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The map label for this gene is hmp [H]

Identifier: 148260011

GI number: 148260011

Start: 1111234

End: 1112325

Strand: Reverse

Name: hmp [H]

Synonym: Acry_1002

Alternate gene names: 148260011

Gene position: 1112325-1111234 (Counterclockwise)

Preceding gene: 148260012

Following gene: 148260010

Centisome position: 32.82

GC content: 68.77

Gene sequence:

>1092_bases
ATGAACATGACGCCGGCCGAGCGCTGCCGTGCCGCGCGCGACGGCAGCCTGTCCGTCTGGGACCCTGAGGTCGACGACGT
GCTGGTCTGCGTCGATGCGCGGCTGGAGACGCACGACGTGCGGACCTTCACCTTCGTCAGCCGCACGCCGTCGCGCTTCA
GCTACTGGCCGGGCCAGTTCCTCGTGTTCGACGTGCCGGTGGGCGGGGAGATCGTGCAGCGCTGCTACACGATCGCCTCC
AGCCCGACGCGGCCGGACCAGATCTCGATCACGGTGAAGCGCAAGCCGGGCGGCGCGGTTTCGCCCTGGCTGCACGACAA
TCTGCGGCCGGGGATGGAGATCCGCGCGATCGGGCCGCTCGGGGATTTCAGCTTCGTGGCGACGCCGGGAGAAAAATACC
TGTTCCTCTCGGGCGGTTCGGGAATCACGCCGCTGATGTCGATGACGCGGGCGCATCAGGACCTCGCACCGGATGCGGAC
ATCGTGTTCATCCATTTCGCGCGGACGCCGGAGGACATCATCTTCCGCGACGAGCTCGCGGTGATGGCGCGGCAGATGCC
GAACCTGCGGGTGATTCCGGTGTGCGAGGCGGATGGCGCCGGCGGGCGCTGGGGCGGGCCGCGCGGGCGGGTGACGCCGC
AGCTGCTCTCGCTGCTGGCGCCGGATTTCGCCGAGCGCTGGATCTTCAACTGCGGGCCGCCGGTCTACATGCAGGTGGTG
CGCGACGGGCTCGTCGGCCTCGGCTACGACATGCGGTATTACTACGAGGAGAGCTTCGATTTCGGCGTGCCGCCGCCGGT
CGAGGAGGTGCTGGCCGCGCAGGGGGCGGAAACCTTCGAGGTGACGTTCAGCAAGTCCGGCCGGACGATCGGGGTGGCGC
CGGGGCAGCATATCCTCGCCGCCGCGCGCGAGGCGGGCATGCGGCTGCCCTCGTCCTGCACCAAGGGCGTGTGCGGCACC
TGCAAGAGCAAGCTCGTCTCGGGACGGGTGGACATGAAGCACCAGGGCGGCATCCGCCAGCGCGAGATCGACCAGGACAT
GATCCTGATCTGCTGCTCGACGCCGCTGACCGATCTCGTGATCGAACGCTGA

Upstream 100 bases:

>100_bases
TGCCGGGGCCGTATTCGGCGGAAACCGAAGGCCAGGTCGAGGCTTTCGCCAACTGGTATGTCCGCCGCATGGCGGCGCAT
CTCGGGATCGAGCCGGCGCG

Downstream 100 bases:

>100_bases
TGCCGCGGCCGCTGAACCCCGCCGCGCTGTCGCATTTCGGCTTCCTGCTGCTGCCGAACTATTCGATGATCGCGGTGGCC
AATGCGATCGAGGCGCTGCG

Product: oxidoreductase FAD-binding subunit

Products: NA

Alternate protein names: Rieske-type oxygenase; RO [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNMTPAERCRAARDGSLSVWDPEVDDVLVCVDARLETHDVRTFTFVSRTPSRFSYWPGQFLVFDVPVGGEIVQRCYTIAS
SPTRPDQISITVKRKPGGAVSPWLHDNLRPGMEIRAIGPLGDFSFVATPGEKYLFLSGGSGITPLMSMTRAHQDLAPDAD
IVFIHFARTPEDIIFRDELAVMARQMPNLRVIPVCEADGAGGRWGGPRGRVTPQLLSLLAPDFAERWIFNCGPPVYMQVV
RDGLVGLGYDMRYYYEESFDFGVPPPVEEVLAAQGAETFEVTFSKSGRTIGVAPGQHILAAAREAGMRLPSSCTKGVCGT
CKSKLVSGRVDMKHQGGIRQREIDQDMILICCSTPLTDLVIER

Sequences:

>Translated_363_residues
MNMTPAERCRAARDGSLSVWDPEVDDVLVCVDARLETHDVRTFTFVSRTPSRFSYWPGQFLVFDVPVGGEIVQRCYTIAS
SPTRPDQISITVKRKPGGAVSPWLHDNLRPGMEIRAIGPLGDFSFVATPGEKYLFLSGGSGITPLMSMTRAHQDLAPDAD
IVFIHFARTPEDIIFRDELAVMARQMPNLRVIPVCEADGAGGRWGGPRGRVTPQLLSLLAPDFAERWIFNCGPPVYMQVV
RDGLVGLGYDMRYYYEESFDFGVPPPVEEVLAAQGAETFEVTFSKSGRTIGVAPGQHILAAAREAGMRLPSSCTKGVCGT
CKSKLVSGRVDMKHQGGIRQREIDQDMILICCSTPLTDLVIER
>Mature_363_residues
MNMTPAERCRAARDGSLSVWDPEVDDVLVCVDARLETHDVRTFTFVSRTPSRFSYWPGQFLVFDVPVGGEIVQRCYTIAS
SPTRPDQISITVKRKPGGAVSPWLHDNLRPGMEIRAIGPLGDFSFVATPGEKYLFLSGGSGITPLMSMTRAHQDLAPDAD
IVFIHFARTPEDIIFRDELAVMARQMPNLRVIPVCEADGAGGRWGGPRGRVTPQLLSLLAPDFAERWIFNCGPPVYMQVV
RDGLVGLGYDMRYYYEESFDFGVPPPVEEVLAAQGAETFEVTFSKSGRTIGVAPGQHILAAAREAGMRLPSSCTKGVCGT
CKSKLVSGRVDMKHQGGIRQREIDQDMILICCSTPLTDLVIER

Specific function: Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI49574502, Length=279, Percent_Identity=26.5232974910394, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787098, Length=328, Percent_Identity=31.7073170731707, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787658, Length=343, Percent_Identity=29.4460641399417, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788104, Length=321, Percent_Identity=24.9221183800623, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788903, Length=216, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323552, Length=198, Percent_Identity=28.2828282828283, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323510, Length=178, Percent_Identity=27.5280898876405, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 39928; Mature: 39928

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMTPAERCRAARDGSLSVWDPEVDDVLVCVDARLETHDVRTFTFVSRTPSRFSYWPGQF
CCCCHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCE
LVFDVPVGGEIVQRCYTIASSPTRPDQISITVKRKPGGAVSPWLHDNLRPGMEIRAIGPL
EEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHCCCCCCCEEEEECCC
GDFSFVATPGEKYLFLSGGSGITPLMSMTRAHQDLAPDADIVFIHFARTPEDIIFRDELA
CCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHEEHHHHH
VMARQMPNLRVIPVCEADGAGGRWGGPRGRVTPQLLSLLAPDFAERWIFNCGPPVYMQVV
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHCCCCHHHHHHH
RDGLVGLGYDMRYYYEESFDFGVPPPVEEVLAAQGAETFEVTFSKSGRTIGVAPGQHILA
HHCHHCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCEEEECCCHHHHH
AAREAGMRLPSSCTKGVCGTCKSKLVSGRVDMKHQGGIRQREIDQDMILICCSTPLTDLV
HHHHHCCCCCCHHHCCHHHHHHHHHHCCCCCCHHCCCCCHHHCCCCEEEEEECCCHHHHH
IER
CCC
>Mature Secondary Structure
MNMTPAERCRAARDGSLSVWDPEVDDVLVCVDARLETHDVRTFTFVSRTPSRFSYWPGQF
CCCCHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCE
LVFDVPVGGEIVQRCYTIASSPTRPDQISITVKRKPGGAVSPWLHDNLRPGMEIRAIGPL
EEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHCCCCCCCEEEEECCC
GDFSFVATPGEKYLFLSGGSGITPLMSMTRAHQDLAPDADIVFIHFARTPEDIIFRDELA
CCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHEEHHHHH
VMARQMPNLRVIPVCEADGAGGRWGGPRGRVTPQLLSLLAPDFAERWIFNCGPPVYMQVV
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHCCCCHHHHHHH
RDGLVGLGYDMRYYYEESFDFGVPPPVEEVLAAQGAETFEVTFSKSGRTIGVAPGQHILA
HHCHHCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCEEEECCCHHHHH
AAREAGMRLPSSCTKGVCGTCKSKLVSGRVDMKHQGGIRQREIDQDMILICCSTPLTDLV
HHHHHCCCCCCHHHCCHHHHHHHHHHCCCCCCHHCCCCCHHHCCCCEEEEEECCCHHHHH
IER
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]