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The map label for this gene is trpGD [H]

Identifier: 148260236

GI number: 148260236

Start: 1371769

End: 1373403

Strand: Reverse

Name: trpGD [H]

Synonym: Acry_1233

Alternate gene names: 148260236

Gene position: 1373403-1371769 (Counterclockwise)

Preceding gene: 148260237

Following gene: 148260235

Centisome position: 40.52

GC content: 73.88

Gene sequence:

>1635_bases
ATGATCCTGCTGATCGACAACTACGACAGTTTCACCTTCAACCTCGTCCAGTTCTTCGGCGATCTCGGGGCGGAATGCGC
GGTGCACCGCAACGACCGGATCAGCGTGGAGGAGGCGCTGGCGATGCGGCCGGAGGCGATCGTGCTCTCGCCCGGGCCGT
GCACGCCGAACGAGGCGGGGATCTGCCTCGACCTCATCGCGGCGGCGGCCGGCAAGGTGCCGATTCTCGGCGTCTGCCTC
GGGCACCAGGCGATCGGCCAGGCCTTCGGCGGGCGGGTGGTGCGCGCGCCGGTGCCGATGCATGGCAAGATCTCGCCGAT
CCGGCACCAGGGCTCGGACGTGTTCGAGACGCTGCCCGACCCGTTCGAGGCGACGCGCTATCACTCGCTGATCGTGGAGC
GCGAGGGGCTGCCGGAGACGCTGATCCCCACCGCCTTCACCGAGGACGGGCTGATCATGGGGCTGCGGCACCGCGACCTG
CCGATCTTCGGCGTGCAGTTCCACCCCGAGAGCATCGCCACCGCGCACGGGCACACGCTGCTGCGCAACTTCCTCGGCAT
CGCCCGCGGGCGGAACCAGGGGCCGGGCGAGATCCTCGCCGATCTCAAGCCGGTGCTCGACCGGCTGGGGCGGGGCGAGA
CGATGTCCGAGGAGCTGGCCGAGGCGGCGTTCGGCGCGGTGATCGACGGCAAGGCGAATGACGCGCAGATCGCCGGGATG
CTGATGGCGATGCGGGTGCGGCGCGAGACGGTGGCGGAGCTGACCGGCGCGGTGCGGGCGATGCGCGCGCGGATGCGGCC
GATCGCGGCGCCGCCGGGGGCGATCGATGTCTGCGGCACCGGCGGCGACGGCGTGGGAACGCTCAACATCTCGACCGCGG
TGACCTTCGTGCTCGCCGGCGCCGGCGTGCCGGTGGCCAAGCACGGCAACCGCGCGCTCTCCTCGCGCGCCGGGGCGGCG
GATGTGCTGGCCGCGCTCGGCGTACCGGTGGAGCCGCCCTTCGAGAGCCTGGCGGCGATCCTGCGCGAGGCGGGCTGCGT
GTTCCTCTACGCGCCGCGCCACCATGCCGGGCTGCGCCACGCCGCCGCGGCGCGGATCGCGCTCGGCACCCGCACGATCT
TCAACCTGCTCGGGCCGCTCGCCAACCCGGCCTCGGTGAAGCGGCAGCTGGTGGGCGTGTTCGACCCCGCCTGGGCGCGG
CCGATGGCGGAGACGCTGGCCGGGCTCGGCACCGAGCGGGCGATGGTGGTGCATGGCCAGGGGCTGGACGAGCTGACCAT
CGCCGGGGAGAGCCATGTCGTCTCGCTCGAGGGCGGCCGGATCGTCGAGATGACGGTGAGCCCGGAGGATGCCGGGCTCG
CCCGCGCGCCGCTGGAGGCGATCATCGGCGGCGATGCCGCGCACAACGCCGCGGCGCTGCGCGACCTGCTCGCCGGCGCG
CCCGGCGCCTATCGCGACGCCGTGCTGCTGAACGCGGCGGCGGCGCTGATGGTGGCGGGACGGGCGGAAACCCTGCGCGA
GGGCGCGGCGCTGGCGGCCCGCTCGATCGATGACGGTGCCGCGGCGGCGGCGCTGGAGCGGCTACGCCGCGCCGGCGCCG
GGCCGCAAGCGGCGACAACCCGGGAAATGGCCTGA

Upstream 100 bases:

>100_bases
CCGATGCCGAGCTCGCCGAGAGCCACGCCAAGGCGCGCGCGCTGTTCCGCGCCGCCGAGGATGCCGGCCAGTACGTCACC
CCCAACGAGGCGCCGGCCCG

Downstream 100 bases:

>100_bases
TCCAATGAACGACAAGATCGAACACGACGTGCTGAAGACGATCTGCGCCGACAAGCTGGCCGAGGTGGAGGCGGCGAAGG
CGGAGACCGGGCTGGAGGAG

Product: bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: Glutamine amidotransferase; Anthranilate phosphoribosyltransferase [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MILLIDNYDSFTFNLVQFFGDLGAECAVHRNDRISVEEALAMRPEAIVLSPGPCTPNEAGICLDLIAAAAGKVPILGVCL
GHQAIGQAFGGRVVRAPVPMHGKISPIRHQGSDVFETLPDPFEATRYHSLIVEREGLPETLIPTAFTEDGLIMGLRHRDL
PIFGVQFHPESIATAHGHTLLRNFLGIARGRNQGPGEILADLKPVLDRLGRGETMSEELAEAAFGAVIDGKANDAQIAGM
LMAMRVRRETVAELTGAVRAMRARMRPIAAPPGAIDVCGTGGDGVGTLNISTAVTFVLAGAGVPVAKHGNRALSSRAGAA
DVLAALGVPVEPPFESLAAILREAGCVFLYAPRHHAGLRHAAAARIALGTRTIFNLLGPLANPASVKRQLVGVFDPAWAR
PMAETLAGLGTERAMVVHGQGLDELTIAGESHVVSLEGGRIVEMTVSPEDAGLARAPLEAIIGGDAAHNAAALRDLLAGA
PGAYRDAVLLNAAAALMVAGRAETLREGAALAARSIDDGAAAAALERLRRAGAGPQAATTREMA

Sequences:

>Translated_544_residues
MILLIDNYDSFTFNLVQFFGDLGAECAVHRNDRISVEEALAMRPEAIVLSPGPCTPNEAGICLDLIAAAAGKVPILGVCL
GHQAIGQAFGGRVVRAPVPMHGKISPIRHQGSDVFETLPDPFEATRYHSLIVEREGLPETLIPTAFTEDGLIMGLRHRDL
PIFGVQFHPESIATAHGHTLLRNFLGIARGRNQGPGEILADLKPVLDRLGRGETMSEELAEAAFGAVIDGKANDAQIAGM
LMAMRVRRETVAELTGAVRAMRARMRPIAAPPGAIDVCGTGGDGVGTLNISTAVTFVLAGAGVPVAKHGNRALSSRAGAA
DVLAALGVPVEPPFESLAAILREAGCVFLYAPRHHAGLRHAAAARIALGTRTIFNLLGPLANPASVKRQLVGVFDPAWAR
PMAETLAGLGTERAMVVHGQGLDELTIAGESHVVSLEGGRIVEMTVSPEDAGLARAPLEAIIGGDAAHNAAALRDLLAGA
PGAYRDAVLLNAAAALMVAGRAETLREGAALAARSIDDGAAAAALERLRRAGAGPQAATTREMA
>Mature_544_residues
MILLIDNYDSFTFNLVQFFGDLGAECAVHRNDRISVEEALAMRPEAIVLSPGPCTPNEAGICLDLIAAAAGKVPILGVCL
GHQAIGQAFGGRVVRAPVPMHGKISPIRHQGSDVFETLPDPFEATRYHSLIVEREGLPETLIPTAFTEDGLIMGLRHRDL
PIFGVQFHPESIATAHGHTLLRNFLGIARGRNQGPGEILADLKPVLDRLGRGETMSEELAEAAFGAVIDGKANDAQIAGM
LMAMRVRRETVAELTGAVRAMRARMRPIAAPPGAIDVCGTGGDGVGTLNISTAVTFVLAGAGVPVAKHGNRALSSRAGAA
DVLAALGVPVEPPFESLAAILREAGCVFLYAPRHHAGLRHAAAARIALGTRTIFNLLGPLANPASVKRQLVGVFDPAWAR
PMAETLAGLGTERAMVVHGQGLDELTIAGESHVVSLEGGRIVEMTVSPEDAGLARAPLEAIIGGDAAHNAAALRDLLAGA
PGAYRDAVLLNAAAALMVAGRAETLREGAALAARSIDDGAAAAALERLRRAGAGPQAATTREMA

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787517, Length=482, Percent_Identity=40.4564315352697, Blast_Score=326, Evalue=3e-90,
Organism=Escherichia coli, GI1789760, Length=185, Percent_Identity=60, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI1786215, Length=141, Percent_Identity=29.7872340425532, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322638, Length=190, Percent_Identity=45.2631578947368, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6320561, Length=326, Percent_Identity=28.2208588957055, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324361, Length=240, Percent_Identity=35.4166666666667, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005940
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase; PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3 [H]

EC number: =4.1.3.27; =2.4.2.18 [H]

Molecular weight: Translated: 56559; Mature: 56559

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLIDNYDSFTFNLVQFFGDLGAECAVHRNDRISVEEALAMRPEAIVLSPGPCTPNEAG
CEEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCCCEEEECCCCCCCCCCC
ICLDLIAAAAGKVPILGVCLGHQAIGQAFGGRVVRAPVPMHGKISPIRHQGSDVFETLPD
HHHHHHHHHCCCCCEEEEECCHHHHHHHHCCEEEECCCCCCCCCCHHHCCCCHHHHHCCC
PFEATRYHSLIVEREGLPETLIPTAFTEDGLIMGLRHRDLPIFGVQFHPESIATAHGHTL
CHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCHHHHHHHHHHH
LRNFLGIARGRNQGPGEILADLKPVLDRLGRGETMSEELAEAAFGAVIDGKANDAQIAGM
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEECCCCCCHHHHHH
LMAMRVRRETVAELTGAVRAMRARMRPIAAPPGAIDVCGTGGDGVGTLNISTAVTFVLAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEHHHHHHHHHHC
AGVPVAKHGNRALSSRAGAADVLAALGVPVEPPFESLAAILREAGCVFLYAPRHHAGLRH
CCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCHHH
AAAARIALGTRTIFNLLGPLANPASVKRQLVGVFDPAWARPMAETLAGLGTERAMVVHGQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHCCCCCCEEEEECC
GLDELTIAGESHVVSLEGGRIVEMTVSPEDAGLARAPLEAIIGGDAAHNAAALRDLLAGA
CCCCEEECCCCEEEEECCCEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
PGAYRDAVLLNAAAALMVAGRAETLREGAALAARSIDDGAAAAALERLRRAGAGPQAATT
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
REMA
CCCC
>Mature Secondary Structure
MILLIDNYDSFTFNLVQFFGDLGAECAVHRNDRISVEEALAMRPEAIVLSPGPCTPNEAG
CEEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCCCEEEECCCCCCCCCCC
ICLDLIAAAAGKVPILGVCLGHQAIGQAFGGRVVRAPVPMHGKISPIRHQGSDVFETLPD
HHHHHHHHHCCCCCEEEEECCHHHHHHHHCCEEEECCCCCCCCCCHHHCCCCHHHHHCCC
PFEATRYHSLIVEREGLPETLIPTAFTEDGLIMGLRHRDLPIFGVQFHPESIATAHGHTL
CHHHHHHHHHEEECCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCHHHHHHHHHHH
LRNFLGIARGRNQGPGEILADLKPVLDRLGRGETMSEELAEAAFGAVIDGKANDAQIAGM
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEECCCCCCHHHHHH
LMAMRVRRETVAELTGAVRAMRARMRPIAAPPGAIDVCGTGGDGVGTLNISTAVTFVLAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEHHHHHHHHHHC
AGVPVAKHGNRALSSRAGAADVLAALGVPVEPPFESLAAILREAGCVFLYAPRHHAGLRH
CCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCHHH
AAAARIALGTRTIFNLLGPLANPASVKRQLVGVFDPAWARPMAETLAGLGTERAMVVHGQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCHHHHHHHCCCCCCEEEEECC
GLDELTIAGESHVVSLEGGRIVEMTVSPEDAGLARAPLEAIIGGDAAHNAAALRDLLAGA
CCCCEEECCCCEEEEECCCEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCC
PGAYRDAVLLNAAAALMVAGRAETLREGAALAARSIDDGAAAAALERLRRAGAGPQAATT
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
REMA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7685830; 10360571; 7556082 [H]