGGTCGACGTCTCCGGCAAGGCGGAGACGGCGCGGGAGGCG
ACCGCCGCCTGCCACGTGAC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MNDKIEHDVLKTICADKLAEVEAAKAETGLEEMRARAKDTPPPRGFARALMDAAASGRTGLIAEIKKASPSAGLIRADFN
PATIARAYQEGGAVCLSVLTDRKYFQGQPAHLQAAREAVDLPVLRKDFILDEWQIYESRAMGADCILLIMAALGDEQARA
FEELASALDMSVLVEVHDEAELDRALGLQARLIGINNRNLKTMQTDIAVSERLAGQIPPERFVVAESGIRDYDDIKRLKA
VGVQGILVGESLMRQDDIVAATRRLLGLGA

Sequences:

>Translated_270_residues
MNDKIEHDVLKTICADKLAEVEAAKAETGLEEMRARAKDTPPPRGFARALMDAAASGRTGLIAEIKKASPSAGLIRADFN
PATIARAYQEGGAVCLSVLTDRKYFQGQPAHLQAAREAVDLPVLRKDFILDEWQIYESRAMGADCILLIMAALGDEQARA
FEELASALDMSVLVEVHDEAELDRALGLQARLIGINNRNLKTMQTDIAVSERLAGQIPPERFVVAESGIRDYDDIKRLKA
VGVQGILVGESLMRQDDIVAATRRLLGLGA
>Mature_270_residues
MNDKIEHDVLKTICADKLAEVEAAKAETGLEEMRARAKDTPPPRGFARALMDAAASGRTGLIAEIKKASPSAGLIRADFN
PATIARAYQEGGAVCLSVLTDRKYFQGQPAHLQAAREAVDLPVLRKDFILDEWQIYESRAMGADCILLIMAALGDEQARA
FEELASALDMSVLVEVHDEAELDRALGLQARLIGINNRNLKTMQTDIAVSERLAGQIPPERFVVAESGIRDYDDIKRLKA
VGVQGILVGESLMRQDDIVAATRRLLGLGA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=258, Percent_Identity=42.2480620155039, Blast_Score=181, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322638, Length=226, Percent_Identity=37.6106194690265, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29335; Mature: 29335

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKIEHDVLKTICADKLAEVEAAKAETGLEEMRARAKDTPPPRGFARALMDAAASGRTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
LIAEIKKASPSAGLIRADFNPATIARAYQEGGAVCLSVLTDRKYFQGQPAHLQAAREAVD
HHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHC
LPVLRKDFILDEWQIYESRAMGADCILLIMAALGDEQARAFEELASALDMSVLVEVHDEA
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHEEEHHHH
ELDRALGLQARLIGINNRNLKTMQTDIAVSERLAGQIPPERFVVAESGIRDYDDIKRLKA
HHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCHHHHHHHHH
VGVQGILVGESLMRQDDIVAATRRLLGLGA
HCCCCEEHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNDKIEHDVLKTICADKLAEVEAAKAETGLEEMRARAKDTPPPRGFARALMDAAASGRTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
LIAEIKKASPSAGLIRADFNPATIARAYQEGGAVCLSVLTDRKYFQGQPAHLQAAREAVD
HHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHC
LPVLRKDFILDEWQIYESRAMGADCILLIMAALGDEQARAFEELASALDMSVLVEVHDEA
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHEEEHHHH
ELDRALGLQARLIGINNRNLKTMQTDIAVSERLAGQIPPERFVVAESGIRDYDDIKRLKA
HHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCHHHHHHHHH
VGVQGILVGESLMRQDDIVAATRRLLGLGA
HCCCCEEHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA